keyword
MENU ▼
Read by QxMD icon Read
search

NPC

keyword
https://www.readbyqxmd.com/read/28328537/long-non-coding-rna-loc100129148-functions-as-an-oncogene-in-human-nasopharyngeal-carcinoma-by-targeting-mir-539-5p
#1
Kai-Yu Sun, Tao Peng, Zhe Chen, Peng Song, Xu-Hong Zhou
Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including human nasopharyngeal carcinoma (NPC). The correlation between lncRNAs expression and NPC development has not been well identified in the recent literature. Recently, high-through put analysis reveals that LOC100129148 is highly expressed in NPC. However, whether the aberrant expression of LOC100129148 in NPC is corrected with tumorigenesis or prognosis has not been investigated. Herein, we identified that LOC100129148 was up-regulated in NPC tissues and cell lines, and higher expression of LOC100129148 resulted in a markedly poorer survival time...
March 21, 2017: Aging
https://www.readbyqxmd.com/read/28327728/in-situ-fe2n-n-doped-porous-carbon-hybrids-as-superior-catalysts-for-oxygen-reduction-reaction
#2
Xiaoxiao Huang, Ziyu Yang, Bing Dong, Yazhou Wang, Tianyu Tang, Yanglong Hou
Developing efficient and economical noble-metal free catalysts for oxygen reduction reaction (ORR) is one of the essential factors for the industrialization of fuel cells. Recent studies on transition metal ORR catalysts have become the priority to practical low-temperature fuel cells. Herein, we proposed a novel in situ design, Fe2N nanoparticles (NPs) in an N doped porous carbon matrix (Fe2N@NPC) derived from metal organic frameworks (MOFs) as high-performance ORR catalysts. The decorated Fe2N NPs increase the amount of Fe-N/C bonding as catalytic site...
March 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28325485/the-effects-of-interprofessional-education-self-reported-professional-competence-among-prehospital-emergency-care-nursing-students-on-the-point-of-graduation-a-cross-sectional-study
#3
M Castrèn, M Mäkinen, J Nilsson, V Lindström
The aim of the study was to investigate whether interprofessional education (IPE) and interprofessional collaboration (IPC) during the educational program had an impact on prehospital emergency care nurses' (PECN) self-reported competence towards the end of the study program. A cross-sectional study using the Nurse Professional Competence (NPC) Scale was conducted. A comparison was made between PECN students from Finland who experienced IPE and IPC in the clinical setting, and PECN students from Sweden with no IPE and a low level of IPC...
March 16, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28321405/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-lymphocyte-to-monocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-nasopharyngeal-carcinoma
#4
Aiying Lu, Haifeng Li, Yuming Zheng, Minzhong Tang, Jun Li, Huihui Wu, Weiming Zhong, Jianquan Gao, Ningjiang Ou, Yonglin Cai
The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28317842/bde-99-impairs-differentiation-of-human-and-mouse-npcs-into-the-oligodendroglial-lineage-by-species-specific-modes-of-action
#5
Katharina Dach, Farina Bendt, Ulrike Huebenthal, Susanne Giersiefer, Pamela J Lein, Heike Heuer, Ellen Fritsche
Polybrominated diphenyl ethers (PBDEs) are bioaccumulating flame retardants causing developmental neurotoxicity (DNT) in humans and rodents. Their DNT effects are suspected to involve thyroid hormone (TH) signaling disruption. Here, we tested the hypothesis whether disturbance of neural progenitor cell (NPC) differentiation into the oligodendrocyte lineage (O4(+) cells) by BDE-99 involves disruption of TH action in human and mouse (h,m)NPCs. Therefore, we quantified differentiation of NPCs into O4(+) cells and measured their maturation via expression of myelin-associated genes (hMBP, mMog) in presence and absence of TH and/or BDE-99...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315691/mir-519-suppresses-nasopharyngeal-carcinoma-cell-proliferation-by-targeting-oncogene-urg4-urgcp
#6
Guodong Yu, Tian Zhang, Ying Jing, Qingmin Bao, Qiang Tang, Yu Zhang
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumor in Southeast Asia, its regulatory mechanism is still to be understood. miR-519 inhibits the progression of several tumors, including cervical cancer, ovarian cancer and gastric cancer. But its role in NPC hasn't been studied. In present study, we found miR-519 was downregulated in NPC cells, its overexpression inhibited NPC cell proliferation and arrested cell cycle at G0/G1 phase, while its knockdown promoted NPC cell proliferation and cell cycle progression...
