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https://www.readbyqxmd.com/read/28918079/clogging-of-an-alpine-streambed-by-silt-sized-particles-insights-from-laboratory-and-field-experiments
#1
Jasmin Fetzer, Markus Holzner, Michael Plötze, Gerhard Furrer
Clogging of streambeds by suspended particles (SP) can cause environmental problems, as it can negatively influence, e.g., habitats for macrozoobenthos, fish reproduction and groundwater recharge. This especially applies in the case of silt-sized SP. Until now, most research has dealt with coarse SP and was carried out in laboratory systems. The aims of this study are to examine (1) whether physical clogging by silt-sized SP exhibits the same dynamics and patterns as by sand-sized SP, and (2) the comparability of results between laboratory and field experiments...
September 7, 2017: Water Research
https://www.readbyqxmd.com/read/28917865/physicochemical-and-structural-properties-of-pregelatinized-starch-prepared-by-improved-extrusion-cooking-technology
#2
Yunfei Liu, Jun Chen, Shunjing Luo, Cheng Li, Jiangping Ye, Chengmei Liu, Robert G Gilbert
Pregelatinized starch was made from indica rice starch using a so-called "improved extrusion cooking technology" (IECT) under 30%-70% moisture content. IECT-pregelatinized starch (IPS) had higher water solubility and water absorbability compared to native starch at low temperature. For pasting properties, the breakdown and setback viscosities of IPS were significantly (p<0.05) lower than native starch, suggesting improved gel stability and reduced short-term retrogradation. The rice starch granules lost their integrity in IPS, and formed a honeycomb-like structure with increased moisture content in the raw material...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917641/changes-in-innervation-of-lumbar-motoneurons-and-organization-of-premotor-network-following-training-of-transected-adult-rats
#3
Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bras
Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and functional re-organization within the spinal cord below the lesion. To begin to understand the nature of this reorganization, we examined synaptic changes to identified gastrocnemius (GS) or tibialis anterior (TA) motoneurons (MNs) in SCT rats after a schedule of early exercise training and delayed 5-HT agonist treatment...
September 13, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28917407/corneal-topography-and-keratometry-changes-after-glued-intraocular-lens-implantation
#4
Dhivya Ashok Kumar, Harspreet Kaur, Amar Agarwal, Sajitha Selvaraj, Sathish Kumar Pandian, Vamsi Chintalpati
PURPOSE: To analyze the alterations in corneal topography and keratometry (K) after glued transscleral-fixated intraocular lens (IOL) implantation. SETTING: Dr. Agarwal's Eye Hospital, Chennai, India. DESIGN: Prospective case series. METHODS: Eyes having glued IOL implantation for aphakia or subluxated lens (>180 degrees) were included. Preoperative autorefractometer and corneal topography was performed. Intraoperative parameters, namely the type, position, and incision size, flap position, and number of sutures were noted...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28916763/maternal-diabetes-causes-developmental-delay-and-death-in-early-somite-mouse-embryos
#5
Jing Zhao, Theodorus B M Hakvoort, Jan M Ruijter, Aldo Jongejan, Jan Koster, Sigrid M A Swagemakers, Aleksandar Sokolovic, Wouter H Lamers
Maternal diabetes causes congenital malformations and delays embryonic growth in the offspring. We investigated effects of maternal diabetes on mouse embryos during gastrulation and early organogenesis (ED7.5-11.5). Female mice were made diabetic with streptozotocin, treated with controlled-release insulin implants, and mated. Maternal blood glucose concentrations increased up to embryonic day (ED) 8.5. Maternal hyperglycemia induced severe growth retardation (approx.1 day) in 53% of the embryos on ED8.5, death in most of these embryos on ED9...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916429/incidence-and-predictors-of-recurrent-restenosis-after-drug-coated-balloon-angioplasty-for-restenosis-of-a-drug-eluting-stent-the-icarus-cooperation
#6
Salvatore Cassese, Bo Xu, Seiji Habara, Harald Rittger, Robert A Byrne, Matthias Waliszewski, María José Pérez-Vizcayno, Runlin Gao, Adnan Kastrati, Fernando Alfonso
INTRODUCTION AND OBJECTIVES: The incidence and predictors of recurrent restenosis after drug-coated balloon (DCB) angioplasty for drug-eluting stent (DES) restenosis remain poorly studied. We sought to evaluate the incidence and predictors of recurrent restenosis among participants in randomized controlled trials receiving DCB angioplasty for DES restenosis. METHODS: The clinical and lesion data of individuals enrolled in 6 randomized controlled trials of DCB angioplasty for DES restenosis were pooled...
