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https://www.readbyqxmd.com/read/28810288/overexpression-of-demeter-a-dna-demethylase-promotes-early-apical-bud-maturation-in-poplar
#1
Daniel Conde, Alicia Moreno-Cortés, Christopher Dervinis, José M Ramos-Sánchez, Matias Kirst, Mariano Perales, Pablo González-Melendi, Isabel Allona
The transition from active growth to dormancy is critical for the survival of perennial plants. We identified a DEMETER-like (CsDML) cDNA from a winter-enriched cDNA subtractive library in chestnut (Castanea sativa Mill.), an economically and ecologically important species. Next, we characterized this DNA demethylase and its putative orthologue in the more experimentally tractable hybrid poplar (Populus tremula x alba), under the signals that trigger bud dormancy in trees. We performed phylogenetic and protein sequence analysis, gene expression profiling and 5mC immunodetection studies to evaluate the role of CsDML and its homologue in poplar, PtaDML6...
August 15, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28809782/dietary-supplementation-of-honey-bee-larvae-with-arginine-and-abscisic-acid-enhances-nitric-oxide-and-granulocyte-immune-responses-after-trauma
#2
Pedro Negri, Leonor Ramirez, Silvina Quintana, Nicolás Szawarski, Matías Maggi, Yves Le Conte, Lorenzo Lamattina, Martin Eguaras
Many biotic and abiotic stressors impact bees' health, acting as immunosupressors and contribute to colony losses. Thus, the importance of studying the immune response of honey bees is central to develop new strategies aiming to enhance bees' fitness to confront the threats affecting them. If a pathogen breaches the physical and chemical barriers, honey bees can protect themselves from infection with cellular and humoral immune responses which represent a second line of defense. Through a series of correlative studies we have previously reported that abscisic acid (ABA) and nitric oxide (NO) share roles in the same immune defenses of Apis mellifera (A...
August 15, 2017: Insects
https://www.readbyqxmd.com/read/28807556/long-term-weight-loss-in-laparoscopic-sleeve-gastrectomy
#3
Matías Sepúlveda, Munir Alamo, Jorge Saba, Cristián Astorga, Raúl Lynch, Hernán Guzmán
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) has become an option as a bariatric surgical technique. There is a lack of long-term results of this procedure in the literature. The aim of this study is to present weight loss results of LSG for up to 7 years of follow-up. METHODS: A retrospective series of patients who underwent LSG between 2008 and 2011 was examined. The primary endpoint was weight loss: percentage of excess weight loss (%EWL), percentage of total weight loss (%TWL), and body mass index (BMI) were reported...
July 25, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28802917/aerobic-exercise-in-adolescence-results-in-an-increase-of-neuronal-and-non-neuronal-cells-and-in-mtor-overexpression-in-the-cerebral-cortex-of-rats
#4
Angélica Begatti Victorino, Fernando Tadeu Serra, Pâmella Pimentel Piñero, Alexandre Aparecido de Almeida, Glauber Menezes Lopim, Ivair Matias Junior, Helio Rubens Machado, Roberto Lent, Francisco Romero Cabral, Fernando Gomez-Pinilla, Ricardo Mario Arida, Sérgio Gomes da Silva
Better cognitive performance and greater cortical and hippocampal volume have been observed in individuals who undertook aerobic exercise during childhood and adolescence. One possible explanation for these beneficial effects is that juvenile physical exercise enables better neural development and hence more cells and neuronal circuitries. It is probable that such effects occur through intracellular signaling proteins associated with cell growth, proliferation and survival. Based on this information, we evaluated the number of neuronal and non-neuronal cells using isotropic fractionation and the expression and activation of intracellular proteins (ERK, CREB Akt, mTOR and p70S6K) in the cerebral cortex and hippocampal formation of the rats submitted to a physical exercise program on a treadmill during adolescence...
