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https://www.readbyqxmd.com/read/28731509/keeping-safe-continuous-glucose-monitoring-cgm-in-persons-with-type-1-diabetes-and-impaired-awareness-of-hypoglycaemia-a-qualitative-study
#1
A F Vloemans, C A J van Beers, M de Wit, W Cleijne, S M Rondags, P H Geelhoed-Duijvestijn, M H H Kramer, E H Serné, F J Snoek
AIM: To further our understanding of individual use and experience of continuous glucose monitoring (CGM) in adults with Type 1 diabetes and impaired awareness of hypoglycaemia, we conducted a qualitative study supplementary to a randomized controlled trial, using semi-structured interviews. METHODS: Twenty-three participants of the IN CONTROL trial were interviewed within 4 weeks after the last study visit. The interview centred around experiences of CGM, taking into account the person's expectations prior to the trial...
July 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28731332/tuning-the-cavity-size-and-chirality-of-self-assembling-3d-dna-crystals
#2
Chad R Simmons, Fei Zhang, Tara MacCulloch, Nour Eddine Fahmi, Nicholas Stephanopoulos, Yan Liu, Nadrian C Seeman, Hao Yan
The foundational goal of structural DNA nanotechnology-the field that uses oligonucleotides as a molecular building block for the programmable self-assembly of nanostructured systems-was to use DNA to construct three-dimensional (3D) lattices for solving macromolecular structures. The programmable nature of DNA makes it an ideal system for rationally constructing self-assembled crystals, and immobilizing guest molecules in a repeating 3D array through their specific stereospatial interactions with the scaffold...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28731074/left-hippocampus-sparing-whole-brain-radiotherapy-wbrt-a-planning-study
#3
Tomas Kazda, Miroslav Vrzal, Tomas Prochazka, Petr Dvoracek, Petr Burkon, Petr Pospisil, Adam Dziacky, Tomas Nikl, Radim Jancalek, Pavel Slampa, Radek Lakomy
AIMS: Unilateral sparing of the dominant (left) hippocampus during whole brain radiotherapy (WBRT) could mitigate cognitive decline, especially verbal memory, similar to the widely investigated bilateral hippocampus avoidance (HA-WBRT). The aim of this planning study is dosimetrical comparison of HA-WBRT with only left hippocampus sparing (LHA-WBRT) plans. METHODS: HA-WBRT plans for 10 patients were prepared in accordance with RTOG 0933 trial and served as baseline for comparisons with several LHA-WBRT plans prepared with an effort: 1) to maintain the same left hippocampus dosimetry ("BEST PTV") and 2) to maintain same dosimetry in planning target volume as in HA-WBRT ("BEST LH")...
July 20, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28730617/methotrexate-for-severe-childhood-atopic-dermatitis-clinical-experience-in-a-tertiary-center
#4
Veronika Dvorakova, Grainne M O'Regan, Alan D Irvine
BACKGROUND/OBJECTIVES: Atopic dermatitis (AD) affects up to 20% of children. Although the majority of patients are adequately controlled using emollients, topical corticosteroids, topical calcineurin inhibitors, or phototherapy, children with moderate to severe AD may require systemic treatment for control. The objective of the current study was to evaluate the efficacy and safety of methotrexate in children with severe AD attending a tertiary referral center. METHODS: A retrospective chart review was undertaken of all children who received methotrexate for severe AD at our tertiary referral center from November 2010 to August 2015...
July 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28729596/revolutionary-self-clearing-dental-mirror
#5
(no author information available yet)
No abstract text is available yet for this article.
July 21, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28729345/recent-advances-in-understanding-and-managing-body-dysmorphic-disorder
#6
REVIEW
Georgina Krebs, Lorena Fernández de la Cruz, David Mataix-Cols
Body dysmorphic disorder (BDD) is a relatively common and disabling psychiatric disorder characterised by excessive and persistent preoccupation with perceived defects or flaws in one's appearance, which are unnoticeable to others, and associated repetitive behaviours (eg, mirror checking). The disorder generally starts in adolescence, but often goes unnoticed and is severely underdiagnosed. Left untreated, BDD typically persists and causes marked functional impairment in multiple domains. This clinical review considers recent advances in the epidemiology and classification of BDD, including its reclassification in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders under the new 'Obsessive-Compulsive and Related Disorders' chapter...