September 12, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28916296/folate-targeted-amphiphilic-cyclodextrin-nanoparticles-incorporating-a-fusogenic-peptide-deliver-therapeutic-sirna-and-inhibit-the-invasive-capacity-of-3d-prostate-cancer-tumours
#7
James C Evans, Meenakshi Malhotra, Katrina Sweeney, Raphael Darcy, Colleen C Nelson, Brett G Hollier, Caitriona M O'Driscoll
The main barrier to the development of an effective RNA interference (RNAi) therapy is the lack of a suitable delivery vector. Modified cyclodextrins have emerged in recent years for the delivery of siRNA. In the present study, a folate-targeted amphiphilic cyclodextrin was formulated using DSPE-PEG5000-folate to target prostate cancer cells. The fusogenic peptide GALA was included in the formulation to aid in the endosomal release of siRNA. Targeted nanoparticles were less than 200nm in size with a neutral surface charge...
September 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28916281/explaining-the-spatiotemporal-variation-of-fine-particle-number-concentrations-over-beijing-and-surrounding-areas-in-an-air-quality-model-with-aerosol-microphysics
#8
Xueshun Chen, Zifa Wang, Jie Li, Huansheng Chen, Min Hu, Wenyi Yang, Zhe Wang, Baozhu Ge, Dawei Wang
In this study, a three-dimensional air quality model with detailed aerosol microphysics (NAQPMS + APM) was applied to simulate the fine particle number size distribution and to explain the spatiotemporal variation of fine particle number concentrations in different size ranges over Beijing and surrounding areas in the haze season (Jan 15 to Feb 13 in 2006). Comparison between observations and the simulation indicates that the model is able to reproduce the main features of the particle number size distribution...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28916169/the-large-and-small-spen-family-proteins-stimulate-axon-outgrowth-during-neurosecretory-cell-remodeling-in-drosophila
#9
Tingting Gu, Tao Zhao, Uday Kohli, Randall S Hewes
Split ends (SPEN) is the founding member of a well conserved family of nuclear proteins with critical functions in transcriptional regulation and the post-transcriptional processing and nuclear export of transcripts. In animals, the SPEN proteins fall into two size classes that perform either complementary or antagonistic functions in different cellular contexts. Here, we show that the two Drosophila representatives of this family, SPEN and Spenito (NITO), regulate metamorphic remodeling of the CCAP/bursicon neurosecretory cells...
September 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28916138/peptide-yy-induces-characteristic-meal-patterns-of-aged-mice
#10
Sachiko Mogami, Chihiro Yamada, Naoki Fujitsuka, Tomohisa Hattori
BACKGROUND & AIM: Changes in eating behavior occur in the elderly due to oral and swallowing dysfunctions. We aimed to clarify the difference between basal meal patterns of young and aged mice in relation to appetite regulating hormones. METHODS: Thirty two of young (7-week-old) and aged (23-25-month-old) C57BL/6 male mice were acclimated to a single housing and then transferred to a highly sensitive automated feeding monitoring device. Feeding behavior was monitored from the onset of the dark phase after habituation to the device...
