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Cox Maze

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https://www.readbyqxmd.com/read/29777366/is-ganglionated-plexus-ablation-effective-for-treating-atrial-fibrillation
#1
Michiko Watanabe, Hiroki Kohno, Yusuke Kondo, Hideki Ueda, Keiichi Ishida, Yusaku Tamura, Shinichiro Abe, Yasunori Sato, Yoshio Kobayashi, Goro Matsumiya
PURPOSE: Very few studies have investigated the efficacy of ganglionated plexus ablation during the conventional maze procedure. In this study, we sought to evaluate its additive effect in reducing recurrent atrial fibrillation after concomitant maze surgery. METHODS: A retrospective study was conducted of 79 patients who underwent Cox maze IV concomitantly with open-heart surgery with (GP group) or without (Maze group) ganglionated plexus mapping. All active ganglionated plexuses were ablated...
May 18, 2018: Surgery Today
https://www.readbyqxmd.com/read/29775722/inflammatory-and-oxidative-mechanisms-potentiate-bifenthrin-induced-neurological-alterations-and-anxiety-like-behavior-in-adult-rats
#2
Brahim Gargouri, Harsharan S Bhatia, Michèle Bouchard, Bernd L Fiebich, Hamadi Fetoui
Bifenthrin (BF) is a synthetic pyrethroid pesticide widely used in several countries to manage insect pests on diverse agricultural crops. Growing evidence indicates that BF exposure is associated with an increased risk of developing neurodegenerative disorders. However, the mechanisms by which BF induces neurological and anxiety alterations in the frontal cortex and striatum are not well known. The present in vivo study was carried out to determine whether reactive oxygen species (ROS)-mediated oxidative stress (OS) and neuroinflammation are involved in such alterations...
May 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29617931/robotic-mitral-valve-replacements-with-bioprosthetic-valves-in-52-patients-experience-from-a-tertiary-referral-hospital
#3
Chia-Cheng Kuo, Hsiao-Huang Chang, Chung-Hsi Hsing, Hiong-Ping Hii, Nan-Chun Wu, Chin-Ming Hsu, Chun-I Chen, Bor-Chih Cheng
OBJECTIVES: Robotic mitral valve replacement (MVR) emerged in the late 1990s as an alternative approach to conventional sternotomy. With the increased use of bioprosthetic valves worldwide and strong patient desire for minimally invasive procedures, the safety and feasibility of robotic MVRs with bioprosthetic valves require investigation. METHODS: Between January 2013 and May 2017, 52 consecutive patients underwent robotic MVRs using the da Vinci Si surgical system (Intuitive Surgical Inc...
March 30, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29590383/the-cox-maze-iv-procedure-in-its-second-decade-still-the-gold-standard
#4
Chawannuch Ruaengsri, Matthew R Schill, Ali J Khiabani, Richard B Schuessler, Spencer J Melby, Ralph J Damiano
Atrial fibrillation (AF) is the most common cardiac arrhythmia and the treatment options include medical treatment and catheter-based or surgical interventions. AF is a major cause of stroke, and its prevalence is increasing. The surgical treatment of AF has been revolutionized over the past 2 decades through surgical innovation and improvements in endoscopic imaging, ablation technology and surgical instrumentation. The Cox-maze (CM) procedure, which was developed by James Cox and introduced clinically in 1987, is a procedure in which multiple incisions are created in both the left and the right atria to eliminate AF while allowing the sinus impulse to reach the atrioventricular node...
