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https://www.readbyqxmd.com/read/28330271/assessment-of-protein-silver-nanoparticles-toxicity-against-pathogenic-alternaria-solani
#1
Sobhy I I Abdel-Hafez, Nivien A Nafady, Ismail R Abdel-Rahim, Abeer M Shaltout, José-Antonio Daròs, Mohamed A Mohamed
Mycogenic synthesis of silver nanoparticles (AgNPs) was carried out in the present investigation using an aqueous extract of endophytic non-pathogenic Alternaria solani F10 (KT721914). The mycosynthesized AgNPs were characterized by means of spectroscopic and microscopic techniques. The surface plasmon resonance found at 430 nm confirmed the formation of stable AgNPs for several weeks at room temperature. Also, the results revealed the formation of spherical and monodispersed AgNPs with an average size of 14...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330190/phyto-synthesis-and-structural-characterization-of-catalytically-active-gold-nanoparticles-biosynthesized-using-delonix-regia-leaf-extract
#2
Preeti Dauthal, Mausumi Mukhopadhyay
Biological methods of nanoparticles synthesis are ecologically sound and sustainable alternative to the conventional methods. On the basis of aforesaid premise, the present study deals with the optimization and fabrication of gold nanoparticles (Au-NPs) using easily available bio-resource, Delonix regia leaf extract. The use of practically nontoxic natural extracts and water allows the synthesis pathways presented to be considered as ''green'' and so permitting the synthesized Au-NPs to be used in sensitive areas, such as bioremediation...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330162/evaluation-of-silver-nanoparticles-synthetic-potential-of-couroupita-guianensis-aubl-flower-buds-extract-and-their-synergistic-antibacterial-activity
#3
T Venkata Rajesh Kumar, J S R Murthy, Madamsetti Narayana Rao, Y Bhargava
The present investigation demonstrates Couroupita guianensis flower buds extract mediated synthesis of stable silver nanoparticles (AgNPs). Instant formation of AgNPs was primarily confirmed by the appearance of yellowish brown colour and characteristic silver SPR band in the UV-visible spectrum. Elemental and crystalline natures of the AgNPs were identified from EDX and XRD pattern, respectively. Spherical morphology and the mono-disparity were revealed from TEM and AFM images. The particle size ranged from 5 to 30 nm and average size of 17 nm was consistent in XRD, TEM and AFM measurements...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329438/influence-of-clinical-use-on-physical-structural-surface-properties-and-electrochemical-potential-of-niti-endodontic-instruments
#4
E S J Pereira, C C F Amaral, J A P Gomes, O A Peters, V T L Buono, M G A Bahia
AIM: To investigate the surface morphology and electrochemical potential of superelastic (SE), M-Wire (MW), and shape memory technology (SMT) NiTi instruments before and after single clinical use in vivo. METHODOLOGY: A total of 60 ProTaper Universal F2 (PTU - SE), ProTaper Next X2 (PTN - MW), Typhoon (TYP), Hyflex (HF) and Vortex Blue (VB), the last three SMT, and size 25, .06 taper (n = 6 of each type) files were examined. Scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS) and electrochemical potential analysis were employed before and after clinical use...
March 22, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28329286/short-course-tlr9-agonist-treatment-impacts-innate-immunity-and-plasma-viremia-in-individuals-with-hiv-infection
#5
Line Vibholm, Mariane H Schleimann, Jesper F Højen, Thomas Benfield, Rasmus Offersen, Katrine Rasmussen, Rikke Olesen, Anders Dige, Jørgen Agnholt, Judith Grau, Maria Buzon, Burghardt Wittig, Mathias Lichterfeld, Andreas Munk Petersen, Xutao Deng, Mohammed Abdel-Mohsen, Satish K Pillai, Sofie Rutsaert, Wim Trypsteen, Ward De Spiegelaere, Linos Vandekerchove, Lars Østergaard, Thomas A Rasmussen, Paul W Denton, Martin Tolstrup, Ole S Søgaard
Background: Treatment with latency reversing agents (LRA) enhances HIV-1 transcription in vivo but only leads to modest reductions in the size of the reservoir, possibly due to insufficient immune-mediated elimination of infected cells. We hypothesized that a single drug molecule - a novel toll-like receptor 9 (TLR9) agonist, MGN1703 - could function as an enhancer of innate immunity and an LRA in vivo. Methods: We conducted a single-arm, open-label study, where 15 virologically suppressed HIV-1 infected individuals on antiretroviral therapy received 60 mg MGN1703 s...
