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https://www.readbyqxmd.com/read/28101487/immunoglobulin-g4-related-thyroid-diseases
#1
REVIEW
Dulani Kottahachchi, Duncan J Topliss
Immunoglobulin G4-related disease (IgG4-RD) is a new disease category involving many organ systems, including the endocrine system in general and the thyroid in particular. Since an initial association was made between hypothyroidism and autoimmune (IgG4-related) pancreatitis, more forms of IgG4-related thyroid disease (IgG4-RTD) have been recognized. Four subcategories of IgG4-RTD have so far been identified: Riedel thyroiditis (RT), fibrosing variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis, and Graves disease with elevated IgG4 levels...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101403/quantitative-assessment-of-hemodynamic-and-structural-characteristics-of-in-vivo-brain-tissue-using-total-diffuse-reflectance-spectrum-measured-in-a-non-contact-fashion
#2
Yinchen Song, Sarahy Garcia, Yisel Frometa, Jessica C Ramella-Roman, Mohammad Soltani, Mohamed Almadi, Jorge J Riera, Wei-Chiang Lin
Here we present a new methodology that investigates the intrinsic structural and hemodynamic characteristics of in vivo brain tissue, in a non-contact fashion, and can be easily incorporated in an intra-operative environment. Within this methodology, relative total diffuse reflectance spectra (RTD(λ)) were acquired from targets using a hybrid spectroscopy imaging system. A spectral interpretation algorithm was subsequently applied to RTD(λ) to retrieve optical properties related to the compositional and structural characteristics of each target...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28069390/continuous-direct-compression-as-manufacturing-platform-for-sustained-release-tablets
#3
B Van Snick, J Holman, C Cunningham, A Kumar, J Vercruysse, T De Beer, J P Remon, C Vervaet
This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two HPMC grades were evaluated as matrix former: standard Methocel CR and directly compressible Methocel DC2. The feeding behavior of each formulation component was investigated by deriving feed factor profiles. The maximum feed factor was used to estimate the drive command which strongly depended upon the density of the material...
January 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28033501/investigation-of-holdup-and-axial-dispersion-of-liquid-phase-in-a-catalytic-exchange-column-using-radiotracer-technique
#4
Rajesh Kumar, H J Pant, Sunil Goswami, V K Sharma, A Dash, S Mishra, K Bhanja, Sadhana Mohan, S M Mahajani
Holdup and axial dispersion of liquid phase in a catalytic exchange column were investigated by measuring residence time distributions (RTD) using a radiotracer technique. RTD experiments were independently carried out with two different types of packings i.e. hydrophobic water-repellent supported platinum catalyst and a mixture (50% (v/v)) of hydrophobic catalyst and a hydrophillic wettable packing were used in the column. Mean residence times and hold-ups of the liquid phase were estimated at different operating conditions...
December 7, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27994858/renal-tubular-dysgenesis-antenatal-ultrasound-scanning-and-molecular-investigations-in-a-saudi-arabian-family
#5
Mohamed H Al-Hamed, Wesam Kurdi, Nada Alsahan, Qaamariya Ambosaidi, Maha Tulbah, John A Sayer
Autosomal recessive renal tubular dysgenesis (RTD) is a rare lethal disease affecting renal development before birth. RTD is manifested by anuria and severe hypotension resulting in oligohydramnios and birth defects known as Potter's syndrome. Homozygous or compound heterozygous mutations in genes encoding components of the renin-angiotensin system (ACE, AGT, AGTR1 and REN) have been reported to cause RTD. A consanguineous family with a history of multiple stillbirths was investigated using prenatal ultrasound and molecular genetic analysis of an affected foetus...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27990798/poly-ethylene-glycol-crowding-as-critical-factor-to-determine-pdna-packaging-scheme-into-polyplex-micelles-for-enhanced-gene-expression
#6
Kaori M Takeda, Kensuke Osada, Theofilus A Tockary, Anjaneyulu Dirisala, Qixian Chen, Kazunori Kataoka
A critical role of polyethylene glycol (PEG) crowding in the packaging of plasmid DNA (pDNA) into polyplex micelles (PMs) was investigated using a series of PEG-b-poly(l-lysine) (PEG-PLys) block copolymers with varying molecular weights of both PEG and PLys segments. Rod-shaped PMs preferentially formed when the tethered PEG chains covering pDNA in a precondensed state were dense enough to overlap one another (reduced tethering density (RTD) > 1), whereas globular PMs were obtained when they were not overlapped (RTD < 1)...
December 19, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27941163/effects-of-accumulating-work-shifts-on-performance-based-fatigue-using-multiple-strength-measurements-in-day-and-night-shift-nurses-and-aides
#7
Brennan J Thompson, Matt S Stock, Victoria K Banuelas
OBJECTIVE: This study aimed to examine the effects of accumulating nursing work on maximal and rapid strength characteristics in female nurses and compare these effects in day versus night shift workers. BACKGROUND: Nurses exhibit among the highest nonfatal injury rates of all occupations, which may be a consequence of long, cumulative work shift schedules. Fatigue may accumulate across multiple shifts and lead to performance impairments, which in turn may be linked to injury risks...
