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https://www.readbyqxmd.com/read/27914000/from-transformation-to-metastasis-deconstructing-the-extracellular-matrix-in-breast-cancer
#1
Shelly Kaushik, Michael W Pickup, Valerie M Weaver
The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment...
December 2, 2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/27913866/communicating-branches-between-lingual-and-hypoglossal-nerve-observation-using-sihler-s-staining-technique
#2
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Yoko Tabira, Moriyoshi Nakamura, Christian Fisahn, R Shane Tubbs, Jingo Kusukawa, Koh-Ichi Yamaki
PURPOSE: Many dental procedures are at risk of injuring the lingual nerve. We performed this study to better elucidate the microanatomy that exists between the ipsilateral lingual and hypoglossal nerves so that iatrogenic injury can be avoided. METHODS: Adult human cadaveric tongues (ten sides) underwent Sihler's staining to identify the microanatomy between the lingual and hypoglossal nerves. RESULTS: The lingual nerve entered the middle part of the anterior two-thirds of the tongue from its lateral side and divided into two to four thick branches...
December 2, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27913802/combined-use-of-a-pconus-and-a-solitaire-stent-report-of-two-cases
#3
Pervinder Bhogal, Marta Aguilar Pérez, Rosa Martinez Moreno, Marcin Miś, Maciej Miś, Hans Henkes
OBJECTIVE: The aim of this study was to report our initial experience of the use of the pCONus neck protection device in conjunction with the Solitaire AB stent to assist in the endovascular management of complex intracranial aneurysms with arteries arising from both the neck and the dome of the aneurysm. METHODS: Two patients with unruptured aneurysms underwent elective endovascular management of their aneurysms, one arising from the middle cerebral artery bifurcation and one from the anterior communicating artery...
December 2, 2016: Interventional Neuroradiology
https://www.readbyqxmd.com/read/27913627/aberrant-interhemispheric-homotopic-functional-and-structural-connectivity-in-amyotrophic-lateral-sclerosis
#4
Jiuquan Zhang, Bing Ji, Jun Hu, Chaoyang Zhou, Longchuan Li, Zhihao Li, Xuequan Huang, Xiaoping Hu
OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is an idiopathic and fatal neurodegenerative disease of the human motor system. While microstructural alterations in corpus callosum (CC) have been identified as a consistent feature of ALS, studies directly examining interhemispheric neural connectivity are still lacking. To shed more light on the pathophysiology of ALS, the present study aims to examine alterations of interhemispheric structural and functional connectivity in individuals with ALS...
December 2, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27913589/integrin-linked-kinase-ilk-deletion-disrupts-oligodendrocyte-development-by-altering-cell-cycle
#5
Rashad Hussain, Wendy B Macklin
: During development, oligodendrocytes are initially specified, after which oligodendrocyte precursor cells (OPCs) migrate and proliferate before differentiating into myelinating cells. Lineage specific programming of oligodendrocytes results from sensing environmental cues through membrane-bound receptors and related intracellular signaling molecules. Integrin linked kinase (ILK) is an important protein expressed at the inner margins of the plasma membrane, which can mediate some of these signals...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27913261/typical-symptoms-of-normal-pressure-hydrocephalus-caused-by-choroid-plexus-papilloma-in-the-cerebellopontine-angle-a-case-report
#6
Hiroshi Ito, Yukiko Nakahara, Masatou Kawashima, Jun Masuoka, Tatsuya Abe, Toshio Matsushima
BACKGROUND: Choroid plexus papillomas (CPPs) are rare benign intracranial tumors. Here, we report a rare case of CPP presenting with typical symptoms of normal-pressure hydrocephalus not with obstructive hydrocephalus. CASE DESCRIPTION: A 45-year-old female presented with a 6-year history of headache and typical symptoms of normal-pressure hydrocephalus (NPH) such as gait disturbance, urinary incontinence, and cognitive dysfunction in addition to the more common symptoms of choroid plexus papillomas (CPP), such as lower cranial nerve dysfunctions and ataxia...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27913246/measuring-content-overlap-during-handoff-communication-using-distributional-semantics-an-exploratory-study
#7
Joanna Abraham, Thomas Kannampallil, Vignesh Srinivasan, William Galanter, Gail Tagney, Trevor Cohen
OBJECTIVE: We develop and evaluate a methodological approach to measure the degree and nature of overlap in handoff communication content within and across clinical professions. This extensible, exploratory approach relies on combining techniques from conversational analysis and distributional semantics. MATERIALS AND METHODS: We audio-recorded handoff communication of residents and nurses on the General Medicine floor of a large academic hospital (n=120 resident and n=120 nurse handoffs)...
