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Jian-Rong Guo, Huan Wang, Xiao-Ju Jin, Dong-Lin Jia, Xun Zhou, Qiang Tao
OBJECTIVE: To explore the effects of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain (CNP) and spinal microglia in a rat model of chronic constriction injury (CCI). METHODS: Male SD rats were assigned into control, sham, CCI, wortmannin, dimethyl sulfoxide (DMSO) and wortmannin-positive control groups. Paw withdrawal mechanical threshold (PWMT) and thermal withdrawal latency (TWL) were recorded. qRT-PCR and Western blotting were used to detect PI3K, Akt and mTOR expressions and their phosphorylation...
August 8, 2017: Oncotarget
Jian-Rong Guo, Huan Wang, Xiao-Ju Jin, Dong-Lin Jia, Xun Zhou, Qiang Tao
OBJECTIVE: To explore the effects of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain (CNP) and spinal microglia in a rat model of chronic constriction injury (CCI). METHODS: Male SD rats were assigned into control, sham, CCI, wortmannin, dimethyl sulfoxide (DMSO) and wortmannin-positive control groups. Paw withdrawal mechanical threshold (PWMT) and thermal withdrawal latency (TWL) were recorded. qRT-PCR and Western blotting were used to detect PI3K, Akt and mTOR expressions and their phosphorylation...
May 5, 2017: Oncotarget
Yan-Ning Wang, Wan-Chun Zhu, Qi-Sheng Huo, Jie-Hui Yu, Ji-Qing Xu
A new 3-D Zn(2+) coordination polymer (CP) [(CH3)2NH2]3[Zn6(ox)4.5(trz)6]⋅4H2O (ox=oxalate; trz=1,2,4-triazolate) 1 was obtained by a simple solvothermal self-assembly. The crystal structural analysis demonstrates that the trz molecules link the Zn(2+) ions into a two-dimensional (2-D) layer network, which is based on the trinuclear Zn3(trz)6 clusters. The ox molecules serve as the linkers to propagate the 2-D layers into a three-dimensional (3-D) network of 1. The thermogravimetry (TG) behavior, photoluminescence property, and the sensing ability of 1 are investigated...
May 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ali Özcan, Salih İlkbaş
In this study, we have performed the preparation of over-oxidized poly(3,4-ethylenedioxythiophene) nanofibers modified pencil graphite electrode (Ox-PEDOT-nf/PGE) to develop a selective and sensitive voltammetric uric acid (UA) sensor. It was noted that the over-oxidation potential and time had a prominent effect on the UA response of the Ox-PEDOT-nf/PGE. Characterizations of PEDOT-nf/PGE and Ox-PEDOT-nf/PGE have been performed by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy and Raman spectroscopy...
September 3, 2015: Analytica Chimica Acta
Gideon Charach, Yoav Michowitz, Ori Rogowski, Lior Charach, Ori Argov, Jacob George, Itamar Grosskopf
Elevated level of antibodies to oxidized low-density lipoproteins (OxLDL-Ab) was shown to reliably predict morbidity and mortality in patients with heart failure (HF). Two hundred and eleven patients aged ≥65 years treated at the Heart Failure Unit, Tel Aviv-Sourasky Medical Center, were included in this retrospective study. The end points were time to the first hospitalization (morbidity), all-cause mortality, and a combination of the two (composite outcome). HF duration ranged from 8 to 10.5 years. Mean follow-up was 5...
November 1, 2015: American Journal of Cardiology
I Gryca, J Palion-Gazda, B Machura, M Penkala, R Kruszyński, J Cano, F Lloret, M Julve
Two new Re(iv) compounds of formulae H2tppz[ReCl6] (1) and [Cu(bpzm)2(μ-Cl)ReCl3(μ-ox)Cu(bpzm)2(μ-ox)ReCl3(μ-Cl)]n (2) [tppz = 2,3,5,6-tetrakis(2-pyridyl)pyrazine and bpzm = bis(pyrazolyl-1-yl)methane] have been prepared and their crystal structures determined by X-ray diffraction on single crystals. Compound 1 is a mononuclear species whose structure consists of octahedral hexachlororhenate(iv) anions and diprotonated H2tppz(2+) cations which are arranged in the unit cell as alternating anionic and cationic layers, held together by electrostatic forces...
