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Tauheed Ishrat, Abdelrahman Y Fouda, Bindu Pillai, Wael Eldahshan, Heba Ahmed, Jennifer L Waller, Adviye Ergul, Susan C Fagan
The aim of this translational, randomized, controlled, blinded preclinical trial was to determine the effect of compound 21 (C21) in embolic stroke. Rats were subjected to embolic-middle cerebral artery occlusion (eMCAO). They received C21 (0.01, 0.03 and 0.06 mg/kg/d) or saline (orally) for five days, with the first-dose given IV at 3 h post-eMCAO. For the time-window study, the optimal-dose of C21 was initiated at 3, 6 or 24 h post-eMCAO and continued for five days. For the combinatorial study, animals received IV-tissue plasminogen activator (tPA) at either 2 or 4 h, with IV-C21 (0...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Mst Ishrat Jahan, Ryuta Tobe, Hisaaki Mihara
The extI gene in Geobacter sulfurreducens encodes a putative outer membrane channel porin, which resides within a cluster of extHIJKLMNOPQS genes. This cluster is highly conserved across the Geobacteraceae and includes multiple putative c -type cytochromes. In silico analyses of the ExtI sequence, together with Western blot analysis and proteinase protection assays, showed that it is an outer membrane protein. The expression level of ExtI did not respond to changes in osmolality and phosphate starvation. An extI -deficient mutant did not show any significant impact on fumarate or Fe(III) citrate reduction or sensitivity to β-lactam antibiotics, as compared with those of the wild-type strain...
March 11, 2018: International Journal of Molecular Sciences
Komal Anjum, Bibi Ibtesam Shagufta, Syed Qamar Abbas, Seema Patel, Ishrat Khan, Sayed Asmat Ali Shah, Najeeb Akhter, Syed Shams-Ul-Hassan
No abstract text is available yet for this article.
March 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Malik Mukhtar Ahmad, Ashraf Alam Wani, Mubashir Sofi, Ishrat Ara
The study was undertaken to ascertain the persistence of Orchol-13, a mineral oil used against insect pests of horticultural fruit crops in soil and apple following the dormant and summer applications of 2 and 0.75% respectively. Soil samples were collected during dormant, while as both soil and apple samples were collected during summer season. Samples were collected at 0, 1, 3, and 5 days post treatment in both the seasons. Average recoveries of paraffinic constituents (which constitute about 60% of mineral oils by composition) from soil and apple at 1 μg ml-1 spiking level were found to be 74...
March 9, 2018: Environmental Monitoring and Assessment
Alamgir A Dar, Ishrat Jan, Ashraf Alam Wani, Sofi Mubashir, Khurshid A Sofi, Javid A Sofi, Irshad H Dar
Chemical investigation was carried out to examine the risk assessment, dissipation behaviour, persistence and half life period of quinalphos on green pea fruit by spraying quinalphos at fruiting stage followed by another application after ten day interval. The samples were extracted by using the quick, easy, cheap, effective, rugged, and safe method, and the residues of quinalphos were analyzed by gas chromatography with electron capture detector. Herein we report a novel, accurate and cost-effective gas chromatography method for the determination of average deposits of quinalphos on green pea...
March 5, 2018: Journal of Separation Science
Sanaz Nasoohi, Saifudeen Ismael, Tauheed Ishrat
Neurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer's disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease burden, not only in terms of health suffering but also in economic costs. Although the clinical presentations differ for these diseases, a growing body of evidence suggests that oxidative stress and inflammatory responses in brain tissue significantly contribute to their pathology...
February 27, 2018: Molecular Neurobiology
Ishrat Jahan Saifi, Km Neelofar, M R Ajmal, Sheelu Shafiq Siddiqi
Glycoxidation of protein may lead to develop diabetes. In the present study, different concentrations of 2-deoxy d-ribose (2-dRib) were used to modify human serum albumin (HSA). Nitro Blue Tetrazolium (NBT) assay results showed that yield of the fructosamine content was directly proportional to the concentration of 2-dRib. UV and fluorescence spectroscopy results showed an increment in hyperchromicity and decrease in fluorescence intensity of 2-dRib modified HSA as compared to native HSA. Further secondary structural changes were confirmed by UV-circular dichroism (UV-CD) and Fourier transform infrared spectroscopy (FT-IR)...