March 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329201/video-assisted-thoracic-surgery-lobectomy-does-not-offer-any-functional-recovery-advantage-in-comparison-to-the-open-approach-3-months-after-the-operation-a-case-matched-analysis%C3%A2
#6
Michele Salati, Alessandro Brunelli, Francesco Xiumè, Marco Monteverde, Armando Sabbatini, Michela Tiberi, Cecilia Pompili, Roberto Palloni, Majed Refai
OBJECTIVES: The objective of the present study was to compare functional loss [forced expiratory volume in one second to forced vital capacity ratio (FEV1), DLCO and VO2max reduction] after VATS versus open lobectomies. METHODS: We performed a prospective observational study on 195 patients who had a pulmonary lobectomy from June 2010 to November 2014 and who were able to complete a 3-months functional evaluation follow-up program. Since the VATS technique was our first choice for performing lobectomies from January 2012, we divided the patients into two groups: the OPEN group (112 patients) and the VATS group (83 patients)...
February 23, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28328991/pre-breeding-food-restriction-promotes-the-optimization-of-parental-investment-in-house-mice-mus-musculus
#7
Adam Dušek, Luděk Bartoš, František Sedláček
Litter size is one of the most reliable state-dependent life-history traits that indicate parental investment in polytocous (litter-bearing) mammals. The tendency to optimize litter size typically increases with decreasing availability of resources during the period of parental investment. To determine whether this tactic is also influenced by resource limitations prior to reproduction, we examined the effect of experimental, pre-breeding food restriction on the optimization of parental investment in lactating mice...
2017: PloS One
https://www.readbyqxmd.com/read/28328845/the-prognostic-role-of-boris-and-socs3-in-human-hepatocellular-carcinoma
#8
Rongce Zhao, Kefei Chen, Jing Zhou, Jingyang He, Jun Liu, Peng Guan, Bo Li, Yang Qin
Brother of regulator of imprinted sites (BORIS) is a DNA-binding protein that is normally expressed in the testes. However, aberrant expression of BORIS is observed in various carcinomas, indicating a malignant role for this protein. Furthermore, abolishment or reduction of suppressor of cytokine signaling 3 (SOCS3) expression directed by promoter methylation is considered significant in hepatocellular carcinoma (HCC) carcinogenesis. This study aims to investigate BORIS and SOCS3 expression in HCC specimens and assess the prognostic significance of these proteins...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328709/the-clinical-and-histological-effect-of-a-low-fluence-q-switched-1-064-nm-neodymium-yttrium-aluminum-garnet-laser-for-the-treatment-of-melasma-and-solar-lentigo-in-asians-prospective-randomized-and-split-face-comparative-study
#9
Chikako Kaminaka, Fukumi Furukawa, Yuki Yamamoto
BACKGROUND: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians. OBJECTIVE: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo. MATERIALS AND METHODS: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28328557/lateral-rectus-muscle-expands-more-than-medial-rectus-following-maximal-deep-balanced-orbital-decompression
#10
Adit Gupta, Alex Nobori, Yi Wang, Daniel Rootman, Robert Goldberg
PURPOSE: It has been reported that extraocular muscles can enlarge following orbital decompression in thyroid eye disease. In this article, the authors studied the changes in extraocular muscles size following maximal deep lateral and medial balanced decompression in a large sample of thyroid eye disease patients. METHODS: Imaging data were reviewed preoperatively and postoperatively. Radiologic proptosis was assessed. Maximal axial muscle width of the medial and lateral recti was measured...