October 21, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Wei-Hui Fang, Lei Zhang, Jian Zhang, Guo-Yu Yang
Two sandwiched cluster organic frameworks, Eu6 (OH)2 Cu9 I6 L12 (ox)3 ⋅H2 O⋅ClO4 (FJ-23, HL=4-pyridin- 4-yl-benzonic acid, ox=oxalate) and Eu6 Cu7 I7 L12 (OAc)6 (H2 O)2 ⋅2 H2 O (FJ-24, OAc=acetate) with bnn hexagonal BN topologies have been successfully made; these frameworks were assembled by nanosized graphene-like lanthanide wheel clusters and nanoscale trigonal prism metalloligands. The cooperation of small equatorial ligands and axially trigonal prism metalloligands plays a key role in the construction of such 5-connected nets...
October 26, 2015: Chemistry: a European Journal
Wenhua Zhao, Viktoria Haller, Andreas Ritsch
OBJECTIVES: Atherosclerosis is the major cause of cardiovascular disease. Epidemiological studies showed that the plasma concentration of high-density lipoprotein (HDL) cholesterol level is inversely related to the incidence of atherosclerosis probably due to its role in reverse cholesterol transport. 1,2,3,4, 6-penta-O-galloyl-β-d-glucose (PGG) is a prototypical gallotannin and the central compound in the biosynthetic pathway of hydrolysable tannin. PGG is highly enriched in a number of medicinal herbals...
October 2015: Atherosclerosis
Ewa Tomaszewska, Piotr Dobrowolski, Marek Bieńko, Łukasz Prost, Sylwia Szymańczyk, Adam Zdybel
The structural quality of the connective tissue is genetically determined and is influenced by hormonal and nutritional modification. An effect of a 2-Ox-rich diet on bone mineralization and structure and expression of non-collagenous protein in articular and growth cartilages of maternal dexamethasone-treated 9-month-old boars was considered in this study. Sows were treated i.m. with dexamethasone at the dose of 0.03 mg kg(-1) body weight every second day during the last 45 days of pregnancy. After the birth, the boars were divided into two groups: administered and not supplemented with 2-Ox for 9 months (0...
November 2015: Connective Tissue Research
Daniele Sanna, Valeria Ugone, Giovanni Micera, Tiziana Pivetta, Elisa Valletta, Eugenio Garribba
The speciation of the potential antitumor agent vanadocene dichloride ([Cp2VCl2], abbreviated with VDC) in the blood plasma was studied by instrumental (EPR, ESI-MS, MS-MS, and electronic absorption spectroscopy) and computational (DFT) methods. The behavior of VDC at pH 7.4 in aqueous solution, the interaction with the most important bioligands of the plasma (oxalate, carbonate, phosphate, lactate, citrate, histidine, and glycine among those with low molecular mass and transferrin and albumin between the proteins) was evaluated...
September 8, 2015: Inorganic Chemistry
Ramazan Tatsız, Veli T Kasumov, Tuncay Tunc, Tuncer Hökelek
The asymmetric unit of the title compound, C22H25F2N4O2, contains two crystallographically independent mol-ecules. In one mol-ecule, the two benzene rings are oriented at a dihedral angle of 1.93 (10)° and in the other mol-ecule the corresponding dihedral angle is 7.19 (9)°. The piperidine rings in the two mol-ecules adopt a similar distorted chair conformation, and both have pseudo-mirror planes passing through the N-O bonds. An intra-molecular O-H⋯N hydrogen bond between the hy-droxy group and the imine N atom is observed in both mol-ecules...