December 9, 2016: Human Factors
https://www.readbyqxmd.com/read/27930453/whole-body-vibration-improves-early-rate-of-torque-development-in-individuals-with-acl-reconstruction
#8
Derek N Pamukoff, Brian Pietrosimone, Eric D Ryan, Dustin R Lee, Lee E Brown, J Troy Blackburn
The purpose of this study was to compare the effect of whole body vibration (WBV) and local muscle vibration (LMV) on early and late quadriceps rate of torque development (RTD), and electromechanical delay (EMD) in individuals with anterior cruciate ligament reconstruction (ACLR). 20 individuals with ACLR were recruited for this study. Participants performed isometric squats while being exposed to WBV, LMV, or no vibration (control) in a randomized order during separate visits. Quadriceps early and late quadriceps RTD, and EMD were assessed during a maximal voluntary isometric knee extension prior to and immediately following WBV, LMV, or control...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27923590/expression-and-the-antigenicity-of-recombinant-coat-proteins-of-tungro-viruses-expressed-in-escherichia-coli
#9
Siew Fung Yee, Chia Huay Chu, Evenni Poili, Magdline Sia Henry Sum
Rice tungro disease (RTD) is a recurring disease affecting rice farming especially in the South and Southeast Asia. The disease is commonly diagnosed by visual observation of the symptoms on diseased plants in paddy fields and by polymerase chain reaction (PCR). However, visual observation is unreliable and PCR can be costly. High-throughput as well as relatively cheap detection methods are important for RTD management for screening large number of samples. Due to this, detection by serological assays such as immunoblotting assays and enzyme-linked immunosorbent assay are preferred...
February 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/27916700/elucidation-and-visualization-of-solid-state-transformation-and-mixing-in-a-pharmaceutical-mini-hot-melt-extrusion-process-using-in-line-raman-spectroscopy
#10
Jeroen Van Renterghem, Ashish Kumar, Chris Vervaet, Jean Paul Remon, Ingmar Nopens, Yvan Vander Heyden, Thomas De Beer
Mixing of raw materials (drug+polymer) in the investigated mini pharma melt extruder is achieved by using co-rotating conical twin screws and an internal recirculation channel. In-line Raman spectroscopy was implemented in the barrels, allowing monitoring of the melt during processing. The aim of this study was twofold: to investigate (I) the influence of key process parameters (screw speed - barrel temperature) upon the product solid-state transformation during processing of a sustained release formulation in recirculation mode; (II) the influence of process parameters (screw speed - barrel temperature - recirculation time) upon mixing of a crystalline drug (tracer) in an amorphous polymer carrier by means of residence time distribution (RTD) measurements...
December 1, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27892984/anatomical-distributions-of-basal-cell-carcinoma-and-squamous-cell-carcinoma-in-a-population-based-study-in-queensland-australia
#11
Padmini Subramaniam, Catherine M Olsen, Bridie S Thompson, David C Whiteman, Rachel E Neale
Importance: Keratinocyte cancers (KCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancers among fair-skinned populations worldwide. Although studies have indicated that the anatomical distribution of BCC and SCC differ, few have compared them directly in well-defined population samples. Objectives: To describe and compare the anatomical distribution of BCC and SCC in a population-based sample in Queensland, Australia...
November 23, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27872640/nucleotide-analogue-related-proximal-renal-tubular-dysfunction-during-long-term-treatment-of-chronic-hepatitis-b-a-cross-sectional-study
#12
Abhasnee Sobhonslidsuk, Jirachaya Wanichanuwat, Pawin Numthavaj, Areepan Sophonsritsuk, Supanna Petraksa, Alongkorn Pugasub, Paisan Jittorntam, Anucha Kongsomgan, Sittiruk Roytrakul, Bunyong Phakdeekitcharoen
Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria were patients who were on adefovir or tenofovir as mono- or add-on therapy with lamivudine (LAM) >1 year. Serum and urine were collected. Fractional excretion of phosphate (FEPO4), uric acid (FEUA), and potassium was calculated...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27816610/forward-psychiatry%C3%A2-%C3%A2-early-intervention-for-mental-health-problems-among-uk-armed-forces-in-afghanistan
#13
N Jones, N T Fear, S Wessely, G Thandi, N Greenberg
BACKGROUND: This observational study examined return to duty (RTD) rates following receipt of early mental health interventions delivered by deployed mental health practitioners. METHOD: In-depth clinical interviews were conducted among 975 UK military personnel referred for mental health assessment whilst deployed in Afghanistan. Socio-demographic, military, operational, clinical and therapy outcomes were recorded in an electronic health record database. Rates and predictors of EVAC were the main outcomes examined using adjusted binary logistic regression analyses...