March 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28315689/in-silico-prediction-of-hpxr-activators-using-structure-based-pharmacophore-modeling
#7
Nao Torimoto-Katori, Ruili Huang, Harutoshi Kato, Rikiya Ohashi, Menghang Xia
The activation of pregnane X receptor (PXR), a member of the nuclear receptor superfamily, can mediate potential drug-drug interactions by regulating the expression of several drug- mediated enzymes and transporters, resulting in reduced therapeutic efficacy or increased toxicity by producing reactive metabolites. Therefore, in the early stage of drug development, it is important to predict these risks using an in silico approach. We constructed a human PXR (hPXR) pharmacophore model based on known structural information of compounds that activate PXR...
March 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28301518/cyclooxygenase-2-expression-is-positively-associated-with-lymph-node-metastasis-in-nasopharyngeal-carcinoma
#8
Gui Yang, Qiaoling Deng, Wei Fan, Zheng Zhang, Peipei Xu, Shihui Tang, Ping Wang, Jun'e Wang, Mingxia Yu
BACKGROUND: Accumulating evidence has demonstrated that cyclooxygenase-2 (COX-2) is involved in head and neck cancers, especially in nasopharyngeal carcinoma (NPC). However, the association between COX-2 expression and lymph node metastasis in NPC remains uncertain. This systematic review and meta-analysis meta-analysis investigated the relationship between COX-2 expression and lymph node metastasis and other signs of disease progression in NPC. METHODS: Previously published studies assessing COX-2 expression and lymph node metastasis in NPC were identified in four English databases and three Chinese ones (Pubmed, Embase, Cochrane Database of Systematic Reviews, Web of Science, China National Knowledge Infrastructure, Wanfang, Vip Journal Integration Platform) up to November 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28296774/pretreatment-hematologic-markers-as-prognostic-factors-in-patients-with-nasopharyngeal-carcinoma-a-systematic-review-and-meta-analysis
#9
Li Su, Mingwei Zhang, Weijian Zhang, Chuanshu Cai, Jinsheng Hong
BACKGROUND: Pretreatment hematologic parameters of the inflammatory response, including lymphocyte, neutrophil, and platelet counts, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio, have emerged as prognostic factors for patients with cancer. This systematic review and meta-analysis aimed to summarize the association between the hematologic markers and prognosis of nasopharyngeal carcinoma (NPC). METHODS: A systematic search of PubMed, Google Scholar, MEDLINE, EMBASE, Web of Science, and the Cochrane Library was conducted up to April 2016...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28296311/analysis-of-setup-error-based-on-ctvision-for-nasopharyngeal-carcinoma-during-igrt
#10
Shuxu Zhang, Xiang Zhou, Quanbin Zhang, Shaohui Jiang, Ruihao Wang, Guoqian Zhang, Huaiyu Lei, Shengqu Lin
The aim of the present study was to investigate the role of CTVision in interfractional setup errors during intensity-modulated radiation therapy (IMRT) in 12 nasopharyngeal carcinoma (NPC) patients. The trend of setup errors as a function of time during a fractionated radiotherapy course was investigated, and the influence of reconstructive thickness on image reconstruction for setup errors was analyzed. The appropriate planning target volume (PTV) margin and planning risk volume (PRV) margin were defined to provide a reference for the design of IMRT for NPC...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291319/molybdenum-carbide-embedded-nitrogen-doped-porous-carbon-nanosheets-as-electrocatalysts-for-water-splitting-in-alkaline-media
#11
Chenbao Lu, Diana Tranca, Jian Zhang, Fermı N Rodrı Guez Hernández, Yuezeng Su, Xiaodong Zhuang, Fan Zhang, Gotthard Seifert, Xinliang Feng