July 1, 2015: Acta Crystallographica. Section E, Crystallographic Communications
Chao Chang, Hua Yang, Shuan-Li Xin, Ji-Xiang Liu, Xiu-Feng Zhao, Li-Jun Liu, Li-Ying Han, Li-Min Meng, Qin Li
OBJECTIVE: Macrophage apoptosis plays a key role in atherosclerotic plaque rupture. This study investigated the effects of recombinant human brain natriuretic peptide (BNP) on oxidised low-density lipoprotein (ox-LDL)-induced macrophage apoptosis and explored the underlying mechanism. METHODS: A model of ox-LDL-induced macrophage injury was established to evaluate the role of BNP. Flow cytometry was employed to detect apoptosis and changes in mitochondrial membrane potential (x0394;x03A8;m), and confocal microscopy was used to determine cellular reactive oxygen species (ROS) levels...
2015: Cardiology
Songchen Xu, Jeffery S Boschen, Abhranil Biswas, Takeshi Kobayashi, Marek Pruski, Theresa L Windus, Aaron D Sadow
An electrophilic, coordinatively unsaturated rhodium complex supported by borate-linked oxazoline, oxazoline-coordinated silylene, and N-heterocyclic carbene donors [{κ(3)-N,Si,C-PhB(Ox(Me2))(Ox(Me2)SiHPh)Im(Mes)}Rh(H)CO][HB(C6F5)3] (, Ox(Me2) = 4,4-dimethyl-2-oxazoline; Im(Mes) = 1-mesitylimidazole) is synthesized from the neutral rhodium silyl {PhB(Ox(Me2))2Im(Mes)}RhH(SiH2Ph)CO () and B(C6F5)3. The unusual oxazoline-coordinated silylene structure in is proposed to form by rearrangement of an unobserved isomeric cationic rhodium silylene species [{PhB(Ox(Me2))2Im(Mes)}RhH(SiHPh)CO][HB(C6F5)3] generated by H abstraction...
September 28, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Paul-Steffen Kuhn, Laura Cremer, Anatolie Gavriluta, Katarina K Jovanović, Lana Filipović, Alfred A Hummer, Gabriel E Büchel, Biljana P Dojčinović, Samuel M Meier, Annette Rompel, Siniša Radulović, Jean Bernard Tommasino, Dominique Luneau, Vladimir B Arion
A series of heteropentanuclear oxalate-bridged Ru(NO)-Ln (4d-4f) metal complexes of the general formula (nBu4N)5[Ln{RuCl3(μ-ox)(NO)}4], where Ln=Y (2), Gd (3), Tb (4), Dy (5) and ox=oxalate anion, were obtained by treatment of (nBu4N)2[RuCl3(ox)(NO)] (1) with the respective lanthanide salt in 4:1 molar ratio. The compounds were characterized by elemental analysis, IR spectroscopy, electrospray ionization (ESI) mass spectrometry, while 1, 2, and 5 were in addition analyzed by X-ray crystallography, 1 by Ru K-edge XAS and 1 and 2 by (13)C NMR spectroscopy...
September 21, 2015: Chemistry: a European Journal
Xueqing Liu, Wenjia Sun, Yanyang Zhao, Beidong Chen, Wei Wu, Li Bao, Ruomei Qi
AIM: To investigate the effect of ginkgolide B on junction proteins and the reduction of monocyte migration in oxidized low-density lipoprotein- (ox-LDL-) treated endothelial cells. METHODS: Human umbilical vein endothelial cells (HUVECs) were used in the present study. Immunofluorescence and Western blot were performed to determine the expression of junctional adhesion molecule-A (JAM-A), connexin 43 (Cx43), and vascular endothelial cadherin (VE-cadherin). Monocyte migration was detected by the Transwell assay...
