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JOURNAL ARTICLE
Serena Jasmine Aleo, Valentina Del Dotto, Martina Romagnoli, Claudio Fiorini, Giada Capirossi, Camille Peron, Alessandra Maresca, Leonardo Caporali, Mariantonietta Capristo, Concetta Valentina Tropeano, Claudia Zanna, Fred N Ross-Cisneros, Alfredo A Sadun, Maria Gemma Pignataro, Carla Giordano, Chiara Fasano, Andrea Cavaliere, Anna Maria Porcelli, Gaia Tioli, Francesco Musiani, Alessia Catania, Costanza Lamperti, Stefania Bianchi Marzoli, Annamaria De Negri, Maria Lucia Cascavilla, Marco Battista, Piero Barboni, Michele Carbonelli, Giulia Amore, Chiara La Morgia, Dmitrii Smirnov, Catalina Vasilescu, Aiman Farzeen, Beryll Blickhaeuser, Holger Prokisch, Claudia Priglinger, Bettina Livonius, Claudia B Catarino, Thomas Klopstock, Valeria Tiranti, Valerio Carelli, Anna Maria Ghelli
Idebenone, the only approved treatment for Leber hereditary optic neuropathy (LHON), promotes recovery of visual function in up to 50% of patients, but we can neither predict nor understand the non-responders. Idebenone is reduced by the cytosolic NAD(P)H oxidoreductase I (NQO1) and directly shuttles electrons to respiratory complex III, bypassing complex I affected in LHON. We show here that two polymorphic variants drastically reduce NQO1 protein levels when homozygous or compound heterozygous. This hampers idebenone reduction...
January 17, 2024: Cell reports medicine
#22
REVIEW
S Minghetti, A Riva, G Arienti, C Peruzzi, R Nacinovich
Peroneal neuropathy and polyneuropathy are displayed with a variable percentage in subjects affected by eating disorders and in particular by anorexia nervosa. Actually, little is known on features of these complications during the paediatric age. We describe the case of a female adolescent with right peroneal palsy and subclinical polyneuropathy associated with anorexia nervosa (AN). We review previous research about peroneal mononeuropathy and polyneuropathy associated with AN, and we develop a diagnostic and therapeutic protocol to help clinicians recognize and treat these disorders...
January 16, 2024: European Journal of Clinical Nutrition
#23
JOURNAL ARTICLE
Christoph M Mooshage, Lukas Schimpfle, Dimitrios Tsilingiris, Zoltan Kender, Taraneh Aziz-Safaie, Anja Hohmann, Julia Szendroedi, Peter Nawroth, Volker Sturm, Sabine Heiland, Martin Bendszus, Stefan Kopf, Johann M E Jende, Felix T Kurz
BACKGROUND: Previous studies on magnetic resonance neurography (MRN) found different patterns of structural nerve damage in type 1 diabetes (T1D) and type 2 diabetes (T2D). Magnetization transfer ratio (MTR) is a quantitative technique to analyze the macromolecular tissue composition. We compared MTR values of the sciatic nerve in patients with T1D, T2D, and healthy controls (HC). METHODS: 3-T MRN of the right sciatic nerve at thigh level was performed in 14 HC, 10 patients with T1D (3 with diabetic neuropathy), and 28 patients with T2D (10 with diabetic neuropathy)...
January 9, 2024: European Radiology Experimental
#24
JOURNAL ARTICLE
Yoshimi Endo, Ogonna K Nwawka, Darryl B Sneag
OBJECTIVE: Describe features of iatrogenic "overshoot" nerve injuries on ultrasound and MRI, which occur when an instrument passes through the bone and injures the nerve after it penetrates the opposite cortex. MATERIALS AND METHODS: After a keyword search of the radiology database at a tertiary care orthopedic hospital from January 2016 to December 2022, those fulfilling the inclusion criteria of (1) instrumentation through the bone during surgery, (2) acute neuropathy immediately after surgery, (3) nerve injury confirmed on electrodiagnostics, and (4) imaging consistent with overshoot nerve injury were included...
January 2, 2024: Skeletal Radiology
#25
JOURNAL ARTICLE
Andriy Ya Sabovchyk
OBJECTIVE: The aim: To study the peculiarities of diabetic polyneuropathy in patients with type 2 diabetes mellitus and concomitant NAFLD. PATIENTS AND METHODS: Materials and methods: We examined 75 patients with type 2 diabetes mellitus, including 31 (41.3%) women and 44 (58.7%) men. The main group included 35 patients with NAFLD (46.7%), and the control group included 40 patients without NAFLD (53.3%). The severity of polyneuropathy was assessed using the Toronto clinical neuropathy score...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
#26
JOURNAL ARTICLE
Sarah H Al-Mazidi, Fawzia ALRouq, Areej S Alsabty, Abdullah Alhajlah, Asma AlYahya, Ahmed Alsabih, Reema Al-Taweraqi, Abdullah S Alahmari, Lina Al-Dakhil, Syed Habib
BACKGROUND: The neurological effect of viral respiratory infections has been acknowledged in many studies. However, patients who recovered from this infection show neurological manifestations and are not being routinely transferred for electrodiagnostic evaluation. AIM: This study aimed to examine the neurological effect of viral respiratory infections on the nerve function using electrophysiology in patients fully recovered from viral respiratory infections...