February 14, 2018: International Journal of Biological Macromolecules
Ishrat Husain, Rumana Ahmad, Anu Chandra, Syed Tasleem Raza, Yogeshwer Shukla, Farzana Mahdi
ETHNOPHARMACOLOGICAL RELEVANCE: India being a multicultural nation, every region of the country offers a distinct culinary flavor and taste. These flavours are attributed to spices and condiments which form the mainstay of Indian cuisine. Most of these spices and condiments are derived from various biodiversity hotspots in India and form the crux of India's multidiverse and multicultural cuisine. Apart from their varying aromas, flavors and tastes, these spices and condiments are known to possess several medicinal properties also...
February 2, 2018: Journal of Ethnopharmacology
Ishrat Jan, Alamgir A Dar, Sofi Mubashir, Ashraf Alam Wani, Malik Mukhtar, Khurshid A Sofi, Irshad H Dar, Javid A Sofi
Residue investigation was carried out to scrutinize the persistence, dissipation behavior, half life, and risk assessment of ethion on green pea fruit by spraying ethion at the fruiting stage followed by another application at 10 day intervals. The samples were extracted by using the quick, easy, cheap, effective, rugged, and safe method, and the residues of ethion were analyzed by gas chromatography with electron capture detection. Herein we report a novel, accurate and cost-effective gas chromatography method for the determination of average deposits of ethion on green pea...
January 26, 2018: Journal of Separation Science
Zubia Begum, Ishrat Younus
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (p < 0.05) increased the number of head dips and rearings as compared to control on respective days of observation...
January 25, 2018: Metabolic Brain Disease
Zertashia Akram, Sadaf Riaz, Mahmood Akhtar Kayani, Sarwat Jahan, Malik Waqar Ahmad, Muhammad Abaid Ullah, Hizbullah Wazir, Ishrat Mahjabeen
Oxidative stress and DNA damage are considered as possible mechanism involved in lead toxicity. To test this hypothesis, DNA damage and expression variations of ALAD, SOD2 and OGG1-2░a genes was studied in a cohort of 100 exposed workers and 100 controls with comet assay and real-time PCR. Results indicated that increased number of comets was observed in exposed workers versus controls (p<0.001). After qPCR analysis, significant down-regulation in ALAD (p<0.0001), SOD2 (p<0.0001) and OGG1-2░a (p<0...
January 16, 2018: Archives of Environmental & Occupational Health
Anshika Tandon, Munesh Kumar Harioudh, Nayab Ishrat, Amit Kumar Tripathi, Saurabh Srivastava, Jimut Kanti Ghosh
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS). Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. However, not much is known about the segments in MD2 that are responsible for LPS interaction or internalization of pathogen inside the defense cells. A 16-residue stretch (MD54) from MD2 protein has been identified that possesses a short heptad repeat sequence and four cationic residues enabling it to participate in both hydrophobic and electrostatic interactions with LPS...
January 8, 2018: Cellular and Molecular Life Sciences: CMLS
Saifudeen Ismael, Sanaz Nasoohi, Tauheed Ishrat
NNucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome may intimately contribute to sustaining damage following traumatic brain injury (TBI). This study aims to examine whether specific modulation of NLPR3 inflammasome by MCC950, a novel selective NLRP3 inhibitor confers protection after experimental TBI. Unilateral cortical impact injury was induced in young adult C57BL/6 mice. MCC950 (50 mg/kg, i.p.) or saline was administration at 1 h and 3 h post TBI. Animals were tested for neurological function, and then sacrificed for edema at 24 or 72 h post TBI...
January 2, 2018: Journal of Neurotrauma
Ishrat Rasool, Dil Afroze, Khursheed Alam Wani, Adfar Yousuf, Imtiyaz Ahmad Bhat, Bilal Rah, Sheeraz Un Nazir, Showket Hussain, Shweta Dubey
INTRODUCTION: Survivin is an apoptosis inhibitor and plays a primary role in cancer development and progression. One of the most common polymorphism of the survivin promoter -31G/C (rs9904341) influences its expression and is associated with the risk of cancer development. This study was conducted to explore survivin promoter gene -31G/C (rs9904341) polymorphism and the risk of breast cancer. PATIENTS AND METHODS: The study group included 190 pathologically confirmed breast cancer patients, in addition to 200 distinct cancer-free controls from Jammu and Kashmir region of India, where breast cancer is the most common cancer in women...
