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https://www.readbyqxmd.com/read/29458062/an-unexpected-degradation-pathway-of-a-1-2-4-triazolo-4-3-a-pyridine-derivative-the-formation-of-two-cationic-pseudodimers-of-an-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor-drug-candidate-in-a-stressed-capsule-formulation
#1
Yande Huang, Qinggang Wang, Yongmei Wu
Degradation of an active pharmaceutical ingredient (API), a 2-(3-(1-(4-chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)propan-2-ol hydrochloride salt, was observed in a capsule formulation stressed at 50°C or 40°C/75% relative humidity conditions for one month. Two unknown degradants were identified as cationic pseudodimers of the API via accurate mass liquid chromatography-mass spectrometry and one- and two-dimensional NMR analyses. A plausible degradation pathway of the API was postulated which led to the identification of two key N-oxide degradants in the stressed capsule formulation at trace levels...
February 16, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29457899/palladium-catalyzed-selective-mono-tetraacetoxylation-of-o-carboranes-with-acetic-acid-via-cross-dehydrogenative-coupling-of-cage-b-h-o-h-bonds
#2
Tao-Tao Xu, Ke Cao, Ji Wu, Cai-Yan Zhang, Junxiao Yang
A selective mono-/tetraacetoxylation of o-carboranes with acetic acid via cross dehydrogenative coupling of cage B-H/O-H bonds has been developed, and a series of mono- and tetraacetoxylated o-carboranes have been synthesized with moderate to good yields as well as good selectivity. Mechanistic studies indicate that the acetoxyl originates from acetic acid directly, and a nucleophilic addition of PdIV -oxo species and dehydration process is proposed.
February 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29457688/a-network-of-regulators-promotes-dehydration-tolerance-in-escherichia-coli
#3
Annie I Chen, Mark Goulian
The ability to survive conditions of low water activity is critical for the survival of many bacteria in the environment and facilitates disease transmission through food and contaminated surfaces. However, the molecular mechanisms that enable bacteria to withstand this condition remain poorly understood. Here we describe a network of regulators in Escherichia coli that are important for this bacterium to survive dehydration. We found that the transcriptional regulator DksA and the general stress response regulator RpoS play a critical role...
February 19, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29457380/two-step-assembly-of-thermoresponsive-gold-nanorods-coated-with-a-single-kind-of-ligand
#4
Ryo Iida, Hideyuki Mitomo, Kenichi Niikura, Yasutaka Matsuo, Kuniharu Ijiro
Gold nanorods (GNRs) coated with a single kind of ligand show thermoreponsive two-step assembly to provide a hierarchical structure. The GNRs (33 nm in length × 14 nm in diameter) coated with a hexa(ethylene glycol) (HEG) derivative form side-by-side assemblies at 30 °C (TA1 ) as a steady state through dehydration. By further heating to over 40 °C (TA2 ), larger assemblies, which are composed of the side-by-side assembled units, are formed as hierarchical structures. The dehydration temperature of the HEG derivative varies depending on the free volume of the HEG unit, which corresponds to the curvature of the GNRs...
February 19, 2018: Small
https://www.readbyqxmd.com/read/29456884/desiccation-resistance-effect-of-cuticular-hydrocarbons-and-water-content-in-drosophila-melanogaster-adults
#5
Jean-Francois Ferveur, Jérôme Cortot, Karen Rihani, Matthew Cobb, Claude Everaerts
Background: The insect cuticle covers the whole body and all appendages and has bi-directionnal selective permeability: it protects against environmental stress and pathogen infection and also helps to reduce water loss. The adult cuticle is often associated with a superficial layer of fatty acid-derived molecules such as waxes and long chain hydrocarbons that prevent rapid dehydration. The waterproofing properties of cuticular hydrocarbons (CHs) depend on their chain length and desaturation number...
