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https://www.readbyqxmd.com/read/28330690/subclinical-leaflet-thrombosis-in-surgical-and-transcatheter-bioprosthetic-aortic-valves-an-observational-study
#1
Tarun Chakravarty, Lars Søndergaard, John Friedman, Ole De Backer, Daniel Berman, Klaus F Kofoed, Hasan Jilaihawi, Takahiro Shiota, Yigal Abramowitz, Troels H Jørgensen, Tanya Rami, Sharjeel Israr, Gregory Fontana, Martina de Knegt, Andreas Fuchs, Patrick Lyden, Alfredo Trento, Deepak L Bhatt, Martin B Leon, Raj R Makkar
BACKGROUND: Subclinical leaflet thrombosis of bioprosthetic aortic valves after transcatheter valve replacement (TAVR) and surgical aortic valve replacement (SAVR) has been found with CT imaging. The objective of this study was to report the prevalence of subclinical leaflet thrombosis in surgical and transcatheter aortic valves and the effect of novel oral anticoagulants (NOACs) on the subclinical leaflet thrombosis and subsequent valve haemodynamics and clinical outcomes on the basis of two registries of patients who had CT imaging done after TAVR or SAVR...
March 19, 2017: Lancet
https://www.readbyqxmd.com/read/28314622/diastolic-function-and-transcatheter-aortic-valve-replacement
#2
John E A Blair, Prashant Atri, Julie L Friedman, James D Thomas, Kent Brummel, Ranya N Sweis, Issam Mikati, S Chris Malaisrie, Charles J Davidson, James D Flaherty
BACKGROUND: Little is known about baseline diastolic dysfunction and changes in diastolic dysfunction grade after transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS) and its impact on overall outcomes. The aim of this study was to describe baseline diastolic dysfunction and changes in diastolic dysfunction grade that occur with TAVR and their relationship to mortality and rehospitalization. METHODS: This was a single-center study evaluating all TAVRs from January 2012 to June 2014...
March 14, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28224928/impact-of-right-ventricular-function-on-outcome-of-severe-aortic-stenosis-patients-undergoing-transcatheter-aortic-valve-replacement
#3
Edward Koifman, Romain Didier, Nirav Patel, Zack Jerusalem, Sarkis Kiramijyan, Itsik Ben-Dor, Smita I Negi, Zuyue Wang, Steven A Goldstein, Michael J Lipinski, Rebecca Torguson, Jiaxiang Gai, Augusto D Pichard, Lowell F Satler, Ron Waksman, Federico M Asch
BACKGROUND: Right ventricular (RV) dysfunction was shown to be associated with adverse outcomes in a variety of cardiac patients and is considered a risk factor for adverse outcome according to the updated Valve Academic Research Consortium criteria. OBJECTIVE: Our goal was to assess the impact of RV function at baseline on 1-year mortality among patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). METHODS: All patients with severe AS treated with TAVR from May 2007 to March 2015 at our center were included in the present study, and baseline and procedural characteristics were recorded for each patient...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28105998/simultaneous-transfemoral-aortic-and-transseptal-mitral-valve-replacement-utilising-sapien-3-valves-in-native-aortic-and-mitral-valves
#4
Mohammad Bashir, Gardar Sigurdsson, Phillip A Horwitz, Firas Zahr
AIMS: Concomitant severe calcific aortic and mitral stenosis is a relatively uncommon but very challenging valvular heart disease to manage. We sought to evaluate the feasibility of a fully percutaneous approach to replace both stenotic native mitral and aortic valves using SAPIEN 3 valves. METHODS AND RESULTS: An 87-year-old woman with chronic kidney disease stage 3, pul-monary hypertension, chronic obstructive pulmonary disease, a permanent pacemaker, and atrial fibrillation was referred with Class III heart failure symptoms...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28064153/comparison-of-valve-performance-of-the-mechanically-expanding-lotus-and-the-balloon-expanded-sapien3-transcatheter-heart-valves-an-observational-study-with-independent-core-laboratory-analysis
#5
Osama I I Soliman, Nahid El Faquir, Ben Ren, Ernest Spitzer, Lennart van Gils, Hans Jonker, Marcel L Geleijnse, Gerrit-Anne van Es, Jan G Tijssen, Nicolas M van Mieghem, Peter P T de Jaegere
AIMS: The Lotus and SAPIEN3 are second-generation transcatheter heart valves, which are designed to minimize paravalvular aortic regurgitation (PAR) after transcatheter aortic valve replacement (TAVR). We sought to compare both devices for valve performance and with emphasis on PAR by independent core laboratory analysis. METHODS AND RESULTS: A total of 162 (79 Lotus and 83 SAPIEN3) consecutive patients (51% female, 80 ± 8 years, Logistic EuroSCORE 14.8 ± 9...