November 2023: Curēus
#27
JOURNAL ARTICLE
Yan Li, Yukun Jia
For investigating the impact of miR-146a rs2910164 polymorphism on the therapeutic efficacy of lipoic acid therapy in patients with type 2 diabetes mellitus (T2DM) peripheral neuropathy (DPN). 106 T2DM-DPN patients in our hospital from Jan. 2020- 2022 were selected. The probe detection method was utilized to determine the polymorphism of the miR-146a rs2910164 gene in peripheral blood. All patients were treated with zinc sulfate for 3 weeks period. According to the treatment effect, 37 patients who were ineffective in treatment will be divided into an ineffective group, and 79 patients who were effective in treatment will be divided into an effective group...
November 30, 2023: Cellular and Molecular Biology
#28
JOURNAL ARTICLE
Neil Eisenstein, Ben Fischer, Selvadurai Nayagam
UNLABELLED: The transfer of a normal tibialis posterior through the interosseous membrane to the dorsum of the foot can restore active ankle dorsiflexion where this has been lost from common peroneal injury, anterior compartment muscle loss, or in some neurological conditions. An appraisal of the indications, planning, and a step-by-step description is provided. HOW TO CITE THIS ARTICLE: Eisenstein N, Fischer B, Nayagam S. Tibialis Posterior Tendon Transfer for the Management of Foot Drop...
2023: Strategies in Trauma and Limb Reconstruction
#29
REVIEW
Frauke Johannes, Rahel Frohofer-Vollenweider, Yvonne Teuschl
BACKGROUND: Femoral cannulated extracorporeal membrane oxygenation (ECMO) has been associated with neurologic complications in the lower extremity ipsilateral to the cannulation. There is uncertainty about the prevalence of these complications and their mechanisms of development. OBJECTIVE: Aim of this systematic review was to investigate the prevalence of neurological complications after ECMO and to describe possible underlying mechanisms. METHOD: A systematic literature search was performed in Medline-Ovid, Embase, Cochrane Library, CINAHL, and PEDro until April 2021 for clinical trials in English or German language which quantified neurologic complications in the lower extremity ipsilateral to the ECMO cannulation of adults...
November 28, 2023: Journal of Intensive Care Medicine
#30
JOURNAL ARTICLE
Shusen Chang, Wei Yang, Hehua Song, Wei Chen, Jian Zhou, Fang Zhang, Xueping Yan, Xiaojin Mo, Kaiyu Nie, Chengliang Deng, Zairong Wei
OBJECTIVE: To investigate the effectiveness of tibial transverse transport (TTT) combined with modified neurolysis in treatment of diabetic foot ulcer (DFU) through a prospective randomized controlled study. METHODS: The patients with DFU and diabetic peripheral neuropathy, who were admitted between February 2020 and February 2022, were selected as the research objects, of which 31 cases met the selection criteria and were included in the study. The patients were divided into two groups by random number table method...
November 15, 2023: Chinese Journal of Reparative and Reconstructive Surgery
#31
JOURNAL ARTICLE
Kanika Thakur, Manu Goyal
BACKGROUND: The management of diabetic peripheral neuropathy (DPN) comprises a multidimensional approach. Along with pharmacological treatment, physiotherapy has gained applaudable popularity in improving the symptoms of DPN. Neuromuscular taping (NMT) is effective in improving motor, sensory, and balance impairments in many neuromuscular and musculoskeletal conditions but no research has conducted to evaluate the effect of NMT on balance, proprioception, pain, and nerve conduction parameters in patients with DPN...
December 2023: Journal of Diabetes and Metabolic Disorders
#32
JOURNAL ARTICLE
Maria Katz, Hannah Mork, Nazik Baghdasaryan, Lukas Hesse, Kai Wille, Jasmin Treichel, Jeremias Motte, Rafael Klimas, Dietrich Sturm, Peter Dieter Schellinger, Hans-Joachim Hettlich, Jörg Philipps
BACKGROUND AND PURPOSE: The role of high-resolution nerve ultrasound (HRUS) and corneal confocal microscopy (CCM) in the early detection of taxane-induced polyneuropathy (TIPN) is unclear. The present prospective longitudinal controlled observational pilot study estimates the role of HRUS and CCM in the early diagnosis of TIPN in breast cancer patients. METHODS: Fifteen breast cancer patients receiving paclitaxel and 15 healthy age matched controls were included...
November 15, 2023: European Journal of Neurology
#33
REVIEW
Nicu Cătălin Drăghici, Vitalie Văcăraș, Roxana Bolchis, Atamyrat Bashimov, Diana Maria Domnița, Silvina Iluț, Livia Livinț Popa, Tudor Dimitrie Lupescu, Dafin Fior Mureșanu
Entrapment neuropathies of the lower limb are a misunderstood and underdiagnosed group of disorders, characterized by pain and dysesthesia, muscular weakness, and specific provoking movements on physical examination. The most frequent of these syndromes encountered in clinical practice are fibular nerve entrapment, proximal tibial neuropathy, sural nerve neuropathy, deep gluteal syndrome or sciatic nerve entrapment, and lateral femoral cutaneous nerve entrapment, also known as meralgia paresthetica. These are commonly mistaken for lumbar plexopathies, radiculopathies, and musculotendinous diseases, which appear even more frequently and have overlapping clinical presentations...