September 12, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28915538/long-term-t3-and-t4-treatment-as-an-alternative-to-aerobic-exercise-training-in-improving-cardiac-function-post-myocardial-infarction
#11
Rayane Brinck Teixeira, Alexsandra Zimmer, Alexandre Luz de Castro, Bruna Gazzi de Lima-Seolin, Patrick Türck, Rafaela Siqueira, Adriane Belló-Klein, Pawan K Singal, Alex Sander da Rosa Araujo
Here we aimed to compare the beneficial effects of T3 and T4 hormone treatment to those provided by aerobic exercise training in Wistar rats post-myocardial infarction (MI). Rats in one group were SHAM-operated and in the other group were subjected to MI surgery. One week after surgery, the MI group animals either received T3 and T4 hormones by gavage or underwent a low intensity aerobic exercise training protocol on a treadmill, and both treatments lasted until 10 weeks after MI. Untreated SHAM-operated and MI groups were also followed for the same duration...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28915284/long-term-comparison-of-a-large-spot-vacuum-assisted-handpiece-vs-the-small-spot-size-traditional-handpiece-of-the-800-nm-diode-laser
#12
Nour J Youssef, Alain G Rizk, Omar A Ibrahimi, Zeina S Tannous
BACKGROUND The 800 nm long-pulsed diode laser machine is safe and effective for permanent hair reduction. Traditionally, most long-pulsed diode lasers used for hair removal had a relatively small spot size. Recently, a long-pulsed diode laser with a large spot size and vacuum assisted suction handpiece was introduced. The treatment parameters of each type of handpiece differ. Short and long-term clinical efficacy, treatment associated pain, and patient satisfaction are important factors to be considered. OBJECTIVE: This study aims to conduct a direct head to head comparison of both handpieces of the 800nm long-pulsed diode laser by evaluating long term hair reduction, treatment associated pain and patient satisfaction...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28915237/dna-replication-stress-restricts-ribosomal-dna-copy-number
#13
Devika Salim, William D Bradford, Amy Freeland, Gillian Cady, Jianmin Wang, Steven C Pruitt, Jennifer L Gerton
Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy number of rDNA repeat units in eukaryotic cells is maintained far in excess of the requirement for ribosome biogenesis. Despite the importance of the repeats for both ribosomal and non-ribosomal functions, it is currently not known how "normal" copy number is determined or maintained. To identify essential genes involved in the maintenance of rDNA copy number, we developed a droplet digital PCR based assay to measure rDNA copy number in yeast and used it to screen the yeast conditional temperature-sensitive mutant collection of essential genes...
September 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28915007/synthesis-and-properties-of-2d-carbon-graphdiyne
#14
Zhiyu Jia, Yongjun Li, Zicheng Zuo, Huibiao Liu, Changshui Huang, Yuliang Li
Graphdiyne (GDY) is a flat material comprising sp(2)- and sp-hybridized carbon atoms with high degrees of π conjugation that features uniformly distributed pores. It is interesting not only from a structural point of view but also from the perspective of its electronic, chemical, mechanical, and magnetic properties. We have developed an in situ homocoupling reaction of hexaethynylbenzene on Cu foil for the fabrication of large-area ordered films of graphdiyne. These films are uniform and composed of graphdiyne multilayers...
September 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28914852/-efficiency-of-immunosuppressive-therapy-in-virus-negative-and-virus-positive-patients-with-morphologically-verified-lymphocytic-myocarditis
#15
O V Blagova, A V Nedostup, E A Kogan, V A Sulimov
AIM: To evaluate the efficiency of immunosuppressive therapy (IST) in virus-negative (V-) and virus-positive (V+) patients with lymphocytic myocarditis (LM). SUBJECTS AND METHODS: 60 patients (45 males) (mean age 46.7±11.8 years) with dilated cardiomyopathy (mean left ventricular (LV) end diastolic size (EDS) 6.7±0.7 cm; ejection fraction (EF) 26.2±9.1%) were examined. The diagnosis of active/borderline LM was verified by right ventricular endomyocardial biopsy in 38 patients, by intraoperative LV biopsy in 10, in the study of explanted hearts from 3 patients and at autopsy in 9...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28914766/development-of-a-sensitive-electrochemical-enzymatic-reaction-based-cholesterol-biosensor-using-nano-sized-carbon-interdigitated-electrodes-decorated-with-gold-nanoparticles