Molybdenum carbide (Mo2C) based catalysts were found to be one of the most promising electrocatalysts for hydrogen evolution reaction (HER) in acid media in comparison with Pt-based catalysts but were seldom investigated in alkaline media, probably due to the limited active sites, poor conductivity, and high energy barrier for water dissociation. In this work, Mo2C-embedded nitrogen-doped porous carbon nanosheets (Mo2C@2D-NPCs) were successfully achieved with the help of a convenient interfacial strategy. As a HER electrocatalyst in alkaline solution, Mo2C@2D-NPC exhibited an extremely low onset potential of ∼0 mV and a current density of 10 mA cm(-2) at an overpotential of ∼45 mV, which is much lower than the values of most reported HER electrocatalysts and comparable to the noble metal catalyst Pt...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28287323/relationship-between-the-comprehensive-nutritional-index-and-the-eortc-qlq-h-n35-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiation-therapy
#12
Yan He, Liping Chen, Linmin Chen, Wen Hu, Cong Wang, Linquan Tang, Haiqiang Mai, Jianmei Li, Liping Wu, Yuying Fan
This study aimed to explore the relationship between the comprehensive nutritional index (CNI) and quality of life in nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiation therapy (IMRT). The nutritional index, which includes total lymphocyte count, hemoglobin and albumin levels, body mass index, and usual body weight percentage, was evaluated pre-treatment and post-treatment in patients who underwent IMRT. The quality of life of NPC patients was measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Cancer Module (EORTC QLQ-H&N35) at four time points: pre-treatment, post-treatment, and 3 and 6 mo after IMRT...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28282615/mln64-induces-mitochondrial-dysfunction-associated-with-increased-mitochondrial-cholesterol-content
#13
Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I Cancino, Nuria Matías, Pablo José Sáez, Alexis Martínez, Alejandra R Álvarez, Carmen Garcia-Ruiz, José C Fernandez-Checa, Silvana Zanlungo
MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in mitochondrial dysfunction. Down-regulation of MLN64 in Niemann-Pick C1 deficient cells decreased mitochondrial cholesterol content, suggesting that MLN64 functions independently of NPC1. However, the role of MLN64 in the maintenance of endosomal cholesterol flow and intracellular cholesterol homeostasis remains unclear...
March 2, 2017: Redox Biology
https://www.readbyqxmd.com/read/28280088/radiomics-features-of-multiparametric-mri-as-novel-prognostic-factors-in-advanced-nasopharyngeal-carcinoma
#14
Shuixing Zhang, Bin Zhang, Jie Tian, Di Dong, Dong Sheng Gu, Yu Hao Dong, Lu Zhang, Zhou Yang Lian, Jing Liu, Xiao Ning Luo, Shu Fang Pei, Xiao Kai Mo, Wen Hui Huang, Fu Sheng Ouyang, Bao Liang Guo, Long Liang, Wenbo Chen, Chang H Liang
PURPOSE: To identify MRI-based radiomics as prognostic factors in patients with advanced nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN: One-hundred and eighteen patients (training cohort: n = 88; validation cohort: n = 30) with advanced NPC were enrolled. A total of 970 radiomics features were extracted from T2-weighted (T2-w) and contrast-enhanced T1-weighted (CET1-w) MRI. Least absolute shrinkage and selection operator (LASSO) regression was applied to select features for progression-free survival (PFS) nomograms...
March 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28277541/the-foxm1-abcc5-axis-contributes-to-paclitaxel-resistance-in-nasopharyngeal-carcinoma-cells
#15
Youxiang Hou, Qianling Zhu, Zheng Li, Yongbo Peng, Xiaohui Yu, Bowen Yuan, Yijun Liu, Youhong Liu, Linglong Yin, Yuchong Peng, Zhenghua Jiang, Jinping Li, Bowen Xie, Yumei Duan, Guolin Tan, Kurban Gulina, Zhicheng Gong, Lunquan Sun, Xuegong Fan, Xiong Li
Paclitaxel is clinically used as a first-line chemotherapeutic regimen for several cancer types, including head and neck cancers. However, acquired drug resistance results in the failure of therapy, metastasis and relapse. The drug efflux mediated by ATP-binding cassette (ABC) transporters and the survival signals activated by forkhead box (FOX) molecules are critical in the development of paclitaxel drug resistance. Whether FOX molecules promote paclitaxel resistance through drug efflux remains unknown. In this study, we developed several types of paclitaxel-resistant (TR) nasopharyngeal carcinoma (NPC) cells...