November 29, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27913196/nf-kb-regulated-exosomal-mir-155-promotes-the-inflammation-associated-with-arsenite-carcinogenesis
#8
Chao Chen, Fei Luo, Xinlu Liu, Lu Lu, Hui Xu, Qianlei Yang, Junchao Xue, Le Shi, Jun Li, Aihua Zhang, Qizhan Liu
In the cancer microenvironment, extracellular communication allows various types of cells to coordinate and execute biological functions. Emerging evidence indicates that exosomes, as mediators of cell communication, are involved in tumor progression. Little is known, however, about the mechanism by which exosomal miRNAs regulate inflammatory infiltration in arsenite-induced liver cancer. The present research aimed to determine if miRNAs secreted from arsenite-transformed human hepatic epithelial (L-02) cells are transferred into normal L-02 and THLE-3 cells, which are functionally active in the recipient cells...
November 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27913161/novel-brain-expressed-rna-identified-at-the-mir137-schizophrenia-associated-locus
#9
Olympia Gianfrancesco, Alix Warburton, David A Collier, Vivien J Bubb, John P Quinn
Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal development and function. However, the involvement of other genes within this region, including DPYD (dihydropyrimidine dehydrogenase), is also plausible. In this communication, we describe a previously uncharacterised, brain-expressed RNA, EU358092, within the schizophrenia-associated region at 1p21...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27913152/development-and-validation-of-an-objective-scoring-tool-for-robot-assisted-radical-prostatectomy-prostatectomy-assessment-and-competency-evaluation-pace
#10
Ahmed A Hussein, Khurshid R Ghani, James Peabody, Richard Sarle, Ronney Abaza, Daniel Eun, Jim Hu, Michael Fumo, Brian Lane, Jeffrey Montgomery, Nobuyuki Hinata, Deborah Rooney, Bryan Comstock, Hei Kit Chan, Sridhar S Mane, James L Mohler, Gregory Wilding, David Miller, Khurshid A Guru
INTRODUCTION: and Background: Comprehensive training and skill acquisition by urologic surgeons are vital to optimize surgical outcomes and patient safety. We sought to develop and validate an objective and procedure specific tool to assess the quality of robot-assisted radical prostatectomy (RARP)-Prostatectomy Assessment and Competence Evaluation (PACE) METHODS: Development and content validation of PACE was performed by deconstruction of RARP into seven key domains utilizing the Delphi methodology...
November 29, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27913118/forces-controlling-organ-growth-and-size
#11
REVIEW
Dominik Eder, Christof Aegerter, Konrad Basler
One of the fundamental questions in developmental biology is what determines the final size and shape of an organ. Recent research strongly emphasizes that besides cell-cell communication, biophysical principals govern organ development. The architecture and mechanics of a tissue guide cellular processes such as movement, growth or differentiation. Furthermore, mechanical cues do not only regulate processes at a cellular level but also provide constant feedback about size and shape on a tissue scale. Here we review several models and experimental systems which are contributing to our understanding of the roles mechanical forces play during organ development...
November 29, 2016: Mechanisms of Development
https://www.readbyqxmd.com/read/27913084/quality-of-communication-about-medicines-in-united-states-hospitals-a-national-retrospective-study
#12
Lauren Mullings, Jayashri Sankaranarayanan
BACKGROUND: Despite the benefits of improving transitions across care, literature is very limited on inpatient "Communication about Medicines" (ComMed) by staff across United States (U.S.) hospitals. OBJECTIVES: To evaluate ComMed quality variations by hospital characteristics. METHODS: In a cross-sectional, retrospective study of publicly available U.S. Medicare's Hospital Consumer Assessment of Health Care Plans Survey (HCAHPS) data (January 2013-September 2014), ComMed quality (high = above average/excellent vs...
