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Xinchun Ye, Delian Kong, Jun Wang, Tauheed Ishrat, Hongjuan Shi, Xiaohui Ding, Guiyun Cui, Fang Hua
Myeloid differentiation primary-response protein-88 (MyD88) is one of adaptor proteins mediating Toll-like receptors (TLRs) signaling. Activation of MyD88 results in the activation of nuclear factor kappa B (NFκB) and the increase of inflammatory responses. Evidences have demonstrated that TLRs signaling contributes to cerebral ischemia/reperfusion (I/R) injury. However, the role of MyD88 in this mechanism of action is disputed and needs to be clarified. In the present study, in a mouse model of cerebral I/R, we examined the activities of NFκB and interferon factor-3 (IRF3), and the inflammatory responses in ischemic brain tissue using ELISA, Western blots, and real-time PCR...
October 4, 2016: Biochemical and Biophysical Research Communications
Parvaiz M Zunga, Shah Faisal Ahmad Tarfarosh, Omar Farooq, Ishrat H Dar, Samia Rashid, Ummer Yaseen
[This corrects the article DOI: 10.7759/cureus.644.].
September 19, 2016: Curēus
Noor-Ul-Ain Jawaed, Syed Yawar Ali Abidi, Fazal-Ur-Rehman Qazi, Shahbaz Ahmed
OBJECTIVE: To evaluate the coronal microleakage of packable composite using conventional incremental and posterior bulk fill flowable composite using Smart Dentine Replacement Single Step technique in the cervical margins of class II cavities in dentine using the dye penetration method. STUDY DESIGN: In-vitroInterventional study. PLACE AND DURATION OF STUDY: Department of Operative Dentistry, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Karachi, from November 2012 to April 2013...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Adel Abu-Heija, Majeda Al-Bash, Noreen Ishrat, Lamya Al-Kharausi
AIM: To find out whether 50 g oral glucose challenge test (OGCT) is an effective screening test for all pregnant women between 24 and 28 weeks gestation. METHOD: A 50 g OGCT test was administered to 307 unselected women at 24-28 weeks of gestation. When venous plasma glucose (VPG) concentration after 1 h was >7.8 mmol/l, OGCT was positive. Women with a positive OGCT underwent 2 h 75 grams oral glucose tolerance test (OGTT) as a confirmatory diagnosis of GDM...
October 2016: Journal of Obstetrics and Gynaecology of India
Ishrat Ferdousee, S M Yasir Arafat, Zuhayer Ahmed
Though fibroadenoma is the most common benign tumor of the breast and is more common under the age of 30, giant fibroadenoma is rare representing less than 4% of all fibroadenomas. A 12 years old girl presented with rapidly enlarging well-circumscribed firm, non-tender mass in right breast for 2 months which was painless and with no history of trauma, nipple discharge, fever, anorexia, weight loss or axillary lymphadenopathy. There was no family history of neoplasms. Clinically, the lump was about 12 × 12 cm and not fixed to skin or underlying structures with the absence of nipple retraction or discharge...
September 1, 2016: Polski Przeglad Chirurgiczny
Lubna Khan, Kamal Malukani, Siddharth Malaiya, Prashant Yeshwante, Saba Ishrat, Shirish S Nandedkar
PURPOSE: To evaluate the role of fine needle aspiration (FNAC) as a diagnostic tool in cases of orbital and ocular adnexal masses. Cytological findings were correlated with histopathological diagnosis wherever possible. METHODS: FNAC was performed in 29 patients of different age groups presenting with orbital and ocular adnexal masses. Patients were evaluated clinically and investigated by non-invasive techniques before fine needle aspiration of the masses. Smears were analyzed by a cytologist in all cases...
July 2016: Journal of Ophthalmic & Vision Research
Talha Shafi, Ishrat Jabeen
ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP/ABCG2) are major determinant of pharmacokinetic, safety and efficacy profiles of drugs thereby effluxing a broad range of endogenous substances across the plasma membrane. Overexpression of these transporters in various tumors is also implicated in the development of multidrug resistance (MDR) and thus, hampers the success of cancer chemotherapy. Modulators of these efflux transporters in combination with chemotherapeutics could be a promising concept to increase the effective intracellular concentration of anticancer drugs...