November 4, 2023: Diagnostics
#34
JOURNAL ARTICLE
C Denys, E Vrieze
We describe the development of slimmer’s paralysis or ‘foot drop’ in a patient with anorexia nervosa caused by a transient peroneal nerve injury. This was caused by extreme weight loss in combination with frequently crossing the legs in the context of anorexia nervosa with body image distortion. The most important interventions were weight recovery, physical therapy and avoiding precipitating factors. The relevance of this case lies in the fact that a physical complication of a predominantly mental illness is described...
2023: Tijdschrift Voor Psychiatrie
#35
JOURNAL ARTICLE
Pan Longci, Q I Chunhui, Shen Xubo, Huang Yixian, Yang Xinrong, Sun Xianjun
OBJECTIVES: To analyze the distribution characteristics of Traditional Chinese Medicine (TCM) syndromes in patients with oxaliplatin-induced peripheral neuropathy (OIPN) and observe the clinical efficacy of Bushen Yiqi formula (, BSYQF) in treating patients with OIPN. METHODS: A total of 89 patients with OIPN were enrolled in this study. The TCM syndrome characteristics were investigated by frequency analysis methodology after collecting and analyzing the TCM syndrome elements of the patients with the OIPN TCM syndrome element scale...
October 2023: Journal of Traditional Chinese Medicine
#36
Mohamed A Khalefa, Shakir Hussain, Edwards C Bache
Ganglion cysts are very rare in the lower limb and when present, ganglion cysts rarely cause compression neuropathy at any site. Peripheral nerve sheath tumors as a whole, are also very rare and mostly presented as a painful lump along the nerve path. Ganglion cysts are non-neoplastic gelatinous cysts, which lack true synovial lining. They can be divided into intraneural cysts which can be found within the epineurium of a peripheral nerve and lead to signs and symptoms of peripheral neuropathy or extraneural cysts which can develop from surrounding joints or tendon sheaths causing gradual nerve compression...
October 2023: Curēus
#37
Fei Zhang, Yunfeng Yu, Shuang Yin, Gang Hu, Xinyu Yang, Keke Tong, Rong Yu
OBJECTIVE: Mecobalamin is a commonly used drug in the treatment of diabetic peripheral neuropathy (DPN). This study aimed to systematically evaluate the efficacy and safety of acupoint injection of mecobalamin for DPN. METHODS: Relevant clinical trials on acupoint injection of mecobalamin for DPN published before 31 January 2023 were searched in eight commonly used databases. After screening and confirming the included studies, meta-analysis and trial sequential analysis were performed...
2023: Frontiers in Neurology
#38
JOURNAL ARTICLE
Zhenzhuang Yan, Weiwei Cao, Lei Miao, Juan Li, Hui Wang, Dandan Xu, Hainan Yu, Yuanxin Zhu
OBJECTIVE: Chemotherapy-induced peripheral neuropathy is one of the major toxicities in multiple myeloma patients, often resulting in dose reductions or treatment interruptions. Repetitive transcranial magnetic stimulation is a safe non-invasive neuromodulation therapy with potential benefits for chemotherapy-induced peripheral neuropathy. The objective of this study was to investigate the efficacy of repetitive transcranial magnetic stimulation treatment on chemotherapy-induced peripheral neuropathy in multiple myeloma patients...
2023: SAGE Open Medicine
#39
Jing-Chun Lin, Mu-Hung Tsai, Wei-Pin Lin, Ta-Shen Kuan, Wei-Chih Lien
BACKGROUND: Neuropathy of the common peroneal nerve caused by compression by a fabella is an extremely rare form of compression neuropathy. Involving both the superficial and deep peroneal nerves, it usually manifests as either impaired sensation from the lower lateral leg to the top of the foot or drop foot, or as a combination of both. CASE SUMMARY: We report the case of a 58-year-old Asian female who presented with inversion of the right foot during the stance phase of gait without sensory complaints related to the lower leg...
October 6, 2023: World Journal of Clinical Cases
#40
JOURNAL ARTICLE
Jiangli Ban, Xiaoyu Pan, Liqun Yang, Zhuoya Jia, Ruoxi Zhen, Xueqing Zhang, Shuchun Chen
PURPOSE: This study aimed to examine the correlation between fibrinogen/albumin (FAR) and diabetic peripheral neuropathy (DPN). PATIENTS AND METHODS: A total of 342 patients were included and categorized into either the DPN group or the Non-DPN (NDPN) group based on their DPN status. The FAR index was determined by calculating the ratio of fibrinogen (FIB) to serum albumin (ALB), multiplied by 100. The participants were then divided into a High-FAR group and a Low-FAR group using the median FAR value as the threshold...
2023: Diabetes, Metabolic Syndrome and Obesity
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