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https://www.readbyqxmd.com/read/29454118/the-factors-affecting-the-difficulty-of-percutaneous-cylindrical-electrode-placement-for-spinal-cord-stimulation
#1
Kyohei Kin, Takashi Agari, Takao Yasuhara, Yousuke Tomita, Ken Kuwahara, Ittetsu Kin, Michiari Umakoshi, Jun Morimoto, Mihoko Okazaki, Tatsuya Sasaki, Isao Date
OBJECTIVE: Optimal placement of electrodes is important for spinal cord stimulation. Unfortunately, factors affecting the difficulty of percutaneous electrode placement are not well known. In this study, we retrospectively evaluated the factors affecting the difficulty of percutaneous electrode placement. METHODS: The authors performed a retrospective analysis of 90 consecutive procedures of percutaneous cylindrical electrodes implantation at the first author's institution...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29448825/radiographic-prognostic-factors-for-selective-soft-tissue-release-after-ponseti-failure-in-young-pediatric-clubfoot-patients
#2
Michael Seungcheol Kang, Il-Yeong Hwang, Soo-Sung Park
BACKGROUND: Selective soft tissue release (SSTR), which includes a combination of abductor hallucis, tibialis posterior, and Achilles lengthening, has been used in patients with recurrent clubfoot deformity after Ponseti treatment. The aim of this study was to investigate the prognostic factors for recurrence of clubfoot deformity after SSTR. METHODS: Consecutive patients with idiopathic clubfoot and residual or recurrent deformity after Ponseti treatment underwent SSTR between 2005 and 2013...
February 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29446684/acute-nonhemorrhagic-adrenal-infarction-in-pregnancy-10-year-mri-incidence-and-patient-outcomes-at-a-single-institution
#3
Shahar A Glomski, Jeffrey P Guenette, Wendy Landman, Servet Tatli
OBJECTIVE: The purpose of this study was to retrospectively investigate the MRI incidence of nonhemorrhagic adrenal infarction in pregnant women undergoing MRI evaluation of acute abdominal or flank pain, assess the MRI features quantitatively, and report patient outcomes. MATERIALS AND METHODS: All abdominal MRI examinations of pregnant women with acute pain at one institution from May 2005 to April 2015 were reviewed. The adrenals were evaluated for abnormal morphologic and signal intensity characteristics described in the literature characterizing nonhemorrhagic adrenal infarction and were compared with the contralateral adrenal by paired t tests...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29445897/brdu-edu-dual-labeling-to-determine-the-cell-cycle-dynamics-of-defined-cellular-subpopulations
#4
Lachlan Harris, Oressia Zalucki, Michael Piper
Measuring the mean duration of synthesis-phase (T s ) and of the total cell-cycle (T c ) within progenitor cell populations can provide important insights into the biology governing these cells. Rather than a passive process that shows little variability across cellular contexts, the cell-cycle is instead highly regulated. For example, in the rodent forebrain, T s is selectively lengthened in radial glial progenitor cells undergoing symmetric versus asymmetric division. This lengthening is thought to minimize the potential for copying errors that can occur during DNA replication...
February 14, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29444612/circadian-clock-synchronization-of-the-cell-cycle-in-zebrafish-occurs-through-a-gating-mechanism-rather-than-a-period-phase-locking-process
#5
Ricardo Laranjeiro, T Katherine Tamai, William Letton, Noémie Hamilton, David Whitmore
Studies from a number of model systems have shown that the circadian clock controls expression of key cell cycle checkpoints, thus providing permissive or inhibitory windows in which specific cell cycle events can occur. However, a major question remains: Is the clock actually regulating the cell cycle through such a gating mechanism or, alternatively, is there a coupling process that controls the speed of cell cycle progression? Using our light-responsive zebrafish cell lines, we address this issue directly by synchronizing the cell cycle in culture simply by changing the entraining light-dark (LD) cycle in the incubator without the need for pharmacological intervention...
