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Sphincter of oddi

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https://www.readbyqxmd.com/read/27888858/novel-findings-in-the-management-of-acute-pancreatitis
#1
Federico Bolado, Enrique de-Madaria
Acute pancreatitis (AP) is a potentially serious disease whose incidence is on the increase. Pancreas divisum does not meet the required criteria to be considered an aetiological factor. Sphincter of Oddi dysfunction may be another cause of idiopathic AP. Less invasive methods cannot replace Sphincter of Oddi manometry in diagnosis. Almost half of patients with systemic inflammatory response syndrome develop organ failure, but the mechanisms involved are not completely understood. Obesity is a risk factor for severity in AP; the cause could be the presence of free unsaturated fatty acids, which have pro-inflammatory activity...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27871582/glucagon-induced-hypertensive-emergency-a-case-report
#2
Aron Legler, Richard K Kim, Nikhil Chawla
Glucagon is well acknowledged as a sphincter of Oddi relaxant for both diagnostic and therapeutic uses in choledocholithiasis, and an empiric treatment for β-blocker overdose. Although it has been implicated in inducing cardiovascular crises in patients with asymptomatic pheochromocytoma, adverse effects in other patient populations have not been characterized. This case report describes a patient with hypertension controlled on β blockers who, after glucagon administration during an intraoperative cholangiography, experienced hypertensive emergency despite adequate pain control...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27865590/sphincter-of-oddi-botulinum-toxin-injection-to-prevent-pancreatic-fistula-after-distal-pancreatectomy
#3
Thilo Hackert, Ulla Klaiber, Ulf Hinz, Tzveta Kehayova, Pascal Probst, Phillip Knebel, Markus K Diener, Lutz Schneider, Oliver Strobel, Christoph W Michalski, Alexis Ulrich, Peter Sauer, Markus W Büchler
BACKGROUND: Postoperative pancreatic fistula represents the most important complication after distal pancreatectomy. The aim of this study was to evaluate the use of a preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula (German Clinical Trials Register number: DRKS00007885). METHODS: This was an investigator-initiated, prospective clinical phase I/II trial with an exploratory study design. We included patients who underwent preoperative endoscopic sphincter botulinum toxin injection (100 units of Botox)...
November 16, 2016: Surgery
https://www.readbyqxmd.com/read/27813508/-recurrent-pancreatitis-secondary-to-sphincter-of-oddi-dysfunction-case-report
#4
Jeannette Calzadilla, Natalia Sanhueza, Solange Farías, Félix González
Dysfunction of the sphincter of Oddi is a rare disease that causes about 20% of recurrent idiopathic pancreatitis. In order to suspect its existence, it is mandatory to have ruled out all other causes of acute pancreatitis. Then, the disease needs to be classified by degree of dysfunction and have a manometry performed as it is considered the gold standard of diagnosis. Manometry is used to guide treatment and its method of choice is usually an endoscopic sphincterotomy. In this article a case of recurrent pancreatitis is discussed, which after a thorough study that ruled out other etiologies, was diagnosed as a pancreatic-type dysfunction of the sphincter of Oddi...
October 21, 2016: Medwave
https://www.readbyqxmd.com/read/27771601/r-gas-under-diaphragm
#5
Maddibande Ramachar Sreevathsa, Khyati Melanta
INTRODUCTION: The most common cause of gas under diaphragm is hollow viscous perforation. In 10% of cases it can be due to rare causes, both abdominal and extra-abdominal, one of them being intra abdominal infection by gas forming organisms. PRESENTATION OF THE CASE: A 51 year old male patient, a poorly controlled diabetic, presented with a second episode of severe pain abdomen and abdominal distention, with lower abdominal tenderness. Plain Xray of the abdomen in erect posture showed gas under the right dome of diaphragm and ultrasound abdomen confirmed gross pneumoperitoneum...
October 14, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27762149/post-cholecystectomy-syndrome-and-sphincter-of-oddi-dysfunction-past-present-and-future
#6
Paul R Tarnasky
Post-cholecystectomy syndrome and the concept of a causal relationship to sphincter of Oddi dysfunction, despite the controversy, has presented a clinically relevant conflict for decades. Historically surgeons, and now gastroenterologists have expended tremendous efforts towards trying to better understand the dilemma that is confounded by unique patient phenotypes. Areas covered: This review encompasses the literature from a century of experience on the topic of post-cholecystectomy syndrome. Relevant historical and anecdotal experiences are examined in the setting of insights from evaluation of recently available controlled data...
December 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27652298/wide-disparities-in-attitudes-and-practices-regarding-type-ii-sphincter-of-oddi-dysfunction-a-survey-of-expert-u-s-endoscopists
#7
Rabindra R Watson, Jason Klapman, Srinadh Komanduri, Janak N Shah, Sachin Wani, Raman Muthusamy
BACKGROUND: Sphincter of Oddi manometry (SOM) is recommended in the evaluation of suspected Type II sphincter of Oddi dysfunction (SOD2), though its utility is uncertain. Little is known about the practice of expert endoscopists in the United States regarding SOD2. METHODS: An anonymous electronic survey was distributed to 128 expert biliary endoscopists identified from U.S. advanced endoscopy training programs. RESULTS: The response rate was 46...
