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https://www.readbyqxmd.com/read/28543603/silver-nanoparticles-antimicrobial-activity-cytotoxicity-and-synergism-with-n-acetyl-cysteine
#1
Selwan Hamed, Mohamed Emara, Riham M Shawky, Ramadan A El-Domany, Tareq Youssef
The fast progression of nanotechnology has led to novel therapeutic interventions. Antimicrobial activities of silver nanoparticles (Ag NPs) were tested against standard ATCC strains of Staphylococcus aureus (ATCC 9144), Escherichia coli (O157:H7), Pseudomonas aeruginosa (ATCC 27853), and Candida albicans (ATCC 90028) in addition to 60 clinical isolates collected from cancer patients. Antimicrobial activity was tested by disk diffusion method and MIC values for Ag NPs alone and in combination with N-acetylcysteine (NAC) against tested pathogens were determined by broth microdilution method...
May 22, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28543404/tumor-necrosis-factor-%C3%AE-induced-apoptosis-in-u937-cells-promotes-cathepsin-d-independent-stefin-b-degradation
#2
Katja Bidovec, Janja Božič, Iztok Dolenc, Boris Turk, Vito Turk, Veronika Stoka
Lysosomal cathepsins were previously found to be involved in tumor necrosis factor-α (TNFα)-induced apoptosis. However, there are opposing views regarding their role as either initiators or amplifiers of the signaling cascade as well as the order of molecular events during this process. In this study, we investigated the role of cathepsin D (catD) in TNFα/cycloheximide-induced apoptosis in U937 human monocytic cells. TNFα-induced apoptosis proceeds through caspase-8 activation, processing of the pro-apoptotic molecule Bid, mitochondrial membrane permeabilization, and caspase-3 activation...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28542135/furanodienone-induces-g0-g1-arrest-and-causes-apoptosis-via-the-ros-mapks-mediated-caspase-dependent-pathway-in-human-colorectal-cancer-cells-a-study-in-vitro-and-in-vivo
#3
Ying Jiang, Xiaoqin Wang, Daode Hu
Furanodienone, a major bioactive constituents of sesquiterpene derived from Rhizoma Curcumae, has been proven to possess the potent anticancer efficacy on human breast cancer cells. Here, we investigated the cytotoxicity of furanodienone on human colorectal carcinoma cell lines in vitro and in vivo, as well as its underlying molecular mechanisms in the induction of apoptosis. In this study, we found that furanodienone significantly inhibited proliferation of RKO and HT-29 cells, induced mitochondrial dysfunction characterized by collapse of mitochondrial transmembrane potential and reduction of ATP level, and promoted the production of reactive oxygen species (ROS) that functions upstream of caspase-dependent apoptosis...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28535741/effects-of-n-acetyl-cysteine-on-oxidative-stress-and-tnf-%C3%AE-gene-expression-in-diclofenac-induced-hepatotoxicity-in-rats
#4
Ali Nouri, Esfandiar Heidarian, Morteza Nikoukar
The consumption of nonsteroidal anti-inflammatory drug, such as diclofenac, can lead to hepatotoxicity. In the present study, protective effect of N-acetyl cysteine (NAC) on diclofenac-induced hepatotoxicity was investigated. Thirty two male rats were divided into four groups. Group 1 (control group) was treated with normal saline (1 ml/kg, i.p.) for 4 days. Group 2 (test without treatment) received diclofenac only (50 mg/kg, i.p.) for 4 days. Groups 3 and 4 received diclofenac (50 mg/kg, i.p.) plus NAC (150mg/kg, p...
May 24, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28532657/mechanistic-link-between-diesel-exhaust-particles-and-respiratory-reflexes
#5
Ryan K Robinson, Mark A Birrell, John J Adcock, Michael A Wortley, Eric D Dubuis, Shu Chen, Catriona M McGilvery, Sheng Hu, Milo Sp Shaffer, Sara J Bonvini, Sarah A Maher, Ian S Mudway, Alexandra E Porter, Chris Carlsten, Teresa D Tetley, Maria G Belvisi
BACKGROUND: Diesel exhaust particles (DEP) are a major component of particulate matter in Europe's largest cities and epidemiological evidence links exposure with respiratory symptoms and asthma exacerbations. Respiratory reflexes are responsible for symptoms and are regulated by vagal afferent nerves which innervate the airway. It is not known how DEP exposure activates airway afferents to elicit symptoms such as cough and bronchospasm. OBJECTIVE: To identify the mechanisms involved in the activation of airway sensory afferents by DEPs...