February 1, 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29443845/raising-the-joint-line-in-tka-is-associated-with-mid-flexion-laxity-a-study-in-cadaver-knees
#6
Thomas Luyckx, Hilde Vandenneucker, Lennart Scheys Ing, Evie Vereecke, Arnout Victor Ing, Jan Victor
BACKGROUND: In a typical osteoarthritic knee with varus deformity, distal femoral resection based off the worn medial femoral condyle may result in an elevated joint line. In a setting of fixed flexion contracture, the surgeon may choose to resect additional distal femur to obtain extension, thus purposefully raising the joint line. However, the biomechanical effect of raising the joint line is not well recognized. QUESTIONS/PURPOSES: (1) What is the effect of the level of the medial joint line (restored versus raised) on coronal plane stability of a TKA? (2) Does coronal alignment technique (mechanical axis versus kinematic technique) affect coronal plane stability of the knee? (3) Can the effect of medial joint-line elevation on coronal plane laxity be predicted by an analytical model? METHODS: A TKA prosthesis was implanted in 10 fresh frozen nonarthritic cadaveric knees with restoration of the medial joint line at its original level (TKA0)...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29442083/cleft-rhinoplasty-columellar-lengthening-comparison-of-techniques
#7
S M Balaji
Background: Nasal deformity in bilateral cleft lip and palate (BCLP) correction is highly challenging. Several solution has been proposed. The aim of the present study is to assess qualitatively and quantitatively the results of Cronin's flap, Fork flap, and Abbe's flap for BCLP rhinoplasty at a follow-up period. Materials and Methods: : Records of all BCLP rhinoplasty performed between 2010 and 2016, fulfilling inclusion and exclusion criteria were collected. From records, qualitative improvement and previously described methods of quantification of columella length were performed...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29440281/3-utr-lengthening-as-a-novel-mechanism-in-regulating-cellular-senescence
#8
Meng Chen, Guoliang Lyu, Miao Han, Hongbo Nie, Ting Shen, Wei Chen, Yichi Niu, Yifan Song, Xueping Li, Huan Li, Xinyu Chen, Ziyue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yufang Zheng, Xinhua Liu, Jinfeng Hu, Gang Wei, Wei Tao, Ting Ni
Cellular senescence has been viewed as a tumor suppression mechanism and also as a contributor to individual aging. Widespread shortening of 3' untranslated regions (3' UTRs) in messenger RNAs (mRNAs) by alternative polyadenylation (APA) has recently been discovered in cancer cells. However, the role of APA in the process of cellular senescence remains elusive. Here, we found that hundreds of genes in senescent cells tended to use distal poly(A) (pA) sites, leading to a global lengthening of 3' UTRs and reduced gene expression...
February 12, 2018: Genome Research
https://www.readbyqxmd.com/read/29437569/myopia-its-historical-contexts
#9
REVIEW
Paulus T V M de Jong
Worldwide, and especially in Asia, myopia is a major vision-threatening disorder. From AD 1600 on, to prevent myopia, authors warned against near work without sufficient pauses. There was an abundance of theories about the causes of myopia, the most common one being the necessity of extra convergence on nearby work with thickened extraocular muscles and elevated intraocular pressure. Ocular tenotomies against myopia were in vogue for a while. Axial lengthening of the eye in myopia was mentioned around 1700, but it took 150 years to become accepted as the most prevalent sign of high myopia...
February 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436921/volumetric-and-linear-measurements-of-lung-tumor-burden-from-non-gated-micro-ct-imaging-correlate-with-histological-analysis-in-a-genetically-engineered-mouse-model-of-non-small-cell-lung-cancer
#10
Aitor Gallastegui, James Cheung, Teresa Southard, Kelly R Hume
In vivo micro-computed tomography (CT) imaging allows longitudinal studies of pulmonary neoplasms in genetically engineered mouse models. Respiratory gating increases the accuracy of lung tumor measurements but lengthens anesthesia time in animals that may be at increased risk for complications. We hypothesized that semiautomated, volumetric, and linear tumor measurements performed in micro-CT images from non-gated scans would have correlation with histological findings. Primary lung tumors were induced in eight FVB mice with two transgenes (FVB/N-Tg(tetO-Kras2)12Hev/J; FVB...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29433312/human-telomeric-g-quadruplex-selective-fluoro-isoquinolines-induce-apoptosis-in-cancer-cells
#11
Subhadip Maiti, Puja Saha, Tania Das, Irene Bessi, Harald Schwalbe, Jyotirmayee Dash
Small molecules that stabilize G-quadruplex structures in telomeres can prevent telomere lengthening by telomerase and subsequently lead to cell death. We herein report two fluoro-isoquinoline derivatives IQ1 and IQ2 as selective ligands for human telomeric G-quadruplex DNA. IQ1 and IQ2 containing different triazolyl side chains have been synthesized by Cu (I) catalyzed azide-alkyne cycloaddition. Fluorescence Resonance Energy Transfer (FRET) melting assay and fluorescence binding titrations indicate that both these ligands exhibit binding preference for telomeric G-quadruplex DNA (h-TELO) over other promoter DNA quadruplexes and duplex DNA...