March 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28275034/critical-evaluation-of-the-quality-and-recommendations-of-clinical-practice-guidelines-for-nasopharyngeal-carcinoma
#16
Yu-Pei Chen, Ya-Qin Wang, Wen-Fei Li, Lei Chen, Cheng Xu, Tai-Xiang Lu, Ai-Hua Lin, Ji-Jin Yao, Yang-Chan Li, Ying Sun, Yan-Ping Mao, Jun Ma
Background: Given the distinct biological characteristics and regional distribution of nasopharyngeal carcinoma (NPC) compared with other head and neck cancers, and uncertainties regarding therapeutic strategies, physicians require high-quality clinical practice guidelines (CPGs) to provide transparent recommendations for NPC treatment. This study aimed to critically appraise the quality of NPC CPGs and assess the consistency of their recommendations. Methods: We identified CPGs that provided recommendations on the diagnosis and management of NPC published up to December 2015...
March 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28269757/correlations-of-the-expressions-of-c-jun-and-egr-1-proteins-with-clinicopathological-features-and-prognosis-of-patients-with-nasopharyngeal-carcinoma
#17
Jia-Teng Zhong, Hai-Jun Wang, Jian Yu, Jing-Hang Zhang, Shi-Feng Wang, Xue Yang, Wei Su
This study intended to explore the correlation of the expressions of c-Jun and Egr-1 proteins with clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2008 to January 2011, 123 NPC patients and 59 patients with chronic rhinitis were enrolled in this study. Fresh NPC and normal nasopharynx tissue specimens were obtained during surgery. Immunohistochemistry (IHC) was adopted to determine the positive expressions of the c-Jun and Egr-1 proteins. A 5-year clinical follow-up was conducted on all NPC patients...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28267540/whole-body-18-f-fdg-pet-ct-for-m-staging-in-the-patient-with-newly-diagnosed-nasopharyngeal-carcinoma-who-needs
#18
Yun-Yan Ren, You-Cai Li, Hu-Bing Wu, Quan-Shi Wang, Yan-Jiang Han, Wen-Lan Zhou, Hong-Sheng Li
OBJECTIVE: Although whole-body fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) ((18)F-FDG PET/CT) is commonly used for M staging of newly diagnosed nasopharyngeal carcinoma (NPC), some patients may not benefit from this procedure. The present study investigated which patients require this modality for M staging. METHODS: Whole-body (18)F FDG PET/CT results and clinical data were collected for 264 patients with newly diagnosed NPC...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28265567/a-study-of-358-cases-of-locally-advanced-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiation-therapy-improving-the-seventh-edition-of-the-american-joint-committee-on-cancer-t-staging-system
#19
Qin Zhou, Yuxiang He, Yajie Zhao, Yin Wang, Weilu Kuang, Liangfang Shen
To evaluate the rationality and limitations of the seventh edition of the American Joint Committee on Cancer (the 7th AJCC edition) T-staging system for locally advanced nasopharyngeal carcinoma (NPC). The prognosis of 358 patients with stage T3/T4 NPC treated with intensity-modulated radiotherapy (IMRT) was analyzed with the Kaplan-Meier method or the log-rank test. The 7th AJCC staging system of NPC has some limitations in that the T category is neither the significant factor in OS/LRFS nor the independent prognostic factor in OS/LRFS/DMFS/DFS (P > 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28265202/mir-20a-5p-promotes-radio-resistance-by-targeting-rab27b-in-nasopharyngeal-cancer-cells
#20
Dabing Huang, Geng Bian, Yueyin Pan, Xinghua Han, Yubei Sun, Yong Wang, Guodong Shen, Min Cheng, Xiang Fang, Shilian Hu
BACKGROUND: MicroRNAs (miRNAs) was reported to be involved in cancer radio-resistance, which remains a major obstacle for effective cancer therapy. METHODS: The differently expressed miRNAs were detected by RNA-seq experiment in nasopharyngeal cancer (NPC) cells. MiR-20a-5p was selected as our target, which was subject to finding its target gene Rab27B via bioinformatics analysis. The qRT-PCR, western blot and the luciferase reporter assays were performed to confirm Rab27B as the target of miR-20a-5p...
2017: Cancer Cell International
keyword
keyword
39944
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"