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https://www.readbyqxmd.com/read/29775110/near-point-of-convergence-in-iranian-schoolchildren-normative-values-and-associated-factors
#1
Hassan Hashemi, Payam Nabovati, Mehdi Khabazkhoob, Abbasali Yekta, Mohammad Hassan Emamian, Akbar Fotouhi
PURPOSE: To determine the distribution of near point of convergence (NPC) and its related factors in 6 to 12-year-old children. METHODS: In a cross-sectional study in 2015, the urban and rural children of Shahroud, north of Iran, were sampled. All rural schoolchildren were invited to the study, and in the urban area, we conducted random cluster sampling. Examinations included measurement of uncorrected and corrected visual acuity, manifest, subjective, and cycloplegic refraction...
May 18, 2018: Strabismus
https://www.readbyqxmd.com/read/29771087/-expression-of-c-fos-in-nasopharyngeal-carcinoma-and-the-relationship-with-chemosensitivity-and-prognosis
#2
Y T Liu, F P Zhao, H B Miao, S Z Fu, S Zhou, X G Zhang, G Qin
Objective: To investigate the expression of C-fos in patients with nasopharyngeal carcinoma(NPC), and analyze the relationship between the expression of C-fos and the clinical characteristics, chemosensitivity and prognosis. Method: Clinical and follow-up data of 75 NPC patients was analyzed retrospectively. The expression of C-fos was detected by immunohistochemical assay, and chemosensitivity was detected by ATP bioluminescent anticancer drug sensitivity detection technology. The relationship between them was studied...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771085/-expression-patterns-and-prognostic-values-of-nrf2-and-keap1-in-nasopharyngeal-carcinoma
#3
X K Ma, J S Liu
Objective: To investigate the expression of Nrf2 and Keap1 in nasopharyngeal carcinoma (NPC) and to analyze the relationship between the expression of Nrf2 and Keap1 and the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma. Method: A total of 108 patients with biopsy-proven nonkeratinizing squamous cell carcinoma-undifferentiated type with available biopsy specimens for tissue microarray (TMA) construction were selected. The relationship between Nrf2 and Keap1 protein expression and the prognosis of radiotherapy in patients with nasopharyngeal carcinoma was analyzed...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771040/-the-value-of-plasma-ebv-dna-testing-in-high-risk-group-of-nasopharyngeal-carcinoma-in-the-nasal-endoscopy
#4
X F He, X Yu, M F Ji, M Y Fu
Objective: The aim of this study is to evaluate the level of plasma EBV DNA and nasal endoscopy in high risk population of nasopharyngeal carcinoma, and to explore the value of EBV DNA testing in nasal endoscopy. Method: The nasopharyngeal carcinoma was screened in High-incidence Area of Zhongshan City. EBV antibody was detected by ELISA, and 427 patients with high risk of nasopharyngeal carcinoma were identified. In the high risk population the plasma EBV-DNA was measured using Fluorescent quantitative PCR, and all patients were used nasal endoscopy in the first two years...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29769697/establishment-of-a-nasopharyngeal-carcinoma-cell-line-capable-of-undergoing-lytic-epstein-barr-virus-reactivation
#5
Yim Ling Yip, Weitao Lin, Wen Deng, Lin Jia, Kwok Wai Lo, Pierre Busson, Benjamin Vérillaud, Xuefeng Liu, Chi Man Tsang, Maria Li Lung, Sai Wah Tsao
Epstein-Barr virus (EBV) infects more than 90% of the adult human population. Undifferentiated nasopharyngeal carcinoma (NPC) is common in Southeast Asia, with a particularly high incidence among southern Chinese. The EBV genome can be detected in practically all cancer cells in undifferentiated NPC. The role of EBV in pathogenesis of undifferentiated NPC remains elusive. NPC cell lines are known to be difficult to establish in culture. The EBV+ve NPC cell lines, even if established in culture, rapidly lost their EBV episomes upon prolonged propagation...