November 23, 2017: Clinical Breast Cancer
Heba A Ahmed, Tauheed Ishrat, Bindu Pillai, Kristopher M Bunting, Ashni Patel, Almira Vazdarjanova, Jennifer L Waller, Ali S Arbab, Adviye Ergul, Susan C Fagan
Growing evidence suggests that renin angiotensin system (RAS) modulators support cognitive function in various animal models. However, little is known about their long-term effects on the brain structure in aged hypertensive animals with chronic cerebral hypoperfusion as well as which specific domains of cognition are most affected. Therefore, in the current study we examined the effects of Candesartan and Compound 21 (C21) (RAS modulators) on aspects of cognition known to diminish with advanced age and accelerate with hypertension and vascular disease...
December 8, 2017: Behavioural Brain Research
Muhammed Omair Husain, Imran B Chaudhry, Nasir Mehmood, Raza Ur Rehman, Ajmal Kazmi, Munir Hamirani, Tayyeba Kiran, Ameer Bukhsh, Paul Bassett, Muhammad Ishrat Husain, Farooq Naeem, Nusrat Husain
BACKGROUND: Evidence for efficacy of cognitive-behavioural therapy (CBT) in treatment of schizophrenia is growing. CBT is effective and cost efficient in treating positive and negative symptoms. To effectively meet the needs of diverse cultural groups, CBT needs to be adapted to the linguistic, cultural and socioeconomic context. We aimed to assess the feasibility, efficacy and acceptability of a culturally adapted CBT for treatment of psychosis (CaCBTp) in a low-income country. METHODS: Rater-blind, randomised, controlled trial of the use of standard duration CBT in patients with psychosis from a low-income country...
December 6, 2017: BMC Health Services Research
Ishrat Younus, Muhammad Ashraf, Anab Fatima, Imran Altaf, Aqeel Javeed
Cytotoxic and antiviral activity of aqueous leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus (FMDV) were determined using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Eight different concentrations of each plant were evaluated. Cytotoxic and antiviral activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. From the tested plant extracts, Azadirachta indica & Moringa oleifera exhibited cytotoxicity at 200 & 100 μ/ml respectively...
November 2017: Pakistan Journal of Pharmaceutical Sciences
Sayed Asmat Ali Shah, Najeeb Akhter, Bibi Nazia Auckloo, Ishrat Khan, Yanbin Lu, Kuiwu Wang, Bin Wu, Yue-Wei Guo
Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products...
November 10, 2017: Marine Drugs
Anthony O Ahmed, Jenae Richardson, Alex Buckner, Sabrina Romanoff, Michelle Feder, Njideka Oragunye, Andriana Ilnicki, Ishrat Bhat, Matthew J Hoptman, Jean-Pierre Lindenmayer
Schizophrenia is associated with an elevated risk of aggression. Cognitive deficits have been associated with inpatient aggression and future violence. The relationship between cognitive deficits and violent behavior has however been inconsistent across studies. In addition, studies have failed to inform how cognitive deficits may contribute to aggression in schizophrenia. The current study examined the association of cognitive deficits with schizophrenia-related aggression and violent offending. It also explored the putative mediating role of negative emotionality on the impact of cognitive deficits on aggression...
November 7, 2017: Psychiatry Research
Ishrat Chaudhuri, Claudia Fruijtier-Pölloth, Yufanyi Ngiewih, Len Levy
Carbon black is produced industrially by the partial combustion or thermal decomposition of gaseous or liquid hydrocarbons under controlled conditions. It is considered a poorly soluble, low toxicity (PSLT) particle. Recently, results from a number of published studies have suggested that carbon black may be directly genotoxic, and that it may also cause reproductive toxicity. Here, we review the evidence from these studies to determine whether carbon black is likely to act as a primary genotoxicant or reproductive toxicant in humans...
November 2, 2017: Critical Reviews in Toxicology
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