Laura M Cox, Bruna K Tatematsu, Lydia Guo, Danielle S LeServe, Julia Mayrink, Marilia G Oliveira, Dustin Donnelly, Roberta C Fonseca, Luisa Lemos, Toby B Lanser, Ana C Rosa, Juliana R Lopes, Luke A Schwerdtfeger, Gabriela F C Ribeiro, Eduardo L C Lobo, Thais G Moreira, Andre G Oliveira, Howard L Weiner, Rafael M Rezende
Intestinal γδ T cells play an important role in shaping the gut microbiota, which is critical not only for maintaining intestinal homeostasis but also for controlling brain function and behavior. Here, we found that mice deficient for γδ T cells (γδ-/- ) developed an abnormal pattern of repetitive/compulsive (R/C) behavior, which was dependent on the gut microbiota. Colonization of WT mice with γδ-/- microbiota induced R/C behavior whereas colonization of γδ-/- mice with WT microbiota abolished the R/C behavior...
January 26, 2024: Brain, Behavior, and Immunity