#16
Deepti Sharma, Jongmin Lee, Junyoung Seo, Heungjoo Shin
We developed a versatile and highly sensitive biosensor platform. The platform is based on electrochemical-enzymatic redox cycling induced by selective enzyme immobilization on nano-sized carbon interdigitated electrodes (IDEs) decorated with gold nanoparticles (AuNPs). Without resorting to sophisticated nanofabrication technologies, we used batch wafer-level carbon microelectromechanical systems (C-MEMS) processes to fabricate 3D carbon IDEs reproducibly, simply, and cost effectively. In addition, AuNPs were selectively electrodeposited on specific carbon nanoelectrodes; the high surface-to-volume ratio and fast electron transfer ability of AuNPs enhanced the electrochemical signal across these carbon IDEs...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28914745/is-digital-tomosynthesis-on-par-with-computed-tomography-for-the-detection-and-measurement-of-pulmonary-nodules
#17
Xiang Wen Lee, Henry M Marshall, Steven C Leong, Rachael L O'Rourke, Karin Steinke, Negar Mirjalili, Rayleen V Bowman, Ian A Yang, Kwun M Fong
Chest digital tomosynthesis (DT) has potential advantages compared to computed tomography (CT) such as radiation dose reduction. However, the role of DT in pulmonary nodule management remains investigative. We compared DT against CT for pulmonary nodule detection and size measurement. A clinical population comprising 54 nodules from 30 patients and a screening population comprising 42 nodules from 52 patients were included. Scans were independently read by two radiologists. Agreement in nodule measurements between readers and between modalities was assessed by Bland-Altman analysis using a 95% level of significance...
September 13, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28913977/the-effect-of-diet-or-exercise-on-ectopic-adiposity-in-children-and-adolescents-with-obesity-a-systematic-review-and-meta-analysis
#18
REVIEW
W Hens, D Vissers, D Hansen, S Peeters, J Gielen, L Van Gaal, J Taeymans
OBJECTIVE: Ectopic fat depostion in youth with obesity is associated with an increased cardiovascular disease risk. The aim of this meta-analysis was to summarize the evidence for the use of diet and/or exercise on ectopic adiposity in this population. METHODS: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Clinical trials that assessed ectopic fat deposition and included study arms with diet and/or exercise were searched in PubMed, PEDro and the Cochrane database...
September 14, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28913909/local-delivery-of-strontium-ranelate-promotes-regeneration-of-critical-size-bone-defects-filled-with-collagen-sponge
#19
Bárbara Furtado Masalskas, Walter Martins Júnior, Graziela Bianchi Leoni, Ana Paula de Souza Faloni, Andrea Márcia Marcaccini, Yara Teresinha Corrêa Silva Sousa, Larissa Moreira Spinola de Castro-Raucci
The effect of local delivery of strontium ranelate (SR) on bone regeneration of critical size bone defects filled with collagen sponge was evaluated. Bone defects of 5 mm diameter created in rat calvaria were filled with collagen sponge (C); collagen sponge with 5 mM Sr(2+) SR (C5SR) or collagen sponge with 50 mM Sr(2+) SR (C50SR). After 2, 4 and 6 weeks, bone volume (BV), bone surface (BS), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) were evaluated by computed microtomography...
September 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28912459/iron-deposition-is-associated-with-differential-macrophage-infiltration-and-therapeutic-response-to-iron-chelation-in-prostate-cancer
#20
Avigdor Leftin, Huiyong Zhao, Mesru Turkekul, Elisa de Stanchina, Katia Manova, Jason A Koutcher
Immune cells such as macrophages are drivers and biomarkers of most cancers. Scoring macrophage infiltration in tumor tissue provides a prognostic assessment that is correlated with disease outcome and therapeutic response, but generally requires invasive biopsy. Routine detection of hemosiderin iron aggregates in macrophages in other settings histologically and in vivo by MRI suggests that similar assessments in cancer can bridge a gap in our ability to assess tumor macrophage infiltration. Quantitative histological and in vivo MRI assessments of non-heme cellular iron revealed that preclinical prostate tumor models could be differentiated according to hemosiderin iron accumulation-both in tumors and systemically...
September 14, 2017: Scientific Reports
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