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https://www.readbyqxmd.com/read/28914127/psychiatric-and-neurological-symptoms-in-patients-with-niemann-pick-disease-type-c-np-c-findings-from-the-international-npc-registry
#1
Olivier Bonnot, Clarissa S Gama, Eugen Mengel, Mercè Pineda, Marie T Vanier, Louise Watson, Marie Watissée, Barbara Schwierin, Marc C Patterson
OBJECTIVES: Niemann-Pick disease type C (NP-C) is a rare inherited neurovisceral disease that should be recognized by psychiatrists as a possible underlying cause of psychiatric abnormalities. This study describes NP-C patients who had psychiatric manifestations at enrolment in the international NPC Registry, a unique multicentre, prospective, observational disease registry. METHODS: Treating physicians' data entries describing psychiatric manifestations in NPC patients were coded and grouped by expert psychiatrists...
September 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28913514/the-incidence-of-needle-stick-and-sharp-injuries-and-their-associations-with-visual-function-among-hospital-nurses
#2
Mohammad Ghasemi, Mehdi Khabazkhoob, Hassan Hashemi, Abbasali Yekta, Payam Nabovati
PURPOSE: To determine the one-year incidence of needle stick and sharp injuries (NSIs and SIs) and their associations with visual function among Iranian nurses. METHODS: In this cross-sectional study, 278 nurses working at one hospital were selected through stratified random sampling. After applying the exclusion criteria, the final analysis was performed on the data of 267 nurses. The data of occupational injuries were collected through a researcher-administered questionnaire...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28913512/the-distribution-of-negative-and-positive-relative-accommodation-and-their-relationship-with-binocular-and-refractive-indices-in-a-young-population
#3
AbbasAli Yekta, Hassan Hashemi, Mehdi Khabazkhoob, Hadi Ostadimoghaddam, Somayeh Ghasemi-Moghaddam, Ebrahim Jafarzadehpur, Fereshteh Shokrollahzadeh
PURPOSE: To determine the distribution of negative relative accommodation (NRA) and positive relative accommodation (PRA) and its relationship with binocular vision indices in a young population. METHODS: In this cross-sectional study conducted in a student population, samples were selected through multistage cluster sampling. All the samples underwent the measurement of uncorrected and corrected visual acuity and refraction. Then far and near cover tests were performed...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28912892/real-time-in-vivo-diagnosis-of-nasopharyngeal-carcinoma-using-rapid-fiber-optic-raman-spectroscopy
#4
Kan Lin, Wei Zheng, Chwee Ming Lim, Zhiwei Huang
We report the utility of a simultaneous fingerprint (FP) (i.e., 800-1800 cm(-1)) and high-wavenumber (HW) (i.e., 2800-3600 cm(-1)) fiber-optic Raman spectroscopy developed for real-time in vivo diagnosis of nasopharyngeal carcinoma (NPC) at endoscopy. A total of 3731 high-quality in vivo FP/HW Raman spectra (normal=1765; cancer=1966) were acquired in real-time from 204 tissue sites (normal=95; cancer=109) of 95 subjects (normal=57; cancer=38) undergoing endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous nasopharyngeal tissues that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in NPC...