April 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29582396/the-effects-of-non-selective-dopamine-receptor-activation-by-apomorphine-in-the-mouse-hippocampus
#5
Luis Enrique Arroyo-García, Rubén Antonio Vázquez-Roque, Alfonso Díaz, Samuel Treviño, Fidel De La Cruz, Gonzalo Flores, Antonio Rodríguez-Moreno
Apomorphine is a dopamine receptor agonist that activates D1 -D5 dopamine receptors and that is used to treat Parkinson's disease (PD). However, the effect of apomorphine on non-motor activity has been poorly studied, and likewise, the effects of dopaminergic activation in brain areas that do not fulfill motor functions are unclear. The aim of this study was to determine how dopamine receptor activation affects behavior, as well as plasticity, morphology, and oxidative stress in the hippocampus. Adult mice were chronically administered apomorphine (1 mg/kg for 15 days), and the effects on memory and learning, synaptic plasticity, dendritic length, inflammatory responses, and oxidative stress were evaluated...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29560440/chronic-voluntary-oral-methamphetamine-induces-deficits-in-spatial-learning-and-hippocampal-protein-kinase-mzeta-with-enhanced-astrogliosis-and-cyclooxygenase-2-levels
#6
Jorge A Avila, Roseanna M Zanca, Denis Shor, Nicholas Paleologos, Amber A Alliger, Maria E Figueiredo-Pereira, Peter A Serrano
Methamphetamine (MA) is an addictive drug with neurotoxic effects on the brain producing cognitive impairment and increasing the risk for neurodegenerative disease. Research has focused largely on examining the neurochemical and behavioral deficits induced by injecting relatively high doses of MA [30 mg/kg of body weight (bw)] identifying the upper limits of MA-induced neurotoxicity. Accordingly, we have developed an appetitive mouse model of voluntary oral MA administration (VOMA) based on the consumption of a palatable sweetened oatmeal mash containing a known amount of MA...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29505831/continuous-manganese-delivery-via-osmotic-pumps-for-manganese-enhanced-mouse-mri-does-not-impair-spatial-learning-but-leads-to-skin-ulceration
#7
Dulcie A Vousden, Elizabeth Cox, Rylan Allemang-Grand, Christine Laliberté, Lily R Qiu, Zsuzsa Lindenmaier, Brian J Nieman, Jason P Lerch
Manganese-enhanced magnetic resonance imaging (MEMRI) is a widely used technique in rodent neuroimaging studies. Traditionally, Mn2+ is delivered to animals via a systemic injection; however, this can lead to toxic effects at high doses. Recent studies have shown that subcutaneously implanted mini-osmotic pumps can be used to continuously deliver manganese chloride (MnCl2 ), and that they produce satisfactory contrast while circumventing many of the toxic side effects. However, neither the time-course of signal enhancement nor the effect of continuous Mn2+ delivery on behaviour, particularly learning and memory, have been well-characterized...
June 2018: NeuroImage
https://www.readbyqxmd.com/read/29487681/surgical-epicardial-left-atrial-appendage-closure-a-true-alternative
#8
Sacha Salzberg, Maximillian Emmert
Left atrial appendage closure was originally described by Madden in 1949 who was the first to perform appendix amputation. This was a very invasive procedure with poor outcome, but preformed for stroke prevention. Much later, it was James Cox whom described the Cox-Maze procedure, which included multiple incisions to create a maze like pathway for the electrical impulse to go undisturbed from the sinus node down to the atrio-ventricular node. Since then cardiac surgeons stopped focusing on the left atrial appendage and went on about seemingly more important things...
December 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29472564/inhibitory-modulation-of-cytochrome-c-oxidase-activity-with-specific-near-infrared-light-wavelengths-attenuates-brain-ischemia-reperfusion-injury
#9
Thomas H Sanderson, Joseph M Wider, Icksoo Lee, Christian A Reynolds, Jenney Liu, Bradley Lepore, Reneé Tousignant, Melissa J Bukowski, Hollie Johnston, Alemu Fite, Sarita Raghunayakula, John Kamholz, Lawrence I Grossman, Karin Przyklenk, Maik Hüttemann
The interaction of light with biological tissue has been successfully utilized for multiple therapeutic purposes. Previous studies have suggested that near infrared light (NIR) enhances the activity of mitochondria by increasing cytochrome c oxidase (COX) activity, which we confirmed for 810 nm NIR. In contrast, scanning the NIR spectrum between 700 nm and 1000 nm revealed two NIR wavelengths (750 nm and 950 nm) that reduced the activity of isolated COX. COX-inhibitory wavelengths reduced mitochondrial respiration, reduced the mitochondrial membrane potential (ΔΨm ), attenuated mitochondrial superoxide production, and attenuated neuronal death following oxygen glucose deprivation, whereas NIR that activates COX provided no benefit...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29410135/risk-factors-of-recurrence-of-atrial-fibrillation-af-after-af-surgery-in-patients-with-af-and-mitral-valve-disease
#10
Yosuke Ishii, Shun-Ichiro Sakamoto, Yasuo Miyagi, Yasuhiro Kawase, Toshiaki Otsuka, Takashi Nitta
The purpose of this study was to determine the 22-year experience of the relationship between preoperative left atrial diameter (LAD) and atrial fibrillation (AF) recurrence after AF surgery. Between November 1993 and April 2015, 244 patients underwent AF surgery concomitant with mitral valve surgery, and were completely followed up in our institute. The full-maze procedure was performed in 231 patients and pulmonary vein isolation in 13. Three quartiles divided the list of sorted LAD data into 4 groups: group Q1: LAD = 40...
