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https://www.readbyqxmd.com/read/28230415/targeting-translational-successes-through-cansort-sci-using-pet-dogs-to-identify-effective-treatments-for-spinal-cord-injury
#1
Sarah A Moore, Nicolas Granger, Natasha Olby, Ingo Spitzbarth, Nick D Jeffery, Andrea Tipold, Yvette S Nout-Lomas, Ronaldo da Costa, Veronika Stein, Linda Noble-Haeusslein, Andrew R Blight, Robert Grossman, D Michele Basso, Jonathan Michael Levine
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to expeditiously evaluate promising interventions in a population of animals that are diagnosed and managed clinically in a manner similar to spinal cord-injured people, while adhering to NIH guidelines for scientific rigor and transparent reporting...
February 23, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28229955/three-dimensional-colloidal-lithography
#2
Hironori Nagai, Austen Poteet, Xu A Zhang, Chih-Hao Chang
Light interactions with colloidal particles can generate a variety of complex three-dimensional (3D) intensity patterns, which can be utilized for nanolithography. The study of particle-light interactions can add more types of intensity patterns by manipulating key factors. Here we investigate a novel 3D nanolithography technique using colloidal particles under two-beam coherent illuminations. The fabricated 3D nanostructures are hollow, nested within periodic structures, and possess multiple chamber geometry...
February 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28229624/do-step-and-biological-grandparents-show-differences-in-investment-and-emotional-closeness-with-their-grandchildren
#3
Peter B Gray, Elizabeth Brogdon
Human children are raised by a variety of caregivers including grandparents. A few studies have assessed potential differences in direct caregiving, financial expenditures, and emotional closeness between biological and step-grandparents. Drawing upon kin selection theory, we hypothesized that step-grandparents would provide less care and be less emotionally close to grandchildren than would biological grandparents. A sample of 341 heterosexual U.S. adults 25-35 years of age in a long-term partnership and with a biological child 5 years of age or younger were recruited via Amazon Mechanical Turk...
January 2017: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://www.readbyqxmd.com/read/28229610/coping-with-celiac-disease-how-heavy-is-the-burden-for-caregivers
#4
Francesca Ferretti, Federica Branchi, Bernardo Dell'Osso, Dario Conte, Luca Elli
BACKGROUND: Celiac disease (CD) is the most common chronic enteropathy demanding a lifelong gluten-free diet. OBJECTIVE: The aim of the study was to identify and estimate the subjective burden of caregivers of celiac patients. METHODS: A cross-sectional observational study was conducted during the regional meeting of the Italian Society for the Celiac Disease in April 2014. A written self-administered anonymous questionnaire enquired into caregivers' demographic profile, natural history of patients' disease and caregivers' self-reported degree of burden at the onset of symptoms (T0), at CD diagnosis (T1) and during follow-up (T2)...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28228540/functional-optics-of-glossy-buttercup-flowers
#5
Casper J van der Kooi, J Theo M Elzenga, Jan Dijksterhuis, Doekele G Stavenga
Buttercup (Ranunculus spp.) flowers are exceptional because they feature a distinct gloss (mirror-like reflection) in addition to their matte-yellow coloration. We investigated the optical properties of yellow petals of several Ranunculus and related species using (micro)spectrophotometry and anatomical methods. The contribution of different petal structures to the overall visual signal was quantified using a recently developed optical model. We show that the coloration of glossy buttercup flowers is due to a rare combination of structural and pigmentary coloration...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28227840/virtual-reality-for-pediatric-neuro-rehabilitation-adaptive-visual-feedback-of-movement-to-engage-the-mirror-neuron-system
#6
Roopeswar Kommalapati, Konstantinos P Michmizos, Roopeswar Kommalapati, Konstantinos P Michmizos, Roopeswar Kommalapati, Konstantinos P Michmizos