2018: PeerJ
https://www.readbyqxmd.com/read/29456709/anterior-spinal-instrumentation-combining-a-prosthetic-disc-nucleus-with-a-flexible-stabilization-device-manufacture-and-use-in-intervertebral-disc-repair
#6
Da Bao, Dawei Li
Artificial disc replacement alone is unable to completely cure cervical degenerative diseases; thus, a stabilization device markedly improves patient recovery. In order to meet this requirement, an anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device (ASI combining PDN/FD) was developed. An artificial disc was designed and manufactured using polyvinyl alcohol hydrogel (PVA-H) with a repeated freeze-melting technique, and subsequently the dehydration and swelling properties of the PVA-H were investigated...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29451981/high-performance-anion-exchange-and-hydrophilic-interaction-liquid-chromatography-approaches-for-comprehensive-mass-spectrometry-based-characterization-of-the-n-glycome-of-a-recombinant-human-erythropoietin
#7
Zoltan Szabo, James R Thayer, Dietmar Reusch, Yury Agroskin, Rosa Viner, Jeff Rohrer, Sachin P Patil, Michael Krawitzky, Andreas Huhmer, Nebojsa Avdalovic, Shaheer H Khan, Yan Liu, Christopher Pohl
Comprehensive characterization of the N-glycome of a therapeutic is challenging because glycans may harbor numerous modifications (e.g. phosphorylation, sulfation, sialic acids with possible O-acetylation). The current report presents a comparison of two chromatographic platforms for the comprehensive characterization of a recombinant human erythropoietin (rhEPO) N-glycome. The two platforms include a common workflow based on 2-AB-derivatization and hydrophilic interaction chromatography (HILIC) and a native N-linked glycan workflow employing high performance anion exchange (HPAE) chromatography...
February 16, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29450929/dehydration-polymerization-for-poly-hetero-arene-conjugated-polymers
#8
Derek Schipper, Rafael Alberto Mirabal, Luke Vanderzwet, Sara Abuadas, Michael Emmett
The lack of scalable and sustainable methods to prepare conjugated polymers belies their importance in many enabling technologies. Accessing high-performance poly(hetero)arene conjugated polymers via dehydration has remained an unsolved problem in synthetic chemistry and has historically required transitional-metal coupling reactions. Here we report a dehydration method that allows access to conjugated heterocyclic materials. Using the technique, we have prepared a series of small molecules and polymers. The reaction avoids using transition metals, proceeds at room temperature, the only required reactant is a simple base and water is the sole by-product...
February 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29449862/characterization-of-transcription-factor-gene-osdrap1-conferring-drought-tolerance-in-rice
#9
Liyu Huang, Yinxiao Wang, Wensheng Wang, Xiuqin Zhao, Qiao Qin, Fan Sun, Fengyi Hu, Yan Zhao, Zichao Li, Binying Fu, Zhikang Li
HIGHLIGHTS Overexpressing and RNA interfering OsDRAP1 transgenic rice plants exhibited significantly improved and reduced drought tolerance, but accompanied with negative effects on development and yield. The dehydration responsive element binding (DREBs) genes are important transcription factors which play a crucial role in plant abiotic stress tolerances. In this study, we functionally characterized a DREB2-like gene, OsDRAP1 conferring drought tolerance (DT) in rice. OsDRAP1 , containing many cis -elements in its promoter region, was expressed in all organs (mainly expressed in vascular tissues) of rice, and induced by a variety of environmental stresses and plant hormones...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29448965/temporo-spatial-dynamics-and-behavioural-patterns-of-2012-cholera-epidemic-in-the-african-mega-city-of-conakry-guinea
#10
Alexandre Blake, Veronique Sarr Keita, Delphine Sauvageot, Mamadou Saliou, Berthe Marie Njanpop, Fode Sory, Bertrand Sudre, Koivogui Lamine, Martin Mengel, Bradford D Gessner, Keita Sakoba
BACKGROUND: Cholera is endemic in Guinea, having suffered consecutive outbreaks from 2004 to 2008 followed by a lull until the 2012 epidemic. Here we describe the temporal-spatial and behavioural characteristics of cholera cases in Conakry during a three-year period, including the large-scale 2012 epidemic. METHODS: We used the national and African Cholera Surveillance Network (Africhol) surveillance data collected from every cholera treatment centre in Conakry city from August 2011 to December 2013...