March 21, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28328497/synergistic-effects-of-nanodrug-ultrasound-hyperthermia-and-thermal-ablation-on-solid-tumors-an-animal-study
#11
Li-Chen Chiu, Sheng-Kai Wu, Win-Li Lin, Gin-Shin Chen
OBJECTIVE: Delivery barriers of nanodrug in large tumors due to heterogeneous blood supply, elevated interstitial pressure and long transport distances can degrade the efficacy of cancer treatment. In this study, we proposed a therapeutic strategy to improve the tumor growth inhibition by injecting pegylated liposomal doxorubicin (PLD), and then applying a short time of ultrasound hyperthermia (HT) on the entire solid tumor, and inflicting ultrasound thermal ablation (Ab) in the low-perfused tumor region...
March 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28328251/predicting-presidential-election-outcomes-from-what-people-watch
#12
Arash Barfar, Balaji Padmanabhan
In a recent article by Barfar and Padmanabhan (2015), we demonstrated how television viewership data could predict presidential election outcomes in the United States. In this article, we examine predictive models using a snapshot of Nielsen's national data on television viewership. The study is conducted with high-dimensional low sample size (HDLSS) data, whereby we conduct a comparative analysis with and without feature reduction on the data from the 2012 elections. We find that simple "single-show models" often provided more insights and predictive accuracies than models from feature reduction...
March 2017: Big Data
https://www.readbyqxmd.com/read/28328166/treatment-of-subchondral-lucencies-in-the-medial-proximal-radius-with-a-bone-screw-in-8-horses
#13
Imma Roquet, J Lane Easter, Richard P C Coomer, Luis J Ezquerra, Chad A Marsh, Steve S Trostle, Elizabeth M Santschi
OBJECTIVE: To describe the results of screw placement through subchondral lucencies (SCL) of the proximal radius in 8 horses. STUDY DESIGN: Retrospective clinical study. ANIMALS: Horses with cubital SCL causing lameness (n=8). METHODS: Medical record review and clinical follow-up. RESULTS: Eight horses with SCL in the proximal radius causing lameness were treated with a screw placed across the lucency...
March 22, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28327993/stepwise-distributed-open-innovation-contests-for-software-development-acceleration-of-genome-wide-association-analysis
#14
Andrew Hill, Po-Ru Loh, Ragu B Bharadwaj, Pascal Pons, Jingbo Shang, Eva Guinan, Karim Lakhani, Iain Kilty, Scott A Jelinsky
BACKGROUND: The association of differing genotypes with disease related phenotypic traits offers great potential to both help identify new therapeutic targets and support stratification of patients who would gain the greatest benefit from specific drug classes. Development of low cost genotyping and sequencing has made collecting large scale genotyping data routine in population and therapeutic intervention studies. In addition, a range of new technologies are being used to capture numerous new and complex phenotypic descriptors...
February 28, 2017: GigaScience
https://www.readbyqxmd.com/read/28327471/motion-compensation-in-extremity-cone-beam-ct-using-a-penalized-image-sharpness-criterion
#15
Alejandro Sisniega, Joseph Stayman, John Yorkston, Jeffrey Siewerdsen, Wojciech Zbijewski
Cone-beam CT (CBCT) for musculoskeletal imaging would benefit from a method to reduce the effects of involuntary patient motion. In particular, the continuing improvement in spatial resolution of CBCT may enable tasks such as quantitative assessment of bone microarchitecture (0.1 mm - 0.2 mm detail size), where even subtle, sub-mm motion blur might be detrimental. We propose a purely image based motion compensation method that requires no fiducials, tracking hardware or prior images. A statistical optimization algorithm (CMA-ES) is used to estimate a motion trajectory that optimizes an objective function consisting of an image sharpness criterion augmented by a regularization term that encourages smooth motion trajectories...
