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https://www.readbyqxmd.com/read/29783024/a-pooled-analysis-of-the-phase-3-revive-trials-randomized-double-blind-studies-to-evaluate-the-safety-and-efficacy-of-iclaprim-versus-vancomycin-for-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#1
David B Huang, G Ralph Corey, Thomas L Holland, Thomas Lodise, William O'Riordan, Mark H Wilcox, Thomas M File, Matthew Dryden, Barbara Balser, Eve Desplats, Antoni Torres
BACKGROUND: Iclaprim, a diaminopyrimidine antibiotic, was compared with vancomycin for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) in two studies (REVIVE-1 and REVIVE-2). OBJECTIVES: We explored the efficacy and tolerability of iclaprim in a pooled analysis of results from both studies. METHODS: REVIVE-1 and REVIVE-2 were Phase 3, double-blind, randomized (1:1), multicenter, active-controlled, non-inferiority (margin of 10%) trials, each designed to enroll 600 patients a piece with ABSSSI...
May 18, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29782939/global-deletion-of-tetraspanin-cd82-attenuates-bone-growth-and-enhances-bone-marrow-adipogenesis
#2
Alexis Bergsma, Sourik S Ganguly, Daniel Dick, Bart O Williams, Cindy K Miranti
CD82 is a widely expressed member of the tetraspanin family of transmembrane proteins known to control cell signaling, adhesion, and migration. Tetraspanin CD82 is induced over 9-fold during osteoclast differentiation in vitro; however, its role in bone homeostasis is unknown. A globally deleted CD82 mouse model was used to assess the bone phenotype. Based on microCT and 4-point bending tests, CD82-deficient bones are smaller in diameter and weaker, but display no changes in bone density. Histomorphometry shows a decrease in size, erosion perimeter, and number of osteoclasts in situ, with a corresponding increase in trabecular surface area, specifically in male mice...
May 18, 2018: Bone
https://www.readbyqxmd.com/read/29782617/patient-specific-neurosurgical-phantom-assessment-of-visual-quality-accuracy-and-scaling-effects
#3
Felipe Wilker Grillo, Victor Hugo Souza, Renan Hiroshi Matsuda, Carlo Rondinoni, Theo Zeferino Pavan, Oswaldo Baffa, Helio Rubens Machado, Antonio Adilton Oliveira Carneiro
Background: Training in medical education depends on the availability of standardized materials that can reliably mimic the human anatomy and physiology. One alternative to using cadavers or animal bodies is to employ phantoms or mimicking devices. Styrene-ethylene/butylene-styrene (SEBS) gels are biologically inert and present tunable properties, including mechanical properties that resemble the soft tissue. Therefore, SEBS is an alternative to develop a patient-specific phantom, that provides real visual and morphological experience during simulation-based neurosurgical training...
2018: 3D Print Med
https://www.readbyqxmd.com/read/29782307/cutaneous-manifestations-of-tuberous-sclerosis
#4
Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782150/-site-and-mutation-specific-predictions-enable-minimal-directed-evolution-libraries
#5
Jeffrey C Moore, Agustina Rodriguez-Granillo, Alejandro Crespo, Sridhar Govindarajan, Mark Welch, Kaori Hiraga, Katrina Lexa, Nicholas Marshall, Matthew David Truppo
Directed evolution experiments designed to improve the activity of a biocatalyst have increased in sophistication from the early days of completely random mutagenesis. Sequence-based and structure-based methods have been developed to identify "hotspot" positions that when randomized provide a higher frequency of beneficial mutations that improve activity. These focused mutagenesis methods reduce library sizes and therefore reduce screening burden, accelerating the rate of finding improved enzymes...
May 21, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29782141/in-situ-assembly-of-well-dispersed-ag-nanoparticles-throughout-electrospun-alginate-nanofibers-for-monitoring-human-breath-smart-fabrics
#6
Jun Zhang, Xiao-Xiong Wang, Bin Zhang, Seeram Ramakrishna, Miao Yu, Jian-Wei Ma, Yun-Ze Long
Alginate nanofibers assembled with sliver nanoparticles throughout the whole nanofiber were fabricated by three steps including electrospinning of Na-alginate nanofibers, ion exchange between the sodium and silver ions, and in situ reduction of silver nanoparticles. The content, distribution and size of the nanoparticles are controllable by tuning reaction conditions. Ag/alginate nanofibers exhibit good humidity sensitivity in a wide humidity range from ambient RH (20%) to 85% RH. Interestingly, these humidity sensors can be attached to a 3M-9001V mask for monitoring human breath during exercise and emotion changes, and this smart exhibits accurate and continuous human-breath tracking no matter how fast or slow as well as how deep or shallow...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29781911/what-is-the-frequency-of-early-dissociation-of-bipolar-cups-and-what-factors-are-associated-with-dissociation
#7
Young-Kyun Lee, Chan Ho Park, Yong-Chan Ha, Kyung-Hoi Koo
BACKGROUND: Dissociation between a prosthetic cup and femoral head is a rare complication of bipolar hemiarthroplasty that usually occurs during closed reduction of a dislocated bipolar cup. The dissociation usually results in reoperation because closed reduction is challenging. To our knowledge, no study has reported on the frequency of bipolar cup-femoral head dissociation, and risk factors for dissociation are unknown. QUESTIONS/PURPOSES: The purposes of this study were (1) to evaluate the frequency of dissociation of prosthetic femoral heads from bipolar cups during manual reduction of a dislocated bipolar hemiarthroplasty; and (2) to explore in a preliminary fashion any prosthesis or patient factors that may be associated with dissociation...