February 2, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29408999/hippocampal-mutant-app-and-amyloid-beta-induced-cognitive-decline-dendritic-spine-loss-defective-autophagy-mitophagy-and-mitochondrial-abnormalities-in-a-mouse-model-of-alzheimer-s-disease
#11
Maria Manczak, Ramesh Kandimalla, Xiangling Yin, P Hemachandra Reddy
The purpose of our study was to determine the toxic effects of hippocampal mutant APP and amyloid beta (Aβ) in 12-month-old APP transgenic mice. Using rotarod and Morris water maze tests, immunoblotting and immunofluorescence, Golgi-cox staining and transmission electron microscopy, we assessed cognitive behavior, protein levels of synaptic, autophagy, mitophagy, mitochondrial dynamics, biogenesis, dendritic protein MAP2 and quantified dendritic spines and mitochondrial number and length in 12-month-old APP mice that express Swedish mutation...
April 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29396769/right-minithoracotomy-versus-conventional-median-sternotomy-for-patients-undergoing-mitral-valve-surgery-and-cox-maze-iv-ablation-with-entirely-bipolar-radiofrequency-clamp
#12
Zhaolei Jiang, Min Tang, Nan Ma, Hao Liu, Fangbao Ding, Chunrong Bao, Ju Mei
Cox-maze IV ablation by bipolar radiofrequency clamp was considered to be only performed through median sternotomy (MS), but impossible through right minithoracotomy (RM). Now, we developed a novel technique of performing Cox-maze IV ablation entirely by bipolar clamp through RM. To compare the outcomes of RM or MS for patients undergoing mitral valve surgery and concomitant Cox-maze IV ablation with entirely bipolar clamp. All 152 patients underwent mitral valve surgery and concomitant Cox-maze IV ablation with bipolar clamp through RM (n = 69) or MS (n = 83) were analyzed for outcome differences...
February 2, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29327638/hybrid-and-surgical-procedures-for-the-treatment-of-persistent-and-longstanding-persistent-atrial-fibrillation
#13
Jose M Sanchez, Ghannam Al-Dosari, Sherman Chu, Ramin Beygui, Tobias Deuse, Nitish Badhwar, Randall J Lee
Atrial fibrillation (AF) is the most common cardiac arrhythmia. The incidence of AF increases with age and is associated with increased stroke, heart failure and mortality. Persistent and long standing persistent AF is difficult to treat and often refractory to medical therapy and catheter ablation. Areas covered: This article reviews the historical development of the surgical Cox-MAZE procedure and current hybrid and minimally invasive surgical approaches for the treatment of persistent and long standing persistent AF...
February 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29323756/juvenile-taiep-rats-have-shorter-dendritic-trees-in-the-dorsal-field-of-the-hippocampus-without-spatial-learning-disabilities
#14
Adriana B Silva-Gómez, Dolores A Bravo-Duran, Jose R Eguibar, Carmen Cortes
Myelin mutant taiep rats show a progressive demyelination in the central nervous system due to an abnormal accumulation of microtubules in the cytoplasm and the processes on their oligodendrocytes. Demyelination is associated with electrophysiological alterations and the mutant had a progressive astrocytosis. The illness is associated with change in cytokine levels and in the expression of different nitric oxide synthase and concomitantly lipoperoxidation in several areas of the brain. However, until now there has been no detailed anatomical analysis of neurons in this mutant...