March 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28327425/protein-drug-nanoconjugates-finding-the-alternative-proteins-as-drug-carrier
#16
Iqra Munir, Sadia Ajmal, Muhammad Raza Shah, Aftab Ahmad, Abdul Hameed, Syed Abid Ali
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) have been performed giving typical UV-maxima with subtle variation in fourier transform infrared spectroscopy (FTIR). Atomic force microscopy (AFM) revealed spherical shaped, polydisperse F-GNPs of varying sizes, complementing the radius of hydration (19...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28327089/uniform-fdg-pet-guided-gradient-dose-prescription-to-reduce-late-radiation-toxicity-upgrade-rt-study-protocol-for-a-randomized-clinical-trial-with-dose-reduction-to-the-elective-neck-in-head-and-neck-squamous-cell-carcinoma
#17
Sven van den Bosch, Tim Dijkema, Martina C Kunze-Busch, Chris H J Terhaard, Cornelis P J Raaijmakers, Patricia A H Doornaert, Frank J P Hoebers, Marije R Vergeer, Bas Kreike, Oda B Wijers, Wim J G Oyen, Johannes H A M Kaanders
BACKGROUND: In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called 'elective dose' in order to achieve control of clinically occult metastases. As a consequence of high-resolution diagnostic imaging, occult tumor volume has significantly decreased in the last decades. Since the elective dose is dependent on occult tumor volume, the currently used elective dose may be higher than necessary. Because bilateral irradiation of the neck contributes to dysphagia, xerostomia and hypothyroidism in a dose dependent way, dose de-escalation to these regions can open a window of opportunity to reduce toxicity and improve quality of life after treatment...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28327087/nt5c2-novel-splicing-variant-expands-the-phenotypic-spectrum-of-spastic-paraplegia-spg45-case-report-of-a-new-member-of-thin-corpus-callosum-spg-subgroup
#18
Mahmoud F Elsaid, Khalid Ibrahim, Nader Chalhoub, Ahmed Elsotouhy, Noora El Mudehki, Alice Abdel Aleem
BACKGROUND: Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of neurodegenerative diseases. Thin Corpus Callosum (TCC) associated HSP is a distinguished subgroup of complex forms. Purines and pyrimidine, the basic DNA and RNA components, are regulating the cell metabolism, having roles in signal transduction, energy preservation and cellular repair. Genetic defects in nucleotide metabolism related genes have been only recently implicated in brain and neurodegenerative diseases' pathogenesis...
March 21, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28326979/a-retrospective-study-of-the-effectiveness-of-four-different-treatments-of-periodontal-disease-in-equine-cheek-teeth
#19
Kirsten Jackson, Lukas M Weber, Marc Tennant
Periodontal disease of equine cheek teeth is common and may lead to tooth loss if left untreated. Limited information is available comparing the effectiveness of treatment methods. The objective of this study was to retrospectively compare the effectiveness of 4 commonly used treatments in reducing periodontal pocket depth (in addition to routine dental treatment and occlusal equilibration). The 4 treatments compared were (1) removal of feed material, lavaging the pocket with dilute chlorhexidine, and then rinsing the mouth with chlorhexidine-containing mouthwash (CL); (2) CL plus placement of metronidazole into the pocket (M); (3) M plus the addition of polyvinyl siloxane temporary filling over the diastema (PVS); and (4) diastema widening to increase the interdental space, then PVS (DW)...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28326895/single-session-high-intensity-focused-ultrasound-treatment-in-large-sized-benign-thyroid-nodules
#20
Brian Hung-Hin Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
BACKGROUND: High-intensity focused ultrasound (HIFU) is a new promising thermal ablation technique for treating benign thyroid nodules, but its effectiveness in larger-sized nodules has been less well described. The present study aimed to evaluate the treatment efficacy (i.e., extent of shrinkage at six months) of large-sized benign thyroid nodules by ultrasound (USG)-guided HIFU ablation. MATERIALS AND METHODS: After ethics approval, all consecutive patients who underwent HIFU ablation of a symptomatic benign thyroid nodule with six or more months of follow-up were analyzed...
March 22, 2017: Thyroid: Official Journal of the American Thyroid Association
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