February 13, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29431837/spin-state-dependence-of-the-structural-and-vibrational-properties-of-solvated-iron-ii-polypyridyl-complexes-from-aimd-simulations-aqueous-fe-bpy-3-cl2-a-case-study
#12
Latévi M Lawson Daku
The accurate description of transition metal complexes in liquid solutions is a challenging fundamental research problem, which must be tackled when it comes to understanding the role of the solvent in the photoinduced low-spin (LS) → high-spin (HS) transition in solvated Fe(ii) complexes. We report an in-depth ab initio molecular dynamics (AIMD) study of the spin-state dependence of the structural and vibrational properties of the prototypical [Fe(bpy)3]2+ (bpy = 2,2'-bipyridine) LS complex in water. The description achieved for the LS and HS solution structures of aqueous [Fe(bpy)3]2+ significantly improves on and actually supersedes the one from our previous AIMD study [Lawson Daku and Hauser, J...
February 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29426634/model-based-directional-analysis-of-cardiovascular-variability-identifies-patients-developing-atrial-fibrillation-after-coronary-artery-bypass-grafting
#13
Vlasta Bari, Marco Ranucci, Beatrice De Maria, Beatrice Cairo, Valeria Pistuddi, Alberto Porta
BACKGROUND: Postoperative atrial fibrillation (AF) might be favored by cardiovascular control impairment. We hypothesize that cardiovascular regulation indexes derived from directional model-based analysis of the spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) can identify subjects at risk to develop AF after coronary artery bypass graft (CABG) surgery. METHODS: Beat-to-beat HP and SAP series were derived from electrocardiogram (ECG) and invasive arterial pressure recorded for 5 min just before CABG surgery in conscious condition...
February 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29425753/effects-of-rhbmp-2-7-heterodimer-and-rada16-hydrogel-scaffold-on-bone-formation-during-rabbit-mandibular-distraction
#14
Ling-Fei Ren, Geng-Sheng Shi, Yong-Qing Tong, Song-Yao Jiang, Feng Zhang
PURPOSE: The effects of a recombinant human bone morphogenetic protein-2/7 (rhBMP-2/7) heterodimer and a RADA16 (Ac-RADARADARADARADA-CONH2) hydrogel scaffold on bone formation during distraction osteogenesis were evaluated. MATERIALS AND METHODS: Forty New Zealand white rabbits, which underwent mandibular lengthening, were randomly divided into 5 groups. One group served as the control group. The others received 2 μg of rhBMP-2 homodimer, 2 μg of rhBMP-2/7 heterodimer, 100 μL of RADA16, or 100 μL of RADA16 plus 2 μg of rhBMP-2/7 heterodimer in the mandibular distraction gap at the beginning of distraction...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29425259/repeating-critical-hematology-and-coagulation-values-wastes-resources-lengthens-turnaround-time-and-delays-clinical-action
#15
Su-Chieh Pamela Sun, JuanDavid Garcia, Joshua A Hayden
Objectives: To determine the need and impact of repeating critical values in hematology and coagulation. Methods: We prospectively evaluated the need for repeating critical values. The cost of this practice was estimated using a workflow analysis. Retrospective chart review before and after removal of this process was performed to assess the clinical impact of removing this practice. Results: Over 95% of the repeated values remained critical and all but one of the repeats were within the expected analytical precision of the assays...
