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https://www.readbyqxmd.com/read/28531943/recent-trends-in-zikv-research-a-step-away-from-cure
#1
REVIEW
Aftab Alam, Nikhat Imam, Anam Farooqui, Shahnawaz Ali, Md Zubbair Malik, Romana Ishrat
Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus has emerged as a potential threat to human health worldwide. Consequences of vertical infections includes microcephaly with brain and eye anomalies, and adult infections includes Guillain-Barrésyndrome (GBS), brain ischemia, myelitis and meningoencephalitis. To develop a better treatment, many efforts are being made, like drug-repurposing concept for FDA-approved drugs for antiviral activity are screened against ZikV infection and emerging as a promising alternative to expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and AGS-v vaccines have been designed and in under clinical trial phases...
May 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28490032/haplotype-based-analysis-of-xrcc3-gene-polymorphisms-in-thyroid-cancer
#2
Romana Sarwar, Ishrat Mahjabeen, Kashif Bashir, Soma Saeed, Mahmood Akhtar Kayani
BACKGROUND/AIMS: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls...
May 10, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28480425/behavioral-evidence-of-antidepressant-like-activity-of-raphanus-sativus-l-var-caudatus-in-mice
#3
Ishrat Younus, And Afshan Siddiq
BACKGROUND: Currently-available antidepressant agents produce various adverse effects, and are expensive. At present, various plants are being evaluated for their possible role against numerous diseases, and no doubt, the role of traditional and complementary medicines in the development of effective therapy is incredible. The present study was designed to evaluate antidepressant-like activity of Raphanus sativus L. Var. caudatus at different doses in mice. MATERIALS AND METHODS: Antidepressant potential of ethanolic extract of Raphanus caudatus L...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28466054/potential-entry-inhibitors-of-the-envelope-protein-e2-of-chikungunya-virus-in-silico-structural-modeling-docking-and-molecular-dynamic-studies
#4
Farah Deeba, Md Zubbair Malik, Irshad Husain Naqvi, Md Shakir Hussain Haider, Zoya Shafat, Priyanka Sinha, Romana Ishrat, Anwar Ahmed, Shama Parveen
Chikungunya fever is an arboviral infection caused by the Chikungunya virus (CHIKV) and is transmitted by Aedes mosquito. The envelope protein (E2) of Chikungunya virus is involved in attachment of virion with the host cell. The present study was conceptualized to determine the structure of E2 protein of CHIKV and to identify the potential viral entry inhibitors. The secondary and tertiary structure of E2 protein was determined using bioinformatics tools. The mutational analysis of the E2 protein suggested that mutations may stabilize or de-stabilize the structure which may affect the structure-function relationship...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28384479/mutant-huntingtin-disrupts-the-nuclear-pore-complex
#5
Jonathan C Grima, J Gavin Daigle, Nicolas Arbez, Kathleen C Cunningham, Ke Zhang, Joseph Ochaba, Charlene Geater, Eva Morozko, Jennifer Stocksdale, Jenna C Glatzer, Jacqueline T Pham, Ishrat Ahmed, Qi Peng, Harsh Wadhwa, Olga Pletnikova, Juan C Troncoso, Wenzhen Duan, Solomon H Snyder, Laura P W Ranum, Leslie M Thompson, Thomas E Lloyd, Christopher A Ross, Jeffrey D Rothstein
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs). Previous studies offered clues that mHTT may disrupt nucleocytoplasmic transport and a mutation of an NUP can cause HD-like pathology. Therefore, we evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, including mouse and fly models, neurons transfected with mHTT, HD iPSC-derived neurons, and human HD brain regions...
April 5, 2017: Neuron
https://www.readbyqxmd.com/read/28379745/endoscopic-skipping-of-the-terminal-ileum-in-pediatric-crohn-disease
#6
Ishrat Mansuri, Joel G Fletcher, David H Bruining, Amy B Kolbe, Jeff L Fidler, Sunil Samuel, Jeanne Tung
OBJECTIVE: Pediatric small-bowel (SB) Crohn disease (CD) may be missed if the terminal ileum (TI) appears normal at endoscopy and SB imaging is not performed. We sought to estimate the prevalence and clinical characteristics of pediatric patients with CD and endoscopic skipping of the TI-that is, pediatric patients with active SB or upper gut inflammation and an endoscopically normal TI. MATERIALS AND METHODS: This retrospective study included pediatric patients with CD who underwent both CT enterography (CTE) or MR enterography (MRE) and ileocolonoscopy within a 30-day period between July 2004 and April 2014...