October 26, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27912963/overcoming-communication-challenges-in-integrative-supportive-cancer-care-the-integrative-physician-the-psycho-oncologist-and-the-patient
#13
Eran Ben-Arye, Efrat Shavit, Haya Wiental, Elad Schiff, Olga Agour, Noah Samuels
BACKGROUND: Complementary/integrative medicine (CIM) services are increasingly being integrated into conventional supportive cancer care, presenting a number of challenges to communication between healthcare professionals (HCPs). The purpose of the present study was to explore the impact of the communication between integrative physicians (IPs) trained in CIM and social workers (SWs) working as psycho-oncologists in the same oncology setting. We examine whether IP-SW communication correlates with the number of patient-SW sessions, as provided within the oncology department...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912935/multi-dimensional-analysis-on-parkinson-s-disease-questionnaire-39-in-parkinson-s-patients-treated-with-bushen-huoxue-granule-a-multicenter-randomized-double-blinded-and-placebo-controlled-trial
#14
Min Li, Hui Ming Yang, Dong Xiao Luo, Jian Zong Chen, Heng Jun Shi
OBJECTIVES: To preliminarily assess the effects of Bushen Huoxue Granule (BHG) on Parkinson's Patients with Parkinson's Disease Questionnaire-39 (PDQ-39)and to provide data for further research. DESIGN: A randomized, double-blinded, placebo controlled study with a 3-month intervention period and a 6-month follow-up. INTERVENTIONS: Participants were patients with Parkinson's Disease (PD) of age ranging from 50 to 80 years and Hoehn and Yahr (H-Y) stage I-IV of the disease...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912860/late-style-as-exile-de-colonising-the-life-course
#15
Heike Hartung
In the collection of essays On Late Style, Edward Said reflects on the new idiom achieved by great artists in their work near the end of their lives as "late style." Drawing on Adorno's essay on Beethoven's late style, Said also focuses on the aesthetic aspects of lateness. Defining the late works of artists as "a form of exile," however, Said moves beyond Adorno's aesthetic conception of late style. Highlighting the artist's abandonment of communication with the established social order, who achieves a contradictory, alienated relationship with it instead, Said compares artistic lateness with the experience of the subject in exile...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27912780/the-influence-of-cost-per-daly-information-in-health-prioritisation-and-desirable-features-for-a-registry-a-survey-of-health-policy-experts-in-vietnam-india-and-bangladesh
#16
Yot Teerawattananon, Sripen Tantivess, Inthira Yamabhai, Nattha Tritasavit, Damian G Walker, Joshua T Cohen, Peter J Neumann
BACKGROUND: Economic evaluation has been implemented to inform policy in many areas, including coverage decisions, technology pricing, and the development of clinical practice guidelines. However, there are barriers to evidence-based policy in low- and middle-income countries (LMICs) that include limited stakeholder awareness, resources and data availability, as well as the lack of capacity to conduct country-specific economic evaluations. This study aims to survey health policy experts' opinions on barriers to use of cost-effectiveness data in these settings and to obtain their advice on how to make a new cost-per-DALY database being developed by Tufts Medical Center more relevant to LMICs...
December 3, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27912744/quality-of-life-after-stroke-in-pakistan
#17
Wardah Khalid, Shafquat Rozi, Tazeen Saeed Ali, Iqbal Azam, Michael T Mullen, Saleem Illyas, Qamar Un-Nisa, Nabila Soomro, Ayeesha Kamran Kamal
BACKGROUND: There is very little information about the quality of life (QOL) of stroke survivors in LMIC countries with underdeveloped non communicable health infrastructures, who bear two thirds of the global stroke burden. METHODOLOGY: We used a sequential mix methods approach. First, a quantitative analytical cross-sectional study was conducted on 700 participants, who constituted 350 stroke survivor and their caregiver dyads. QOL of stroke survivor was assessed via Stroke Specific Quality of Life Scale (SSQOLS) whereas QOL of caregivers was assessed through RAND-36...
December 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27912243/vomeronasal-receptors-in-vertebrates-and-the-evolution-of-pheromone-detection
#18
Liliana Silva, Agostinho Antunes
Pheromones were identified as chemical signals used for intraspecific communication in insects (e.g., sexual attraction) in the 1950s. However, only almost 40 years later the vomeronasal receptors type-1 (V1R) and type-2 (V2R) were identified, usually associated with the presence of a vomeronasal organ (VNO). VRs are widespread in amphibians, reptiles, and mammals, but birds lost the VNO. Similarly, fishes lack VRs and a VNO but can still detect pheromones, instead using the olfactory receptors related to class A and class C G protein-coupled receptors...
November 28, 2016: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/27912172/brain-heart-communication-evidence-for-central-pacemaker-oscillations-with-a-dominant-frequency-at-0-1hz-in-the-cingulum
#19
Gert Pfurtscheller, Andreas R Schwerdtfeger, Annemarie Seither-Preisler, Clemens Brunner, Christoph Stefan Aigner, Joana Brito, Marciano P Carmo, Alexandre Andrade
OBJECTIVES: In the brain and heart, oscillations at about 0.1Hz are conspicuous. It is therefore worthwhile to study the interaction between intrinsic BOLD oscillations (0.1Hz) and slow oscillations in heart rate interval (RRI) signals and differentiate between their neural and vascular origin. METHODS: We studied the phase-coupling with a 3T scanner with high scanning rate between BOLD signals in 22 regions and simultaneously recorded RRI oscillations in 23 individuals in two resting states...
November 10, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27912108/encouraging-early-discussion-of-life-expectancy-and-end-of-life-care-a-randomised-controlled-trial-of-a-nurse-led-communication-support-program-for-patients-and-caregivers
#20
Adam Walczak, Phyllis N Butow, Martin H N Tattersall, Patricia M Davidson, Jane Young, Ronald M Epstein, Daniel S J Costa, Josephine M Clayton
BACKGROUND: Patients are often not given the information needed to understand their prognosis and make informed treatment choices, with many consequently experiencing less than optimal care and quality-of-life at end-of-life. OBJECTIVES: To evaluate the efficacy of a nurse-facilitated communication support program for patients with advanced, incurable cancer to assist them in discussing prognosis and end-of-life care. DESIGN: A parallel-group randomised controlled trial design was used...
October 21, 2016: International Journal of Nursing Studies
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