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JOURNAL ARTICLE
A Dudek, W Sienkiewicz, E Lepiarczyk, J Kaleczyc
The trapezius muscle (TRAP) belongs to the scapulothoracic group of muscles, which play a crucial role in the integrity and strength of the upper limb, trunk, head, and neck movements and, thus, in maintaining balance. Combined retrograde tracing (using fluorescent tracer Fast Blue, FB) and double-labelling immunohistochemistry were applied to investigate the chemical coding of motoneurons projecting to the porcine TRAP. FB-positive (FB+) motoneurons supplying the cervical (c-TRAP) and thoracic part (th-TRAP) of the right (injected with the tracer) TRAP were located within the IX-th Rexed lamina in the ipsilateral ventral horn of the grey matter of the spinal medulla...
March 20, 2024: Polish Journal of Veterinary Sciences
#22
JOURNAL ARTICLE
Jing Wang, Zhenyu Yang, Xiuming He, Yeyang Wang, Dixin Luo, Wangyang Xu, Hongtao Zhang, Xiaozhong Zhou
Spinal facet joint osteoarthritis (FJOA) is an OA disease with pathogenesis and progression uncovered. Our present study was performed to elucidate the role of DNM3OS on spinal FJOA. In this study, spine facet joint tissue of patients were collected. In vitro and in vivo models were constructed with SW1353 cells and rats. Hematoxylin and eosin (HE) staining, Safranin O-fast Green, Alcian blue staining, and Tolueine blue O (TBO) staining were employed for histology analyses. Quantitative PCR, western blotting, and Immunofluorescence were performed to evaluate the expression of genes...
June 2024: Non-Coding RNA Research
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JOURNAL ARTICLE
Xiaolong Qiao, Linlin Li, Qiulian Liu, Yuanming Zhang, Guangting Han, Haoxi Ben, Haiguang Zhao, Wei Jiang
The traditional textile degumming process produces abundant wastewater, which contains a lot of monosaccharides and oligosaccharides. It is of great economic and environmental significance to utilize these carbohydrates in high value. In this study, high performance liquid chromatography (HPLC) was used to analyze the carbohydrate components in kenaf degumming wastewater, and then the production of C-dots using the wastewater was explored. The results showed that the types and content in the degumming wastewater were monosaccharides (glucose, xylose and arabinose) and oligosaccharides (dextran, xylan and araban)...
March 16, 2024: International Journal of Biological Macromolecules
#24
JOURNAL ARTICLE
Kentaro Fukuta, Dai-Ichiro Kato, Juri Maeda, Atsuhiro Tsuruta, Hirobumi Suzuki, Yukio Nagano, Hisao Tsukamoto, Kazuki Niwa, Makoto Terauchi, Atsushi Toyoda, Asao Fujiyama, Hideki Noguchi
The Genji firefly, Nipponoluciola cruciata, is an aquatic firefly endemic to Japan, inhabiting a wide area of the Japanese archipelago. The luminescence of fireflies is a scientifically interesting phenomenon, and many studies have evaluated this species in Japan. In this study, we sequenced the whole genome of male N. cruciata and constructed a high-quality genome assembly of 662 Mb with a BUSCO completeness of 99.1% in the genome mode. Using the detected set of 15,169 protein-coding genes, the genomic structures and genetic background of luminescence-related genes were also investigated...
April 1, 2024: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
#25
JOURNAL ARTICLE
Wei Wu, Yuhui Yang, Leilei Hu, Jiangkun Zhu, Yangyang Gao, Youhao Wei, Conghao Wu, Haitao Cai
With the progress of forgery and decryption, the traditional encryption technology is apparent not enough, which strongly requires the development of advanced multidimensional encryption strategies and technologies. Photo-stimuli responsive fluorescent materials are promising as candidate materials for advanced information encryption. Here, we have reported new photo-stimuli responsive materials by encapsulating photochromic molecules spiropyrans (SPs) into naphthalimide-functionalized silica aerogels. By introducing different modification groups (dimethylamino) into 1,8-naphthalimide, we obtained two kinds of silica aerogels that emit blue and green colors...
