Cecilie S Jørgensen, Henriette T Horsdal, Veera M Rajagopal, Jakob Grove, Thomas D Als, Konstantinos Kamperis, Mette Nyegaard, G Bragi Walters, Viðar Örn Eðvarðsson, Hreinn Stefánsson, Merete Nordentoft, David Michael Hougaard, Thomas Werge, Ole Mors, Preben Bo Mortensen, Esben Agerbo, Søren Rittig, Kári Stefánsson, Anders D Børglum, Ditte Demontis, Jane H Christensen
BACKGROUND: Nocturnal enuresis (bedwetting) is a common disorder affecting 10-16% of 7-year-old children globally. Nocturnal enuresis is highly heritable, but its genetic determinants remain unknown. We aimed to identify genetic variants associated with nocturnal enuresis and explore its genetic architecture and underlying biology. METHODS: We did a genome-wide association study (GWAS) of nocturnal enuresis. Nocturnal enuresis cases were identified in iPSYCH2012, a large Danish population-based case cohort established to investigate mental disorders, on the basis of 10th revision of the International Statistical Classification of Diseases (ICD-10) diagnoses and redeemed desmopressin prescriptions in Danish registers...
March 2021: Lancet Child & Adolescent Health