keyword
MENU ▼
Read by QxMD icon Read
search

Ishrat

keyword
https://www.readbyqxmd.com/read/29746329/descemet-membrane-endothelial-keratoplasty-after-penetrating-keratoplasty-features-for-success
#1
Adi Einan-Lifshitz, Avner Belkin, Nir Sorkin, Zale Mednick, Tanguy Boutin, Ishrat Gill, Mohammad Karimi, Clara C Chan, David S Rootman
PURPOSE: To evaluate Descemet membrane endothelial keratoplasty (DMEK) in the setting of failed penetrating keratoplasty (PKP) and to identify factors associated with DMEK success and failure after PKP. METHODS: A retrospective chart review of patients who underwent DMEK for failed PKP at Toronto Western Hospital, Canada, between 2014 and 2017 was performed. Demographic characteristics, number of previous transplants, intraoperative and postoperative complications, best spectacle-corrected visual acuity (BSCVA), and endothelial cell density were analyzed...
May 8, 2018: Cornea
https://www.readbyqxmd.com/read/29706030/preconception-management-of-thyroid-dysfunction
#2
Onyebuchi E Okosieme, Ishrat Khan, Peter N Taylor
Uncorrected thyroid dysfunction in pregnancy has well recognised deleterious effects on fetal and maternal health. The early gestation period is one of critical fetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for ensuring optimal thyroid disease outcomes in pregnancy. Preconception planning in women with hypothyroidism should pre-empt and mirror the adaptive changes of the thyroid gland by careful levothyroxine dose adjustments to ensure adequate fetal thyroid hormone delivery in pregnancy...
April 29, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29701718/structure-function-mutational-analysis-and-prediction-of-the-potential-impact-of-high-risk-non-synonymous-single-nucleotide-polymorphism-on-poliovirus-2a-protease-stability-using-comprehensive-informatics-approaches
#3
Amna Younus, Saba Munawar, Muhammad Faraz Bhatti, Aqsa Ikram, Faryal Mehwish Awan, Ishrat Jabeen, Nasar Virk, Hussnain Ahmed Janjua, Muhammad Arshad
Polio viral proteinase 2A performs several essential functions in genome replication. Its inhibition prevents viral replication, thus making it an excellent substrate for drug development. In this study, the three-dimensional structure of 2A protease was determined and optimized by homology modelling. To predict the molecular basis of the interaction of small molecular agonists, docking simulations were performed on a structurally diverse dataset of poliovirus 2A protease (PV2Apr °) inhibitors. Docking results were employed to identify high risk missense mutations that are highly damaging to the structure, as well as the function, of the protease...
April 26, 2018: Genes
https://www.readbyqxmd.com/read/29671209/the-radish-raphanus-sativus-l-var-caudatus-reduces-anxiety-like-behavior-in-mice
#4
Afshan Siddiq, Ishrat Younus
Inclusion of vegetables in the diet not only provides dietary fiber, vitamins, minerals, trace elements but also significantly reduces the risk of several diseases. Raphanus sativus L. Var. caudatus belongs to the family Brassicaceae are pods of Radish, and are commonly known as Mungra or Sungra in Pakistan and India. The English name for this species is Rat-tailed radish. This variety of radish is unique, less familiar to the population, and not commonly used as a food source. Furthermore there have been very few studies that report on the potential antioxidant and anti-cancer capabilities of this radish...
April 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29665392/sugar-osmolytes-induced-stabilization-of-rnase-a-in-macromolecular-crowded-cellular-environment
#5
Moin Ishrat, Md Imtaiyaz Hassan, Faizan Ahmad, Asimul Islam
Organisms synthesize sugar osmolytes during environmental stresses to protect proteins against denaturation. These studies were carried out in dilute buffer whereas intracellular milieu within cells has cytoplasmic concentration of macromolecules in the range of 80-400 mg ml-1 . Is the stabilizing effect of sugar osmolytes on the protein in dilute buffer different from that when protein is in cellular environment? To answer this question, we have measured and analysed the effect of sugar osmolytes on the structural and thermodynamic stability of ribonuclease A in the presence of dextran 70 at multiple concentrations of six sugars at different pH values...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29623517/mini-review-on-photosensitization-by-plants-in-grazing-herbivores
#6
REVIEW
Syeda M Hussain, Valdo Rodrigues Herling, Paulo Henrique Mazza Rodrigues, Ishrat Naz, Hamayun Khan, Muhammad Tahir Khan
Photosensitization is severe dermatitis or oxidative/chemical changes in the epidermal tissues activated by the light-induced excitation of molecules within the tissue. It is a series of reactions mediated through light receptors and is more common when the plant-produced metabolites are heterocyclic/polyphenols in nature. The areas affected are exposed body parts and mostly non-pigmented areas with least ultraviolet protection. Similarly, cellular alteration also occurs in the affected animal's dermal tissues and body parts and grazing animals by the accumulation and activation of photodynamic molecules...
