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https://www.readbyqxmd.com/read/28804675/transition-in-dental-treatment-utilization-in-jammu-and-kashmir-india-a-10-year-retrospective-study
#1
Aasim Farooq Shah, Manu Batra, A Ishrat
BACKGROUND: Utilization of health services is the actual attendance by the members of the public at health care facilities to receive care. Utilization, serves as an important tool for oral health policy decision-making. The aim of the present study was to retrospectively gauge and assess the utilization pattern of the dental treatments which was given in hospital for last 10 years. MATERIALS AND METHODS: This retrospective infirmary based study was carried out at Sheri Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, India...
December 2016: Nepal journal of epidemiology
https://www.readbyqxmd.com/read/28793909/-6-gingerol-from-zingiber-officinale-potentiates-glp-1-mediated-glucose-stimulated-insulin-secretion-pathway-in-pancreatic-%C3%AE-cells-and-increases-rab8-rab10-regulated-membrane-presentation-of-glut4-transporters-in-skeletal-muscle-to-improve-hyperglycemia-in
#2
Mehdi Bin Samad, Md Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir, J M A Hannan
BACKGROUND: [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Lepr(db/db) diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of [6]-Gingerol and the mechanism(s) through which [6]-Gingerol ameliorates hyperglycemia...
August 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28765427/poor-knowledge-of-safety-aspects-of-long-term-steroid-use-among-patients-and-healthcare-professionals
#3
Kate Grounds, Ishrat Khan, Mohammed Adlan, Lakdasa Premawardhana
No abstract text is available yet for this article.
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28702175/costs-of-hospitalization-with-respiratory-syncytial-virus-illness-among-children-aged-5-years-and-the-financial-impact-on-households-in-bangladesh-2010
#4
Mejbah Uddin Bhuiyan, Stephen P Luby, Nadia Ishrat Alamgir, Nusrat Homaira, Katharine Sturm-Ramirez, Emily S Gurley, Jaynal Abedin, Rashid Uz Zaman, Asm Alamgir, Mahmudur Rahman, Ismael R Ortega-Sanchez, Eduardo Azziz-Baumgartner
BACKGROUND: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory illness in young children and results in significant economic burden. There is no vaccine to prevent RSV illness but a number of vaccines are in development. We conducted this study to estimate the costs of severe RSV illness requiring hospitalization among children <5 years and associated financial impact on households in Bangladesh. Data of this study could be useful for RSV vaccine development and also the value of various preventive strategies, including use of an RSV vaccine in children if one becomes available...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28669343/pharmacoinformatic-approaches-to-design-novel-inhibitors-of-protein-kinase-b-pathways-in-cancer
#5
Noreen Akhtar, Ishrat Jabeen
BACKGROUND: Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine kinases with three structurally homologous mammalian isoforms, Akt1 (PKBα), Akt2 (PKBβ), and Akt3 (PKBγ). Various immunohistochemical studies have reported that the constitutive hyperactivation of Akt signaling is responsible for several types of human cancers. Thus, inhibition of Akt activation represents a promising concept to induce cell apoptosis in various cancers. However, till date none of them could reach the market for routine clinical usage to circumvent cell proliferation in cancer due to lack of isoform selectivity and off-target toxicity...
June 23, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28660505/de-novo-formation-of-dioxins-from-milled-model-fly-ash
#6
Ishrat Mubeen, Alfons Buekens, Zhiliang Chen, Shengyong Lu, Jianhua Yan
Municipal solid waste incineration (MSWI) fly ash has been classified as hazardous waste and needs treatment in an environmentally safe manner. Mechanochemical (MC) treatment is such a detoxification method, since it destroys dioxins and solidifies heavy metals. Milling, however, also introduces supplemental metals (Fe, Ni, Cr, Mn…), following wear of both steel balls and housing. Milling moreover reduces the particle size of fly ash and disperses catalytic metal, potentially rising the reactivity of fly ash to form and destroy 'dioxins', i...
June 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28645628/the-association-between-socioeconomic-status-and-subclinical-atherosclerosis-in-a-rural-bangladesh-population
#7
Michael Garshick, Fen Wu, Ryan Demmer, Faruque Parvez, Alauddin Ahmed, Mahbub Eunus, Rabiul Hasan, Jabun Nahar, Ishrat Shaheen, Golam Sarwar, Moise Desvarieux, Habibul Ahsan, Yu Chen
BACKGROUND: In Bangladesh, CVD accounts for the majority of non-communicable mortality. The purpose of this study was to determine the role of socioeconomic status (SES) on subclinical atherosclerosis measured as carotid intima-media thickness (IMT) in a rural Bangladesh population. METHODS: Carotid IMT was measured between 2010 and 2011 in 1022 participants (average age 46, 40% male) randomly selected from the Health Effects of Arsenic Longitudinal Study (HEALS), a population-based prospective cohort study based in rural Bangladesh...