August 31, 2016: Current Cancer Drug Targets
Brent E Salvig, Alev H Gulum, Stephanie A Walters, Leigh B Edwards, T Neal Fourakre, Susan C Marvin, Michael S McKenzie, Michelle V Moseley, Ishrat J Ansari
OBJECTIVE: To assess the effect of pharmacist screening for osteoporosis risk with increased bone mineral density (BMD) testing. DESIGN: Prospective, quasi-experiment. SETTING: Veterans Affairs medical center Community Living Centers (CLC), home-based primary care, and outpatient geriatric clinic. PARTICIPANTS: Patients with a routine pharmacist interaction were included. Exclusion criteria included hospice, dialysis, and respite care...
2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Peerzada Y Yousuf, Arshid H Ganie, Ishrat Khan, Mohammad I Qureshi, Mohamed M Ibrahim, Maryam Sarwat, Muhammad Iqbal, Altaf Ahmad
Carbon (C) and nitrogen (N) are two essential elements that influence plant growth and development. The C and N metabolic pathways influence each other to affect gene expression, but little is known about which genes are regulated by interaction between C and N or the mechanisms by which the pathways interact. In the present investigation, proteome analysis of N-efficient and N-inefficient Indian mustard, grown under varied combinations of low-N, sufficient-N, ambient [CO2], and elevated [CO2] was carried out to identify proteins and the encoding genes of the interactions between C and N...
2016: Frontiers in Plant Science
Sehrish Badar, Syed Waseemuddin Ahmed, Zafar Alam Mahmood, Sheikh Abdul Khaliq, Iqbal Azhar, Ishrat Younus
No abstract text is available yet for this article.
July 2016: Iranian Journal of Public Health
Nazeem Ishrat Siddiqui, Sarfaraz Alam Khan, Mohammad Shoeb, Sukhwant Bose
INTRODUCTION: Phase Angle (PhA) is a ratio of whole body reactance and resistance obtained from Bioelectrical Impedance Analysis (BIA). It indicates cellular health and integrity and is considered as prognostic tool in medical disorders. In spite of prognostic potentials of PhA, it has limited usefulness in clinical practice and in population studies because of non-availability of normal population reference limits for comparison. Moreover, it is influenced by various factors like age, sex, race and body composition (i...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Aftab Alam, Shahnwaz Ali, Shahzaib Ahamad, Md Zubbair Malik, Romana Ishrat
Recently, Zika virus has emerged as a potential threat to human health worldwide. Zika is the member of Flaviviridae, is transmitted to humans by mosquitoes. It is related to other pathogenic vector borne flaviviruses including dengue, West-Nile and Japanese encephalitis viruses, but produces a comparatively mild disease in humans. Despite of its epidemic outbreak and lack of potential medication, there is a need for improved vaccine /drugs. The use of computational technique will bring some facts into the research limelight...
August 3, 2016: Immunology
Omar Farooq, Ishrat H Dar, Mohd Iqbal Dar, Samia Rashid, Parvaiz M Zunga, Shah Faisal Ahmad Tarfarosh
A 58-year-old male farmer, with no significant history of any chronic morbidity, was admitted via the Emergency Department of SMHS Hospital, Srinagar, with a history of an injury to the hand 20 days earlier followed by a three-day history of dysmasesis (difficulty chewing), progressing to trismus and generalized stiffness interfering with his daily activities. The patient was clinically managed as tetanus on grounds of high clinical suspicion. The patient was treated for a week and discharged without any sequelae to follow-up in the Neurology Outpatient Department of the SMHS Hospital and is currently doing well...
June 17, 2016: Curēus
Nitin Nema, Saba Ishrat, Abha Verma, Manoj Kela
A 23-year-old man with a history of alcoholism presented with vomiting, fever, and sharp epigastric pain radiating to the back and flanks. He was diagnosed as a case of acute alcoholic pancreatitis on the basis of clinical findings and investigations. On the next day of presentation, he developed sudden bilateral visual loss. His best-corrected visual acuity was finger counting at one-foot distance in both eyes. He had diffuse whitening in the circumpapillary area, haloes around the retinal vessels (Purtscher flecken) and intra-retinal hemorrhages on ophthalmoscopic examination...
