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https://www.readbyqxmd.com/read/29455126/removal-mechanisms-of-volatile-organic-compounds-vocs-from-effluent-of-common-effluent-treatment-plant-cetp
#1
Ashwini V Padalkar, Rakesh Kumar
This study investigated the occurrence, removal and influence of plant-operating conditions on removal mechanisms of 83 VOCs in different treatment units of a CETP in Mumbai, treating industrial waste on primary and secondary level. A mass balance approach was used to predict VOC removal by volatilization, stripping, weir drop, adsorption, and biodegradation. Results indicate that ∼17% of VOCs were removed by stripping in equalization tank and ∼8% were removed by weir drop in primary clari-flocculator respectively...
February 1, 2018: Chemosphere
https://www.readbyqxmd.com/read/29433777/lipid-metabolism-potential-and-mechanism-of-cpe-iii-from-chickpea-cicer-arietinum-l
#2
Zhaohui Xue, Xiaonan Hou, Wancong Yu, Haichao Wen, Qian Zhang, Dan Li, Xiaohong Kou
The effects of CPe-III on hyperlipidemic mice were investigated, along with molecular docking and dynamics analyses between CPe-III and CETP. This study was conducted in order to explore the lipid metabolism potential and mechanism of CPe-III. CPe-III significantly (P<0.05) reduced serum total cholesterol, triglyceride and hepatic triglyceride levels and increased serum superoxide dismutase activity. CPe-III reversed liver changes induced by a high-fat diet and significantly (P<0.05) reduced kidney and epididymal fat indices...
February 2018: Food Research International
https://www.readbyqxmd.com/read/29424255/the-therapeutic-potential-of-cetp-inhibitors-a-patent-review
#3
Xinran Wang, Wei Li, Lijuan Hao, Honglei Xie, Chenzhou Hao, Chunchi Liu, Wenyan Li, Xuqiong Xiong, Dongmei Zhao
Epidemiological studies have identified that high levels of low-density lipoprotein-cholesterol (LDL-C) and low levels of high-density lipoprotein-cholesterol (HDL-C) are two independent causes of cardiovascular disease (CVD). Statins, niacin and fibrate are used for the treatment of CVD. However, some defects are shown in the treatment process. Thus, there is a demand for better treatment strategies that confer preferable efficacy with fewer side effects. Cholesteryl ester transfer protein (CETP) promotes the movement of CEs from HDL to LDL and VLDL in exchange for triglycerides (TGs)...
February 9, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29404214/gene-based-association-study-for-lipid-traits-in-diverse-cohorts-implicates-bace1-and-sidt2-regulation-in-triglyceride-levels
#4
Angela Andaleon, Lauren S Mogil, Heather E Wheeler
Plasma lipid levels are risk factors for cardiovascular disease, a leading cause of death worldwide. While many studies have been conducted on lipid genetics, they mainly focus on Europeans and thus their transferability to diverse populations is unclear. We performed SNP- and gene-level genome-wide association studies (GWAS) of four lipid traits in cohorts from Nigeria and the Philippines and compared them to the results of larger, predominantly European meta-analyses. Two previously implicated loci met genome-wide significance in our SNP-level GWAS in the Nigerian cohort, rs34065661 in CETP associated with HDL cholesterol (P = 9...
2018: PeerJ
https://www.readbyqxmd.com/read/29396305/disconnect-between-genes-associated-with-ischemic-heart-disease-and-targets-of-ischemic-heart-disease-treatments
#5
C M Schooling, J V Huang, J V Zhao, M K Kwok, S L Au Yeung, S L Lin
BACKGROUND: Development of pharmacological treatments to mitigate ischemic heart disease (IHD) has encompassed disappointing results and expensive failures, which has discouraged investment in new approaches to prevention and control. New treatments are most likely to be successful if they act on genetically validated targets. We assessed whether existing pharmacological treatments for IHD reduction are acting on genetically validated targets and whether all such targets for IHD are currently being exploited...
January 30, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29373723/cetp-inhibition-and-hdl-what-is-the-trial-revealing
#6
Lina Badimon
No abstract text is available yet for this article.