July 20, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28728802/-psychotherapies-for-the-treatment-of-phantom-limb-pain
#7
Katherine Cárdenas, Mariana Aranda
INTRODUCTION: The phantom limb pain has been described as a condition in which patients experience a feeling of itching, spasm or pain in a limb or body part that has been previously amputated. Such pain can be induced by a conflict between the representation of the visual and proprioceptive feedback of the previously healthy limb. The phantom limb pain occurs in at least 42 to 90% of amputees. Regular drug treatment of phantom limb pain is almost never effective. METHODS: A systematic review of the literature was conducted in Medline and Cochrane using the MESH terms "phantom limb pain" and "psychotherapy", published in the last 10 years, in English and Spanish, finding 49 items...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28728567/settings-and-artefacts-relevant-for-doppler-ultrasound-in-large-vessel-vasculitis
#8
REVIEW
L Terslev, A P Diamantopoulos, U Møller Døhn, W A Schmidt, S Torp-Pedersen
Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Doppler parameters, including spectral Doppler, and how the settings differ from those used in arthritic conditions and provide recommendations for optimal adjustments. This is addressed through relevant Doppler physics, focusing, for example, on the Doppler shift equation and how angle correction ensures correctly displayed blood velocity...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28727920/ballistic-penetration-of-highly-charged-nanoaerosol-particles-through-a-lipid-monolayer
#9
Victor N Morozov, Yuri M Shlyapnikov, Igor L Kanev, Elena Andreevna Shlyapnikova
To be used as a drug, inhaled nanoaerosol particles (NAPs) must first penetrate the lipid layer on top of the lung fluid before they will be able to reach the lung epithelium. We investigated how the penetration of NAPs through a model lipid monolayer (LM) depends upon their charging level and size. It was shown that deposition of NAPs 20-200 nm in diameter and charged to the Rayleigh limit gradually increased the surface tension of a dipalmitoylphosphatidylcholine monolayer (DPPC), indicating a loss of lipid molecules from the monolayer...
July 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28726606/opiate-injection-associated-skin-soft-tissue-and-vascular-infections-england-uk-1997-2016
#10
Dan Lewer, Magdalena Harris, Vivian Hope
In England, UK, hospital admissions caused by bacterial infections associated with opioid use have increased annually since 2012, after 9 years of decline, mirroring trends in overdose deaths. The increase occurred among persons of both sexes and in all age groups and suggests preventive measures need reviewing.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28725009/the-salivary-microbiome-as-an-indicator-of-carcinogenesis-in-patients-with-oropharyngeal-squamous-cell-carcinoma-a-pilot-study
#11
Axel Wolf, Christine Moissl-Eichinger, Alexandra Perras, Kaisa Koskinen, Peter V Tomazic, Dietmar Thurnher
This study aimed to undertake an initial, comparative analysis of the oral salivary microbiome of patients with oral and oropharyngeal squamous cell carcinoma versus healthy controls. This project, conceived as a pilot study, included 11 patients (1 female, 10 male, mean age 61.6 yrs., SD = 8.2 yrs.) and 11 healthy controls (1 female, 10 male, mean age 46.7 yrs., SD = 15.1 yrs.). Samples of saliva were analysed by high-throughput sequencing of the 16S rRNA gene using the MiSeq platform. Sequence data revealed microbial changes that may mirror disease progression and reflect clinical preconditions such as age, alcohol consumption, tumour size, lymph node status, smoking habit, and tumour HPV-positivity...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724428/mirroring-the-cantos-revolution-is-anti-inflammatory-therapy-for-diabetes-just-around-the-corner
#12
EDITORIAL
Alexander Tenenbaum, Enrique Z Fisman
No abstract text is available yet for this article.
July 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28724363/comparing-patient-and-healthcare-worker-experiences-during-a-dengue-outbreak-in-singapore-understanding-the-patient-journey-and-the-introduction-of-a-point-of-care-test-poct-toward-better-care-delivery
#13
Qinghui Tan, Zoe J-L Hildon, Shweta Singh, Jin Jing, Tun Linn Thein, Richard Coker, Hubertus J M Vrijhoef, Yee Sin Leo
BACKGROUND: In the aftermath of an upsurge in the number of dengue cases in 2013 and 2014, the SD BIOLINE Dengue Duo rapid diagnostic Point-of-Care Test (POCT) kit was introduced in Tan Tock Seng Hospital, Singapore in June 2013. It is known that the success of POCT usage is contingent on its implementation within the health system. We evaluated health services delivery and the Dengue Duo rapid diagnostic test kit application in Singapore from healthcare workers' perspectives and patient experiences of dengue at surge times...