2017: Theranostics
https://www.readbyqxmd.com/read/28912878/triterpenoids-from-ganoderma-lucidum-inhibit-the-activation-of-ebv-antigens-as-telomerase-inhibitors
#5
Dong-Shu Zheng, Liang-Shu Chen
Nasopharyngeal carcinoma (NPC) is a malignant disease that threatens the health of humans. To find effective agents for the inhibition of Epstein-Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigation of Ganoderma lucidum was carried out in the present study. Five triterpenoids were identified, including ganoderic acid A (compound 1), ganoderic acid B (compound 2), ganoderol B (compound 3), ganodermanontriol (compound 4), and ganodermanondiol (compound 5), on the basis of spectroscopic analysis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28910895/-correlation-analysis-of-the-epstein-barr-virus-recruited-regulatory-t-cells-in-nasopharyngeal-carcinoma-of-immune-escape
#6
P Bi, J Wang, J Lu, X Liu, F Wang, Y F Luo, S D Peng, X P Li
Objective: To investigate the relation of Epstein-Barr virus (EBV)-induced immune escape to regulatory T cells(Treg) in nasopharyngeal carcinoma(NPC). Methods: We recruited 83 patients who were pathologically diagnozed as nasopharyngeal carcinoma and treated in Nanfang Hospital from January to September 2016. CD4(+) CD25(+) FOXP3(+) Treg in peripheral blood was examined by flow cytometry and the level of EBV DNA in the blood was detected by quantitative real-time polymerase chain reaction(qRT-PCR)in 83 patients and 51 healthy adults as control...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28906488/novel-chimeric-transcript-rrm2-c2orf48-promotes-metastasis-in-nasopharyngeal-carcinoma
#7
Ping Han, Ren-Hui Chen, Fang Wang, Jia-Yi Zeng, Shi-Tong Yu, Li-Hua Xu, Qian Cai, Fa-Ya Liang, Tian-Liang Xia, Zhi-Rui Lin, Qian Zhong, Xiao-Ming Huang
Recently, chimeric transcripts have been found to be associated with the pathogenesis and poor prognosis of malignant tumors. Through our preliminary experiment, a novel chimeric transcript called chimeric transcript RRM2-c2orf48 was detected in C666-1, a classical cell line of human nasopharyngeal carcinoma (NPC). Therefore, the objective of this study was to demonstrate the existence and expression of novel chimeric transcript RRM2-c2orf48 and to explore the main functions and mechanisms of RRM2-c2orf48 in NPC...
September 14, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28906411/prognostic-value-of-maximum-standard-uptake-value-metabolic-tumor-volume-and-total-lesion-glycolysis-of-positron-emission-tomography-computed-tomography-in-patients-with-nasopharyngeal-carcinoma-a-systematic-review-and-meta-analysis
#8
Qingfang Li, Jing Zhang, Wei Cheng, Chenjing Zhu, Linyan Chen, Fan Xia, Manni Wang, Fuyao Yang, Xuelei Ma
BACKGROUND: The maximal standard uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC) perform as new prognostic factors, but the outcomes of the published articles were inconclusive. In this meta-analysis, we evaluated the prognostic value of SUVmax, MTV, and TLG of PET/CT in patients with NPC. METHODS: Relevant English articles were searched in PubMed and EMBASE...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28903550/combination-of-tumor-volume-and-epstein-barr-virus-dna-improved-prognostic-stratification-of-stage-ii-nasopharyngeal-carcinoma-in-the-imrt-era-a-large-scale-cohort-study
#9
Qiu-Yan Chen, Shao-Yan Guo, Lin-Quan Tang, Tong-Yu Lu, Bo-Lin Chen, Qi-Yu Zhong, Meng-Sha Zou, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, Hai-Qiang Mai
Purpose: Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods: By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above...
September 13, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28903038/lipidomic-and-transcriptomic-basis-of-lysosomal-dysfunction-in-progranulin-deficiency
#10
Bret M Evers, Carlos Rodriguez-Navas, Rachel J Tesla, Janine Prange-Kiel, Catherine R Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L White, Joachim Herz
Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that PGRN is involved in lysosomal homeostasis and lipid metabolism. PGRN deficiency alters lysosome abundance and morphology in mouse neurons. Using an unbiased lipidomic approach, we found that brain lipid composition in humans and mice with PGRN deficiency shows disease-specific differences that distinguish them from normal and other pathologic groups...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28901826/nuclear-networking
#11
Wei Xie, Brian Burke
Nuclear lamins are intermediate filament proteins that represent important structural components of metazoan nuclear envelopes (NEs). By combining proteomics and superresolution microscopy, we recently reported that both A- and B-type nuclear lamins form spatially distinct filament networks at the nuclear periphery of mouse fibroblasts. In particular, A-type lamins exhibit differential association with nuclear pore complexes (NPCs). Our studies reveal that the nuclear lamina network in mammalian somatic cells is less ordered and more complex than that of amphibian oocytes, the only other system in which the lamina has been visualized at high resolution...