January 11, 2018: Synapse
https://www.readbyqxmd.com/read/29312724/long-term-results-of-radiofrequency-maze-procedure-for-persistent-atrial-fibrillation-with-concomitant-mitral-surgery
#15
Chia-Chen Wu, Jen-Ping Chang, Mien-Cheng Chen, Cheng-I Cheng, Wen-Jung Chung
Background: The radiofrequency (RF) maze procedure can effectively restore sinus rhythm in most patients with persistent atrial fibrillation (AF) and mitral disease. However, long-term results and predictors for late AF recurrence are still under investigation. Methods: From December 1995 to November 2011, 207 consecutive patients with persistent AF and mitral disease underwent RF maze procedure and concomitant mitral surgery. The mean age was 54±12.4 year-old...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29274913/oral-anticoagulation-may-not-be-necessary-for-patients-discharged-in-sinus-rhythm-after-the-cox-maze-iv-procedure
#16
Takashi Murashita, J Scott Rankin, Lawrence M Wei, Harold G Roberts, Mohamad A Alkhouli, Vinay Badhwar
OBJECTIVES: Oral anticoagulants have inherent risks. In the absence of clear evidence, anticoagulant use after surgical ablation for atrial fibrillation remains variable. This study examined patient outcomes with and without oral anticoagulants after successful surgical ablation. METHODS: From October 2011 to April 2016, 239 consecutive patients underwent biatrial Cox Maze IV operations for persistent atrial fibrillation. All patients received endocardial left atrial appendage obliteration...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29250276/comparison-of-the-efficancy-and-complication-rates-of-the-hybrid-maze-complete-cox-maze-and-catheter-ablation-in-the-treatment-of-atrial-fibrillation
#17
Ivo K Genev, Lindsey A Tompkins, Manorama M Khare, Farhad Farokhi
Introduction: Atrial fibrillation is the most common cardiac arrhythmia in the United States. It has been associated with a reduction in patient quality of life and more serious complications such as stroke and heart failure. The aim of this study was to compare the efficacy of commonly performed invasive procedures in keeping patients in normal sinus rhythm. Methods and Results: A retrospective chart review was performed on all patients who underwent primary radiofrequency catheter ablation, the complete Cox-maze, or the hybrid maze at OSF Saint Anthony Medical Center between January 2010 and December 2013 (n=140)...
February 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29248960/predictors-of-the-need-for-pacemaker-implantation-after-the-cox-maze-iv-procedure-for-atrial-fibrillation
#18
Naoki Masaki, Shunsuke Kawamoto, Naotaka Motoyoshi, Osamu Adachi, Kiichiro Kumagai, Satoshi Kawatsu, Yukihiro Hayatsu, Shintaro Katahira, Katsuhiro Hosoyama, Masatoshi Akiyama, Yoshikatsu Saiki
PURPOSE: The Cox maze IV (CMIV) procedure is being used increasingly frequently for surgical ablation of atrial fibrillation (AF). This study aimed to identify the risk factors of the need for postoperative pacemaker implantation (PMI) after CMIV. METHODS: Preoperative, intraoperative, and postoperative data were retrospectively collected from 67 consecutive patients who underwent CMIV at our institution; 7 (10.4%) required PMI (as a treatment of brady AF or sick sinus syndrome)...
December 16, 2017: Surgery Today
https://www.readbyqxmd.com/read/29246544/long-term-outcome-following-concomitant-mitral-valve-surgery-and-cox-maze-procedure-for-atrial-fibrillation
#19
Niv Ad, Sari D Holmes, Paul S Massimiano, Anthony J Rongione, Lisa M Fornaresio
OBJECTIVE: Atrial fibrillation (AF) is associated with increased early and long-term morbidity/mortality following valve surgery. This study examined long-term influence of concomitant full Cox maze (CM) and mitral valve procedures on freedom from atrial arrhythmia and stroke. METHODS: This sample comprised patients who underwent CM with a mitral valve procedure (N = 473). Data on rhythm, medication status, and clinical events captured according to Heart Rhythm Society guidelines at 6, 9, 12, 18, and 24 months and yearly thereafter up to 7 years...
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29229533/xanthoceraside-attenuates-amyloid-%C3%AE-peptide-1-42-induced-memory-impairments-by-reducing-neuroinflammatory-responses-in-mice
#20
Yue Qi, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Qian Xu, Qing Jiao, Li-Hua Wang, Li-Bo Zou
Xanthoceraside, a novel triterpenoid saponin extracted from the husks of Xanthoceras sorbifolia Bunge, has neuroprotective effects in vivo and anti-inflammatory properties in vitro. However, the exact mechanism of xanthoceraside on anti-amyloid beta (Aβ)-induced neuroinflammatory responses has not been elucidated. Therefore, we used intracerebroventricular injection of amyloid1-42 (Aβ1-42 ) to establish a mouse model to test the effects of xanthoceraside on Aβ-induced cognitive impairments and the TLR2/NF-κB and MAPK pathways...
February 5, 2018: European Journal of Pharmacology
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