Ariel Waisman, Federico Sevlever, Denisse Saulnier, Marcos Francia, Renata Blanco, Guadalupe Amín, Antonella Lombardi, Celeste Biani, María Belén Palma, Agustina Scarafía, Joaquín Smucler, Alejandro La Greca, Lucía Moro, Gustavo Sevlever, Alejandra Guberman, Santiago Miriuka
In the mouse embryo, the transition from the preimplantation to the postimplantation epiblast is governed by changes in the gene regulatory network (GRN) that lead to transcriptional, epigenetic, and functional changes. This transition can be faithfully recapitulated in vitro by the differentiation of mouse embryonic stem cells (mESCs) to epiblast-like cells (EpiLCs), that reside in naïve and formative states of pluripotency, respectively. However, the GRN that drives this conversion is not fully elucidated...
May 7, 2024: Scientific Reports