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Spina bifida

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https://www.readbyqxmd.com/read/28918465/congenital-lumbar-kyphosis-with-skin-ulceration-and-osteomyelitis-in-a-myelomeningocele-child-a-case-report
#1
Benoit Vibert, Marco Turati, Pierre-Yves Rabattu, Marco Bigoni, Ahmad Eid, Aurélien Courvoisier
INTRODUCTION: Kyphosis is a frequent problem in children with spina bifida, and this deformity may cause different complications as respiratory insufficiency, bowel dysfunction, and skin ulcers. CASE REPORT: We report on a 13-year-old myelomeningocele male with a lumbar kyphoscoliosis associated to a septic skin ulceration that resulted in an acute sepsis. An X-ray revealed a kyphosis of 110° and a scoliosis of 25° between T9 and L5. The wound and blood cultures showed Staphylococcus aureus colonization, and an appropriate antibiotic therapy was started...
September 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28915235/transamniotic-stem-cell-therapy-trascet-a-novel-strategy-for-the-prenatal-management-of-congenital-anomalies
#2
REVIEW
Dario O Fauza
Transamniotic Stem Cell Therapy, or TRASCET, is an emerging therapeutic concept for the management of congenital anomalies based on the augmentation of the biological role of select populations of stem cells that already occur in the amniotic fluid, for targeted therapeutic benefit. Amniotic fluid-derived mesenchymal stem cells (afMSCs) play a central role in the enhanced ability of the fetus to repair tissue damage. This germane recent finding constitutes the biological foundation for the use of afMSCs in TRASCET...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28915233/the-utility-of-stem-cells-in-pediatric-urinary-bladder-regeneration
#3
REVIEW
Philip M Iannaccone, Vasil Galat, Matthew I Bury, Yongchao C Ma, Arun K Sharma
Pediatric patients with a neurogenic urinary bladder caused by developmental abnormalities including spina bifida exhibit chronic urological problems. Surgical management in the form of enterocystoplasty is used to enlarge the bladder but is associated with significant clinical complications. Thus, alternative methods to enterocystoplasty have been explored through the incorporation of stem cells with tissue engineering strategies. Within the context of this review, we will examine the use of bone marrow stem cells and induced pluripotent stem cells (iPSCs) as they relate to bladder regeneration at the anatomic and molecular levels...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28912114/understanding-the-natural-progression-of-spina-bifida-prospective-study
#4
Judy Thibadeau, Matthew R Reeder, Jennifer Andrews, Katherine Ong, Marcia L Feldkamp, Sydney Rice, Ann Alriksson-Schmidt
BACKGROUND: Spina bifida (SB) is monitored through birth defects surveillance across the United States and in most developed countries. Although much is known about the management of SB and its many comorbid conditions in affected individuals, there are few systematic, longitudinal studies on population-based cohorts of children or adults. The natural history of SB across the life course of persons with this condition is not well documented. Earlier identification of comorbidities and secondary conditions could allow for earlier intervention that might enhance the developmental trajectory for children with SB...
September 14, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28905112/extracorporeal-membrane-oxygenation-in-spina-bifida-and-h1n1-induced-acute-respiratory-distress-syndrome
#5
Oliver Jansen, Oliver Kamp, Christian Waydhas, Valentin Rausch, Thomas Armin Schildhauer, Justus Strauch, Dirk Buchwald, Uwe Hamsen
Acute respiratory distress syndrome (ARDS) is characterized as an acute hypoxemic and/or hypercapnic respiratory failure seen in critically ill patients and is still, although decreased over the past few years, associated with high mortality. Furthermore, ARDS may be a life-threatening complication of H1N1 pneumonia. We report on a 45-year-old spina bifida patient with confirmed H1N1 influenza virus infection causing acute respiratory failure, who was successfully weaned from 42-day veno-venous extracorporeal membrane oxygenation (vv-ECMO) treatment with an excellent outcome...