May 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29769101/a-new-strategy-for-volumetric-modulated-arc-therapy-planning-using-autoplanning-based-multicriteria-optimization-for-nasopharyngeal-carcinoma
#6
Juanqi Wang, Zhi Chen, Weiwei Li, Wei Qian, Xiaosheng Wang, Weigang Hu
BACKGROUND: A new strategy for making the appropriate choice of the representative optimization parameters in planning processes and accurate selection criteria during Pareto surface navigation for general multicriteria optimization (MCO) was recommended in the study. The purpose was to combine both benefits of AutoPlanning optimization and MCO (APMCO) for achieving an individual volumetric-modulated arc therapy (VMAT) plan according to the clinically achieved patient-specific tradeoff among conflicting priorities...
May 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29765233/patterns-of-local-failures-and-suggestions-for-reduction-of-clinical-target-volume-for-nasopharyngeal-carcinoma-patients-without-cervical-lymph-node-metastasis
#7
Yujiao Li, Xiaomin Ou, Chunying Shen, Tingting Xu, Weiwei Li, Chaosu Hu
Background: To demonstrate the robustness of clinical target volume delineation for nasopharyngeal carcinoma (NPC) patients, this study makes a detailed analysis of the initial irradiated dose of the recurrent site and local failure patterns after intensity-modulated radiation therapy (IMRT). Based on this analysis, further improvement of delineation recommendations may be made in order to improve the quality-of-life in NPC, without decreasing the local control and survival rate. Methods: In total, 382 newly diagnosed non-metastatic NPC patients were retrospectively enrolled, receiving elective neck irradiation to levels II, III, and VA...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29764509/ultrasound-guided-fine-needle-aspiration-of-retropharyngeal-lymph-nodes-after-radiotherapy-for-nasopharyngeal-carcinoma-a-novel-technique-for-accurate-diagnosis
#8
Long-Jun He, Chuanbo Xie, Yin Li, Lin-Na Luo, Ke Pan, Xiao-Yan Gao, Li-Zhi Liu, Jian-Ming Gao, Guang-Yu Luo, Hong-Bo Shan, Ming-Yuan Chen, Chong Zhao, Wei-Jun Fan, Ping Yang, Guo-Liang Xu, Jian-Jun Li
BACKGROUND: Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the pathological results. However, RLN sampling is difficult and imminent in the clinic setting. We recently developed a novel minimally invasive technique termed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for sampling RLN tissues sufficient for pathological or cytological diagnosis...
May 9, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764502/decreased-macrophage-inflammatory-protein-mip-1%C3%AE-and-mip-1%C3%AE-increase-the-risk-of-developing-nasopharyngeal-carcinoma
#9
Meng-Jie Yang, Jie Guo, Yan-Fang Ye, Sui-Hong Chen, Li-Xia Peng, Chu-Yang Lin, Ting Hu, Shang-Hang Xie, Chuan-Bo Xie, Qi-Hong Huang, Yu-Qiang Lu, Qing Liu, Chao-Nan Qian, Su-Mei Cao
BACKGROUND: The association of circulating inflammation markers with nasopharyngeal carcinoma (NPC) is still largely unclear. This study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study in southern China. METHODS: The serum levels of 33 inflammatory cytokines were first measured in a hospital-based case-control study (150 NPC patients and 150 controls) using multiplex assay platforms...
April 3, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764493/nasopharyngeal-brushing-a-convenient-and-feasible-sampling-method-for-nucleic-acid-based-nasopharyngeal-carcinoma-research
#10
Pei-Fen Zhang, Xiao-Hui Zheng, Xi-Zhao Li, Tian Tian, Shao-Dan Zhang, Ye-Zhu Hu, Wei-Hua Jia
BACKGROUND: Tissue specimens for nasopharyngeal carcinoma (NPC) research are scarce because of sampling difficulties. Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC diagnosis. The present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for research. METHODS: Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC patients...
April 12, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764490/efficacy-of-the-hypoxia-activated-prodrug-evofosfamide-th-302-in-nasopharyngeal-carcinoma-in-vitro-and-in-vivo
#11
Yan Huang, Ying Tian, Yuanyuan Zhao, Cong Xue, Jianhua Zhan, Lin Liu, Xiaobo He, Li Zhang
BACKGROUND: Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia-inducible factor-1α (HIF-1α) is overexpressed in nasopharyngeal carcinoma (NPC) tissues, we performed the present study to evaluate the efficacy profile of evofosfamide in NPC. METHODS: We evaluated the efficacy of evofosfamide as a single agent or combined with cisplatin (DDP) in the NPC cell lines CNE-2, HONE-1 and HNE-1, and in nude mouse xenograft tumor models...