January 6, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28039604/socioeconomic-and-racial-disparities-a-case-control-study-of-patients-receiving-transcatheter-aortic-valve-replacement-for-severe-aortic-stenosis
#6
Anna Sleder, Shiloh Tackett, Matthew Cerasale, Chetan Mittal, Iyad Isseh, Ryhm Radjef, Andrew Taylor, Rashad Farha, Oleksandra Lupak, Dana Larkin, Lois Lamerato, George Divine, Kimberlydawn Wisdom, Kimberly Baker-Genaw, William O'Neill
BACKGROUND: We sought to quantify socioeconomic disparities in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) at an urban, tertiary referral center. METHODS: This retrospective case-control study identified 67 patients with severe AS (aortic valve [AV] area ≤1 cm(2) or AV area index ≤0.60 cm(2)/m(2) or AV velocity ≥40 mmHg) who underwent TAVR from November 5, 2013 to June 10, 2014. Study subjects were matched to controls with severe AS without TAVR in a 4:1 age-frequency match...
December 30, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28017714/long-term-valve-performance-of-tavr-and-savr-a-report-from-the-partner-i-trial
#7
Melissa A Daubert, Neil J Weissman, Rebecca T Hahn, Philippe Pibarot, Rupa Parvataneni, Michael J Mack, Lars G Svensson, Deepika Gopal, Samir Kapadia, Robert J Siegel, Susheel K Kodali, Wilson Y Szeto, Raj Makkar, Martin B Leon, Pamela S Douglas
OBJECTIVES: The aim of this study was to evaluate the long-term performance of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) through longitudinal echocardiographic analysis. BACKGROUND: The long-term performance of the SAPIEN TAVR is not well-described. Therefore, we examined the hemodynamic and valvular profile of the SAPIEN TAVR over 5 years. METHODS: All patients receiving TAVR or SAVR with first post-implant (FPI) and 5-year echoes were analyzed for aortic valve (AV) peak velocity, AV mean gradient, AV area, peak left ventricular (LV) outflow tract and in-stent velocities, Doppler velocity index, aortic regurgitation (AR), LV mass index, stroke volume index, and cardiac index...
December 8, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27720271/sustained-elevation-of-vascular-endothelial-growth-factor-and-angiopoietin-2-levels-after-transcatheter-aortic-valve-replacement
#8
Jeremy Ben-Shoshan, Arie Steinvil, Yaron Arbel, Yan Topilsky, Leehee Barak, Michal Entin-Meer, Ran Levy, Arie Lorin Schwartz, Gad Keren, Ariel Finkelstein, Shmuel Banai
BACKGROUND: Transcatheter aortic valve replacement (TAVR) exposes the systemic vasculature to increased mechanical forces. Endothelial adaptation to mechanical stimuli is associated with angiogenic activation through various growth factors. We studied the potential angiogenic shift evoked by TAVR. METHODS: From a cohort of 69 consecutive patients undergoing TAVR, we excluded patients with conditions known to affect angiogenic factors, and serum vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-1 and Ang-2 were assessed by ELISA...
June 25, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27692595/local-versus-general-anesthesia-in-transcatheter-aortic-valve-replacement
#9
Avais Jabbar, Ayush Khurana, Ashfaq Mohammed, Rajiv Das, Azfar Zaman, Richard Edwards
Transcatheter aortic valve replacement (TAVR) is conventionally performed under general anesthesia (GA) allowing intraoperative transoesophageal echocardiogram imaging. We present our experience in patients having the procedure under local anesthesia (LA), who were subsequently transferred to a low dependency unit postprocedure, to assess safety and length of hospital stay. We retrospectively assessed all the transfemoral TAVR procedures conducted at our center from January 03, 2011. Of 216 patients, 145 had the procedure under GA and 71 under LA...
December 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27577944/simultaneous-transcatheter-aortic-valve-implantation-and-drive-by-endovascular-aortic-aneurysm-repair-a-case-of-lotus-valve-retrieved-and-replaced-due-to-an-undersized-valve-after-an-endovascular-aneurysm-repair
#10
Hashrul N Rashid, Liam M McCormick, Robert P Gooley, Ian T Meredith
A 79-year-old man with stable chronic obstructive pulmonary disease was found to have an abdominal aortic aneurysm and worsening dyspnoea. Echocardiography demonstrated critical aortic stenosis. Simultaneous endovascular aneurysm repair (EVAR) and transcatheter aortic valve replacement (TAVR) was recommended due to high surgical risk. Procedural strategy was to perform balloon valvuloplasty (BAV), followed by EVAR then TAVR. The initial 25 mm Lotus valve adopted a barrel shape suggestive of an undersized valve and was thus replaced with a 27 mm valve...