May 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28532282/synthesis-of-ph-responsive-n-acetyl-cysteine-modified-starch-derivatives-for-oral-delivery
#6
Kwanghyok Jong, Benzhi Ju, Shufen Zhang
In this study, a novel type of pH-responsive polymer PyHES-NAC ((2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES)) - (N-Acetyl-cysteine (NAC)) was synthesized. First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC. Aqueous PyHES-NAC solutions exhibited a good transference between hydrophobic (or self-assembly) and hydrophilic static along with the change of pH value and protective properties of drugs under acidic conditions...
May 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28529596/andrographolide-induces-apoptotic-and-non-apoptotic-death-and-enhances-tumor-necrosis-factor-related-apoptosis-inducing-ligand-mediated-apoptosis-in-gastric-cancer-cells
#7
Sung-Chul Lim, Ho Jong Jeon, Keun Hong Kee, Mi Ja Lee, Ran Hong, Song Iy Han
Andrographolide, a natural compound isolated from Andrographis paniculata, has been reported to possess antitumor activity. In the present study, the effect of andrographolide in human gastric cancer (GC) cells was investigated. Andrographolide induced cell death with apoptotic and non-apoptotic features. At a low concentration, andrographolide potentiated apoptosis and reduction of clonogenicity triggered by recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL). Exposure of GC cells to andrographolide altered the expression level of several growth-inhibiting and apoptosis-regulating proteins, including death receptors...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28527359/nanocubes-of-indium-oxide-induce-cytotoxicity-and-apoptosis-through-oxidative-stress-in-human-lung-epithelial-cells
#8
Maqusood Ahamed, Mohd Javed Akhtar, M A Majeed Khan, Hisham A Alhadlaq, Ali Aldalbahi
The demand for semiconductor indium oxide (In2O3) nanocrystals is increasing because of their diverse applications, including in biomedicine. However, there is a scarcity of studies on the biological interaction of indium oxide nanocrystals. Here, we explored the underlying mechanisms of toxicity induced by indium oxide nanocubes in human lung epithelial (A549) cells. Prepared indium oxide nanocubes were crystalline with an average size of 21nm. Biointeraction studies have shown that indium oxide nanocubes induce cell viability reduction and cell membrane damage in a dose- and time-dependent manner...
May 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28517024/treatment-of-severe-alcoholic-hepatitis-past-present-and-future
#9
REVIEW
Nicolas Lanthier, Peter Stärkel
Alcoholic hepatitis manifests as a clinical syndrome characterized by recent jaundice and liver function deterioration in an actively drinking patient. The principal cause of alcoholic hepatitis is alcoholic steatohepatitis defined histologically by the coexistence of steatosis, hepatocyte ballooning and satellitosis. While non-severe alcoholic hepatitis usually responds to alcohol abstinence, severe alcoholic hepatitis, identified by Maddrey scoring ≥ 32, has a bad prognosis and is traditionally treated by a 28-day course of prednisone therapy...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28512265/chaetocin-enhances-dendritic-cell-function-via-the-induction-of-heat-shock-protein-and-cancer-testis-antigens-in-myeloma-cells
#10
Manh-Cuong Vo, Thanh-Nhan Nguyen-Pham, Hyun-Ju Lee, Sung-Hoon Jung, Nu-Ri Choi, My-Dung Hoang, Hyeoung-Joon Kim, Je-Jung Lee
Dendritic cells (DC)-based vaccines are considered useful in cancer immuno-therapy, and the interactions of DC and dying tumor cells are important and promising for cancer immunotherapy. We investigated whether chaetocin could be used to induce death of myeloma cells, for loading onto DCs can affect DCs function. In this study, we show that the dying myeloma cells treated with chaetocin resulted in the induction of heat shock protein (HSP) 90, which was inhibited by antioxidant N-acetyl cysteine, and showed an increase in the expression of MAGE-A3 and MAGE-C1/CT7...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28499416/cardioprotective-potential-of-n-acetyl-cysteine-against-hyperglycaemia-induced-oxidative-damage-a-protocol-for-a-systematic-review
#11
Phiwayinkosi V Dludla, Bongani B Nkambule, Stephanie C Dias, Rabia Johnson
BACKGROUND: Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM include increased myocardial left ventricular wall thickness and remodelling that result in reduced cardiac efficiency. To prevent this, an increasing number of pharmacological compounds such as N-acetyl cysteine (NAC) are explored for their antioxidant properties. A few studies have shown that NAC can ameliorate hyperglycaemia-induced oxidative damage within the heart...