February 7, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29420377/modified-lengthening-temporalis-myoplasty-involving-an-extended-lazy-s-incision-to-avoid-facial-scar-formation
#16
Tomito Oji, Akiteru Hayashi, Akihiro Ogino, Kiyoshi Onishi
BACKGROUND: Lengthening temporalis myoplasty is a faster and less invasive alternative to free muscle transfer for smile reconstruction. However, it requires a nasolabial fold incision, which leaves a midfacial scar. Based on esthetic considerations, a modified approach, involving an extended lazy-S (parotidectomy) incision instead of a nasolabial fold incision, was developed. METHODS: A cadaveric study involving 10 hemifaces was conducted. From February 2013 to March 2016, the modified lengthening temporalis myoplasty procedure was employed in 10 patients...
February 7, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29417207/gradual-fibular-transfer-by-ilizarov-external-fixator-in-post-traumatic-and-post-infection-large-tibial-bone-defects
#17
Mohammed Anter Meselhy, Mohamed Salah Singer, Abdelsamie M Halawa, Gamal Ahmed Hosny, Adel H Adawy, Osama M Essawy
INTRODUCTION: Several reconstructive procedures have been used in management of large tibial bone defects including bone graft, bone transport (distraction osteogenesis) using various external fixators, and vascularized bone graft. Each of these procedures has its limitations and complications. The study describes gradual medial fibular transfer using Ilizarov external fixators in management of patients with large tibial defect, either following infection or trauma. PATIENTS AND METHODS: Between May 2011 and June 2013, 14 patients were prospectively included in the current study...
February 7, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29416962/internal-suture-augmentation-technique-to-protect-the-anterior-cruciate-ligament-reconstruction-graft
#18
Mohamed Aboalata, Ashraf Elazab, Abdelsamie Halawa, Andreas B Imhoff, Yehia Bassiouny
The anterior cruciate ligament suture augmentation technique is a method to augment anterior cruciate ligament reconstruction (ACLR) with autologous hamstring tendons using a braided ultrahigh-molecular weight polyester or polyethylene suture or suture tape and fixed on both the femoral and tibial sides independent of the graft to act as a backup or secondary stabilizer until complete integration and ligamentization of the graft take place. The technique is proposed to allow early rehabilitation and return to sports after ACLR and may be advantageous in patients with a high body mass index and in cases with small grafts (7 or 7...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29416384/profile-of-tocilizumab-and-its-potential-in-the-treatment-of-giant-cell-arteritis
#19
REVIEW
Susan Patricia Mollan, John Horsburgh, Bhaskar Dasgupta
Giant cell arteritis (GCA) remains a medical emergency due to the threat of permanent sight loss. High-dose glucocorticoids (GCs) are effective in inducing remission in the majority of patients, however, relapses are common which lengthen GC therapy. GC toxicity remains a major morbidity in this group of patients, and conventional steroid-sparing therapies have not yet shown enough of a clinical benefit to change the standard of care. As the understanding of the underlying immunopathophysiology of GCA has increased, positive clinical observations have been made with the use of IL-6 receptor inhibitor therapies, such as tocilizumab (TCZ)...
2018: Eye and Brain
https://www.readbyqxmd.com/read/29415728/genetic-variation-analysis-of-pcv1-strains-isolated-from-guangxi-province-of-china-in-2015
#20
Liang Cao, Wenchao Sun, Huijun Lu, Mingyao Tian, Changzhan Xie, Guanyu Zhao, Jicheng Han, Wei Wang, Min Zheng, Rui Du, Ningyi Jin, Aidong Qian
BACKGROUND: Porcine circovirus type 1 (PCV1) was discovered in 1974 as a contaminant of a porcine kidney (PK-15) cell line and was generally accepted to be nonpathogenic. But recently it was shown to cause lesions in experimentally infected pig fetuses. Serological evidence and genetic studies suggested that PCV1 was widespread in domestic pigs. Thus, the molecular epidemiology and genetic variation of PCV1 are still necessary to understand. RESULTS: Here 247 tissue samples were collected from piglets in Guangxi Province, China and performed whole-genome sequencing of the PCV1 genome...
February 7, 2018: BMC Veterinary Research
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