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https://www.readbyqxmd.com/read/28096968/a-novel-atheroprotective-role-of-mf59-like-adjuvant-when-co-administered-with-cetp-vaccine-in-rabbit-model-of-atherosclerosis
#1
Tamara Aghebati, Amir Hooshang Mohammadpour, Mohammad Afshar, Mahmoud Reza Jaafari, Khalil Abnous, Saeed Nazemi, Sobhan Issazadeh, Saeed Hashemzadeh, Mohammad Zare, Ali Badiee
OBJECTIVES: In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. MATERIALS AND METHODS: Tetanus toxoid- CETP peptide (TT-CETP) was mixed with Alum/CpG or MF59-like and administered subcutaneously for total five times in rabbit model of atherosclerosis...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28073362/elevated-levels-of-pre%C3%AE-1-high-density-lipoprotein-are-associated-with-cholesterol-ester-transfer-protein-the-presence-and-severity-of-coronary-artery-disease
#2
Xiao-Min Bu, Dong-Mei Niu, Jia Wu, Yun-Long Yuan, Jia-Xi Song, Jun-Jun Wang
BACKGROUND: Preβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable. METHODS: Preβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects...
January 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28070240/newer-perspectives-of-coronary-artery-disease-in-young
#3
REVIEW
Amitesh Aggarwal, Saurabh Srivastava, M Velmurugan
Coronary artery disease (CAD) occurring in less than 45 years of age is termed as young CAD. Recent studies show a prevalence of 1.2% of CAD cases in this age group. Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%. Conventional risk factors such as smoking, diabetes, hypertension, obesity and family history seems to be as important as in older CAD subjects. But the prevalence of these risk factors seems to vary in younger subjects...
December 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/28065481/differences-in-the-interaction-between-cetp-taq1b-polymorphism-and-dietary-fat-intake-on-lipid-profile-of-normolipedemic-and-dyslipidemic-patients-with-type-2-diabetes-mellitus
#4
Zahra Kalantar, Mohamad Reza Eshraghian, Gity Sotoudeh, Mahmoud Djalali, Anahita Mansouri, Ehsan Alvandi, Fatemeh Javadi, Maryam Mahmoudi, Fariba Koohdani
BACKGROUND & AIM: Dyslipidemia is one of the major complications in patients with type 2 diabetes mellitus (T2DM). Dietary fat intake and genetic factors including CETP Taq1B polymorphism could also affect lipid profile concentrations, in particular HDL-c. We decided to study the frequency of this polymorphism and its interaction with dietary fat intake on HDL-c concentration among Iranian T2DM patients with and without dyslipidemia. METHODS: In this comparative study, serum samples were collected from 55 patients with dyslipidemia and 129 patients without dyslipidemia...
December 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28057378/beneficial-effect-of-cetp-gene-polymorphism-in-combination-with-a-mediterranean-diet-influencing-lipid-metabolism-in-metabolic-syndrome-patients-cordioprev-study
#5
Antonio Garcia-Rios, Juan Francisco Alcala-Diaz, Francisco Gomez-Delgado, Javier Delgado-Lista, Carmen Marin, Ana Leon-Acuña, Antonio Camargo, Fernando Rodriguez-Cantalejo, Ruth Blanco-Rojo, Gracia Quintana-Navarro, Jose Maria Ordovas, Francisco Perez-Jimenez, Jose Lopez-Miranda, Pablo Perez-Martinez
The cholesteryl ester transfer protein (CETP) gene has been implicated in high-density lipoprotein (HDL-C) metabolism. However, little is known about the impact of this gene on metabolic syndrome (MetS) patients and its interaction with diet. Here, we evaluate whether the consumption of a Mediterranean diet, compared with a Low-fat diet, interacts with the rs3764261 SNP at the CETP locus to modify lipid metabolism in MetS patients. Plasma lipid concentrations and rs3764261 genotypes were determined in 424 MetS subjects participating in the CORDIOPREV clinical trial (NCT00924937)...
December 24, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28050232/identification-of-cetp-as-a-molecular-target-for-estrogen-positive-breast-cancer-cell-death-by-cholesterol-depleting-agents
#6
Luke Esau, Sunil Sagar, Dhinoth Bangarusamy, Mandeep Kaur
Cholesterol and its metabolites act as steroid hormone precursors, which promote estrogen receptor positive (ER+) breast cancer (BC) progression. Development of cholesterol targeting anticancer drugs has been hindered due to the lack of knowledge of viable molecular targets. Till now, Cholesteryl ester transfer protein (CETP) has been envisaged as a feasible molecular target in atherosclerosis, but for the first time, we show that CETP contributes to BC cell survival when challenged with cholesterol depleting agents...