May 12, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28499252/crosstalk-between-hdac6-and-nox2-based-nadph-oxidase-mediates-hiv-1-tat-induced-pro-inflammatory-responses-in-astrocytes
#12
Gi Soo Youn, Hyundong Cho, Donggyu Kim, Soo Young Choi, Jinseu Park
Histone deacetylase 6 (HDAC6) likely is important in inflammatory diseases. However, how HDAC6 exerts its effect on inflammatory processes remains unclear. HIV-1 transactivator of transcription (Tat) activates NADPH oxidase resulting in generation of reactive oxygen species (ROS), leading to extensive neuro-inflammation in the central nervous system. We investigated the correlation of HDAC6 and NADPH oxidase in HIV-1 Tat-stimulated astrocytes. HDAC6 knockdown attenuated HIV-1 Tat-induced ROS generation and NADPH oxidase activation...
May 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28497199/arachidonic-acid-induces-are-nrf2-dependent-heme-oxygenase-1-transcription-in-rat-brain-astrocytes
#13
Chih-Chung Lin, Chien-Chung Yang, Yu-Wen Chen, Li-Der Hsiao, Chuen-Mao Yang
Arachidonic acid (AA) is a major product of phospholipid hydrolysis catalyzed by phospholipase A2 during neurodegenerative diseases. AA exerts as a second messenger to regulate various signaling components which may be involved in different pathophysiological processes. Astrocytes are the main types of CNS resident cells which maintain and support the physiological function of brain. AA has been shown to induce ROS generation through activation of NADPH oxidases (Noxs) which may play a key role in the expression of heme oxygenase-1 (HO-1)...
May 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28496415/inflammatory-effects-of-menthol-vs-non-menthol-cigarette-smoke-extract-on-human-lung-epithelial-cells-a-double-hit-on-trpm8-by-reactive-oxygen-species-and-menthol
#14
An-Hsuan Lin, Meng-Han Liu, Hsin-Kuo B Ko, Diahn-Warng Perng, Tzong-Shyuan Lee, Yu Ru Kou
Clinical studies suggest that smokers with chronic obstructive pulmonary disease who use menthol cigarettes may display more severe lung inflammation than those who smoke non-menthol cigarette. However, the mechanisms for this difference remain unclear. Menthol is a ligand of transient receptor potential melastatin-8 (TRPM8), a Ca(2+)-permeant channel sensitive to reactive oxygen species (ROS). We previously reported that exposure of human bronchial epithelial cells (HBECs) to non-menthol cigarette smoke extract (Non-M-CSE) triggers a cascade of inflammatory signaling leading to IL-8 induction...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28495234/oxidative-stress-induced-akt-downregulation-mediates-green-tea-toxicity-towards-prostate-cancer-cells
#15
Anna Maria Posadino, Hoa Thi Phu, Annalisa Cossu, Roberta Giordo, Marco Fois, Duong Thi Bich Thuan, Antonio Piga, Salvatore Sotgia, Angelo Zinellu, Ciriaco Carru, Gianfranco Pintus
Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on prostate cancer cells (PC3), analyze the potential signals involved and elucidate whether anti- or pro-oxidant effects may be implicated. Treatment of PC3 cells with 30 and 100μg/ml PE significantly decreased cell viability and proliferation. At the tested concentrations, PE did not exert any antioxidant activity, eliciting instead a pro-oxidant effect at concentrations 30 and 100μg/ml, which was consistent with the observed PE cytotoxicity...
May 7, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28492308/visualizing-the-conversion-process-of-alcohol-induced-fatty-liver-to-steatohepatitis-in-vivo-with-a-fluorescent-nanoprobe
#16
Limin Yang, Yuanyuan Chen, Wei Pan, Hongyu Wang, Na Li, Bo Tang
Excess alcohol consumption and the associated development of alcoholic liver disease (ALD) is a major public health challenge in the world-wide. Since patients with the severe stages of ALD no longer benefit from clinical therapies, early warning of ALD holds significant promise for increasing the cure rate of ALD. Herein, we develop a bicolor fluorescent nanoprobe for dynamically monitoring the conversion process of alcohol-induced fatty liver to steatohepatitis in vivo through simultaneous imaging of microRNA 155 and osteopontin mRNA, which are related to fatty liver and steatohepatitis respectively...