March 13, 2024: ACS Applied Materials & Interfaces
#26
JOURNAL ARTICLE
Yongjin Luo, Zhen Liu, Xiaoxia Hu
The study aims to search and identify differentially expressed genes (DEGs) in cervical cancer tissues as novel biomarkers to predict cervical cancer prognosis. The Cancer Genome Atlas (TCGA) data on gene expression profiles in cervical cancer were downloaded and analyzed using R software to identify DEGs in cervical cancer tissues. miRNAs targeted by differentially expressed long non-coding RNAs (DElncRNAs) and mRNAs targeted by microRNAs (miRNAs) were identified using the online miRcode, miRTarBase, TargetScan, and miRDB tools...
March 11, 2024: Reproductive Sciences
#27
JOURNAL ARTICLE
Christian Vaillancourt, Manya Charette, Soha Khorsand, Erica Shligold, Chelsea Lanos, Jennifer Dale-Tam, Alexandre Tran, Loree Boyle, Sylvie Aucoin, Jerry Maniate, Hilary Meggison, Michael Hartwick, Glenn Posner
OBJECTIVE: We sought to evaluate the impact of a COVID-19 Code Blue policy on in-hospital cardiac arrest (IHCA) processes of care, cardiopulmonary resuscitation (CPR) quality metrics, and survival to hospital discharge. METHODS: We completed a health record review of consecutive IHCA for which resuscitation was attempted. We report Utstein outcomes and CPR quality metrics 33 months before (July,2017-March,2020) and after (April,2020-December,2022) the implementation of a COVID-19 Code Blue policy requiring all team members to don personal protective equipment including gown, gloves, mask, and eye protection for all IHCA...
March 8, 2024: Resuscitation
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JOURNAL ARTICLE
Jacqueline M Soegaard Ballester, Sara P Ginzberg, Caitlin B Finn, Jesse Passman, Stephen P Miranda, Rachel Blue, Jacob Stein, Najjia N Mahmoud, Rachel R Kelz, Heather Wachtel
BACKGROUND: Federal regulations require a history and physical (H&P) update performed ≤30 days before a planned procedure. We evaluated the utility and burdens of H&P update visits by determining impact on operative management, suitability for telehealth, and visit time and travel burden. STUDY DESIGN: We identified H&P update visits performed in our health system during 2019 for 8 surgical specialties. As available, up to 50 visits per specialty were randomly selected...
March 8, 2024: Journal of the American College of Surgeons
#29
RANDOMIZED CONTROLLED TRIAL
Naoyuki Tominaga, Eiji Sadashima, Tomonori Aoki, Minoru Fujita, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori, Takashi Ikeya, Taiki Aoyama, Yoshinori Sato, Takaaki Kishino, Naoki Ishii, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Hiroki Sato, Sho Suzuki, Toshiaki Narasaka, Junnosuke Hayasaka, Tomohiro Funabiki, Yuzuru Kinjo, Akira Mizuki, Shu Kiyotoki, Tatsuya Mikami, Ryosuke Gushima, Hiroyuki Fujii, Yuta Fuyuno, Takuto Hikichi, Yosuke Toya, Kazuyuki Narimatsu, Noriaki Manabe, Koji Nagaike, Tetsu Kinjo, Yorinobu Sumida, Sadahiro Funakoshi, Kiyonori Kobayashi, Tamotsu Matsuhashi, Yuga Komaki, Kuniko Miki, Kazuhiro Watanabe, Mitsuru Kaise, Naoyoshi Nagata
The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and to develop a high-accuracy prediction tool. The analysis included 8254 cases of acute hematochezia patients who were admitted urgently based on the judgment of emergency physicians or gastroenterology consultants (from the CODE BLUE J-study). Patients were randomly assigned to a derivation cohort and a validation cohort in a 2:1 ratio using a random number table. Assuming that factors present at the time of admission are involved in mortality within 30 days of admission, and adding management factors during hospitalization to the factors at the time of admission for mortality within 1 year, prognostic factors were established...