July 4, 2017: Nucleus
https://www.readbyqxmd.com/read/28900497/pretreatment-nomograms-for-local-and-regional-recurrence-after-radical-radiation-therapy-for-primary-nasopharyngeal-carcinoma
#12
Fo-Ping Chen, Li Lin, Zhen-Yu Qi, Guan-Qun Zhou, Rui Guo, Jiang Hu, Ai-Hua Lin, Jun Ma, Ying Sun
Background: The aim of this study was to build nomograms to predict local recurrence (LR) and regional recurrence (RR) in patients with nasopharyngeal carcinoma (NPC) underwent intensity-modulated radiation therapy (IMRT). Patients and Methods : A total of 1811 patients with non-metastatic NPC treated with IMRT (with or without chemotherapy) between October 2009 and February 2012 at our center were involved for building the nomograms. Nomograms for LR-free rate and RR-free rate at 3- and 5- year were generated as visualizations of Cox proportional hazards regression models, and validated using bootstrap resampling, estimating discrimination and calibration...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28900496/decreased-overall-and-cancer-specific-mortality-with-neoadjuvant-chemotherapy-in-locoregionally-advanced-nasopharyngeal-carcinoma-treated-by-intensity-modulated-radiotherapy-multivariate-competing-risk-analysis
#13
Jian Zhang, Hao Peng, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma
Background: Value of neoadjuvant chemotherapy (NACT) is still controversial in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Based on competing risk analysis model, we aim at evaluating the efficacy of NACT in decreasing cancer-specific mortality for LA-NPC (except T3-4N0) treated by intensity-modulated radiotherapy (IMRT). Methods: Data on 957 patients with LA-NPC were retrospectively reviewed. The cumulative incidence of cancer-specific and non-cancer-specific (competing) mortality was determined by univariate and multivariate competing risk analysis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28893937/epstein-barr-virus-infection-and-nasopharyngeal-carcinoma
#14
REVIEW
Sai Wah Tsao, Chi Man Tsang, Kwok Wai Lo
Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chinese population. A strong association between NPC risk and the HLA locus at chromosome 6p has been identified, indicating a link between the presentation of EBV antigens to host immune cells and NPC risk. EBV infection in NPC is clonal in origin, strongly suggesting that NPC develops from the clonal expansion of a single EBV-infected cell...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28893862/molecular-profile-of-nasopharyngeal-carcinoma-analysing-tumour-suppressor-gene-promoter-hypermethylation-by-multiplex-ligation-dependent-probe-amplification
#15
Marc Ooft, Jolique van Ipenburg, Rob van Loo, Rick de Jong, Cathy Moelans, Weibel Braunius, Remco de Bree, Paul van Diest, Senada Koljenović, Rob Baatenburg de Jong, Jose Hardillo, Stefan Willems
AIMS: To assess differences in methylation profiles, and thus pathogenesis, between Epstein-Barr virus (EBV)-positive and negative nasopharyngeal carcinomas (NPCs). Also, promoter hypermethylation is a common phenomenon in early carcinogenesis to inactivate tumour suppressor genes. Since epigenetic changes are reversible, the therapeutic application of methylation inhibitors could provide treatment options. METHODS: We evaluated promoter hypermethylation profiles of 22 common tumour suppressor genes in 108 NPCs using methylation-specific multiplex ligation-dependent probe amplification...