April 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28327186/clinical-behavioural-and-pharmacogenomic-factors-influencing-the-response-to-levothyroxine-therapy-in-patients-with-primary-hypothyroidism-protocol-for-a-systematic-review
#7
Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce, Scott Wilkes
BACKGROUND: Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28257802/assessment-of-influenza-a-neuraminidase-subtype-n1-potency-by-elisa
#8
Hongquan Wan, Ishrat Sultana, Laura K Couzens, Samuel Mindaye, Maryna C Eichelberger
Antibodies that inhibit neuraminidase (NA) activity of influenza virus provide resistance against disease and have been associated with milder epidemics. Although studies have demonstrated a correlation between NA inhibition antibody titers and vaccine efficacy, neither the quantity nor form of NA is measured in seasonal and pandemic influenza vaccines. In this report, we describe development of enzyme-linked immunosorbent assays (ELISAs) that are suitable for quantitation of the native form of NA of subtype N1...
March 10, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28155203/pilot-study-of-a-culturally-adapted-psychoeducation-cape-intervention-for-bipolar-disorder-in-pakistan
#9
Muhammad Ishrat Husain, Imran B Chaudhry, Raza R Rahman, Munir M Hamirani, Nasir Mehmood, Peter M Haddad, John Hodsoll, Allan H Young, Farooq Naeem, Nusrat Husain
BACKGROUND: Despite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions in bipolar disorder in Pakistan. AIM: The purpose of the study was to assess the feasibility and acceptability of a culturally adapted bipolar psychoeducation programme (CaPE) in Pakistan. METHODS: Thirty-four euthymic bipolar I and II outpatients were randomized to either 12 weekly sessions of individual psychoeducation plus Treatment As Usual (Intervention) or Treatment As Usual (TAU) (Control)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28120069/middle-temporal-gyrus-versus-inferior-temporal-gyrus-transcortical-approaches-to-high-grade-astrocytomas-in-the-mediobasal-temporal-lobe-a-comparison-of-outcomes-functional-restoration-and-surgical-considerations
#10
Alfredo Quinones-Hinojosa, Shaan M Raza, Ishrat Ahmed, Jordina Rincon-Torroella, Kaisorn Chaichana, Alessandro Olivi
INTRODUCTION: High-grade astrocytomas of the mesial temporal lobe may pose surgical challenges. Several approaches (trans-sylvian, subtemporal, and transcortical) have been designed to circumnavigate the critical neurovascular structures and white fiber tracts that surround this area. Considering the paucity of literature on the transcortical approach for these lesions, we describe our institutional experience with transcortical approaches to Grade III/IV astrocytomas in the mesial temporal lobe...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28106087/dynamical-states-possibilities-and-propagation-of-stress-signal
#11
Md Zubbair Malik, Shahnawaz Ali, Soibam Shyamchand Singh, Romana Ishrat, R K Brojen Singh
The stress driven dynamics of Notch-Wnt-p53 cross-talk is subjected to a few possible dynamical states governed by simple fractal rules, and allowed to decide its own fate by choosing one of these states which are contributed from long range correlation with varied fluctuations due to active molecular interaction. The topological properties of the networks corresponding to these dynamical states have hierarchical features with assortive structure. The stress signal driven by nutlin and modulated by mediator GSK3 acts as anti-apoptotic signal in this system, whereas, the stress signal driven by Axin and modulated by GSK3 behaves as anti-apoptotic for a certain range of Axin and GSK3 interaction, and beyond which the signal acts as favor-apoptotic signal...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096697/mir-486-3p-mir-139-5p-and-mir-21-as-biomarkers-for-the-detection-of-oral-tongue-squamous-cell-carcinoma
#12
Zujian Chen, Tianwei Yu, Robert J Cabay, Yi Jin, Ishrat Mahjabeen, Xianghong Luan, Lei Huang, Yang Dai, Xiaofeng Zhou
Oral tongue squamous cell carcinoma (TSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to test the feasibility of performing the microRNA profiling analysis on archived TSCC specimens and to assess the potential diagnostic utility of the identified microRNA biomarkers for the detection of TSCC. TaqMan array-based microRNA profiling analysis was performed on 10 archived TSCC samples and their matching normal tissues. A panel of 12 differentially expressed microRNAs was identified...
2017: Biomarkers in Cancer
https://www.readbyqxmd.com/read/28081250/cutaneous-deficiency-of-filaggrin-and-stat3-exacerbates-vaccinia-disease-in-vivo
#13
Yong He, Ishrat Sultana, Kazuyo Takeda, Jennifer L Reed
RATIONALE: Defects in filaggrin and STAT3 are associated with atopic dermatitis (AD) and susceptibility to severe skin infection. METHODS: We evaluated skin infection with the current smallpox vaccine, ACAM-2000, in immunosuppressed mice with combined cutaneous deficiency in filaggrin and STAT3. In parallel, early events post-infection with ACAM-2000 were investigated in cultured keratinocytes in which filaggrin expression was knocked down via siRNA. RESULTS: Immunosuppressed, filaggrin-deficient mice, treated with the topical STAT3 inhibitor Stattic® prior to ACAM-2000 infection, demonstrated rapid weight loss, prolonged vaccinia burden in skin, and dermatitis...