2015: Oxidative Medicine and Cellular Longevity
Du Seok Choi, Nak Hyun Kim, Byung Kook Hwang
Phosphoenolpyruvate carboxykinase, a member of the lyase family, is involved in the metabolic pathway of gluconeogenesis in organisms. Although the major function of PEPCK in gluconeogenesis is well established, it is unclear whether this enzyme is involved in plant immunity. Here, we isolated and identified the pepper (Capsicum annuum) PEPCK (CaPEPCK1) gene from pepper leaves infected with Xanthomonas campestris pv. vesicatoria (Xcv). CaPEPCK1 was strongly expressed in pepper leaves during the incompatible interaction with avirulent Xcv and in response to environmental stresses, especially salicylic acid (SA) treatment...
September 2015: Plant Molecular Biology
Ahmed A Soliman, Othman I Alajrawy, Fawzy A Attabi, Mohamed R Shaaban, W Linert
A series of new ternary palladium(II) complexes of the type [Pd(L1-4)ox]·xH2O where L=formamidine ligands and ox=oxalate, were synthesized and characterized by elemental analyses, magnetic susceptibility, UV-Vis, infrared (IR) and mass spectroscopy and thermal analysis. The spectroscopic data indicated that the formamidine ligands act as bidentate N2 donors and the oxalate as O2 ligand. The complexes (1-4) are diamagnetic and the optimization of their structures indicated that the geometry is distorted square planer with O-Pd-O and N-Pd-N bond angles ranged 82...
January 5, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Rafael Manfro, Fabiano Silva Fonseca, Marcelo Carlos Bortoluzzi, Wilson Roberto Sendyk
INTRODUCTION: Anorganic bovine xenogenous grafts show the best performance as bone substitutes in implantodontics. Bio-Oss is the world's most widely used and investigated anorganic bone substitute. This article compares two anorganic bovine bone substitutes (Bone-Fill and Gen-Ox anorganic) with Bio-Oss. MATERIALS AND METHODS: Eight New Zealand rabbits were implanted with 4 titanium cylinders randomly filled with Bio-Oss, Bone-Fill, Gen-Ox anorganic or a blood clot...
December 2014: Journal of Maxillofacial and Oral Surgery
Ryota Sakamoto, Kiyohito Okumiya, Hongxin Wang, Qingxiang Dai, Michiko Fujisawa, Taizo Wada, Hissei Imai, Yumi Kimura, Yasuko Ishimoto, Eriko Fukutomi, Wingling Chen, Kwanchit Sasiwongsaroj, Emiko Kato, Ri-Li Ge, Kozo Matsubayashi
OBJECTIVE: Several environmental factors including hypoxia have been reported to contribute to oxidative stress in individuals living in the highlands. However, little is known about the role of oxidized low-density lipoprotein (ox-LDL) among community-dwelling elderly in the Qinghai-Tibet plateau. METHODS: The study population comprised 168 community-dwelling elderly subjects aged 60 years or older (male to female ratio, 70:98; mean age, 65.8 years) living in Haiyan County, located 3000 to 3200 m above sea level, 30 km northwest of Xining, Qinghai...
September 2015: Wilderness & Environmental Medicine
Piotr Dobrowolski, Ewa Tomaszewska, Paulina Kurlak, Stefan G Pierzynowski
Gastrectomy (Gx) leads to osteopenia/osteoporosis in humans and animals. However, little is known about the influence of Gx on the cartilage in this regard. Recent studies have demonstrated a protective effect of 2-oxoglutaric acid (2-Ox) on bone and cartilage. Hence, the purpose of this study was to investigate whether 2-Ox can mitigate eventual Gx-induced cartilage impairment. Twenty female Sprague-Dawley rats were subjected to Gx and randomly divided into two groups: Gx + 2-Ox and Gx. Another 20 rats were sham-operated (ShO) and randomly divided into two groups: ShO + 2-Ox and ShO...
January 2016: Experimental Biology and Medicine
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