July 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28724153/actual-and-standardized-patient-evaluations-of-medical-students-skills
#14
Amelia L Sattler, Sylvia Bereknyei Merrell, Steven Y Lin, Erika Schillinger
BACKGROUND AND OBJECTIVES: Physicians must communicate effectively with patients. Actual patients (APs) rarely evaluate medical students' clinical skills; instead, standardized patients (SPs) provide proxy ratings. It is unclear how well SP ratings mirror AP experiences. The aim of this study was to compare AP and SP assessments of medical students' communication skills and professionalism. We hypothesized that their perspectives would be similar, but distinct, and offer insight about how to more reliably include the patient's voice in medical education...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28723694/exosomes-a-cancer-theranostics-road-map
#15
Angeliki Panagiotara, Athina Markou, Evi S Lianidou, George P Patrinos, Theodora Katsila
Interindividual variability is yet to be fully characterized, and for this, optimum patient stratification and companion diagnostics are still lacking. Especially when complex disease phenotypes and/or polygenic diseases are considered, patient monitoring and disease management become rather challenging, while acquired resistance to therapy and/or toxicity events are among the unmet needs in the clinic. No doubt, biomarkers are of great importance to disease management and tailor-made theranostics. Microfluidics has gathered great attention lately, mostly due to its low-invasive nature compared to tissue biopsies...
July 20, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/28723233/treatment-patterns-and-clinical-outcomes-with-pazopanib-in-patients-with-advanced-soft-tissue-sarcomas-in-a-compassionate-use-setting-results-of-the-spire-study
#16
Hans Gelderblom, Ian R Judson, Charlotte Benson, Ofer Merimsky, Giovanni Grignani, Daniela Katz, Klaus W Freivogel, Dara Stein, Minesh Jobanputra, Arron Mungul, Stephanie C Manson, Roberta Sanfilippo
BACKGROUND: A named patient program (NPP) was designed to provide patients with advanced soft-tissue sarcoma (aSTS) access to pazopanib, a multitargeted tyrosine kinase inhibitor. The SPIRE study was a retrospective chart review of participating patients. PATIENTS AND METHODS: Eligibility criteria for the NPP and SPIRE mirrored those of the pivotal phase-III study, PALETTE, which compared pazopanib with placebo in patients ≥18 years with aSTS and whose disease had progressed during or following prior chemotherapy or were otherwise unsuitable for chemotherapy...
July 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28722468/evaluating-the-recovery-curve-for-clinically-assessed-reaction-time-after-concussion
#17
Gianluca Del Rossi
CONTEXT:   A change in reaction time is one of various clinical measures of neurocognitive function that can be monitored after concussion and has been reported to be among the most sensitive indicators of cognitive impairment. OBJECTIVE:   To determine the timeline for clinically assessed simple reaction time to return to baseline after a concussion in high school athletes. DESIGN:   Observational study. SETTING:   Athletic training room...
July 19, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28721400/weight-adjusted-lean-body-mass-and-calf-circumference-are-protective-against-obesity-associated-insulin-resistance-and-metabolic-abnormalities
#18
Toshinari Takamura, Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai, Takeshi Urabe, Shuichi Kaneko
BACKGROUND: To test the hypothesis that preserved muscle mass is protective against obesity-associated insulin resistance and metabolic abnormalities, we analyzed the relationship of lean body mass and computed tomography-assessed sectional areas of specific skeletal muscles with insulin resistance and metabolic abnormalities in a healthy cohort. METHODS: A total of 195 subjects without diabetes who had completed a medical examination were included in this study...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28720908/negative-reflecting-meta-mirrors
#19
Rui Yang, Dong Li, Dongxing Gao, Aofang Zhang, Bowei Hu, Pei Yang, Zhenya Lei, Jiacheng Li
Using the gradient phase discontinuities that meta-mirrors provide, we show that the incident wave can be reflected anomalously with a broad angle range of negative reflections. Such reversed behaviors promote the immediate applications for the planar meta-mirrors to steer the signals more arbitrarily and the convex meta-mirrors to focus and collimate electromagnetic fields. We practically implement these negative reflecting meta-mirrors through an arrangement of subwavelength ring patches and generate the desired phase distribution by also considering the incident angle...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720525/motor-resonance-during-action-observation-is-gaze-contingent-a-tms-study
#20
Giorgia D'Innocenzo, Claudia C Gonzalez, Alexander V Nowicky, A Mark Williams, Daniel T Bishop
When we observe others performing an action, visual input to our mirror neuron system is reflected in the facilitation of primary motor cortex (M1), a phenomenon known as 'motor resonance'. However, it is unclear whether this motor resonance is contingent upon our point-of-gaze. In order to address this issue, we collected gaze data from participants as they viewed an intransitive action - thumb abduction/adduction - under four conditions: with natural gaze behaviour (free viewing) and with their gaze fixated on each of three predetermined loci at various distances from the prime mover...
July 15, 2017: Neuropsychologia
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