September 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28640888/mechanisms-of-acute-neurovascular-protection-with-at1-blockade-after-stroke-effect-of-prestroke-hypertension
#8
Ahmed Alhusban, Anna Kozak, Bindu Pillai, Heba Ahmed, Mohammed A Sayed, Maribeth H Johnson, Tauheed Ishrat, Adviye Ergul, Susan C Fagan
Stroke is a leading cause of adult disability worldwide. Improving stroke outcome requires an orchestrated interplay that involves up regulation of pro-survival pathways and a concomitant suppression of pro-apoptotic mediators. In this investigation, we assessed the involvement of eNOS in the AT1 blocker-mediated protective and pro-recovery effects in animals with hypertension. We also evaluated the effect of acute eNOS inhibition in hypertensive animals. To achieve these goals, spontaneously hypertensive rats (SHR) were implanted with blood pressure transmitters, and randomized to receive either an eNOS inhibitor (L-NIO) or saline one hour before cerebral ischemia induction...
2017: PloS One
https://www.readbyqxmd.com/read/28582760/current-status-and-future-therapeutic-perspectives-of-glioblastoma-multiforme-gbm-therapy-a-review
#9
REVIEW
Komal Anjum, Bibi Ibtesam Shagufta, Syed Qamar Abbas, Seema Patel, Ishrat Khan, Sayed Asmat Ali Shah, Najeeb Akhter, Syed Shams Ul Hassan
Glioblastoma multiforme (GBM) is the deadliest form of heterogeneous brain cancer. It affects an enormous number of patients every year and the survival is approximately 8 to 15 months. GBM has driven by complex signaling pathways and considered as a most challenging to treat. Standard treatment of GBM includes surgery, radiation therapy, chemotherapy and also the combined treatment. This review article described inter and intra- tumor heterogeneity of GMB. In addition, recent chemotherapeutic agents, with their mechanism of action have been defined...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531943/recent-trends-in-zikv-research-a-step-away-from-cure
#10
REVIEW
Aftab Alam, Nikhat Imam, Anam Farooqui, Shahnawaz Ali, Md Zubbair Malik, Romana Ishrat
Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus has emerged as a potential threat to human health worldwide. Consequences of vertical infections includes microcephaly with brain and eye anomalies, and adult infections includes Guillain-Barrésyndrome (GBS), brain ischemia, myelitis and meningoencephalitis. To develop a better treatment, many efforts are being made, like drug-repurposing concept for FDA-approved drugs for antiviral activity are screened against ZikV infection and emerging as a promising alternative to expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and AGS-v vaccines have been designed and in under clinical trial phases...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28490032/haplotype-based-analysis-of-xrcc3-gene-polymorphisms-in-thyroid-cancer
#11
Romana Sarwar, Ishrat Mahjabeen, Kashif Bashir, Soma Saeed, Mahmood Akhtar Kayani
BACKGROUND/AIMS: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28480425/behavioral-evidence-of-antidepressant-like-activity-of-raphanus-sativus-l-var-caudatus-in-mice
#12
Ishrat Younus, And Afshan Siddiq
BACKGROUND: Currently-available antidepressant agents produce various adverse effects, and are expensive. At present, various plants are being evaluated for their possible role against numerous diseases, and no doubt, the role of traditional and complementary medicines in the development of effective therapy is incredible. The present study was designed to evaluate antidepressant-like activity of Raphanus sativus L. Var. caudatus at different doses in mice. MATERIALS AND METHODS: Antidepressant potential of ethanolic extract of Raphanus caudatus L...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28466054/potential-entry-inhibitors-of-the-envelope-protein-e2-of-chikungunya-virus-in-silico-structural-modeling-docking-and-molecular-dynamic-studies
#13
Farah Deeba, Md Zubbair Malik, Irshad Husain Naqvi, Md Shakir Hussain Haider, Zoya Shafat, Priyanka Sinha, Romana Ishrat, Anwar Ahmed, Shama Parveen
Chikungunya fever is an arboviral infection caused by the Chikungunya virus (CHIKV) and is transmitted by Aedes mosquito. The envelope protein (E2) of Chikungunya virus is involved in attachment of virion with the host cell. The present study was conceptualized to determine the structure of E2 protein of CHIKV and to identify the potential viral entry inhibitors. The secondary and tertiary structure of E2 protein was determined using bioinformatics tools. The mutational analysis of the E2 protein suggested that mutations may stabilize or de-stabilize the structure which may affect the structure-function relationship...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28384479/mutant-huntingtin-disrupts-the-nuclear-pore-complex
#14
Jonathan C Grima, J Gavin Daigle, Nicolas Arbez, Kathleen C Cunningham, Ke Zhang, Joseph Ochaba, Charlene Geater, Eva Morozko, Jennifer Stocksdale, Jenna C Glatzer, Jacqueline T Pham, Ishrat Ahmed, Qi Peng, Harsh Wadhwa, Olga Pletnikova, Juan C Troncoso, Wenzhen Duan, Solomon H Snyder, Laura P W Ranum, Leslie M Thompson, Thomas E Lloyd, Christopher A Ross, Jeffrey D Rothstein
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs). Previous studies offered clues that mHTT may disrupt nucleocytoplasmic transport and a mutation of an NUP can cause HD-like pathology. Therefore, we evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, including mouse and fly models, neurons transfected with mHTT, HD iPSC-derived neurons, and human HD brain regions...