August 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28802138/inhibition-of-bioenergetic-metabolism-by-the-combination-of-metformin-and-2-deoxyglucose-highly-decreases-viability-of-feline-mammary-carcinoma-cells
#5
María Florencia Arbe, Chiara Fondello, Lucrecia Agnetti, Gabriel Martín Álvarez, Matías Nicolás Tellado, Gerardo Claudio Glikin, Liliana María Elena Finocchiaro, Marcela Solange Villaverde
Feline mammary carcinoma (FMC) is a highly aggressive pathology that has been proposed as an interesting model of breast cancer disease, especially for the hormone refractory subgroup. Recently, cancer cell metabolism has been described as a hallmark of cancer cells. Here, we investigate the effects and mechanism of metabolic modulation by metformin (MET, anti-diabetic drug), 2-deoxyglucose (2DG, hexokinase inhibitor) or a combination of both drugs, MET/2DG on two established FMC cells lines: AlRB (HER2 (3+) and Ki67<5%) and AlRATN (HER2 (-) and Ki67>15%)...
August 3, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28797804/a-game-of-two-gene-expression-analysis-of-brain-cyp19a1b-and-gonadal-cyp19a1a-aromatase-in-females-of-a-neotropical-cichlid-fish-through-the-parental-care-period-and-removal-of-the-offspring
#6
Martín R Ramallo, Renato M Honji, Agustina Birba, Leonel Morandini, María L Varela, Griselda Genovese, Renata G Moreira, Gustavo M Somoza, Matías Pandolfi
For many species parental behavior is essential for the survival of the offspring. While the ultimate causes of teleost parental behavior have been widely studied, comparatively little is known about its proximate causes. The aim of this study was to analyze the yet unexplored, potential dual role of brain and gonadal aromatases, the enzymes responsible for the conversion of androgens to estrogens in the brains and gonads of teleosts, respectively, on the different stages of the maternal care period of the biparental cichlid Cichlasoma dimerus, locally known as chanchita...
August 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28792467/fusarium-mycotoxins-in-swiss-wheat-a-survey-of-growers-samples-between-2007-and-2014-shows-strong-year-and-minor-geographic-effects
#7
Susanne Vogelgsang, Tomke Musa, Irene Bänziger, Andreas Kägi, Thomas D Bucheli, Felix E Wettstein, Matias Pasquali, Hans-Rudolf Forrer
To assess the occurrence of Fusarium toxins in wheat in Switzerland, an eight-year survey was conducted by analysing a total of 686 harvest samples from growers using LC-MS/MS. Between 2007 and 2010, 527 samples were obtained from 17 cantons. Between 2011 and 2014, 159 samples were collected from the canton Berne. The most frequent toxins detected were deoxynivalenol (DON), zearalenone (ZEA) and nivalenol (NIV). The overall mean DON content in all samples was 607 µg/kg, and 11% exceeded the European limit for unprocessed cereals for foodstuffs (1250 µg/kg)...
August 9, 2017: Toxins
https://www.readbyqxmd.com/read/28790116/targeted-proteomics-identifies-proteomic-signatures-in-liquid-biopsies-of-the-endometrium-to-diagnose-endometrial-cancer-and-assist-in-the-prediction-of-the-optimal-surgical-treatment
#8
Elena Martinez, Antoine Lesur, Laura Devis, Silvia Cabrera, Xavier Matias-Guiu, Marc Hirschfeld, Jasmin Asberger, Jan van Oostrum, María de Los Ángeles Casares de Cal, Antonio Gómez-Tato, Jaume Reventos, Bruno Domon, Eva Colas, Antonio Gil-Moreno
PURPOSE: Endometrial cancer (EC) diagnosis relies on the observation of tumor cells in endometrial biopsies obtained by aspiration i.e., uterine aspirates), but it is associated with 22% undiagnosed patients and up to 50% of incorrectly assigned EC histotype and grade. We aimed to identify biomarker signatures in the fluid fraction of these biopsies to overcome these limitations. EXPERIMENTAL DESIGN: The levels of 52 proteins were measured in the fluid fraction of uterine aspirates from 116 patients by LC-PRM, the latest generation of targeted mass-spectrometry acquisition...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28790039/answering-medical-questions-at-the-point-of-care-a-cross-sectional-study-comparing-rapid-decisions-based-on-pubmed-and-epistemonikos-searches-with-evidence-based-recommendations-developed-with-the-grade-approach