Sensorimotor therapy gives optimal results when patients are cognitively engaged into highly repetitive tasks, a goal that most children find hard to pursue. This paper presents the key developments of our ongoing effort to design an interactive rehabilitation environment that motivates physically impaired children throughout their therapy. The continuous motivation is achieved by the system adapting fundamental therapeutic components to the performance of each child. The relevant movement is mirrored to an animated character projected in front of the child...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227603/data-fusion-of-multiple-kinect-sensors-for-a-rehabilitation-system
#7
Huibin Du, Yiwen Zhao, Jianda Han, Zheng Wang, Guoli Song, Huibin Du, Yiwen Zhao, Jianda Han, Zheng Wang, Guoli Song, Guoli Song, Yiwen Zhao, Huibin Du, Jianda Han, Zheng Wang
Kinect-like depth sensors have been widely used in rehabilitation systems. However, single depth sensor processes limb-blocking, data loss or data error poorly, making it less reliable. This paper focus on using two Kinect sensors and data fusion method to solve these problems. First, two Kinect sensors capture the motion data of the healthy arm of the hemiplegic patient; Second, merge the data using the method of Set-Membership-Filter (SMF); Then, mirror this motion data by the Middle-Plane; In the end, control the wearable robotic arm driving the patient's paralytic arm so that the patient can interactively and initiatively complete a variety of recovery actions prompted by computer with 3D animation games...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227561/mirror-therapy-combined-with-functional-electrical-stimulation-for-rehabilitation-of-stroke-survivors-ankle-dorsiflexion
#8
Ghadir Salhab, Ahmad Rifaii Sarraj, Soha Saleh, Ghadir Salhab, Ahmad Rifaii Sarraj, Soha Saleh, Ahmad Rifaii Sarraj, Ghadir Salhab, Soha Saleh
This study investigates the effect of combining both mirror therapy with Electrical Stimulation (ES) on improvement of the function of lower extremity compared to conventional therapy. 18 stroke survivors (sub acute stage) were recruited, 9 of them were randomly assigned to receive conventional treatment and another 9 started the mirror therapy combined with ES treatment. Duration of each session in both interventions was 50 minutes, done 4 times per week over two weeks. After 2 weeks, subjects took one week rest before switching they type of treatment; those started with conventional therapy continued with mirror therapy combined with ES, and vice versa...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227403/abnormal-interhemispheric-resting-state-functional-connectivity-in-primary-open-angle-glaucoma
#9
Peng Zhou, Jieqiong Wang, Ting Li, Ningli Wang, Junfang Xian, Huiguang He, Peng Zhou, Jieqiong Wang, Ting Li, Ningli Wang, Junfang Xian, Huiguang He, Ningli Wang, Junfang Xian, Huiguang He, Ting Li, Jieqiong Wang, Peng Zhou
Glaucoma is the second leading cause of blindness and it has been the topic of massive studies to explore the underlying mechanisms of the disease. Resting-state neuroimaging studies have been widely applied to investigate the functional damage of the brain, but little is known about the alterations of the interhemispheric resting-state functional connectivity (RSFC) in patients with primary open-angle glaucoma (POAG). In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to explore the interhemispheric RSFC of the brain in POAG patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226905/passthoughts-authentication-with-low-cost-eareeg
#10
Max T Curran, Jong-Kai Yang, Nick Merrill, John Chuang, Max T Curran, Jong-Kai Yang, Nick Merrill, John Chuang, Jong-Kai Yang, Max T Curran, John Chuang, Nick Merrill
Personal and wearable computing are moving toward smaller and more seamless devices. We explore how this trend could be mirrored in an authentication scheme based on electroencephalography (EEG) signals collected from the ear. We evaluate this model using a low cost, single-channel, consumer grade device for data collection. Using data from 12 study participants who performed a set of 5 mental tasks, we achieve a 44% reduction in half total error rate (HTER) compared with a random classifier, corresponding to a 72% authentication accuracy in within-participants analyses and a 60% reduction and 80% accuracy in between-participant analyses...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226896/evaluation-of-biofouling-for-implantable-micro-dialysis-system