May 3, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764487/effect-of-induction-chemotherapy-with-cisplatin-fluorouracil-with-or-without-taxane-on-locoregionally-advanced-nasopharyngeal-carcinoma-a-retrospective-propensity-score-matched-analysis
#12
Guo-Ying Liu, Xing Lv, Yi-Shan Wu, Min-Jie Mao, Yan-Fang Ye, Ya-Hui Yu, Hu Liang, Jing Yang, Liang-Ru Ke, Wen-Ze Qiu, Xin-Jun Huang, Wang-Zhong Li, Xiang Guo, Yan-Qun Xiang, Wei-Xiong Xia
BACKGROUND: Available data in the literature comparing different induction chemotherapy (IC) regimens on locoregionally advanced nasopharyngeal carcinoma (NPC) are scarce. The purpose of the present study was to evaluate the outcomes of locoregionally advanced NPC patients who were treated with taxane, cisplatin and 5-fluorouracil (TPF) or cisplatin and 5-fluorouracil (PF) as IC followed by concurrent chemoradiotherapy (CCRT). METHODS: In total, 1879 patients with locoregionally advanced NPC treated with IC and CCRT from a prospectively maintained database were included in the present observational study...
May 10, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764469/chibby-suppresses-aerobic-glycolysis-and-proliferation-of-nasopharyngeal-carcinoma-via-the-wnt-%C3%AE-catenin-lin28-let7-pdk1-cascade
#13
Cheng-Fu Cai, Guo-Dong Ye, Dong-Yan Shen, Wei Zhang, Mao-Li Chen, Xin-Xin Chen, Da-Xiong Han, Yan-Jun Mi, Qi-Cong Luo, Wang-Yu Cai, Shu-Yu Yang
BACKGROUND: Great progress has been achieved in the study of the aerobic glycolysis or the so-called Warburg effect in a variety of cancers; however, the regulation of the Warburg effect in Nasopharyngeal carcinoma (NPC) has not been completely defined. METHODS: Gene expression pattern of NPC cells were used to test associations between Chibby and β-catenin expression. Chibby siRNAs and over-expression vector were transfected into NPC cells to down-regulate or up-regulate Chibby expression...
May 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29764160/combinatorial-strategies-of-radiotherapy-and-immunotherapy-in-nasopharyngeal-carcinoma
#14
Eugenia L L Yeo, You Quan Li, Khee-Chee Soo, Joseph T S Wee, Melvin L K Chua
Immunotherapy and radiation therapy (RT) have each demonstrated clinical success in the treatment of nasopharyngeal carcinoma (NPC) when utilized independently. Several characteristics of NPC make it particularly well suited for immunotherapeutic strategies, such as the association with viral infections like EBV and human papilloma virus (HPV), upregulation of PD-L1 expression, and the high number of tumor infiltrating lymphocytes. Immune checkpoint blockade is one such immunotherapeutic strategy that is gaining popularity rapidly...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29764118/longitudinal-assessment-of-intravoxel-incoherent-motion-diffusion-weighted-imaging-in-evaluating-the-radio-sensitivity-of-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiation-therapy
#15
Youping Xiao, Ying Chen, Yunbin Chen, Zhuangzhen He, Yiqi Yao, Jianji Pan
Purpose: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) was evaluated regarding its ability to preliminarily predict the short-term treatment response of nasopharyngeal carcinoma (NPC) following intensity-modulated radiation therapy. Methods: IVIM-DWI with 14 b-factors (0-1,000 s/mm2) was performed with a 3T MR system on 47 consecutive NPCs before, during (end of the 5th, 10th, 15th, 20th, and 25th fractions), and after fractional radiotherapy...