September 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27651353/prophylaxis-of-pancreatitis-with-intravenous-ketoprofen-in-a-consecutive-population-of-ercp-patients-a-randomized-double-blind-placebo-controlled-trial
#8
Fernanda de Quadros Onófrio, Julio Carlos Pereira Lima, Guilherme Watte, Romnei Lenon Lehmen, Daniela Oba, Gabriela Camargo, Carlos Eduardo Oliveira Dos Santos
Background Acute pancreatitis is the most common complication after ERCP, occurring in about 4 % of the procedures. Only the placement of pancreatic duct prosthesis and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have shown benefit in the prevention of post-ERCP pancreatitis (PEP). Although the benefit of rectal administration of indomethacin or diclofenac is recommended by some studies and society guidelines especially in a selected group of high-risk patients, there is so far, no standardization of time or route of NSAID administration...
September 20, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27606143/comparative-relaxant-effects-of-ataciguat-and-zaprinast-on-sheep-sphincter-of-oddi
#9
Erol Çakmak, Özlem Yönem, Bülent Saraç, Mesut Parlak, Cumali Çelik, Hilmi Ataseven, İhsan Bağcivan
BACKGROUND: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the more post-ERCP complications decrease. AIMS: To compare the relaxant effects of ataciguat (a novel soluble guanylyl cyclase activator) and zaprinast (an inhibitor of phosphodiesterase 5) on sheep SO in vitro, thus testing whether they can be used during ERCP...
July 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27604474/early-precut-is-as-efficient-as-pancreatic-stent-in-preventing-post-ercp-pancreatitis-in-high-risk-subjects-a-randomized-study
#10
David Zagalsky, Martin Alejandro Guidi, Cecilia Curvale, Juan Lasa, Julio de Maria, Hernan Ianniccillo, Hui Jer Hwang, Raúl Matano
BACKGROUND: The most common adverse event of endoscopic retrograde cholangiopancreatography is pancreatitis. Precut sphincterotomy has been regarded as a risk factor. Some authors have stated that early precut may actually reduce post-ERCP pancreatitis risk. However, early precut as a preventive measure has not been compared to other preventive measures, such as pancreatic duct stent placement. AIM: To compare the efficacy of early precut sphincterotomy versus pancreatic duct stent placement in high-risk subjects undergoing endoscopic retrograde cholangiopancreatography for the prevention of post-endoscopic cholangiopancreatography...
September 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27597425/impact-of-endoscopic-papillary-large-balloon-dilation-on-sphincter-of-oddi-function-a-prospective-randomized-study
#11
Young Koog Cheon, Tae Yoon Lee, Soo-Nyung Kim, Chan Sup Shim
BACKGROUND AND AIMS: Endoscopic papillary balloon dilation (≤8 mm in diameter) preserves sphincter of Oddi (SO) function. However, it is still unknown whether papillary function is preserved after endoscopic papillary large-balloon dilation (EPLBD, ≥12 mm in diameter). We investigated SO function after EPLBD with or without endoscopic sphincterotomy (EST) by endoscopic manometry, up to 1 year after the procedure. METHODS: This was a prospective randomized study involving patients with bile duct stones ≥12 mm...
September 3, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27555792/translational-and-clinical-perspectives-on-sphincter-of-oddi-dysfunction
#12
REVIEW
Kondal Rao Kyanam Kabir Baig, Charles Melbern Wilcox
Sphincter of Oddi dysfunction is a complex pathophysiologic entity that is associated with significant morbidity causing abdominal pain, nausea, and vomiting. The purpose of this review is to describe the anatomy and physiology of the sphincter of Oddi, to understand the pathologic mechanisms thought to be responsible for symptomatology, review recent major studies, explore endoscopic and pharmacologic therapies and their efficacy, and to explore future research avenues.
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27530895/can-endoscopic-papillectomy-be-curative-for-early-ampullary-adenocarcinoma-of-the-ampulla-of-vater
#13
María-Victoria Alvarez-Sanchez, Inés Oria, Olivia B Luna, Jean Pialat, Rodica Gincul, Christine Lefort, Raphael Bourdariat, Fabien Fumex, Vincent Lepilliez, Jean Yves Scoazec, Angel Salgado-Barreira, Anne Isabelle Lemaistre, Bertrand Napoléon
BACKGROUND: The therapeutic role of endoscopic papillectomy (EP) for early ampullary cancer (AC) is still controversial. The aim of the present study was to evaluate the curative potential of EP for early AC and to identify predictors of lymph node metastases (LNMs). METHODS: We retrospectively reviewed 173 patients who were prospectively included in a database and who underwent EP between 1999 and 2013. Adenocarcinoma was present in 28 resected specimens. An additional surgery was proposed in cases of duodenal submucosal infiltration, duct ingrowth, R1 resection or lymphovascular invasion...