May 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28487634/ryr2-mediated-ca-2-release-and-mitochondrial-ros-generation-partake-in-the-synaptic-dysfunction-caused-by-amyloid-%C3%AE-peptide-oligomers
#17
Carol D SanMartín, Pablo Veloso, Tatiana Adasme, Pedro Lobos, Barbara Bruna, Jose Galaz, Alejandra García, Steffen Hartel, Cecilia Hidalgo, Andrea C Paula-Lima
Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer's disease, trigger persistent and low magnitude Ca(2+) signals in neurons. We reported previously that these Ca(2+) signals, which arise from Ca(2+) entry and subsequent amplification by Ca(2+) release through ryanodine receptor (RyR) channels, promote mitochondrial network fragmentation and reduce RyR2 expression. Here, we examined if AβOs, by inducing redox sensitive RyR-mediated Ca(2+) release, stimulate mitochondrial Ca(2+)-uptake, ROS generation and mitochondrial fragmentation, and also investigated the effects of the antioxidant N-acetyl cysteine (NAC) and the mitochondrial antioxidant EUK-134 on AβOs-induced mitochondrial dysfunction...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28482716/dihydromyricetin-induces-apoptosis-and-cytoprotective-autophagy-through-ros-nf-%C3%AE%C2%BAb-signaling-in-human-melanoma-cells
#18
Ding-Zhou Zhou, Hai-Ying Sun, Jing-Qi Yue, Yong Peng, Yi-Ming Chen, Zhi-Jian Zhong
Dihydromyricetin (DHM), a Rattan tea extract, has recently been shown to have anti-cancer activity in mammalian cells. In the present study, we investigated the effect of DHM on human melanoma cells. Apart from induction of apoptosis, we demonstrated that DHM induced an autophagic response. Moreover, pharmacological inhibition or genetic blockade of autophagy enhanced DHM-induced cell death and apoptosis, indicating the cytoprotective role of autophagy in DHM-treated human melanoma cells. Further study suggested that the nuclear factor kappa B (NF-κB) signaling pathway was involved in DHM-induced autophagy...
May 8, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28475371/phytochemical-constituents-and-antioxidant-activity-of-echinops-albicaulis
#19
Lashyn Kiyekbayeva, Nesma M Mohamed, Orazbekov Yerkebulan, Enas I Mohamed, Datkhayev Ubaidilla, Akhtayeva Nursulu, Mamurova Assem, Radhakrishnan Srivedavyasasri, Samir A Ross
Two thiophenes; 5-(3-buten-1-ynyl)-2,2'-bithiophene (2) and α-tertthienyl (9), two alkaloids; echinopsine (10) and echinorine (11), three flavonoids; genkwanin (5), apigenin (6), and rutin (7), two triterpenoids; lupeol acetate (1) and lupeol linoleate (4), together with 2,6,10-trimethyldodeca-2,6,10-triene (4) and β-sitosterol glucoside (8) were isolated from the aerial parts of Echinops albicaulis. Antioxidant, antimicrobial and antiprotozoal activities were evaluated. E. albicaulis aqueous methanolic extract (50, 10, and 1 mg/mL) showed significant antioxidant activity comparable to the potent antioxidant, N-acetyl cysteine, moreover, the aqueous methanolic extract (1 mg/mL) significantly reduced intracellular reactive oxygen species in active cell cultures of human peripheral blood mononuclear cells under oxidative stress more than the reference antioxidant N-acetyl cysteine...
May 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28468627/the-omega-3-polyunsaturated-fatty-acid-docosahexaenoic-acid-inhibits-proliferation-and-progression-of-non-small-cell-lung-cancer-cells-through-the-reactive-oxygen-species-mediated-inactivation-of-the-pi3k-akt-pathway
#20
Yuanqin Yin, Chengguang Sui, Fandong Meng, Ping Ma, Youhong Jiang
BACKGROUND: Docosahexaenoic acid(DHA) inhibits tumor growth and progression in various cancers, including lung cancer. However, the mechanisms involved remain unclear. The aim of this study was to identify the mechanism of DHA in inhibiting progression of non-small cell lung cancer (NSCLC) in vitro. METHODS: The proliferation of A549 was tested by MTT, and cell apoptosis was analysed using flow cytometer. The migration and invasion were examined respectively by wound healing assay and Transwell invasion assay...
May 3, 2017: Lipids in Health and Disease
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