September 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28892580/correlation-of-quantitative-parameters-of-magnetic-resonance-perfusion-weighted-imaging-with-vascular-endothelial-growth-factor-microvessel-density-and-hypoxia-inducible-factor-1%C3%AE-in-nasopharyngeal-carcinoma-evaluation-on-radiosensitivity-study
#16
Ying Hu, Hong E, Xiaoping Yu, Feiping Li, Longwu Zeng, Qiang Lu, Xuping Xi, Liangfang Shen
OBJECTIVES: To investigate the correlation of parameters of magnetic resonance perfusion-weighted imaging (MR-PWI) with the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and microvessel density (MVD) in nasopharyngeal carcinoma (NPC) so as to explore the value of predicting radiosensitivity. DESIGN: A prospective study. SETTING: Department of Head-and-neck radiotherapy in Hunan Cancer Hospital...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28889265/manganese-and-the-insulin-igf-signaling-network-in-huntington-s-disease-and-other-neurodegenerative-disorders
#17
Miles R Bryan, Aaron B Bowman
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting in motor impairment and death in patients. Recently, several studies have demonstrated insulin or insulin-like growth factor (IGF) treatment in models of HD, resulting in potent amelioration of HD phenotypes via modulation of the PI3K/AKT/mTOR pathways. Administration of IGF and insulin can rescue microtubule transport, metabolic function, and autophagy defects, resulting in clearance of Huntingtin (HTT) aggregates, restoration of mitochondrial function, amelioration of motor abnormalities, and enhanced survival...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28887732/clinical-outcomes-of-concurrent-chemoradiotherapy-with-volumetric-modulated-arc-therapy-in-patients-with-locally-advanced-nasopharyngeal-carcinoma
#18
Nobuki Imano, Yuji Murakami, Takeo Nakashima, Yuki Takeuchi, Ippei Takahashi, Yoshiko Doi, Ikuno Nishibuchi, Tomoki Kimura, Koichi Wadasaki, Tsutomu Ueda, Katsuhiro Hirakawa, Yasushi Nagata
PURPOSE: The purpose of this study was to analyze the clinical results of concurrent chemoradiotherapy (CCRT) with volumetric modulated arc therapy (VMAT) for nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: Patients with stage II-IVB NPC who received CCRT with VMAT between 2010 and 2014 were included in this study. The planned dose was 70 Gy in 35 fractions. RESULTS: Twenty patients aged between 28 and 85 years (median 60 years) were assessed...
September 8, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28887410/a-coarse-grained-computational-model-of-the-nuclear-pore-complex-predicts-phe-gly-nucleoporin-dynamics
#19
Joan Pulupa, Manas Rachh, Michael D Tomasini, Joshua S Mincer, Sanford M Simon
The phenylalanine-glycine-repeat nucleoporins (FG-Nups), which occupy the lumen of the nuclear pore complex (NPC), are critical for transport between the nucleus and cytosol. Although NPCs differ in composition across species, they are largely conserved in organization and function. Transport through the pore is on the millisecond timescale. Here, to explore the dynamics of nucleoporins on this timescale, we use coarse-grained computational simulations. These simulations generate predictions that can be experimentally tested to distinguish between proposed mechanisms of transport...
September 8, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28887038/resveratrol-protects-against-mitochondrial-dysfunction-through-autophagy-activation-in-human-nucleus-pulposus-cells
#20
Baolong Zhang, Linfei Xu, Naiqiang Zhuo, Jieliang Shen
Intervertebral disc degeneration (IVDD) is closely related with aging, whereas mitochondrial damage is a common feature of aging that results in cell apoptosis. Resveratrol (RES) is a natural antioxidant that protects against mitochondrial dysfunction in various cells. This study aimed to investigate the protective role of RES against mitochondrial dysfunction and human nucleus pulposus cell (NPC) apoptosis. We found that mitochondrial dysfunction and NPC apoptosis could be induced under oxidative stress by 100 μmol/l of H2O2...
September 5, 2017: Biochemical and Biophysical Research Communications
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