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Andrew A Fanous, Sabareesh K Natarajan, Patrick K Jowdy, Travis M Dumont, Maxim Mokin, Jihnhee Yu, Adam Goldstein, Michael M Wach, James L Budny, L Nelson Hopkins, Kenneth V Snyder, Adnan H Siddiqui, Elad I Levy
No abstract text is available yet for this article.
November 2016: Neurosurgery
Travis J Wilder, William G Williams
No abstract text is available yet for this article.
November 2016: Journal of Thoracic and Cardiovascular Surgery
David J Tennent, Christina M Hylden, Anthony E Johnson, Travis C Burns, Jason M Wilken, Johnny G Owens
INTRODUCTION: Quadriceps strength after arthroscopic knee procedures is frequently diminished several years postoperation. Blood flow restriction (BFR) training uses partial venous occlusion while performing submaximal exercise to induce muscle hypertrophy and strength improvements. The purpose of this study was to evaluate BFR as a postoperative therapeutic intervention after knee arthroscopy. METHODS: A randomized controlled pilot study comparing physical therapy with and without BFR after knee arthroscopy was conducted...
October 5, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Mark Xavier Cicero, Travis Whitfill, Frank Overly, Janette Baird, Barbara Walsh, Jorge Yarzebski, Antonio Riera, Kathleen Adelgais, Garth D Meckler, Carl Baum, David Christopher Cone, Marc Auerbach
OBJECTIVE: Paramedics and emergency medical technicians (EMTs) triage pediatric disaster victims infrequently. The objective of this study was to measure the effect of a multiple-patient, multiple-simulation curriculum on accuracy of pediatric disaster triage (PDT). METHODS: Paramedics, paramedic students, and EMTs from three sites were enrolled. Triage accuracy was measured three times (Time 0, Time 1 [two weeks later], and Time 2 [6 months later]) during a disaster simulation, in which high and low fidelity manikins and actors portrayed 10 victims...
October 17, 2016: Prehospital Emergency Care
Adam N Wallace, Sebastian R McWilliams, Sarah E Connolly, John S Symanski, Devin Vaswani, Anderanik Tomasian, Ross Vyhmeister, Ashley M Lee, Thomas P Madaelil, Travis J Hillen, Jack W Jennings
PURPOSE: To evaluate the safety and effectiveness of cryoablation of musculoskeletal metastases in terms of achieving pain palliation and local tumor control. MATERIALS AND METHODS: A retrospective review was performed of 92 musculoskeletal metastases in 56 patients treated with percutaneous image-guided cryoablation. Mean age of the cohort was 53.9 y ± 15.1, and cohort included 48% (27/56) men. Median tumor volume was 13.0 cm(3) (range, 0.5-577.2 cm(3)). Indications for treatment included pain palliation (41%; 38/92), local tumor control (15%; 14/92), or both (43%; 40/92)...
October 13, 2016: Journal of Vascular and Interventional Radiology: JVIR
J Travis Hunsucker, Kelli Z Hunsucker, Harrison Gardner, Geoffrey Swain
The role of hydrodynamic wall shear stresses on the development of the fouling community structure and resulting frictional drag were examined using a commercially available fouling release coating. Immersed test panels were exposed to three different hydrodynamic treatments, one static and two dynamic (corresponding to an estimated wall shear stress of 7.0  and 25.5 Pa). The drag of the panels was measured in a hydrodynamic test chamber at discrete time intervals over 35 days. The fouling community composition on the static panels was significantly different from the organisms observed on the dynamic panels...
November 2016: Biofouling
Travis C Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth T Gammon, Frederick F Lang, Amy B Heimberger, Pratip K Bhattacharya
This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved...
November 2016: Magnetic Resonance Imaging Clinics of North America
Amy E Taylor, Richard M Martin, Milan S Geybels, Janet L Stanford, Irene Shui, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Nora Pashayan, Kay-Tee Khaw, William Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Jenny Donovan, Marcus R Munafò
Coffee consumption has been shown in some studies to reduce the risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian randomisation analysis to investigate the causal effects of coffee consumption on prostate cancer risk and progression. We used two genetic variants robustly associated with caffeine intake (rs4410790 and rs2472297) as proxies for coffee consumption in a sample of 46,687 men of European ancestry from 25 studies in the PRACTICAL consortium...