April 6, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29623021/biochemical-aspects-of-mammalian-melanocytes-and-the-emerging-role-of-melanocyte-stem-cells-in-dermatological-therapies
#7
REVIEW
Sharique A Ali, Ishrat Naaz
Skin color in animals is richer than human beings and is determined by different types of pigments. Melanin is the key pigment responsible for the diverse pigmentation found in animal and human skin, hair, and eyes. Melanin pigment is synthesized by melanocytes and is consecutively transferred to adjacent keratinocytes; here, it acts as an internal sunscreen to defend from ultraviolet (UV) damage. Any defect in the process of melanocytes development and/or melanin synthesis results in esthetic problem of abnormal pigmentation...
January 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29552790/haplotype-analysis-of-xrcc1-gene-polymorphisms-and-the-risk-of-thyroid-carcinoma
#8
Kashif Bashir, Romana Sarwar, Shazia Fatima, Soma Saeed, Ishrat Mahjabeen, Mahmood Akhtar Kayani
PURPOSE: Variants in DNA repair genes may alter the repair mechanisms that make the persons vulnerable to DNA damage. These polymorphic variants in the DNA repair pathway genes, such as XRCC1, have been associated with susceptibility of several types of cancer including thyroid cancer. This study was designed to explore the link between XRCC1 polymorphisms and modulation of thyroid cancer risk. METHODS: Our study consisted of 456 thyroid cancer patients and 400 controls...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29537907/dose-response-therapeutic-time-window-and-tpa-combinatorial-efficacy-of-compound-21-a-randomized-blinded-preclinical-trial-in-a-rat-model-of-thromboembolic-stroke
#9
Tauheed Ishrat, Abdelrahman Y Fouda, Bindu Pillai, Wael Eldahshan, Heba Ahmed, Jennifer L Waller, Adviye Ergul, Susan C Fagan
The aim of this translational, randomized, controlled, blinded preclinical trial was to determine the effect of compound 21 (C21) in embolic stroke. Rats were subjected to embolic-middle cerebral artery occlusion (eMCAO). They received C21 (0.01, 0.03 and 0.06 mg/kg/d) or saline (orally) for five days, with the first-dose given IV at 3 h post-eMCAO. For the time-window study, the optimal-dose of C21 was initiated at 3, 6 or 24 h post-eMCAO and continued for five days. For the combinatorial study, animals received IV-tissue plasminogen activator (tPA) at either 2 or 4 h, with IV-C21 (0...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29534491/characterization-of-a-novel-porin-like-protein-exti-from-geobacter-sulfurreducens-and-its-implication-in-the-reduction-of-selenite-and-tellurite
#10
Mst Ishrat Jahan, Ryuta Tobe, Hisaaki Mihara
The extI gene in Geobacter sulfurreducens encodes a putative outer membrane channel porin, which resides within a cluster of extHIJKLMNOPQS genes. This cluster is highly conserved across the Geobacteraceae and includes multiple putative c -type cytochromes. In silico analyses of the ExtI sequence, together with Western blot analysis and proteinase protection assays, showed that it is an outer membrane protein. The expression level of ExtI did not respond to changes in osmolality and phosphate starvation. An extI -deficient mutant did not show any significant impact on fumarate or Fe(III) citrate reduction or sensitivity to β-lactam antibiotics, as compared with those of the wild-type strain...
March 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29525678/corrigendum-to-current-status-and-future-therapeutic-perspectives-of-glioblastoma-multiforme-gbm-therapy-a-review-biomed-pharmacother-92-2017-681-689
#11
Komal Anjum, Bibi Ibtesam Shagufta, Syed Qamar Abbas, Seema Patel, Ishrat Khan, Sayed Asmat Ali Shah, Najeeb Akhter, Syed Shams-Ul-Hassan
No abstract text is available yet for this article.
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29524034/mineral-oil-residues-in-soil-and-apple-under-temperate-conditions-of-kashmir-india
#12
Malik Mukhtar Ahmad, Ashraf Alam Wani, Mubashir Sofi, Ishrat Ara
The study was undertaken to ascertain the persistence of Orchol-13, a mineral oil used against insect pests of horticultural fruit crops in soil and apple following the dormant and summer applications of 2 and 0.75% respectively. Soil samples were collected during dormant, while as both soil and apple samples were collected during summer season. Samples were collected at 0, 1, 3, and 5 days post treatment in both the seasons. Average recoveries of paraffinic constituents (which constitute about 60% of mineral oils by composition) from soil and apple at 1 μg ml-1 spiking level were found to be 74...
March 9, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29505694/risk-assessment-dissipation-behavior-and-persistence-of-quinalphos-in-on-green-pea-by-gas-chromatography-with-electron-capture-detector
#13
Alamgir A Dar, Ishrat Jan, Ashraf A Wani, Sofi Mubashir, Khurshid A Sofi, Javid A Sofi, Irshad H Dar
Chemical investigation was carried out to examine the risk assessment, dissipation behavior, persistence, and half-life period of quinalphos in/on green pea fruit by spraying quinalphos at fruiting stage followed by another application after 10-day interval. The samples were extracted by using the quick, easy, cheap, effective, rugged, and safe method, and the residues of quinalphos were analyzed by gas chromatography with electron capture detector. Herein, we report a novel, accurate, and cost-effective gas chromatography method for the determination of average deposits of quinalphos in/on green pea...