February 15, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29448603/selective-production-of-p-xylene-from-dimethylfuran-and-ethylene-over-tungstated-zirconia-catalysts
#11
Jin-Sil Lee, Sang-Yun Kim, Soo-Jin Kwon, Tae-Wan Kim, Soon-Young Jeong, Chul-Ung Kim, Kwan-Young Lee
p-Xylene (PX) is an important large-volume commodity chemical in the petrochemical industry. Therefore, research on producing PX from bio-mass-derived resources is a considerable interest in relation to future alternative technologies. Recently, a new potential route for the direct and selective production of bio-based PX was reported, referred to as the Diels-Alder cycloaddition of biomassderived 2,5-dimethylfuran (DMF) and ethylene followed by the dehydration of an intermediate. Here, we prepared tungstated zirconia (WOx-ZrO2) materials at different calcination temperatures and times as solid acid catalysts for PX production...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448580/acrolein-production-by-gas-phase-glycerol-dehydration-using-po%C3%A2-nb%C3%A2-o-5-catalysts
#12
Kyu Am Lee, HeeKyoung Ryoo, Byung Chol Ma, Youngchul Kim
In this study, modified niobium oxide were prepared to study the addictive effects on the catalytic performance for gas-phase glycerol dehydration. The catalysts were characterized by N2 adsorption/desorption, XRD, NH3-TPD, FT-IR. The amount of phosphoric acid was up to 50 wt% in niobium. As a result, the highest glycerol conversion was achieved over 20 wt% PO4/Nb2O5. It indicates that the optimal amount of phosphoric acid leads the catalyst to have appropriate acidity which is an important factor for gas-phase glycerol dehydration...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447168/quantitative-proteome-profile-of-water-deficit-stress-responses-in-eastern-cottonwood-populus-deltoides-leaves
#13
Paul E Abraham, Benjamin J Garcia, Lee E Gunter, Sara S Jawdy, Nancy Engle, Xiaohan Yang, Daniel A Jacobson, Robert L Hettich, Gerald A Tuskan, Timothy J Tschaplinski
Drought stress is a recurring feature of world climate and the single most important factor influencing agricultural yield worldwide. Plants display highly variable, species-specific responses to drought and these responses are multifaceted, requiring physiological and morphological changes influenced by genetic and molecular mechanisms. Moreover, the reproducibility of water deficit studies is very cumbersome, which significantly impedes research on drought tolerance, because how a plant responds is highly influenced by the timing, duration, and intensity of the water deficit...
2018: PloS One
https://www.readbyqxmd.com/read/29446580/is-there-any-difference-between-the-symptomatology-and-clinical-findings-of-viral-agents-causing-dehydration
#14
Suat Biçer, Defne Çöl, Öznur Küçük, Gülay Ç Erdağ, Tuba Giray, Meltem Uğraş, Ayça Vitrinel, Çiğdem Kaspar
BACKGROUND: Acute gastroenteritis is responsible for dehydration in many children. The viruses like rotavirus, norovirus, and adenovirus are considered the main causative agents of gastroenteritis. The goal of this study is the evaluation of the symptoms, clinical findings and hospitalization requirements in pediatric patients with dehydration secondary to viral gastroenteritis. METHODS: The distribution of age, symptoms, clinical and laboratory findings and hospitalization requirements of 156 viral acute gastroenteritis patients with moderate dehydration were evaluated retrospectively...
April 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29446017/transformation-of-heavy-metal-fractionation-under-changing-environments-a-case-study-of-a-drainage-system-in-an-e-waste-dismantling-community
#15
Seelawut Damrongsiri
The change in environmental conditions during the transportation of contaminated soil and sediment was expected to affect the transformation of heavy metal fractionation. This study disclosed the serious contamination of copper (Cu), lead (Pb), and zinc (Zn) in the sewer sediment of an e-waste dismantling community in Thailand which may be caused by flushed contaminated soil and e-waste fragments. Two environmental conditions were simulated to observe the transformation of heavy metal fractionation. The anoxic sewer condition was induced using high substrate and sulfate in a closed container...