October 14, 2016: International Journal of Cancer. Journal International du Cancer
Kyuichi Kadota, Camelia S Sima, Maria E Arcila, Cyrus Hedvat, Mark G Kris, David R Jones, Prasad S Adusumilli, William D Travis
The potential clinical impact of KRAS and epidermal growth factor receptor (EGFR) mutations has been investigated in lung adenocarcinomas; however, their prognostic value remains controversial. In our study, we sought to investigate the prognostic significance of driver mutations using a large cohort of early-stage lung adenocarcinomas. We reviewed patients with pathologic early-stage, lymph node-negative, solitary lung adenocarcinoma who had undergone surgical resection (1995 to 2005; stage I/II=463/19). Tumors were classified according to the IASLC/ATS/ERS classification and genotyped by Sequenom MassARRAY system and polymerase chain reaction-based assays...
October 12, 2016: American Journal of Surgical Pathology
Stanley M Kozakowski, Alexandra Travis, Ashley Bentley, Gerald Fetter
This is the 35th national study conducted by the American Academy of Family Physicians (AAFP) that reports retrospectively the percentage of graduates from MD-granting and DO-granting medical schools who entered Accreditation Council for Graduate Medical Education (ACGME)-accredited family medicine residency programs as first-year residents. Approximately 8.7% of the 18,929 students graduating from US MD-granting medical schools and 15.5% of the 5,314 students graduating from DO-granting medical schools between July 2014 and June 2015 entered an ACGME family medicine residency in 2015...
October 2016: Family Medicine
Zahraa Al-Hilli, Veljko Strajina, Travis J McKenzie, Geoffrey B Thompson, David R Farley, M Regina Castro, Alicia Algeciras-Schimnich, Melanie L Richards
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently associated with cervical lymph node metastases. Guidelines recommend performing ultrasound-guided fine-needle aspiration cytology (FNAC) for suspicious nodes to guide management. No specific recommendations are available for the use of FNA thyroglobulin assay (FNA-Tg). This study investigated the diagnostic value of performing FNAC and FNA-Tg. METHODS: Patient demographics, preoperative investigations, surgery, and lymph node pathology were collected for patients with PTC who underwent lateral neck lymphadenectomy and central compartment reexploration from January 2000 to July 2015...
October 13, 2016: Annals of Surgical Oncology
J Tyler Youngquist, Travis C Korosh, Brian F Pfleger
Free fatty acids (FFA) are an attractive platform chemical that serves as a functional intermediate in metabolic pathways for producing oleochemicals. Many groups have established strains of Escherichia coli capable of producing various chain-length mixtures of FFA by heterologous expression of acyl-ACP thioesterases. For example, high levels of dodecanoic acid are produced by an E. coli strain expressing the Umbellularia californica FatB2 thioesterase, BTE. Prior studies achieved high dodecanoic acid yields and productivities under phosphate-limiting media conditions...
October 13, 2016: Journal of Industrial Microbiology & Biotechnology
Dene R Littler, Hayley E Bullen, Katherine L Harvey, Travis Beddoe, Brendan S Crabb, Jamie Rossjohn, Paul R Gilson
The ubiquitous second messenger cAMP mediates signal transduction processes in the malarial parasite that regulate host erythrocyte invasion and the proliferation of merozoites. In Plasmodium falciparum the central receptor for cAMP is the single regulatory subunit (R) of Protein kinase A (PKA). To aid the development of compounds that can selectively dysregulate parasite PKA signalling we solved the structure of the PKA regulatory subunit in complex with cAMP and a related analog that displays antimalarial activity: Sp-2Cl-cAMPS...
October 13, 2016: Journal of Biological Chemistry
Carrie E McCurdy, Simon Schenk, Byron Hetrick, Julie Houck, Brian G Drew, Spencer Kaye, Melanie Lashbrook, Bryan C Bergman, Diana L Takahashi, Tyler A Dean, Travis Nemkov, Ilya Gertsman, Kirk C Hansen, Andrew Philp, Andrea L Hevener, Adam J Chicco, Kjersti M Aagaard, Kevin L Grove, Jacob E Friedman
Maternal obesity is proposed to alter the programming of metabolic systems in the offspring, increasing the risk for developing metabolic diseases; however, the cellular mechanisms remain poorly understood. Here, we used a nonhuman primate model to examine the impact of a maternal Western-style diet (WSD) alone, or in combination with obesity (Ob/WSD), on fetal skeletal muscle metabolism studied in the early third trimester. We find that fetal muscle responds to Ob/WSD by upregulating fatty acid metabolism, mitochondrial complex activity, and metabolic switches (CPT-1, PDK4) that promote lipid utilization over glucose oxidation...