May 17, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29781411/phenotypic-plasticity-in-clutch-size-regulation-among-populations-of-a-potential-invasive-fruit-fly-from-environments-that-vary-in-host-heterogeneity-and-isolation
#8
M Aluja, A Birke, F Díaz-Fleischer, J Rull
Phenotypic plasticity is thought to evolve in response to environmental unpredictability and can shield genotypes from selection. However, selection can also act on plastic traits. Egg-laying behaviour, including clutch size regulation, is a plastic behavioural trait among tephritid fruit flies. We compared plasticity in clutch size regulation among females of Anastrepha ludens populations stemming from environments that differed in the degree of predictability in egg-laying opportunities. Clutch size regulation in response to hosts of different sizes was compared among flies from (a) a wild, highly isolated population, (b) a wild population that switches seasonally from a small wild host fruit that varies greatly in abundance to an abundant large-sized commercial host, and (c) a laboratory population...
May 21, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29780971/acquisition-of-bioelectrical-signals-with-small-electrodes
#9
Vijay Viswam, Marie Obien, Urs Frey, Felix Franke, Andreas Hierlemann
Although the mechanisms of recording bioelectrical signals from different types of electrogenic cells (neurons, cardiac cells etc.) by means of planar metal electrodes have been extensively studied, the recording characteristics and conditions for very small electrode sizes are not yet established. Here, we present a combined experimental and computational approach to elucidate, how the electrode size influences the recorded signals, and how inherent properties of the electrode, such as impedance, noise, and transmission characteristics shape the signal...
March 29, 2018: IEEE Biomedical Circuits and Systems Conference: Healthcare Technology: [proceedings]
https://www.readbyqxmd.com/read/29780915/solitary-retinal-hemangioblastoma-findings-in-octa-pre-and-post-laser-therapy
#10
Brian W Chou, Peter L Nesper, Lee M Jampol, Rukhsana G Mirza
Purpose: To report optical coherence tomography angiography (OCTA) findings pre- and post-thermal laser therapy of a rare, asymptomatic, unilateral, isolated retinal hemangioblastoma. Observations: A 40-year-old asymptomatic Caucasian man was found to have an isolated, unilateral retinal hemangioblastoma after referral for possible retinal hole. Comparison of OCTAs pre- and post-thermal laser therapy demonstrated a significant reduction of blood flow toward and within the lesion, in addition to contraction of the lesion and constriction of the accompanying feeder vessels...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780829/the-effect-of-c-arm-mobility-and-field-of-vision-on-radiation-exposure-in-the-treatment-of-proximal-femoral-fractures-a-randomized-clinical-trial
#11
Mahmut Kalem, Kerem Başarır, Hakan Kocaoğlu, Ercan Şahin, Hakan Kınık
Objectives: To examine the effect of fluoroscopy devices with different sizes of image intensifier and C-arm maneuverability on operating time, fluoroscopy time, radiation dose and reduction, and fixation quality at intertrochanteric femoral fractures. Design: Single-center, randomized, prospective study. Setting: Academic Level I trauma hospital. Patients and Intervention: 34 patients treated with cephalomedullary nailing for a stable, intertrochanteric proximal femur fracture (OTA A1)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780433/influence-of-metal-deposition-and-activation-method-on-the-structure-and-performance-of-carbon-nanotube-supported-palladium-catalysts
#12
Wouter S Lamme, Jovana Zečević, Krijn P de Jong
The effects of the metal deposition and activation methods on metal particle size and distribution were investigated for carbon nanotube supported Pd catalysts. The Pd precursor was loaded by incipient wetness impregnation, ion adsorption, and deposition precipitation and was activated by thermal treatment under a nitrogen atmosphere or in the liquid phase by reduction by formaldehyde or sodium borohydride. Regardless of the metal precursor loading method, activation under a N2 atmosphere at 500 °C led to homogeneously distributed 4 nm Pd particles...
April 9, 2018: ChemCatChem
https://www.readbyqxmd.com/read/29780232/cerebral-arteriovenous-malformations-in-the-era-of-embolization-for-angiographic-cure-a-single-center-experience-in-egypt
#13
Mohamed K Elewa
Background: Embolization for cerebral arteriovenous malformations (AVMs) has evolved in the last decade with evolution in both equipment and material. Embolization targets have expanded to include angiographic cure. Methods: To discuss the technical and management outcomes of our first cerebral AVM case series treated with embolization. The clinical, angiographic, treatment, and outcome variables of consecutive cerebral arteriovenous malformation cases, treated with curative embolization, between January 2011 and June 2017 in one regional center, were retrospectively analyzed...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29780174/cereal-progenitors-differ-in-stand-harvest-characteristics-from-related-wild-grasses
#14
Catherine Preece, Natalie F Clamp, Gemma Warham, Michael Charles, Mark Rees, Glynis Jones, Colin P Osborne
The domestication of crops in the Fertile Crescent began approximately 10,000 years ago indicating a change from a hunter-gatherer lifestyle to a sedentary, agriculture-based existence. The exploitation of wild plants changed during this transition, such that a small number of crops were domesticated from the broader range of species gathered from the wild. However, the reasons for this change are unclear.Previous studies have shown unexpectedly that crop progenitors are not consistently higher yielding than related wild grass species, when growing without competition...