March 4, 2024: Scientific Reports
#30
JOURNAL ARTICLE
Jianye Yang, Wenbin Hu, Jiaming Zhao
Homeobox A1 (HOXA1) is a protein coding gene involved in regulating immunity signaling. This study aims to explore the function and mechanism of HOXA1 in asthma. An asthma mouse model was established via ovalbumin (OVA) induction. Airway hyperresponsiveness was evaluated by the value of pause enhancement (Penh). Inflammatory cells in bronchoalveolar lavage fluid (BALF) were detected by Trypan blue and Wright staining. The pathological morphology of lung tissues was assessed by H&E staining. The IgE and inflammatory biomarkers (IL-1β, IL-6, IL-17, and TNF-α) in BALF and lung tissues were measured by ELISA...
2024: Critical Reviews in Immunology
#31
JOURNAL ARTICLE
Mahnoor Malik, Fatima Malik, Tehsin Fatma, Muhammad Qasim Hayat, Atif Jamal, Alvina Gul, Muhammad Faraz Bhatti
Penicillium expansum is an important phytopathogenic fungus that causes blue mold disease. In this study, the novel mitochondrial genome of P. expansum was sequenced, assembled, annotated, and compared with the previously published Penicillium mitogenomes. P. expansum mitogenome is composed of circular DNA molecules with a genome size of 25,496 bp. It encodes 16 protein-encoding genes (PCGs), two rRNA genes, and 25 tRNA genes. Comparative analysis with six other Penicillium species revealed that gene length, GC content, AT skew, and GC skew were variable among the core protein-coding genes...
February 26, 2024: Gene
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JOURNAL ARTICLE
Honglu Diao, Shuo Xiao, Tong Zhou, Taylor E Martin, Wendy T Watford, Xiaoqin Ye
The uterus is transiently receptive for embryo implantation. It remains to be understood why the uterus does not reject a semi-allogeneic embryo (to the biological mother) or an allogeneic embryo (to a surrogate) for implantation. To gain insights, we examined uterine early response genes approaching embryo attachment on day 3 post coitum (D3) at 22 hours when blue dye reaction, an indication of embryo attachment, had not manifested in mice. C57BL/6 pseudo-pregnant (control) and pregnant mouse uteri were collected on D3 at 22 hours for microarray analysis...
March 2024: Reproductive and developmental medicine
#33
JOURNAL ARTICLE
Tomonori Aoki, Eiji Sadashima, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga, Yoshinori Sato, Takaaki Kishino, Naoki Ishii, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Minoru Fujita, Hiroki Sato, Yoku Hayakawa, Mitsuhiro Fujishiro, Mitsuru Kaise, Naoyoshi Nagata
BACKGROUND: The rebleeding risks and outcomes of endoscopic treatment for acute lower gastrointestinal bleeding (ALGIB) may differ depending on the bleeding location, type, and etiology of stigmata of recent hemorrhage (SRH) but have yet to be fully investigated. We aimed to identify high risk endoscopic SRH and to propose an optimal endoscopic treatment strategy. METHODS: We retrospectively analyzed 2699 ALGIB patients with SRH at 49 hospitals (CODE BLUE-J Study), of whom 88...
February 14, 2024: Endoscopy
#34
JOURNAL ARTICLE
P Baldet, K Mori, G Decros, B Beauvoit, S Colombié, S Prigent, P Pétriacq, Y Gibon
Vital ascorbate is involved in numerous processes, in particular in response to abiotic but also biotic stresses whose frequency and amplitude increase with climate change. Ascorbate levels vary greatly depending on species, tissues or stages of development, but also in response to stress. Since its discovery, its biosynthetic pathway was intensely studied and it appeared that GDP-L-galactose phosphorylase (GGP) is by far the most controlling enzyme. Like other enzymes of this pathway, its expression is induced by various environmental but also developmental factors...