August 30, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27547146/transcatheter-aortic-valve-in-valve-replacement-instead-of-a-4th-sternotomy-in-a-21-year-old-woman-with-aortic-homograft-failure
#11
José G Díez, Michael Schechter, Kathryn G Dougherty, Ourania Preventza, Joseph S Coselli
Transcatheter aortic valve replacement (TAVR) is a well-established method for replacing native aortic valves; however, it was conceived for elderly patients with aortic valve stenosis, and the lack of data on long-term durability has led practitioners to restrict the use of TAVR to patients who have short life expectancies. Here, we describe the case of a 21-year-old woman who had undergone 3 previous open aortic valve replacements and who presented with symptoms of recurrent valvular failure. Transthoracic echocardiograms and computed tomographic angiograms revealed a degenerating aortic root homograft with substantial calcification, moderate-to-severe aortic valve stenosis, and severe aortic valve regurgitation...
August 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27502848/impact-of-baseline-mitral-regurgitation-on-short-and-long-term-outcomes-following-transcatheter-aortic-valve-replacement
#12
Sarkis Kiramijyan, Marco A Magalhaes, Edward Koifman, Romain Didier, Ricardo O Escarcega, Sa'ar Minha, Nevin C Baker, Smita I Negi, Rebecca Torguson, Jiaxiang Gai, Petros Okubagzi, Federico M Asch, Michael A Gaglia, Itsik Ben-Dor, Lowell F Satler, Augusto D Pichard, Ron Waksman
BACKGROUND: The prevalence of concomitant significant mitral regurgitation (MR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) ranges from 2% to 33%. The impact of significant MR on post-TAVR outcomes remains controversial. METHODS: The data from a cohort of patients with symptomatic severe AS undergoing TAVR at out institution were retrospectively analyzed. The last transthoracic echocardiogram (TTE) before the index TAVR procedure was selected as the baseline assessment of the degree of MR...
August 2016: American Heart Journal
https://www.readbyqxmd.com/read/27491485/safety-and-efficacy-of-self-expanding-tavr-in%C3%A2-patients-with-aortoventricular%C3%A2-angulation
#13
Jeffrey J Popma, Michael J Reardon, Steven J Yakubov, James B Hermiller, J Kevin Harrison, Thomas G Gleason, John V Conte, G Michael Deeb, Stanley Chetcuti, Jae K Oh, Michael J Boulware, Jian Huang, David H Adams
OBJECTIVES: The aim of this study was to determine the relationship between aortoventricular (AoV) angulation on clinical outcomes after self-expanding transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis who were deemed suboptimal for surgery. BACKGROUND: Multidetector computed tomographic (MDCT) imaging of the aortovalvular complex has become a prerequisite for case planning with self-expanding TAVR. The effect of aortic angulation, an index of an unfolded or "horizontal" aorta, on procedural outcome after self-expanding TAVR is not known...
August 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27437665/evaluation-of-flow-after-transcatheter-aortic-valve-replacement-in-patients-with-low-flow-aortic-stenosis-a-secondary-analysis-of-the-partner-randomized-clinical-trial
#14
Venkatesh Y Anjan, Howard C Herrmann, Philippe Pibarot, William J Stewart, Samir Kapadia, E Murat Tuzcu, Vasilis Babaliaros, Vinod H Thourani, Wilson Y Szeto, Joseph E Bavaria, Susheel Kodali, Rebecca T Hahn, Mathew Williams, D Craig Miller, Pamela S Douglas, Martin B Leon
IMPORTANCE: Low-flow (LF) severe aortic stenosis (AS) is an independent predictor of mortality in patients undergoing aortic valve replacement (AVR). Little is known about improvement in flow after AVR and its effects on survival. OBJECTIVE: To determine whether higher flow (left-ventricular stroke volume index [LVSVI]) after transcatheter AVR (TAVR) would indicate better clinical outcomes in this at-risk population. DESIGN, SETTING, AND PARTICIPANTS: A substudy analysis of data from the Placement of Aortic Transcatheter Valves (PARTNER) randomized clinical trial and continued-access registry was conducted...