September 2016: Genes & Cancer
https://www.readbyqxmd.com/read/28018294/zebrafish-models-for-dyslipidemia-and-atherosclerosis-research
#7
REVIEW
Amnon Schlegel
Atherosclerotic cardiovascular disease is the leading cause of death. Elevated circulating concentrations of lipids are a central pathogenetic driver of atherosclerosis. While numerous effective therapies for this condition have been developed, there is substantial unmet need for this pandemic illness. Here, I will review nutritional, physiological, genetic, and pathological discoveries in the emerging zebrafish model for studying dyslipidemia and atherosclerosis. The technical and physiological advantages and the pharmacological potential of this organism for discovery and validation of dyslipidemia and atherosclerosis targets are stressed through summary of recent findings...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27927063/inflammation-and-beyond-new-directions-and-emerging-drugs-for-treating-atherosclerosis
#8
Marie-Jeanne Bertrand, Jean-Claude Tardif
Cardiovascular (CV) atherosclerotic disease remains the leading cause of morbidity and mortality worldwide, despite the advances in contemporary therapies. Inflammation is an important process in atherosclerosis, leading to plaque rupture and acute coronary syndrome. Although statin therapy has substantially reduced CV events in primary and secondary prevention, many treated patients will have recurrent adverse CV events despite the standard of care. Thus, drug development aiming to target inflammatory pathways seems a promising avenue for novel therapies in atherosclerosis...
December 22, 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27904507/impact-of-variants-in-cetp-and-apo-ai-genes-on-serum-hdl-cholesterol-levels-in-men-and-women-from-the-polish-population
#9
Marta Włodarczyk, Małgorzata Wrzosek, Grażyna Nowicka, Beata Jabłonowska-Lietz
INTRODUCTION: Polymorphisms in the cholesterol ester transfer protein (CETP) gene and apolipoprotein AI (apo AI) gene are identified as the most common genetic factors influencing high-density lipoprotein cholesterol (HDL cholesterol) levels. Low HDL cholesterol is an important risk factor for cardiovascular disease. We investigated the effect of the TaqIB polymorphism of the CETP gene and the 75G/A polymorphism of the apo AI gene on the HDL cholesterol concentration in a sample of Polish adults...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27900865/-treatment-of-dyslipidemia-is-here-still-place-for-cetp-inhibitors
#10
Ján Murín, Miroslav Pernický, Soňa Kiňová
In the treatment of dyslipidemias about 5-6 years back a new class of drugs emerged, CETP (cholesteryl ester transfer protein)-inhibitors. Their benefit was due to an increase of HDL-cholesterol (HDL-C) serum levels. This treatment mode was supported by epidemiological and clinical studies, as people with high serum HDL-C levels suffered less from cardiovascular (CV) events. Three studies with CETP inhibitors (ILLUMINATE with torcetrapib, dal-OUTCOMES with dalcetrapib and ACCELERATE with evacetrapib) were unfortunately negative, and torcetrapib was even harmful to patients due to an increase of aldosterone serum levels...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27900488/additive-antiatherogenic-effects-of-cetp-rs708272-on-serum-ldl-subfraction-levels-in-patients-with-chd-under-statin-therapy
#11
Deniz Kanca, Uzay Gormus, Bengu Tokat, Allison P Eronat, Zehra Bugra, Oğuz Ozturk, Hulya Yilmaz-Aydogan
Recently, subfraction analysis of serum low density lipoprotein (LDL) is considered to be a better predictor of the risk of coronary heart disease (CHD) compared to the other lipid parameters. The aim of this study was to examine the effects of the HDL-associated Taq1B (rs708272) SNP of cholesterol ester transfer protein (CETP) gene on serum LDL subfractions in patients with CHD. Serum lipid levels were measured enzymatically and LDL subfraction analysis was carried out by the Lipoprint System (Quantimetrix, CA, USA)...
November 30, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27899788/serum-lipid-transfer-proteins-in-hypothyreotic-patients-are-inversely-correlated-with-thyroid-stimulating-hormone-tsh-levels
#12
Anna Skoczyńska, Anna Wojakowska, Barbara Turczyn, Katarzyna Zatońska, Maria Wołyniec, Natalia Rogala, Andrzej Szuba, Grażyna Bednarek-Tupikowska
BACKGROUND Plasma cholesteryl ester transfer protein (CETP) activity is often decreased in patients with hypothyroidism, whereas less is known about the phospholipid transfer protein (PLTP). We aimed to evaluate simultaneously serum CETP and PLTP activity in patients diagnosed with hypothyroidism. MATERIAL AND METHODS The selection criteria for control group members (without thyroid dysfunction) in this case to case study were levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides similar to those in study group patients (101 patients diagnosed with hypothyroidism)...