February 13, 2024: Journal of Experimental Botany
#35
JOURNAL ARTICLE
Caitlin M Gordon, Jason T Tan, Roxane R Carr
OBJECTIVES: This study aims to describe the effectiveness of low initial alprostadil dosages to maintain a patent ductus arteriosus (PDA) in infants with ductal-dependent congenital heart disease (DDCHD). Secondary objectives were to describe any adverse drug events, describe prescribing trends, describe ductus arteriosus diameter changes, and compare the safety and efficacy of very low and low initial alprostadil dosage regimens. METHODS: This retrospective observational cohort study at the British Columbia's Women's and Children's Hospital neonatal intensive care unit and pediatric intensive care unit examined neonates admitted with DDCHD who received alprostadil to maintain ductal patency...
2024: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
#36
JOURNAL ARTICLE
Amanda Jo Shigle, Kara Piechowski, Nicholas Sandoval, Amber Chiplinski, William Blake Hays
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: The benefits of pharmacists' involvement in medical emergencies are well established, but optimal methods of training pharmacists for emergency response are unknown...
February 2, 2024: American Journal of Health-system Pharmacy: AJHP
#37
Hager Barakizou, Selma Chaieb
Methemoglobinemia is due to oxidization of divalent ferro-iron of hemoglobin to ferri-iron of methemoglobin (MetHb) which is incapable of transferring oxygen to tissues. This disease may be acquired by intoxication with oxidizing agents or inherited with a mutation of CYB5R3, the gene coding for the methemoglobin reductase or cytochrome B5 reductase 3 responsible for the reduction of MetHb to hemoglobin. We report the case of 2 sisters aged respectively of 15 and 8 months. They were born to a second-degree consanguineous marriage with a history of precocious and unexplained deaths in 3 relatives...
2024: Clinical Medicine Insights. Pediatrics
#38
JOURNAL ARTICLE
Nicholas Smirnoff, Glen L Wheeler
Ascorbate (vitamin C) is one of the most abundant primary metabolites in plants. Its complex chemistry enables it to function as an antioxidant, free radical scavenger and as a reductant for iron and copper. Ascorbate biosynthesis occurs via the mannose/L-galactose pathway in green plants and the evidence for this pathway being the major route is reviewed. Ascorbate accumulation is leaves is responsive to light, reflecting various roles in photoprotection. GDP-L-galactose phosphorylase (GGP) is the first dedicated step in the pathway and is important in controlling ascorbate synthesis...
February 1, 2024: Journal of Experimental Botany
#39
JOURNAL ARTICLE
Yujie Wu, Minghui Zhao, Haoyun Deng, Tian Wang, Yumeng Xin, Weifeng Dai, Jiancao Huang, Tingting Zhou, Xiaowen Sun, Ning Liu, Dajun Xing
The coding privilege of end-spectral hues (red and blue) in the early visual cortex has been reported in primates. However, the origin of such bias remains unclear. Here, we provide a complete picture of the end-spectral bias in visual system by measuring fMRI signals and spiking activities in macaques. The correlated end-spectral biases between the LGN and V1 suggest a subcortical source for asymmetric coding. Along the ventral pathway from V1 to V4, red bias against green peaked in V1 and then declined, whereas blue bias against yellow showed an increasing trend...
January 15, 2024: Nature Communications
#40
JOURNAL ARTICLE
Mina Zarei, Mohammad Hossein Morowvat
BACKGROUND: Cancer is among the leading causes of death worldwide, imposing high costs on the health systems of all societies. Extensive biological studies are required to discover appropriate therapies. Escherichia coli has long been regarded as one of the main biotechnological bio-factories to produce recombinant protein-based therapeutics. In the present study, five strains of E. coli were compared to achieve the maximum production of a previously designed recombinant immunotoxin-carrying MAP30 toxin against VEGF-overexpressed cancer cells in a benchtop bioreactor...
2024: Recent Patents on Biotechnology
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