October 6, 2016: JCI Insight
Jason M Schon, Brady T Williams, Melanie B Venderley, Grant J Dornan, Jonathon D Backus, Travis Lee Turnbull, Robert F LaPrade, Thomas O Clanton
BACKGROUND: Historically, syndesmosis injuries have been repaired with screw fixation; however, some suggest that suture-button constructs may provide a more accurate anatomic and physiologic reduction. The purpose of this study was to compare changes in the volume of the syndesmotic space following screw or suture-button fixation using a preinjury and postoperative 3-D computed tomography (CT) model. The null hypothesis was that no difference would be observed among repair techniques...
October 12, 2016: Foot & Ankle International
Holly A Rogers, Travis S Schmidt, Brittanie L Dabney, Michelle L Hladik, Barbara J Mahler, Peter C Van Metre
Direct and indirect ecological effects of the widely used insecticide bifenthrin on stream ecosystems are largely unknown. To investigate such effects, a manipulative experiment was conducted in stream mesocosms that were colonized by aquatic insect communities and exposed to bifenthrin-contaminated sediment; implications for natural streams were interpreted through comparison of mesocosm results to a survey of 100 Midwestern streams, USA. In the mesocosm experiment, direct effects of bifenthrin exposure included reduced larval macroinvertebrate abundance, richness, and biomass at concentrations (EC50's ranged from 197...
October 12, 2016: Environmental Science & Technology
Shan Yu, Aaron D Pearson, Reyna K V Lim, David T Rodgers, Sijia Li, Holly B Parker, Meredith Weglarz, Eric N Hampton, Michael J Bollong, Jiayin Shen, Claudio Zambaldo, Danling Wang, Ashley K Woods, Timothy M Wright, Peter G Schultz, Stephanie A Kazane, Travis S Young, Matthew S Tremblay
Phosphodiesterase 4 (PDE4) inhibitors are approved for the treatment of some moderate to severe inflammatory conditions. However, dose-limiting side effects in the central nervous system and gastrointestinal tract, including nausea, emesis, headache, and diarrhea, have impeded the broader therapeutic application of PDE4 inhibitors. We sought to exploit the wealth of validation surrounding PDE4 inhibition by improving the therapeutic index through generation of an antibody-drug conjugate (ADC) that selectively targets immune cells through the CD11a antigen...
October 12, 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
Christoph Meinert, Karsten Schrobback, Peter A Levett, Cameron Lutton, Robert L Sah, Travis J Klein
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the tissue is mechanically loaded. Here, we developed a cytocompatible, bilayered hydrogel system that permits control of surface frictional properties without affecting other bulk physicochemical characteristics such as compressive modulus, mass swelling ratio, and water content...
October 8, 2016: Acta Biomaterialia
Jing Zhang, Xiaohong Song, Marella J Ma, Li Xiao, Tsuyoshi Kenri, Hongmei Sun, Travis Ptacek, Shaoli Li, Ken B Waites, T Prescott Atkinson, Keigo Shibayama, Kevin Dybvig, Yanmei Feng
AIM: To characterize inter- and intra-strain variability of variable-number tandem repeats (VNTRs) in Mycoplasma pneumoniae to determine the optimal multilocus VNTR analysis scheme for improved strain typing. METHODS: Whole genome assemblies and next-generation sequencing data from diverse M. pneumoniae isolates were used to characterize VNTRs and their variability, and to compare the strain discriminability of new VNTR and existing markers. RESULTS: We identified 13 VNTRs including five reported previously...
October 12, 2016: Future Microbiology
Travis L Sunderland, John F Berry
The first set of five heterobimetallic MM'(form)4 (form = formamidinate) complexes has been successfully synthesized containing a BiRh core. The Bi-Rh bond distances lie between 2.5196(6) and 2.572[2] Å, consistent with Bi-Rh single bonds. All complexes have rich electrochemistry, with the [BiRh]4+/5+ redox couples spanning ~ 700 mV and showing a strong correlation to remote ligand substitution. Visible spectroscopy shows two features for complexes 1 - 5 at ~ 459 and ~ 551 nm, unique to BiRh paddlewheel complexes that are attributed to LMCT bands into the Bi-Rh * orbital...
October 11, 2016: Chemistry: a European Journal
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