April 5, 2017: Neuron
https://www.readbyqxmd.com/read/28379745/endoscopic-skipping-of-the-terminal-ileum-in-pediatric-crohn-disease
#15
COMPARATIVE STUDY
Ishrat Mansuri, Joel G Fletcher, David H Bruining, Amy B Kolbe, Jeff L Fidler, Sunil Samuel, Jeanne Tung
OBJECTIVE: Pediatric small-bowel (SB) Crohn disease (CD) may be missed if the terminal ileum (TI) appears normal at endoscopy and SB imaging is not performed. We sought to estimate the prevalence and clinical characteristics of pediatric patients with CD and endoscopic skipping of the TI-that is, pediatric patients with active SB or upper gut inflammation and an endoscopically normal TI. MATERIALS AND METHODS: This retrospective study included pediatric patients with CD who underwent both CT enterography (CTE) or MR enterography (MRE) and ileocolonoscopy within a 30-day period between July 2004 and April 2014...
June 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28327186/clinical-behavioural-and-pharmacogenomic-factors-influencing-the-response-to-levothyroxine-therapy-in-patients-with-primary-hypothyroidism-protocol-for-a-systematic-review
#16
Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce, Scott Wilkes
BACKGROUND: Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28257802/assessment-of-influenza-a-neuraminidase-subtype-n1-potency-by-elisa
#17
Hongquan Wan, Ishrat Sultana, Laura K Couzens, Samuel Mindaye, Maryna C Eichelberger
Antibodies that inhibit neuraminidase (NA) activity of influenza virus provide resistance against disease and have been associated with milder epidemics. Although studies have demonstrated a correlation between NA inhibition antibody titers and vaccine efficacy, neither the quantity nor form of NA is measured in seasonal and pandemic influenza vaccines. In this report, we describe development of enzyme-linked immunosorbent assays (ELISAs) that are suitable for quantitation of the native form of NA of subtype N1...
March 10, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28155203/pilot-study-of-a-culturally-adapted-psychoeducation-cape-intervention-for-bipolar-disorder-in-pakistan
#18
Muhammad Ishrat Husain, Imran B Chaudhry, Raza R Rahman, Munir M Hamirani, Nasir Mehmood, Peter M Haddad, John Hodsoll, Allan H Young, Farooq Naeem, Nusrat Husain
BACKGROUND: Despite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions in bipolar disorder in Pakistan. AIM: The purpose of the study was to assess the feasibility and acceptability of a culturally adapted bipolar psychoeducation programme (CaPE) in Pakistan. METHODS: Thirty-four euthymic bipolar I and II outpatients were randomized to either 12 weekly sessions of individual psychoeducation plus Treatment As Usual (Intervention) or Treatment As Usual (TAU) (Control)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28120069/middle-temporal-gyrus-versus-inferior-temporal-gyrus-transcortical-approaches-to-high-grade-astrocytomas-in-the-mediobasal-temporal-lobe-a-comparison-of-outcomes-functional-restoration-and-surgical-considerations
#19
Alfredo Quinones-Hinojosa, Shaan M Raza, Ishrat Ahmed, Jordina Rincon-Torroella, Kaisorn Chaichana, Alessandro Olivi
INTRODUCTION: High-grade astrocytomas of the mesial temporal lobe may pose surgical challenges. Several approaches (trans-sylvian, subtemporal, and transcortical) have been designed to circumnavigate the critical neurovascular structures and white fiber tracts that surround this area. Considering the paucity of literature on the transcortical approach for these lesions, we describe our institutional experience with transcortical approaches to Grade III/IV astrocytomas in the mesial temporal lobe...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28106087/dynamical-states-possibilities-and-propagation-of-stress-signal
#20
Md Zubbair Malik, Shahnawaz Ali, Soibam Shyamchand Singh, Romana Ishrat, R K Brojen Singh
The stress driven dynamics of Notch-Wnt-p53 cross-talk is subjected to a few possible dynamical states governed by simple fractal rules, and allowed to decide its own fate by choosing one of these states which are contributed from long range correlation with varied fluctuations due to active molecular interaction. The topological properties of the networks corresponding to these dynamical states have hierarchical features with assortive structure. The stress signal driven by nutlin and modulated by mediator GSK3 acts as anti-apoptotic signal in this system, whereas, the stress signal driven by Axin and modulated by GSK3 behaves as anti-apoptotic for a certain range of Axin and GSK3 interaction, and beyond which the signal acts as favor-apoptotic signal...
January 20, 2017: Scientific Reports
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