February 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29443520/cosolvent-effects-on-polymer-hydration-drive-hydrophobic-collapse
#16
Divya Nayar, Nico F A van der Vegt
Water-mediated hydrophobic interactions play an important role in self-assembly processes, aqueous polymer solubility, and protein folding, to name a few. Cosolvents affect these interactions however the implications for hydrophobic polymer collapse and protein folding equilibria are not well-understood. This study examines cosolvent effects on the hydrophobic collapse equilibrium of a generic 32-mer hydrophobic polymer in urea, trimethylamine-N-oxide (TMAO), and acetone aqueous solutions using molecular dynamics simulations...
February 14, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29443395/subcutaneous-infusion-of-fluids-for-hydration-or-nutrition-a-review
#17
REVIEW
Riccardo Caccialanza, Thierry Constans, Paolo Cotogni, Gary P Zaloga, Alessandro Pontes-Arruda
Subcutaneous infusion, or hypodermoclysis, is a technique whereby fluids are infused into the subcutaneous space via small-gauge needles that are typically inserted into the thighs, abdomen, back, or arms. In this review, we provide an overview of the technique, summarize findings from studies that have examined the use of subcutaneous infusion of fluids for hydration or nutrition, and describe the indications, advantages, and disadvantages of subcutaneous infusion. Taken together, the available evidence suggests that, when indicated, subcutaneous infusion can be effective for administering fluids for hydration or nutrition, with minimal complications, and has similar effectiveness and safety to the intravenous route...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29442750/cooked-food-waste-an-efficient-and-less-expensive-precursor-for-the-generation-of-activated-carbon
#18
Thangavelu Krithiga, Xavier Janet Sabina, Baskaran Rajesh, Hamid Ilbeygi, Adka Nityananda Shetty, Ramanjaneya Reddy, Jayabalan Karthikeyan
Activated carbon was synthesized from cooked food waste, especially dehydrated rice kernels, by chemical activation method using NaOH and KOH as activating agents. It was then characterized by ultimate and proximate analysis, BET surface analysis, XRD, FTIR, Raman and SEM. The XRD patterns and Raman spectra confirmed the amorphous nature of the prepared activated carbons. Ultimate analysis showed an increase in the carbon content after activation of the raw carbon samples. Upon activation with NaOH and KOH, the surface area of the carbon sample was found to have increased from 0...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442351/milk-alkali-syndrome-mas-as-a-complication-of-the-treatment-of-hypoparathyroidism
#19
Agata Skwarek, Janusz Pachucki, Tomasz Bednarczuk, Zuzanna Żurecka, Michał Popow
Milk-alkali syndrome (MAS), characterized by renal failure, metabolic alkalosis and hypercalcemia, is a severe and life-threatening complication of the treatment of hypoparathyroidism. The clinical course is often sudden and is not preceded by any prodromal symptoms. Occurrence does not depend on the duration of hypoparathyroidism treatment, although it is closely related to the applied therapy, especially the dose of calcium carbonate and active vitamin D preparations. Drugs influencing the glomerular filtration rate (angiotensin receptor blockers, sartans, aldosterone receptor antagonists, thiazide diuretics), lack of adequate routine control, changing the calcium carbonate supplementation, dehydration, a diet rich in pH-basic foods (i...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29441775/-hydrating-cleansing-efficacy-and-tolerability-of-new-formulations-with-hyaluronic-acid-0-2-for-intimate-hygiene-in-the-woman-in-fertile-age-and-menopause
#20
Francesca Albani, Adriana Bonfigli, Francesca Consolaro, Luigi Rigano, Monica Campisi
Dehydration of genital areas, known as vaginal dryness, frequently affects woman's life, from fertile to postmenopausal period, and must be treated with specific products, including proper intimate cleansing. Based on that, two new cleanser formulations, characterized by Hyaluronic Acid 0.2% as main ingredient, have been developed (Hyalo Gyn® Intimo Active and Hyalo Gyn® Intimo Advance), with the aim to provide an effective hydration of the vaginal, vulvar, perianal and anal areas beyond guaranteeing daily intimate hygiene...
April 2018: Minerva Ginecologica
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