#9
Ariel Izcovich, Juan Martín Criniti, Federico Popoff, Martín Alberto Ragusa, Cristel Gigler, Carlos Gonzalez Malla, Manuela Clavijo, Matias Manzotti, Martín Diaz, Hugo Norberto Catalano, Ignacio Neumann, Gordon Guyatt
INTRODUCTION: Using the best current evidence to inform clinical decisions remains a challenge for clinicians. Given the scarcity of trustworthy clinical practice guidelines providing recommendations to answer clinicians' daily questions, clinical decision support systems (ie, assistance in question identification and answering) emerge as an attractive alternative. The trustworthiness of the recommendations achieved by such systems is unknown. OBJECTIVE: To evaluate the trustworthiness of a question identification and answering system that delivers timely recommendations...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28789712/effects-of-lipid-based-nutrient-supplements-v-micronutrient-powders-on-nutritional-and-developmental-outcomes-among-peruvian-infants
#10
Susana L Matias, Alejandro Vargas-Vásquez, Ricardo Bado Pérez, Lorena Alcázar Valdivia, Oscar Aquino Vivanco, Amelia Rodriguez Martín, Jose Pedro Novalbos Ruiz
OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on children's Hb, linear growth and development, compared with supplementation with micronutrient powder (MNP). DESIGN: The study was a two-arm parallel-group randomized controlled trial, where participants received either LNS or MNP for daily consumption during 6 months. Supplements were delivered by staff at government-run health centres. Hb, anthropometric, motor development, language development and problem-solving indicators were measured by trained research assistants when children were 12 months of age...
August 9, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28782657/the-search-for-novel-diagnostic-and-prognostic-biomarkers-in-cholangiocarcinoma
#11
REVIEW
Rocio I R Macias, Jesus M Banales, Bruno Sangro, Jordi Muntané, Matias A Avila, Elisa Lozano, Maria J Perugorria, Francisco J Padillo, Luis Bujanda, Jose J G Marin
The poor prognosis of cholangiocarcinoma (CCA) is in part due to late diagnosis, which is currently achieved by a combination of clinical, radiological and histological approaches. Available biomarkers determined in serum and biopsy samples to assist in CCA diagnosis are not sufficiently sensitive and specific. Therefore, the identification of new biomarkers, preferably those obtained by minimally invasive methods, such as liquid biopsy, is important. The development of innovative technologies has permitted to identify a significant number of genetic, epigenetic, proteomic and metabolomic CCA features with potential clinical usefulness in early diagnosis, prognosis or prediction of treatment response...
August 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28778018/antibacterial-activity-and-antibiotic-modulating-potential-of-the-essential-oil-obtained-from-eugenia-jambolana-in-association-with-led-lights
#12
Nara L F Pereira, Pedro E A Aquino, José G A S Júnior, Janyketchuly S Cristo, Marcos A Vieira Filho, Flávio F Moura, Najla M N Ferreira, Maria K N Silva, Eloiza M Nascimento, Fabrina M A Correia, Francisco A B Cunha, Aline A Boligon, Henrique D M Coutinho, Jaime Ribeiro-Filho, Edinardo F F Matias, Maria I F Guedes
Bacterial resistance has risen as an important health problem with impact on the pharmaceutical industry because many antibiotics have become ineffective, which has affected their commercialization. The Brazilian biodiversity is marked by a vast variety of natural products with significant therapeutic potential, which could bring new perspectives in the treatment of infections caused by resistant microorganisms. The present study aimed to evaluate the antibacterial effect of the essential oil obtained from Eugenia jambolana (EjEO) using the method of microdilution method to determine the Minimum Inhibitory Concentration (MIC)...