May 2018: Journal of Ecology
https://www.readbyqxmd.com/read/29779880/in-vitro-comparison-of-acyclovir-ganciclovir-and-cidofovir-against-equid-alphaherpesvirus-3-and-evaluation-of-their-efficacy-against-six-field-isolates
#15
María A Vissani, Osvaldo Zabal, María S Tordoya, Viviana Parreño, Etienne Thiry, María Barrandeguy
Equid alphaherpesvirus 3 (EHV3) is the etiological agent of equine coital exanthema (ECE), which is a venereal, highly contagious disease, characterized by the formation of papules, vesicles, pustules and ulcers on the external genitalia of mares and stallions. EHV3 remains in a latent state after a successful infection and there are latently infected animals in which the virus is reactivated and generally re-excreted subclinically. There are no available vaccines for this condition and prevention is based on the clinical examination of mares prior to mating, which allows to segregate those showing clinical signs...
May 17, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29779258/hyperpolarized-porous-silicon-nanoparticles-potential-theragnostic-material-for-%C3%A2-%C3%A2-si-magnetic-resonance-imaging
#16
Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy Son Luu, Shivanand Pudakalakatti, Caitlin McCowan, Yaewon Kim, Niki Zacharias, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for ²⁹Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their ²⁹Si MR signals; the particles demonstrated long ²⁹Si spin-lattice relaxation (T₁) times (~ 25 mins), which suggests potential applicability for medical imaging...
May 20, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29778679/efficient-metal-adsorption-and-microbial-reduction-from-rawal-lake-wastewater-using-metal-nanoparticle-coated-cotton
#17
Attarad Ali, Ayesha Gul, Abdul Mannan, Muhammad Zia
This study was designed to investigate removal of toxic metals and reduction of bacterial count from Rawal Lake wastewater with novel nanocomposite sorbents. Iron, zinc and silver oxide nanoparticles (NPs) were attached on cotton. The nanocomposites (iron NPs on cotton (FeCt), zinc NPs on cotton (ZnCt) and silver NPs on cotton (AgCt)) were characterized by FTIR, XRD and SEM, which showed successful adsorption of 10-30 nm size nanoparticles. Batch experiments were performed to determine the adsorption capacity of nanocomposite for metal removal...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778561/severe-xanthomatosis-in-heterozygous-familial-hypercholesterolemia
#18
Sumayah Aljenedil, Isabelle Ruel, Kevin Watters, Jacques Genest
BACKGROUND: Familial hypercholesterolemia is a genetic lipoprotein disorder characterized by elevated plasma low-density lipoprotein cholesterol level, (tendinous xanthomas, xanthelasmas, and premature arcus corneus) and early onset atherosclerotic cardiovascular disease. Familial hypercholesterolemia is caused by mutations in the low-density lipoprotein receptor, apolipoprotein B or proprotein convertase subtilisin/kexin type 9 genes. Rare mutations in low-density lipoprotein receptor adapter protein 1, APOE p...
April 3, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29778448/multi-charged-labeling-of-oligosaccharides-and-n-linked-glycans-by-hexahistidine-based-tags-for-capillary-electrophoresis-mass-spectrometry-analysis
#19
Jan Partyka, Jana Krenkova, Richard Cmelik, Frantisek Foret
The labeling by amino acids and peptides was investigated for sensitive and fast analyses of oligosaccharides and N-linked glycans by capillary electrophoresis-mass spectrometry (CE-MS). Peptide tags with a various number of histidine residues were tested for maltooligosaccharide labeling in order to investigate the effect of the size of labels and a number of charges on CE-MS analysis. Nevertheless, the reductive amination labeling of N-linked glycans by a hexahistidine tag resulted in a multiple products formation, therefore a peptide tag was modified by hydrazine functionality in order to perform labeling by hydrazone formation chemistry...
May 16, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29778146/performance-and-mechanism-of-cr-vi-removal-by-zero-valent-iron-loaded-onto-expanded-graphite
#20
Congbin Xu, Wenjie Yang, Weijiang Liu, Hongliang Sun, Chunlei Jiao, Ai-Jun Lin
Zero-valent iron (ZVI) was loaded on expanded graphite (EG) to produce a composite material (EG-ZVI) for efficient removal of hexavalent chromium (Cr(VI)). EG and EG-ZVI were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) analysis. EG-ZVI had a high specific surface area and contained sub-micron sized particles of zero-valent iron. Batch experiments were employed to evaluate the Cr(VI) removal performance...
May 2018: Journal of Environmental Sciences (China)
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