February 1, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29366228/lps-reduces-hepatic-cetp-expression-by-mature-resident-macrophages
#7
Yanan Wang, Zhuang Li, Sam Van Der Tuin, Inge Verkouter, Jan Van Klinken, Albert Groen, Patrick Rensen, Ko Willems Van Dijk
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366213/no-association-between-cetp-concentration-and-intima-media-thickness-in-the-general-population-the-neo-study
#8
Tim Christen, Stella Trompet, Raymond Noordam, Lisanne L Blauw, Patrick Cn Rensen, Ko Willems Van Dijk, Frits R Rosendaal, Renée De Mutsert, J Wouter Jukema
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366208/changes-in-adipose-tissue-transcriptome-of-apoe3l-cetp-mice-during-the-development-of-the-metabolic-syndrome
#9
Dimitris Nasias, Dimitris Kardassis
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366068/cardiovascular-safety-of-bcr-abl1-tyrosine-kinase-inhibitors-imatinib-and-ponatinib-decrease-plasma-cholesterol-and-atherosclerosis-in-apoe3-leiden-cetp-mice
#10
Marianne Pouwer, Elsbet Pieterman, Lars Verschuren, Martien Caspers, Kees Kluft, Ricardo Garcia, Frank Lee, Jurjan Aman, Wouter Jukema, Hans Princen
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365842/influence-of-lcat-and-cetp-activity-on-the-reverse-cholesterol-transport-and-modification-of-hdl-particles-in-statin-treated-coronary-artery-disease-patients-and-healthy-subjects
#11
Sandra Vladimirov, Tamara Gojkovic, Vesna Spasojevic-Kalimanovska, Aleksandra Zeljkovic, Jelena Vekic, Dimitra Kalimanovska-Ostric, Zorana Jelic-Ivanovic
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365832/consumption-of-policosanol-for-8-weeks-10-mg-day-enhances-hdl-functionality-via-cetp-inhibition-and-reduces-blood-pressure-and-visceral-fat-in-young-and-middle-aged-subjects
#12
https://www.readbyqxmd.com/read/29365825/downregulation-of-cetp-by-glucocorticoids-consequences-for-hdl-metabolism-in-humans-as-observed-in-an-rct
#13
Robin Dullaart, Jorien Werumeus Buning, Lidya Dimova, Frank Perton, Uwe Tietge, André Van Beek
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29356705/genetics-of-familial-hypercholesterolemia-a-tool-for-development-of-novel-lipid-lowering-pharmaceuticals
#14
Andrea Volta, G Kees Hovingh, Aldo Grefhorst
PURPOSE OF REVIEW: Familial hypercholesterolemia is characterized by high LDL cholesterol and an elevated risk to develop coronary heart disease. Mutations in LDL receptor-mediated cholesterol uptake are the main cause of familial hypercholesterolemia. However, multiple mutations in various other genes are also associated with high LDL cholesterol and even familial hypercholesterolemia. Thus, pharmaceuticals that target these genes and proteins might be attractive treatment options to reduce LDL cholesterol...
January 19, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29332048/frequency-of-cardiovascular-genetic-risk-factors-in-a-calabrian-population-and-their-effects-on-dementia
#15
Raffaele Maletta, Nicoletta Smirne, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Rosanna Colao, Gianfranco Puccio, Sabrina A M Curcio, Valentina Laganà, Francesca Frangipane, Chiara Cupidi, Maria Mirabelli, Franca Vasso, Giusi Torchia, Maria G Muraca, Raffaele Di Lorenzo, Giuseppina Rose, Alberto Montesanto, Giuseppe Passarino, Amalia C Bruni
BACKGROUND: Several genetic variants playing a key role in cholesterol levels, blood pressure, and vascular dysfunction influence the risk of Alzheimer's disease (AD) and vascular dementia (VaD). The many meta-analysis studies carried out on large numbers of samples in different populations have not provided clear results to date, because a trans-ethnic shift of risk genotypes in different populations is often observed. OBJECTIVES: To determine genotypes allele frequencies of the polymorphisms most frequently identified to be correlated with cardio-cerebrovascular disease and AD in a Southern Italy population and to investigate their possible association with dementia...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29317226/oral-delivery-of-highly-lipophilic-poorly-water-soluble-drugs-self-emulsifying-drug-delivery-systems-sedds-to-improve-oral-absorption-and-enable-high-dose-toxicology-studies-of-a-cetp-inhibitor-in-preclinical-species
#16
Xue-Qing Chen, Theresa Ziemba, Christine Huang, Ming Chang, Carrie Xu, Jennifer X Qiao, Tammy C Wang, Heather J Finlay, Mark E Salvati, Leonard P Adam, Olafur Gudmundsson, Michael J Hageman
BMS-A is a highly lipophilic compound (clogP 10.5) with poor aqueous solubility (< 0.0001 mg/mL at pH 6.5). The compound exhibits low oral exposure when dosed as cosolvent solution formulations. The purpose of this study was to evaluate lipid-based formulations for enabling high-dose toxicology studies and enhancing toxicology margins of BMS-A in pre-GLP studies in non-rodent species. The solubility of BMS-A was screened in lipid and cosolvent/surfactant excipients and prototype formulations were developed...