August 16, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27513967/periarticular-morphine-induced-sphincter-of-oddi-spasm-causing-severe-pain-and-bradycardia-in-an-awake-patient-under-spinal-anesthesia-an-important-diagnostic-consideration
#14
Yuri Koumpan, Dale Engen, Robert Tanzola, Tarit Saha
Sphincter of Oddi spasm from opioids has been documented, presenting as severe epigastric pain and potentially overlooked in a differential diagnosis. We present a case of sphincter of Oddi spasm from periarticular morphine in a patient under spinal anesthesia, causing severe distress and treated effectively with glucagon. It is important for anesthesiologists using opioids to consider it as a cause of perioperative pain and be familiar with treatment as it may be refractory by conventional use of opioids for pain relief...
October 1, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27503161/opium-related-sphincter-of-oddi-dysfunction-causing-double-duct-sign
#15
Vishal Sharma, Surinder Singh Rana, Vinita Chaudhary, Narendra Dhaka, Manish Manrai, Jegan Sivalingam, Ravi Sharma, Usha Dutta, Deepak Kumar Bhasin
Double duct sign where there is a simultaneous dilatation of both the common bile duct (CBD) and pancreatic duct is usually associated with sinister causes like malignancies of pancreatic head or ampulla. Occasionally, benign causes like chronic pancreatitis or sphincter of Oddi dysfunction (SOD) may cause double duct sign. Chronic opium abuse is a rare cause of the double duct sign, and endoscopic ultrasound (EUS) findings of this rare entity have been occasionally reported. We report about a 54-year-old male with a history of chronic alcohol and opioid abuse evaluated for episodes of abdominal pain and found to have opioid-related SOD and improved with biliary sphincterotomy...
July 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27441545/biliary-atresia-current-concepts-and-future-prospects-review
#16
K Chakhunashvili, I Pavlenishvili, M Kakabadze, D Kordzaia, D Chakhunashvili, Z Kakabadze
Treatment of biliary atresia is a major challenge in pediatric surgery. Early diagnosis and availability of Kasai procedure with its modern modifications improve outcome of biliary atresia treatment. But Kasai procedure does not fully restore anatomical integrity of biliary tract, because Oddi sphincter is not included in reconstructed system. Constant reflux of intestinal content into the biliary tree is a cause of recurrent cholangitis and change in biliary epithelium that, which is a predisposing factor for cholangiocarcinoma...
June 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27435328/management-of-sphincter-of-oddi-dysfunction-teaching-an-old-sod-new-tricks
#17
EDITORIAL
Tilak Shah, Alvin Zfass, Mitchell L Schubert
No abstract text is available yet for this article.
September 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27371265/role-of-ercp-in-patients-with-idiopathic-recurrent-acute-pancreatitis
#18
REVIEW
Piyush Somani Md, Udayakumar Navaneethan Md
Recurrent acute pancreatitis (RAP) is defined based on the occurrence of two or more episodes of acute pancreatitis. RAP is differentiated from chronic pancreatitis based on the presence of a normal morphological appearance of the pancreas between episodes. RAP can be due to a variety of etiologies including common bile duct stones or sludge, sphincter of Oddi dysfunction (SOD), pancreas divisum (PD), anomalous pancreaticobiliary junction, genetic mutations, and alcohol related. In approximately 30 % of patients, the etiology of RAP is unclear and the term "idiopathic" is used...
September 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27350732/effects-of-sphincter-of-oddi-motility-on-the-formation-of-cholesterol-gallstones
#19
Zhong-Hou Rong, Hong-Yuan Chen, Xin-Xing Wang, Zhi-Yi Wang, Guo-Zhe Xian, Bang-Zhen Ma, Cheng-Kun Qin, Zhen-Hai Zhang
AIM: To investigate the mechanisms and effects of sphincter of Oddi (SO) motility on cholesterol gallbladder stone formation in guinea pigs. METHODS: Thirty-four adult male Hartley guinea pigs were divided randomly into two groups, the control group (n = 10) and the cholesterol gallstone group (n = 24), which was sequentially divided into four subgroups with six guinea pigs each according to time of sacrifice. The guinea pigs in the cholesterol gallstone group were fed a cholesterol lithogenic diet and sacrificed after 3, 6, 9, and 12 wk...
June 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27348319/a-comparison-of-bilateral-side-by-side-metal-stents-deployed-above-and-across-the-sphincter-of-oddi-in-the-management-of-malignant-hilar-biliary-obstruction
#20
Natalie Cosgrove, Ali A Siddiqui, Douglas G Adler, Haroon Shahid, Avik Sarkar, Ashish Sharma, Thomas E Kowalski, David Loren, Matthew Warndorf, Jennifer Chennat, Satish Munigala, Georgios I Papachristou
BACKGROUND AND AIMS: The optimal method for endoscopic placement of bilateral self-expanding metal stents (SEMS) for the management of malignant hilar biliary obstruction has not been determined. The aim of this study was to compare the efficacies and complication rates between SEMS placed above and across the sphincter of Oddi (SO) in patients with malignant hilar biliary obstruction. MATERIALS AND METHODS: A retrospective review of patients with malignant hilar strictures who underwent bilateral SEMS placement at 3 centers was performed...
June 24, 2016: Journal of Clinical Gastroenterology
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