August 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27313280/self-expanding-transcatheter-aortic-valve-replacement-versus-surgical-valve-replacement-in-patients-at-high-risk-for-surgery-a-study-of-echocardiographic-change-and-risk-prediction
#15
Stephen H Little, Jae K Oh, Linda Gillam, Partho P Sengupta, David A Orsinelli, João L Cavalcante, James D Chang, David H Adams, George L Zorn, Amy W Pollak, Sahar S Abdelmoneim, Michael J Reardon, Hongyan Qiao, Jeffrey J Popma
BACKGROUND: The CoreValve US High-Risk Clinical Study compared clinical outcomes and serial echocardiographic findings in patients with severe aortic valve stenosis after transcatheter aortic valve replacement (TAVR) with a self-expanding bioprosthesis or surgical aortic valve replacement (SAVR). METHODS AND RESULTS: Eligible patients were randomly assigned 1:1 to TAVR with a self-expanding bioprosthesis or SAVR (N=747). Echocardiograms were obtained at baseline, discharge, 30 days, 6 months, and 1 year after the procedure and were analyzed at a central core laboratory...
June 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27190101/early-clinical-and-echocardiographic-outcomes-after-sapien-3-transcatheter-aortic-valve-replacement-in-inoperable-high-risk-and-intermediate-risk-patients-with-aortic-stenosis
#16
Susheel Kodali, Vinod H Thourani, Jonathon White, S Chris Malaisrie, Scott Lim, Kevin L Greason, Mathew Williams, Mayra Guerrero, Andrew C Eisenhauer, Samir Kapadia, Dean J Kereiakes, Howard C Herrmann, Vasilis Babaliaros, Wilson Y Szeto, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, Jonathon Leipsic, Philipp Blanke, Brian K Whisenant, Rakesh M Suri, Raj R Makkar, Girma M Ayele, Lars G Svensson, John G Webb, Michael J Mack, Craig R Smith, Martin B Leon
AIMS: Based on randomized trials using first-generation devices, transcatheter aortic valve replacement (TAVR) is well established in the treatment of high-risk (HR) patients with severe aortic stenosis (AS). To date, there is a paucity of adjudicated, prospective data evaluating outcomes with newer generation devices and in lower risk patients. We report early outcomes of a large, multicentre registry of inoperable, HR, and intermediate-risk (IR) patients undergoing treatment with the next-generation SAPIEN 3 transcatheter heart valve (THV)...
July 21, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27145743/echocardiographic-determinants-of-lv-functional-improvement-after-transcatheter-aortic-valve-replacement
#17
Jinling Chen, Nasir Nawaz, Zachary Fox, Caroline Komlo, Saif Anwaruddin, Nimesh Desai, Dinesh Jagasia, Howard C Herrmann, Yuchi Han
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an established therapy in high-risk patients with severe aortic stenosis. Among patients with reduced left ventricular ejection fraction (LVEF), it is unclear which patients will derive maximal benefit from TAVR. METHODS: Clinical and echocardiographic data of patients with severe aortic stenosis and low LVEF (≤50%) who underwent TAVR at a single institution during 2009-2013 were retrospectively analyzed...
May 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27084789/mitral-paravalvular-leak-closure-by-antegrade-percutaneous-approach-using-amplatzer-pfo-closure-device
#18
R Hilling-Smith, A Chong, S Cox
Percutaneous closure of paravalvular leaks is becoming a more widely practiced technique. We describe the technique we used to deploy an Amplatzer PFO closure device to treat a prosthetic mitral paravalvular leak. The procedure was performed under real time 3D trans-oesophageal echo and fluoroscopic guidance requiring a trans-septal puncture and utilising an 035″ Safari wire which was developed for TAVR implantation. An excellent result was achieved acutely and at 4 month follow-up. © 2016 Wiley Periodicals, Inc...
April 16, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27067863/first-case-of-a-left-atrial-dissection-after-transcatheter-aortic-valve-replacement
#19
M Rizwan Sardar, Georges I Kaddissi, Sajjad A Sabir, Simon K Topalian
The left atrial dissection is a very infrequently encountered complication after valve replacement and never seen after Transcatheter aortic valve replacement (TAVR). We present an 84-year-old female, who underwent successful transapical TAVR and consequently developed contained left atrial dissection seen on transesophageal echocardiogram. The patient remained stable throughout the procedure and was monitored in critical care unit with conservative management. Although there is low associated intraop mortality, prompt recognition is paramount with follow-up serial imaging...
June 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27031938/spontaneous-echo-contrast-and-tavr-a-smoking-gun
#20
COMMENT
Paul N Fiorilli, Saif Anwaruddin
No abstract text is available yet for this article.
April 2016: Journal of Invasive Cardiology
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