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COMPARATIVE STUDY
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A possible antienuretic effect of reboxetine in children and adolescents with attention deficit/hyperactivity disorder: case series.

UNLABELLED: Reboxetine is a selective norepinephrine reuptake inhibitor.

OBJECTIVES: To evaluate the antienuretic effect of reboxetine in children with attention deficit and mood disorders.

METHODS: Six children aged 12-15 years with primary nocturnal enuresis and with attention deficit/hyperactivity disorder with or without other comorbid disorders were treated with reboxetine (4-8 mg/day). Monitoring of enuretic frequency was recorded at baseline and once a week for 6 weeks.

RESULTS: A statistically significant decrease in bedwetting was noted along the assessment points (p < 0.001), with the maximal change noted in the first week of treatment (p = 0.004). Reboxetine was well tolerated with minimal and transient side effects.

CONCLUSIONS: reboxetine may possess an antienuretic effect in some children with the attention deficit/hyperactivity disorder.

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