#11
T Ota, N To, Y Kanno, N Miki, T Ota, N To, Y Kanno, N Miki, T Ota, Y Kanno, N Miki, N To
Implantable artificial kidney can drastically improve the quality of life of the renal disease patients. In previous study, our group has developed a multi-layered micro dialysis device which is composed of micro stainless steel channels and nano-porous polyethersulfone (PES) membranes. The device conducts hemofiltration without dialysis fluids, which is advantageous in miniaturization. We investigated the water-permeability of the PES membrane through in vivo experiments using rat model of renal disease for 5 hours and verified the effectiveness of the device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226711/computer-aided-planning-and-reconstruction-of-cranial-3d-implants
#12
Markus Gall, Xing Li, Xiaojun Chen, Dieter Schmalstieg, Jan Egger, Markus Gall, Xing Li, Xiaojun Chen, Dieter Schmalstieg, Jan Egger, Jan Egger, Markus Gall, Xing Li, Dieter Schmalstieg, Xiaojun Chen
In this contribution, a prototype for semiautomatic computer-aided planning and reconstruction of cranial 3D Implants is presented. The software prototype guides the user through the workflow, beginning with loading and mirroring the patient's head to obtain an initial curvature of the cranial implant. However, naïve mirroring is not sufficient for an implant, because human heads are in general too asymmetric. Thus, the user can perform Laplacian smoothing, followed by Delaunay triangulation, for generating an aesthetic looking and well-fitting implant...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225838/-mental-simulation-in-frontotemporal-dementia
#13
Daniel G Politis, Wanda Y Rubinstein, María E Tabernero
: There is a common network for perception and execution of actions necessary for the acquisition of Theory of Mind, and the mirror neuron system could be the neural substrate. OBJECTIVE: To study the presence of apraxia and their relationship to Theory of Mind in patients with behavioral variant of Frontotemporal Dementia. METHODS: 24 patients were assessed, and the cognitive praxis assessment battery and theory of mind were administered...
May 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28225703/do-acute-hospitalised-patients-in-australia-have-a-different-body-mass-index-to-the-general-australian-population-a-point-prevalence-study
#14
Diane M Dennis, Vicki Carter, Michelle Trevenen, Jacinta Tyler, Luisa Perrella, Erika Lori, Ian Cooper
Objective The aim of the present study was to provide a current snapshot of the body mass index (BMI) of the entire patient cohort of an Australian tertiary hospital on one day and compare these data with current published Australian and state (Western Australia) population norms.Methods A single-centre prospective point prevalence study was performed whereby BMI was calculated following actual measurement of patient weight (nurse) and height (physiotherapist) on one day during 2015. Variables were summarised descriptively, and one-way analysis of variance was used to investigate the relationship between continuous BMI and hospital speciality...
February 23, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28225107/chirality-in-curved-polyaromatic-systems
#15
Michel Rickhaus, Marcel Mayor, Michal Juríček
Carbon allotropes constituted of sp(2)-hybridised carbon atoms display a variety of properties that arise from their delocalised π-conjugated electronic structure. Apart from carbon's planar allotropic form graphene, bent or curved structures, such as carbon nanotubes or fullerenes, respectively, have been discovered. In this Tutorial Review, we analyse and conceptually categorise chiral synthetic molecular fragments of non-planar sp(2)-carbon allotropes, including hypothetical forms of carbon that have been proposed to exist as stable entities...