September 13, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28904629/reliability-of-patellar-height-indices-in-children-with-cerebral-palsy-and-spina-bifida
#6
S A Rethlefsen, K K Barrett, T A L Wren, G Blumstein, D Gargiulo, D D Ryan, R M Kay
BACKGROUND: The Koshino (KI) and Caton-Deschamps (CDI) indices are used to measure patellar height in children, with the CDI showing excellent reliability in typically developing (TD) children. Reliability of such measures in children with cerebral palsy (CP) and spina bifida (SB) is unknown. METHODS: Lateral knee radiographs were reviewed retrospectively for children with TD (n = 49), CP (n = 48) and SB (n = 42). Five raters took measurements from radiographs twice, at least two weeks apart...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28901576/theory-of-mind-in-spina-bifida-relationship-with-intellectual-and-executive-functioning
#7
Jan Stubberud
This article investigates emotion recognition ability, a central aspect of Theory of Mind (ToM), in a group of individuals with spina bifida myelomeningocele (SBM) experiencing executive function deficits, and examine associations between emotion recognition, and intellectual and executive functioning. A total of 38 adult subjects with SBM were included in this study, participating in a randomized controlled trial evaluating the effects of a cognitive rehabilitation intervention for executive dysfunction. Reading the Mind in the Eyes Test (RMET) was used as a measure of emotion recognition, and neuropsychological tests and questionnaires were utilized as executive function measures...
October 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28885344/surgical-treatment-for-lumbar-hyperlordosis-after-resection-of-a-spinal-lipoma-associated-with-spina-bifida-a-case-report
#8
Tatsuya Sato, Ikuho Yonezawa, Shingo Onda, Kei Yoshikawa, Hiromitsu Takano, Yukitoshi Shimamura, Takatoshi Okuda, Kazuo Kaneko
RATIONALE: A hyperlordosis deformity of the lumbar spine is relatively rare, and surgical treatment has not been comprehensively addressed. In this case report, we describe the clinical presentation, surgical treatment, and medium-term follow-up of a patient presenting with a progressive lumbar hyperlordosis deformity after resection of a spinal lipoma associated with spina bifida. PATIENT CONCERNS: The patient was a 20-year-old woman presenting with a progressive hyperlordosis deformity of the lumbar spine associated with significant back pain (visual analog pain score of 89/100 mm), but with no neurological symptoms...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28883729/maternal-exposure-to-nanosized-titanium-dioxide-suppresses-embryonic-development-in-mice
#9
Fashui Hong, Yingjun Zhou, Xiaoyang Zhao, Lei Sheng, Ling Wang
Although nanoscale titanium dioxide (nano-TiO2) has been extensively used in industrial food applications and daily products for pregnant women, infants, and children, its potential toxicity on fetal development has been rarely studied. The main objective of this investigation was to establish the effects of maternal exposure of nano-TiO2 on developing embryos. Female imprinting control region mice were orally administered nano-TiO2 from gestational day 0 to 17. Our findings showed that Ti concentrations in maternal serum, placenta, and fetus were increased in nano-TiO2-exposed mice when compared to controls, which resulted in reductions in the contents of calcium and zinc in maternal serum, placenta, and fetus, maternal weight gain, placental weight, fetal weight, number of live fetuses, and fetal crown-rump length as well as cauda length, and caused an increase in the number of both dead fetuses and resorptions...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28880702/the-feasibility-and-validity-of-body-worn-sensors-to-supplement-timed-walking-tests-for-children-with-neurological-conditions
#10
Lavan Sivarajah, Kyra J Kane, Joel Lanovaz, Derek Bisaro, Alison Oates, Ming Ye, Kristin E Musselman
AIMS: The 10-meter walk test (10 mWT) and Timed Up and Go (TUG) are assessments of speed/time with a ceiling effect in pediatric populations. This study aimed to (1) determine whether collecting spatiotemporal data with inertial sensors (Mobility Lab, APDM Inc.) during these tests improves their discriminative validity, and (2) evaluate the clinical feasibility of Mobility Lab. METHODS: Fifteen children with spina bifida (SB) or cerebral palsy (CP) (7.9 ± 3.1 years old) and fifteen age- and sex-matched typically-developing (TD) children completed the 10 mWT and TUG wearing Mobility Lab...
September 7, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28876688/management-of-myelomeningocele-in-the-province-of-kwazulu-natal-south-africa
#11
M N Mnguni, B Enicker, T E Madiba
BACKGROUND: Spina bifida is the most common of congenital anomalies of the central nervous system that are compatible with life. The most frequent form is myelomeningocele. METHOD: Setting: Neurosurgery Unit, Inkosi Albert Luthuli Central Hospital. Patients: Consecutive children with diagnosis myelomeningocele who were managed at from January 2006 to December 2014. Design: Retrospective analysis of children with myelomeningocele. Multiple logistic regression analysis identified clinical, demographic and surgical variables that were associated with outcome...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28863840/title-page-of-a-systematic-review-of-the-risks-factors-associated-with-the-onset-and-natural-progression-of-spina-bifida
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28856575/muscle-bone-interactions-in-pediatric-bone-diseases
#13
REVIEW
Louis-Nicolas Veilleux, Frank Rauch
PURPOSE: Here, we review the skeletal effects of pediatric muscle disorders as well as muscle impairment in pediatric bone disorders. RECENT FINDINGS: When starting in utero, muscle disorders can lead to congenital multiple contractures. Pediatric-onset muscle weakness such as cerebral palsy, Duchenne muscular dystrophy, spinal muscular atrophy, or spina bifida typically are associated with small diameter of long-bone shafts, low density of metaphyseal bone, and increased fracture incidence in the lower extremities, in particular, the distal femur...