January 6, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29304079/particle-number-analysis-of-lipoprotein-subclasses-by-gel-permeation-hplc-in-patients-with-cholesteryl-ester-transfer-protein-deficiency
#17
Takeshi Okada, Tohru Ohama, Mitsuyo Okazaki, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Yinghong Zhu, Ayami Saga, Takuya Kobayashi, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
OBJECTIVE: We previously reported that patients with cholesteryl ester transfer protein (CETP) deficiency (CETP-D) have a higher prevalence of atherosclerotic cardiovascular disease, in spite of increased HDL-C levels. However, characterization of HDL in CETP-D has not been well described. Therefore, we examined HDL particle number (PN) rather than HDL-C level. APPROACH AND RESULTS: Nine patients with CETP-D and 9 normolipidemic subjects were enrolled. We performed gel permeation high-performance liquid chromatography (GP-HPLC) analysis, determined the cholesterol and triglyceride composition of all lipoprotein subclasses, and calculated the PN of each subclass, which consisted of 3 VLDL (large, medium, and small), 4 LDL (large, medium, small, and very small), and 5 HDL (very large, large, medium, small, and very small) subclasses...
2018: PloS One
https://www.readbyqxmd.com/read/29301387/pharmacogenetics-of-vascular-risk-factors-in-alzheimer-s-disease
#18
REVIEW
Ramón Cacabelos, Arun Meyyazhagan, Juan C Carril, Pablo Cacabelos, Óscar Teijido
Alzheimer's disease (AD) is a polygenic/complex disorder in which genomic, epigenomic, cerebrovascular, metabolic, and environmental factors converge to define a progressive neurodegenerative phenotype. Pharmacogenetics is a major determinant of therapeutic outcome in AD. Different categories of genes are potentially involved in the pharmacogenetic network responsible for drug efficacy and safety, including pathogenic, mechanistic, metabolic, transporter, and pleiotropic genes. However, most drugs exert pleiotropic effects that are promiscuously regulated for different gene products...
January 3, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29287689/present-therapeutic-role-of-cholesteryl-ester-transfer-protein-inhibitors
#19
REVIEW
Nicola Ferri, Alberto Corsini, Cesare R Sirtori, Massimiliano Ruscica
Therapeutic interventions aimed at increasing high-density lipoprotein (HDL) levels, in order to reduce the residual cardiovascular (CV) risk of optimally drug treated patients have not provided convincing results, so far. Transfer of cholesterol from extrahepatic tissues to the liver appears to be the major atheroprotective function of HDL, and an elevation of HDL levels could represent an effective strategy. Inhibition of the cholesteryl ester transfer protein (CETP), raising HDL-cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) levels, reduces low-density lipoprotein-cholesterol (LDL-C) and apoB levels, thus offering a promising approach...
December 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29280647/-relation-of-variant-rs180077-of-gen-cholesterol-ester-transfer-protein-variant-with-fat-mass-hdl-cholesterol-in-obese-subjects-with-diabetes-mellitus-type-2
#20
Daniel Antonio De Luis, Olatz Izaola, David Primo, Susana García Calvo, Emilia Gómez Hoyos, Juan José López Gómez, Ana Ortola, Cristina Serrano, Esther Delgado, Beatriz Torres Torres
BACKGROUND: There is few evidence of cholesterol ester transfer protein (CETP) in subjects with obesity and diabetes mellitus. OBJECTIVES: We examined the association of the polymorphism (rs1800777) of CETP gene on anthropometric parameters, lipid profile and adipokines in subjects with obesity and diabetes mellitus type 2. MATERIAL AND METHODS: A population of 229 obese subjects with diabetes mellitus type 2 was enrolled. An electrical bioimpedance, blood pressure, dietary intake, exercise and biochemical analyses were recorded...
November 14, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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