February 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28225071/resolution-of-tlr2-induced-inflammation-through-manipulation-of-metabolic-pathways-in-rheumatoid-arthritis
#16
Trudy McGarry, Monika Biniecka, Wei Gao, Deborah Cluxton, Mary Canavan, Siobhan Wade, Sarah Wade, Lorna Gallagher, Carl Orr, Douglas J Veale, Ursula Fearon
During inflammation, immune cells activated by toll-like receptors (TLRs) have the ability to undergo a bioenergetic switch towards glycolysis in a manner similar to that observed in tumour cells. While TLRs have been implicated in the pathogenesis of rheumatoid arthritis (RA), their role in regulating cellular metabolism in synovial cells, however, is still unknown. In this study, we investigated the effect of TLR2-activation on mitochondrial function and bioenergetics in primary RA-synovial fibroblast cells (RASFC), and further determined the role of glycolytic blockade on TLR2-induced inflammation in RASFC using glycolytic inhibitor 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28225053/genetically-predicted-milk-consumption-and-bone-health-ischemic-heart-disease-and-type-2-diabetes-a-mendelian-randomization-study
#17
Q Yang, S L Lin, S L Au Yeung, M K Kwok, L Xu, G M Leung, C M Schooling
BACKGROUND/OBJECTIVES: Milk provides protein and micronutrients, and is recommended by some dietary guidelines, particularly for bone health. Meta-analysis of small randomized controlled trials suggests that milk may increase bone mineral density, but they are very heterogeneous. No randomized controlled trial has assessed the effects of milk on major chronic diseases. Previous Mendelian randomization studies of milk did not consider bone health, found no effects on ischemic heart disease (IHD) or type 2 diabetes (T2D) but higher body mass index...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28224497/hidden-markov-models-in-population-genomics
#18
Julien Y Dutheil
With the advent of sequencing techniques population genomics took a major shift. The structure of data sets has evolved from a sample of a few loci in the genome, sequenced in dozens of individuals, to collections of complete genomes, virtually comprising all available loci. Initially sequenced in a few individuals, such genomic data sets are now reaching and even exceeding the size of traditional data sets in the number of haplotypes sequenced. Because all loci in a genome are not independent, this evolution of data sets is mirrored by a methodological change...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28223991/the-comparison-of-expressed-candidate-secreted-proteins-from-two-arbuscular-mycorrhizal-fungi-unravels-common-and-specific-molecular-tools-to-invade-different-host-plants
#19
Laurent Kamel, Nianwu Tang, Mathilde Malbreil, Hélène San Clemente, Morgane Le Marquer, Christophe Roux, Nicolas Frei Dit Frey
Arbuscular mycorrhizal fungi (AMF), belonging to the fungal phylum Glomeromycota, form mutualistic symbioses with roots of almost 80% of land plants. The release of genomic data from the ubiquitous AMF Rhizophagus irregularis revealed that this species possesses a large set of putative secreted proteins (RiSPs) that could be of major importance for establishing the symbiosis. In the present study, we aimed to identify SPs involved in the establishment of AM symbiosis based on comparative gene expression analyses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28223932/cerebrospinal-fluid-levels-of-amyloid-beta-1-43-mirror-1-42-in-relation-to-imaging-biomarkers-of-alzheimer-s-disease
#20
Ina S Almdahl, Camilla Lauridsen, Per Selnes, Lisa F Kalheim, Christopher Coello, Beata Gajdzik, Ina Møller, Marianne Wettergreen, Ramune Grambaite, Atle Bjørnerud, Geir Bråthen, Sigrid B Sando, Linda R White, Tormod Fladby
Introduction: Amyloid beta 1-43 (Aβ43), with its additional C-terminal threonine residue, is hypothesized to play a role in early Alzheimer's disease pathology possibly different from that of amyloid beta 1-42 (Aβ42). Cerebrospinal fluid (CSF) Aβ43 has been suggested as a potential novel biomarker for predicting conversion from mild cognitive impairment (MCI) to dementia in Alzheimer's disease. However, the relationship between CSF Aβ43 and established imaging biomarkers of Alzheimer's disease has never been assessed...
2017: Frontiers in Aging Neuroscience
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