November 3, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27708537/construction-and-evaluation-of-cytomegalovirus-dna-quantification-system-with-real-time-detection-polymerase-chain-reaction
#14
Yuki Hatayama, Yuki Hashimoto, Ayako Hara, Toru Motokura
BACKGROUND: For patients with reactivation of human cytomegalovirus (CMV), a highly sensitive and accurate CMV quantification system is essential to monitor viral load. METHODS: We constructed a real-time detection PCR (RTD-PCR) system for CMV DNA and evaluated its linearity, lower detection limit, dynamic range and accuracy using two CMV standards. We used 219 clinical samples derived from 101 patients to compare the system with the pp65 antigen test. RESULTS: The 95% detection limit was determined to be 556 IU/mL (95% CI, 440-797 IU/mL), and the quantification range was between 10(2) and 10(6) copies or IU/mL (r = 0...
September 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/27705850/fate-and-mass-balance-of-contaminants-of-emerging-concern-during-wastewater-treatment-determined-using-the-fractionated-approach
#15
Zeina Baalbaki, Tamanna Sultana, Thomas Maere, Peter A Vanrolleghem, Chris D Metcalfe, Viviane Yargeau
Contaminants of emerging concern (CECs) are often poorly removed from wastewater using conventional treatment technologies and there is limited understanding of their fate during treatment. Inappropriate sampling strategies lead to inaccuracies in estimating removals of CECs. In this study, we used the "fractionated approach" that accounts for the residence time distribution (RTD) in treatment units to investigate the fate of 26 target CECs in a municipal wastewater treatment plant (WWTP) that includes primary, secondary and tertiary treatment steps...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27670838/patterns-of-structural-and-defense-investments-in-fine-roots-of-scots-pine-pinus-sylvestris-l-across-a-strong-temperature-and-latitudinal-gradient-in-europe
#16
Marcin Zadworny, M Luke McCormack, Roma Żytkowiak, Piotr Karolewski, Joanna Mucha, Jacek Oleksyn
Plant functional traits may be altered as plants adapt to various environmental constraints. Cold, low fertility growing conditions are often associated with root adjustments to increase acquisition of limiting nutrient resources, but they may also result in construction of roots with reduced uptake potential but higher tissue persistence. It is ultimately unclear whether plants produce fine roots of different structure in response to decreasing temperatures and whether these changes represent a trade-off between root function or potential root persistence...
September 27, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27659901/high-quality-reference-transcript-datasets-hold-the-key-to-transcript-specific-rna-sequencing-analysis-in-plants
#17
REVIEW
John W S Brown, Cristiane P G Calixto, Runxuan Zhang
525 I. 525 II. 526 III. 527 IV. 527 V. 529 VI. 529 529 References 529 SUMMARY: Re-programming of the transcriptome involves both transcription and alternative splicing (AS). Some genes are regulated only at the AS level with no change in expression at the gene level. AS data must be incorporated as an essential aspect of the regulation of gene expression. RNA-sequencing (RNA-seq) can deliver both transcriptional and AS information, but accurate methods to analyse the added complexity in RNA-seq data are needed...
January 2017: New Phytologist
https://www.readbyqxmd.com/read/27620399/torque-onset-determination-unintended-consequences-of-the-threshold-method
#18
Raffy Dotan, Glenn Jenkins, Thomas D O'Brien, Steve Hansen, Bareket Falk
BACKGROUND: Compared with visual torque-onset-detection (TOD), threshold-based TOD produces onset bias, which increases with lower torques or rates of torque development (RTD). PURPOSE: To compare the effects of differential TOD-bias on common contractile parameters in two torque-disparate groups. METHODS: Fifteen boys and 12 men performed maximal, explosive, isometric knee-extensions. Torque and EMG were recorded for each contraction. Best contractions were selected by peak torque (MVC) and peak RTD...
December 2016: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/27592862/echo-intensity-and-muscle-thickness-as-predictors-of-athleticism-and-isometric-strength-in-middle-school-boys
#19
Matt S Stock, Jacob A Mota, Jennah M Hernandez, Brennan J Thompson
INTRODUCTION: We examined correlations among echo intensity and muscle thickness versus measures of athleticism and isometric strength in healthy children. METHODS: B-mode ultrasonography was used to examine the vastus lateralis (VL) and rectus femoris (RF) in 28 boys (mean age = 12 years). Tests of athleticism included jump height and peak velocity, sprint speed, and agility. Peak torque and the rate of torque development (RTD) at 100 and 200 milliseconds from torque onset were assessed...
September 4, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27585090/comparison-of-cutting-oil-emulsion-treatment-by-electrocoagulation-flotation-in-bubble-column-and-airlift-reactors
#20
Nattawin Chawaloesphonsiya, Chayanin Prommajun, Kritchart Wongwailikhit, Pisut Painmanakul
Separation of nanoscale oil droplets in the cutting-oil emulsion by electrocoagulation-flotation (ECF) was carried out in a bubble column reactor (BCR) and an external-loop airlift reactor (ALR). Under the batch operation, aluminium electrode provided the highest efficiency of 99% and required the shortest separating time compared to iron and graphite electrodes. The separation performance was also affected by the electrode gap and current density due to the amount of produced aluminium ions and turbulence by bubble motions...
September 1, 2016: Environmental Technology
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