November 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27895466/pharmacokinetics-pharmacodynamics-and-safety-of-ckd-519-a-cetp-inhibitor-in-healthy-subjects
#13
Choon Ok Kim, Eun Sil Oh, Chungam Choi, Yeonjoo Kim, Sera Lee, Semi Kim, Min Soo Park
CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg) and randomized to CKD-519 (n=6) or matching placebo (n=2)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27890377/corrigendum-to-cetp-polymorphisms-confer-genetic-contribution-to-centenarians-of-hainan-south-of-china-asian-pac-j-trop-med-9-9-2016-872-876
#14
Yun-Xia Zhang, Ya Su, Li Tang, Ze-Xing Yang, Dai-Feng Zhou, Yi-Min Qiu
No abstract text is available yet for this article.
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27868450/pharmacological-management-of-diabetic-dyslipidemia
#15
T D Filippatos, M Florentin, M Georgoula, M S Elisaf
Diabetes mellitus is associated with increased cardiovascular disease (CVD) risk. Areas covered: Main goal of hypolipidemic treatment in diabetic patients is low-density lipoprotein cholesterol (LDL-C) lowering with the use of statins. Addition of ezetimibe is useful in diabetic patients who cannot achieve their LDL-C target. However, many diabetic patients have increased residual CVD risk, which is mainly attributed to high triglycerides and low high-density lipoprotein (HDL-C) values. The addition of fenofibrate targets these variables and possibly reduces residual CVD risk, but a possible beneficial effect has been shown only in a pre-specified subgroup analysis in patients with high triglycerides and low HDL-C values...
December 2, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27827461/association-and-interaction-of-apoa5-bud13-cetp-lipa-and-health-related-behavior-with-metabolic-syndrome-in-a-taiwanese-population
#16
Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Shih-Jen Tsai
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. In this replication study, we reassessed whether these genes are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects were assessed in this study...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27823564/molecular-docking-and-pharmacophore-modeling-studies-of-fluorinated-benzamides-as-potential-cetp-inhibitors
#17
Reema Abu Khalaf, Sarah Al-Rawashdeh, Dima Sabbah, Ghassan Abu Sheikha
BACKGROUND: Hyperlipidemia is one of the most common chronic diseases worldwide. Cholesteryl ester transfer protein (CETP) is a hydrophobic glycoprotein that facilitates the transfer of cholesteryl ester from the atheroprotective high-density lipoprotein (HDL) to the proatherogenic low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). METHODS: In this work, synthesis and characterization of five fluorinated 3-benzylamino benzamides 8a-8c, 13a and 13b that target CETP activity was carried out...
November 4, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27817213/progress-and-future-opportunities-in-the-development-of-vaccines-against-atherosclerosis
#18
Dania Govea-Alonso, Josué Beltrán-López, Jorge A Salazar-González, Juan Vargas-Morales, Sergio Rosales-Mendoza
Atherosclerosis represents a serious global health problem that demands new therapeutic and prophylactic interventions. Considering that atherosclerosis has autoimmune and inflammatory components, immunotherapy is a possible focus to treat this disease. Areas covered: Based on the analysis of the current biomedical literature, this review describes the status on the development of vaccines against atherosclerosis. Several targets have been identified including sequences of apolipoprotein B100 (ApoB100), cholesteryl ester transfer protein (CETP), heat shock proteins (HSP), extracellular matrix proteins, T cell receptor β chain variable region 31 (TRBV31), the major outer membrane protein (MOMP), and the outer membrane protein 5 (Pomp5) from Chlamydia pneumoniae...
November 6, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27791990/a-meta-analytic-evaluation-of-cholesteryl-ester-transfer-protein-cetp-c-629a-polymorphism-in-association-with-coronary-heart-disease-risk-and-lipid-changes
#19
Shouwei Lin, Ruozhu Dai, Rong Lin
Lipid metabolism plays an essential role in the pathogenesis of atherosclerosis, a major cause for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) is an important glycoprotein involved in lipid metabolism by transferring cholesteryl esters to apolipoprotein B-containing lipoproteins in exchange for triglycerides. The objective of this meta-analysis was to evaluate the association of CETP C-629A polymorphism with CHD risk and lipid changes. Four public databases were searched, and data from 17 qualified articles were extracted in duplicate and analyzed by STATA software...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27776442/6-mo-aerobic-exercise-intervention-enhances-the-lipid-peroxide-transport-function-of-hdl
#20
Sanna Tiainen, Riitta Luoto, Markku Ahotupa, Jani Raitanen, Tommi Vasankari
During acute exercise, the concentration of oxidized high-density lipoprotein (HDL) lipids (ox-HDL) is reported to increase suggesting that HDL may function in decreasing the concentration of oxidized low-density lipoprotein (LDL) lipids. However, the effect of exercise intervention on the lipid peroxide transport function of HDL is unknown. A randomized controlled trial with sedentary women (N = 161), aged 43-63, with no current use of hormone therapy, were randomized into a 6-month (mo) exercise group and a control group...
2016: Free Radical Research
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