May 14, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29763377/influence-of-polg-on-radiosensitivity-of-nasopharyngeal-carcinoma-cells
#16
Ruiqing Chen, Zeng Wang, Ruilong Lan, Fei Huang, Jinrong Chen, Yuanteng Xu, Hengshan Zhang, Lurong Zhang
BACKGROUND AND OBJECTIVE: There is a high incidence of nasopharyngeal carcinoma (NPC), malignant head and neck tumors, in southern China. Radioresistance is the main cause affecting the efficacy of NPC treatments. The POLG gene particularly plays an important role in radiation-induced damage repair. In this study, the authors established RNAi CNE-1 and CNE-2 knockdown in two NPC cell lines to observe whether this gene affects the radiosensitivity of NPC cells. MATERIALS AND METHODS: Four short hairpin RNA (shRNA) expression plasmids targeting POLG gene were constructed and transfected into the NPC cell lines CNE-1 and CNE-2...
May 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29761987/-comparison-of-planning-quality-and-delivery-efficiency-between-volumetric-modulated-arc-therapy-and-dynamic-intensity-modulated-radiation-therapy-for-nasopharyngeal-carcinoma-with-more-than-4-prescribed-dose-levels
#17
Pengfei Jia, Jun Xu, Xiaoxi Zhou, Jian Chen, Lemin Tang
The aim of this study is to compare the planning quality and delivery efficiency between dynamic intensity modulated radiation therapy (d-IMRT) and dual arc volumetric modulated arc therapy (VMAT) systematically for nasopharyngeal carcinoma (NPC) patients with multi-prescribed dose levels, and to analyze the correlations between target volumes and plan qualities. A total of 20 patients of NPC with 4-5 prescribed dose levels to achieve simultaneous integrated boost (SIB) treated by sliding window d-IMRT in our department from 2014 to 2015 were re-planned with dual arc VMAT...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29760803/effectiveness-of-cetuximab-in-combination-with-concurrent-chemoradiotherapy-in-locoregionally-advanced-nasopharyngeal-carcinoma-a-1-2-propensity-score-matched-analysis
#18
Li-Rong Wu, Huan-Feng Zhu, Jianhua Xu, Xue-Song Jiang, Li Yin, Ning Jiang, Dan Zong, Fei-Jiang Wang, Sheng-Fu Huang, Xiu-Hua Bian, Jian-Feng Wu, Dan Song, Wen-Jie Guo, Ju-Ying Liu, Xia He
Background : This study aimed to compare concurrent chemoradiotherapy (CCRT) plus cetuximab (C) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma(NPC). Methods : A total of 682 locoregionally advanced NPC patients who had undergone chemoradiotherapy with or without cetuximab were included. Propensity score-matching method was used to match patients. Progression-free survival (PFS), overall survival (OS), locoregional relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) were compared between the two treatment arms...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29760649/brain-region-dependent-rejection-of-neural-precursor-cell-transplants
#19
Nina Fainstein, Tamir Ben-Hur
The concept of CNS as an immune-privileged site has been challenged by the occurrence of immune surveillance and allogeneic graft rejection in the brain. Here we examined whether the immune response to allogeneic neural grafts is determined by the site of implantation in the CNS. Dramatic regional differences were observed between immune responses to allogeneic neural precursor/stem cell (NPC) grafts in the striatum vs. the hippocampus. Striatal grafts were heavily infiltrated with IBA-1+ microglia/macrophages and CD3+ T cells and completely rejected...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29760646/dgcr8-promotes-neural-progenitor-expansion-and-represses-neurogenesis-in-the-mouse-embryonic-neocortex
#20
Nadin Hoffmann, Stefan C Weise, Federica Marinaro, Tanja Vogel, Davide De Pietri Tonelli
DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these proteins exert crucial functions in corticogenesis. The identification of mechanisms of DGCR8- or DROSHA-dependent regulation of gene expression in conditional knockout mice are often complicated by massive apoptosis. Here, to investigate DGCR8 functions on amplification/differentiation of neural progenitors cells (NPCs) in corticogenesis, we overexpress Dgcr8 in the mouse telencephalon, by in utero electroporation ( IU Ep)...
2018: Frontiers in Neuroscience
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