2017: PloS One
https://www.readbyqxmd.com/read/28019642/recent-updates-on-melanocyte-biology-and-the-use-of-promising-bioactive-compounds-for-the-treatment-of-hypopigmentary-disorders-a-review
#14
Sharique A Ali, Ishrat Naaz, Kamal Uddin Zaidi, Ayesha Sharique Ali
Skin pigmentation is a broadly appearing phenomenon in nature which plays an important task of determining the appearance and biology of all vertebrates including human beings. Skin color is a crucial attribute, determined by the synthesis of melanin pigment within melanocytes by the process of melanogenesis and is regulated by many extrinsic as well as intrinsic factors. Tyrosinase catalyzes the key step of melanogenesis, dysfunction of tyrosinase leads to reduce melanin production which results in severe clinical and aesthetical problems of hypopigmentation...
December 23, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27934984/control-of-apoptosis-by-smar1
#15
Md Zubbair Malik, Md Jahoor Alam, Romana Ishrat, Subhash M Agarwal, R K Brojen Singh
The nuclear matrix associated protein SMAR1 is sensitive to p53 and acts as a stress inducer as well as a regulator in the p53 regulatory network. Depending on the amount of stress SMAR1 stimulates, it can drive the p53 dynamics in the system to various dynamical states which correspond to various cellular states. The behavior of p53 in these dynamical states is found to be multifractal, due to the mostly long range correlations and large scale fluctuations imparted by stress. This fractal behavior is exhibited in the topological properties of the networks constructed from these dynamical states, and is a signature of self-organization to optimize information flow in the dynamics...
December 9, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27922924/fixation-stability-recording-how-long-for-eyes-with-central-vision-loss
#16
Luminita Tarita-Nistor, Ishrat Gill, Esther G González, Martin J Steinbach
PURPOSE: Fixation examination with the MP-1 microperimeter (Nidek Technologies Srl., Vigonza, PD, Italy) determines the preferred retinal loci and fixation stability in patients with central vision loss. It is typically done for periods of 15 to 30 s as per the manual's recommendations, which are arbitrary. In this study, we examined (1) whether fixation stability depends on the duration of recording and (2) whether fixation stability changes over time. METHODS: Raw eye-position data from 76 patients with bilateral central vision loss (mean age = 80 ± 9...
December 5, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27766653/changing-labor-and-delivery-practice-focus-on-achieving-practice-and-documentation-standardization-with-the-goal-of-improving-neonatal-outcomes
#17
Paul D Burstein, David M Zalenski, John L Edwards, Ishrat Z Rafi, Jennifer F Darden, Cassandra Firneno, Palmira Santos
OBJECTIVE: To establish multifactorial shoulder dystocia response and management protocol to promote sustainable practice change. DATA SOURCES/STUDY SETTING: Primary data collection was conducted over 3 years. Implementation of the protocol spanned 13 months. Data collection occurred at five sites, which were chosen for their diversity in both patient mix and geographical location. STUDY DESIGN: Case study evaluation methodology was used to examine clinician engagement and protocol adoption...
December 2016: Health Services Research
https://www.readbyqxmd.com/read/27717824/myd88-contributes-to-neuroinflammatory-responses-induced-by-cerebral-ischemia-reperfusion-in-mice
#18
Xinchun Ye, Delian Kong, Jun Wang, Tauheed Ishrat, Hongjuan Shi, Xiaohui Ding, Guiyun Cui, Fang Hua
Myeloid differentiation primary-response protein-88 (MyD88) is one of adaptor proteins mediating Toll-like receptors (TLRs) signaling. Activation of MyD88 results in the activation of nuclear factor kappa B (NFκB) and the increase of inflammatory responses. Evidences have demonstrated that TLRs signaling contributes to cerebral ischemia/reperfusion (I/R) injury. However, the role of MyD88 in this mechanism of action is disputed and needs to be clarified. In the present study, in a mouse model of cerebral I/R, we examined the activities of NFκB and interferon factor-3 (IRF3), and the inflammatory responses in ischemic brain tissue using ELISA, Western blots, and real-time PCR...
October 4, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27688991/correction-generalized-tetanus-initially-presenting-with-dysmasesis
#19
Parvaiz M Zunga, Shah Faisal Ahmad Tarfarosh, Omar Farooq, Ishrat H Dar, Samia Rashid, Ummer Yaseen
[This corrects the article DOI: 10.7759/cureus.644.].
September 19, 2016: Curēus
https://www.readbyqxmd.com/read/27671178/an-in-vitroevaluation-of-microleakage-at-the-cervical-margin-between-two-different-class-ii-restorative-techniques-using-dye-penetration-method
#20
Noor-Ul-Ain Jawaed, Syed Yawar Ali Abidi, Fazal-Ur-Rehman Qazi, Shahbaz Ahmed
OBJECTIVE: To evaluate the coronal microleakage of packable composite using conventional incremental and posterior bulk fill flowable composite using Smart Dentine Replacement Single Step technique in the cervical margins of class II cavities in dentine using the dye penetration method. STUDY DESIGN: In-vitroInterventional study. PLACE AND DURATION OF STUDY: Department of Operative Dentistry, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Karachi, from November 2012 to April 2013...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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