August 30, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28845735/effect-of-diagnosis-body-site-and-experience-on-text-entry-rate-of-individuals-with-physical-disabilities-a-systematic-review
#14
Heidi Horstmann Koester, Sajay Arthanat
OBJECTIVE: This study systematically reviewed the research on computer text entry by people with physical disabilities, and conducted a quantitative synthesis of text entry rates associated with individuals' diagnosis, body site used with the interface and their level of experience. METHOD: We searched 10 databases and included studies in which: typing speed was reported; the access interface was available for public use; and individuals with physical impairments were in the study population...
August 28, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28843754/thoracic-intradural-extramedullary-epidermoid-tumor-the-relevance-for-resection-of-classical-subarachnoid-space-microsurgical-anatomy-in-modern-spinal-surgery-technical-note-and-review-of-the-literature
#15
Giuseppe Mv Barbagallo, Massimiliano Maione, Giuseppe Raudino, Francesco Certo
BACKGROUND: Intradural epidermoid tumors of the spinal cord are commonly associated with spinal cord dysraphism or invasive procedures. We report the particular relationships between spinal subarachnoid compartments and a thoracic intradural-extramedullary epidermoid tumor, highlighting the relevant anatomical changes, which may influence microsurgery. METHODS: A 40 year old woman suffering from compressive myelopathy due to a thoracic epidermoid tumor extending from T3 to T4, and not associated with spina bifida, trauma, previous surgery or lumbar spinal puncture, underwent microsurgical excision...
August 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28836807/health-self-management-transition-readiness-and-adaptive-behavior-in-persons-with-cerebral-palsy-or-myelomeningocele
#16
Seth Warschausky, Jacqueline N Kaufman, William Schutt, Michael Evitts, Edward A Hurvitz
PURPOSE/OBJECTIVE: This study was conducted to examine the associations between generic and condition-specific health self-management and levels of adaptive behavior in 2 groups of transition-age youth with congenital neurodevelopmental conditions. METHOD: The sample included 43 adolescents/young adults diagnosed with cerebral palsy (CP) and 36 with spina bifida/myelomeningocele (SBM), ages 13-29, mean age 18.96 (4.77), 51.9% female. Health self-management was assessed with the Transition Readiness Assessment Questionnaire (TRAQ) completed by the child, and the Kennedy Krieger Independence Scales-Spina Bifida (KKIS-SB) completed by the parent/guardian...
August 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28836806/the-kennedy-krieger-independence-scales-sickle-cell-disease-executive-components-of-transition-readiness
#17
Kelly E Jones, Lisa A Jacobson, Reem A Tarazi
PURPOSE/OBJECTIVE: Youth with sickle cell disease (SCD) are at an increased risk for executive dysfunction and simultaneously have increased self-management needs compared to typical adolescents. This unique combination may contribute, in part, to difficulties during transition to young adulthood. Current measures assessing adaptive skills do not assess the executive components (e.g., initiation, prospective memory) of SCD-related self-care tasks. Modeled on the KKIS-Spina Bifida (Jacobson et al...
August 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28834111/parenting-stress-in-caregivers-of-children-with-chronic-physical-condition-a-meta-analysis
#18
REVIEW
Martin Pinquart
On the basis of the parenting stress model we compared levels of parenting stress in families with and without a child with a chronic physical condition and analysed correlates of parenting stress in families with a child with a chronic condition. A systematic search through electronic databases identified 547 relevant studies that were included in a random-effects meta-analysis. Parents of children with a chronic condition showed small to moderate elevations of general parenting stress and stress related to the parent-child relationship in particular...
August 18, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28832491/committee-opinion-no-720-maternal-fetal-surgery-for-myelomeningocele
#19
(no author information available yet)
Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28832482/committee-opinion-no-720-summary-maternal-fetal-surgery-for-myelomeningocele
#20
(no author information available yet)
Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies...
September 2017: Obstetrics and Gynecology
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