May 2016: Oman Journal of Ophthalmology
Yasmin A Begum, K A Talukder, Ishrat J Azmi, Mohammad Shahnaij, A Sheikh, Salma Sharmin, A-M Svennerholm, Firdausi Qadri
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a common cause of bacterial infection leading to acute watery diarrhea in infants and young children as well as in travellers to ETEC endemic countries. Ciprofloxacin is a broad-spectrum antimicrobial agent nowadays used for the treatment of diarrhea. This study aimed to characterize ciprofloxacin resistant ETEC strains isolated from diarrheal patients in Bangladesh. METHODS: A total of 8580 stool specimens from diarrheal patients attending the icddr,b Dhaka hospital was screened for ETEC between 2005 and 2009...
2016: PloS One
Fen Wu, Yu Chen, Ryan T Demmer, Faruque Parvez, Rina Rani Paul, Ishrat Shaheen, Golam Sarwar, Alauddin Ahmed, Mahbub Eunus, Nafiz Ahsan, Nur Mohammad Habibullah, Tariqul Islam, Tatjana Rundek, Habibul Ahsan, Moise Desvarieux
AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population. METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m(2) ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT)...
July 9, 2016: Journal of Clinical Periodontology
Ishrat Younus, Afshan Siddiq, Humera Ishaq, Laila Anwer, Sehrish Badar, Muhammad Ashraf
The aim of this study was to evaluate antiviral activity of chloroformic leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Antiviral and cytotoxic activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. The concentrations which resulted in cell survival percentages of greater than 50% are considered to be effective antiviral concentrations...
July 2016: Pakistan Journal of Pharmaceutical Sciences
Jenny R Roberts, Robert R Mercer, Aleksandr B Stefaniak, Mohindar S Seehra, Usha K Geddam, Ishrat S Chaudhuri, Angelos Kyrlidis, Vamsi K Kodali, Tina Sager, Allison Kenyon, Suzan A Bilgesu, Tracy Eye, James F Scabilloni, Stephen S Leonard, Natalie R Fix, Diane Schwegler-Berry, Breanne Y Farris, Michael G Wolfarth, Dale W Porter, Vincent Castranova, Aaron Erdely
BACKGROUND: Graphene, a monolayer of carbon, is an engineered nanomaterial (ENM) with physical and chemical properties that may offer application advantages over other carbonaceous ENMs, such as carbon nanotubes (CNT). The goal of this study was to comparatively assess pulmonary and systemic toxicity of graphite nanoplates, a member of the graphene-based nanomaterial family, with respect to nanoplate size. METHODS: Three sizes of graphite nanoplates [20 μm lateral (Gr20), 5 μm lateral (Gr5), and <2 μm lateral (Gr1)] ranging from 8-25 nm in thickness were characterized for difference in surface area, structure,, zeta potential, and agglomeration in dispersion medium, the vehicle for in vivo studies...
2016: Particle and Fibre Toxicology
Christine Marie George, Lauren Oldja, Shwapon Biswas, Jamie Perin, R Bradley Sack, Shahnawaz Ahmed, Mohammad Shahnaij, Rashidul Haque, Tahmina Parvin, Ishrat J Azmi, Sazzadul Islam Bhuyian, Kaisar A Talukder, Abu G Faruque
OBJECTIVE: To investigate the relationship between unsafe child feces disposal, environmental enteropathy, and impaired growth, we conducted a prospective cohort study of 216 young children in rural Bangladesh. STUDY DESIGN: Using a prospective cohort study design in rural Bangladesh, unsafe child feces disposal, using the Joint Monitoring Program definition, was assessed using 5-hour structured observation by trained study personnel as well as caregiver reports...
September 2016: Journal of Pediatrics
Sarfaraz Alam Khan, Nazeem Ishrat Siddiqui
OBJECTIVES: To assess pharmacotherapeutics (PT) knowledge of second professional medical undergraduates. MATERIALS AND METHODS: It is a questionnaire-based cross-sectional study. The questionnaire was designed to objectively assess the current level of knowledge of PT acquired by the second MBBS students in a medical college in India. Thirty Type-A multiple choice questions (MCQs) related with the PT of common and important medical conditions and some emergency conditions were administered to 125 participants...
May 2016: Indian Journal of Pharmacology
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