March 5, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29488135/thioredoxin-interacting-protein-txnip-in-cerebrovascular-and-neurodegenerative-diseases-regulation-and-implication
#14
REVIEW
Sanaz Nasoohi, Saifudeen Ismael, Tauheed Ishrat
Neurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer's disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease burden, not only in terms of health suffering but also in economic costs. Although the clinical presentations differ for these diseases, a growing body of evidence suggests that oxidative stress and inflammatory responses in brain tissue significantly contribute to their pathology...
February 27, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29454056/biophysical-and-immunological-characterization-of-2-drib-modified-hsa-and-its-implications-in-diabetes-mellitus
#15
Ishrat Jahan Saifi, Km Neelofar, M R Ajmal, Sheelu Shafiq Siddiqi
Glycoxidation of protein may lead to develop diabetes. In the present study, different concentrations of 2-deoxy d-ribose (2-dRib) were used to modify human serum albumin (HSA). Nitro Blue Tetrazolium (NBT) assay results showed that yield of the fructosamine content was directly proportional to the concentration of 2-dRib. UV and fluorescence spectroscopy results showed an increment in hyperchromicity and decrease in fluorescence intensity of 2-dRib modified HSA as compared to native HSA. Further secondary structural changes were confirmed by UV-circular dichroism (UV-CD) and Fourier transform infrared spectroscopy (FT-IR)...
July 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29408310/phytochemical-characterization-and-biological-activity-evaluation-of-ethanolic-extract-of-cinnamomum-zeylanicum
#16
Ishrat Husain, Rumana Ahmad, Anu Chandra, Syed Tasleem Raza, Yogeshwer Shukla, Farzana Mahdi
ETHNOPHARMACOLOGICAL RELEVANCE: India being a multicultural nation, every region of the country offers a distinct culinary flavor and taste. These flavors are attributed to spices and condiments which form the mainstay of Indian cuisine. Most of these spices and condiments are derived from various biodiversity hotspots in India and form the crux of India's multidiverse and multicultural cuisine. Apart from their varying aromas, flavors and tastes, these spices and condiments are known to possess several medicinal properties also...
March 22, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29377614/quantification-dissipation-behavior-and-risk-assessment-of-ethion-in-green-pea-by-gas-chromatography-electron-capture-detector
#17
Ishrat Jan, Alamgir A Dar, Sofi Mubashir, Ashraf Alam Wani, Malik Mukhtar, Khurshid A Sofi, Irshad H Dar, Javid A Sofi
Residue investigation was carried out to scrutinize the persistence, dissipation behavior, half-life, and risk assessment of ethion on green pea fruit by spraying ethion at the fruiting stage followed by another application at 10 day intervals. The samples were extracted by using a quick, easy, low-cost, effective, rugged, and safe method, and the residues of ethion were analyzed by gas chromatography with electron capture detection. Here we report a novel, accurate, and cost-effective gas chromatography method for the determination of average deposits of ethion on green pea...
January 26, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29372452/hibiscus-rosa-sinensis-mediate-anxiolytic-effect-via-modulation-of-ionotropic-gaba-a-receptors-possible-mechanism-of-action
#18
Zubia Begum, Ishrat Younus
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (p < 0.05) increased the number of head dips and rearings as compared to control on respective days of observation...
January 25, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29336731/lead-induces-dna-damage-and-alteration-of-alad-and-antioxidant-genes-mrna-expression-in-construction-site-workers
#19
Zertashia Akram, Sadaf Riaz, Mahmood Akhtar Kayani, Sarwat Jahan, Malik Waqar Ahmad, Muhammad Abaid Ullah, Hizbullah Wazir, Ishrat Mahjabeen
Oxidative stress and DNA damage are considered as possible mechanisms involved in lead toxicity. To test this hypothesis, DNA damage and expression variations of aminolevulinic acid dehydratase (ALAD), superoxide dismutase 2 (SOD2), and 8-oxoguanine DNA glycosylase 2a (OGG1-2a) genes was studied in a cohort of 100 exposed workers and 100 controls with comet assay and real-time polymerse chain reaction (PCR). Results indicated that increased number of comets was observed in exposed workers versus controls (p < 0...
January 16, 2018: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29313060/an-md2-derived-peptide-promotes-lps-aggregation-facilitates-its-internalization-in-thp-1-cells-and-inhibits-lps-induced-pro-inflammatory-responses
#20
Anshika Tandon, Munesh Kumar Harioudh, Nayab Ishrat, Amit Kumar Tripathi, Saurabh Srivastava, Jimut Kanti Ghosh
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS). Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. However, not much is known about the segments in MD2 that are responsible for LPS interaction or internalization of pathogen inside the defense cells. A 16-residue stretch (MD54) from MD2 protein has been identified that possesses a short heptad repeat sequence and four cationic residues enabling it to participate in both hydrophobic and electrostatic interactions with LPS...
January 8, 2018: Cellular and Molecular Life Sciences: CMLS
keyword
keyword
32574
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"