July 26, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28774613/monohalogenated-acetamide-induced-cellular-stress-and-genotoxicity-are-related-to-electrophilic-softness-and-thiol-thiolate-reactivity
#13
Justin A Pals, Elizabeth D Wagner, Michael J Plewa, Menghang Xia, Matias S Attene-Ramos
Haloacetamides (HAMs) are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an SN2 reaction mechanism. Toxicity of the monohalogenated HAMs (iodoacetamide, IAM; bromoacetamide, BAM; or chloroacetamide, CAM) varied depending on the halogen substituent. The aim of this research was to investigate how the halogen atom affects the reactivity and toxicological properties of HAMs, measured as induction of oxidative/electrophilic stress response and genotoxicity...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28764601/improved-water-quality-and-reduction-of-odorous-compounds-in-anaerobic-lagoon-columns-receiving-pre-treated-pig-wastewater
#14
Ariel A Szogi, John H Loughrin, Matias B Vanotti
Large volumes of wastewater from confined pig production are stored in anaerobic lagoons. Control methods are needed to reduce contributions to air pollution by foul odors from these lagoons. In a replicated pilot-scale lagoon column experiment, we evaluated the effect of pig wastewater pre-treatment on water quality improvements and reduction in concentration of selected malodor compounds in lagoons receiving liquid from: 1) flocculant enhanced solid-liquid separation (SS), and 2) solid-liquid separation plus biological N treatment using nitrification-denitrification (SS+NDN)...
August 2, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28763945/oxidative-stability-of-iron-fortified-goat-and-cow-milk-and-their-peptide-isolates
#15
A Smialowska, L Matia-Merino, A J Carr
The oxidation potential of iron fortified goat and cow milks and casein phosphopeptides obtained from each species of milk was determined using malondialdehyde as an oxidation product marker. There was a reduction in oxidation when iron was 'bound' to milk or peptides compared to free ferrous sulphate in solution. However, goat milk produced significantly lower amounts of malondialdehyde of 0.46±0.04μgMDA/ml after 3days at 30°C compared to the blank of 1.25±0.16μgMDA/ml. The goat peptides produced non-significantly different levels of malondialdehyde compared to the blank containing no ferrous sulphate...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28760453/in%C3%A2-vitro-evaluation-of-the-antibacterial-potential-and-modification-of-antibiotic-activity-of-the-eugenia-uniflora-l-essential-oil-in-association-with-led-lights
#16
Nara L F Pereira, Pedro E A Aquino, José G A S Júnior, Janyketchuly S Cristo, Marcos A Vieira Filho, Flávio F Moura, Najla M N Ferreira, Maria K N Silva, Eloiza M Nascimento, Fabrina M A Correia, Francisco A B Cunha, Aline A Boligon, Henrique D M Coutinho, Edinardo F F Matias, Maria I F Guedes
Due to the great biodiversity of its flora, Brazil provides combat tools against bacterial resistance with the utilization of natural products with vegetable origin. Therefore, the present study had as its objective to evaluate the antibacterial potential of the Eugenia uniflora essential oil (EuEO) in vitro, as well as to analyze the modulatory effect of the oil against antibiotics by gaseous contact and to compare them when associated with a LED apparatus. The chemical components were characterised by gas chromatography which revealed the presence of the isoflurane-germacrene, considered the major component (61...
July 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28760052/primary-hyperparathyroidism-in-pregnancy-treated-with-cinacalcet-a-case-report
#17
Irene Gonzalo García, Mónica Robles Fradejas, María de Los Angeles Martín Macías, Ana Biain Ciganda, Zuriñe Bustinza Beaskoetxea, Enrique Ruiz Pérez, Gonzalo Fernández Matia, Javier Martínez Guisasola
No abstract text is available yet for this article.
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28758950/tgf%C3%AE-controls-ovarian-cancer-cell-proliferation
#18
REVIEW
Elisenda Alsina-Sanchís, Agnès Figueras, Alvaro Lahiguera, Marta Gil-Martín, Beatriz Pardo, Josep M Piulats, Lola Martí, Jordi Ponce, Xavier Matias-Guiu, August Vidal, Alberto Villanueva, Francesc Viñals
There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the signaling pathways involved is required. The Transforming Growth Factor (TGFβ) family controls different cellular responses in development and cell homeostasis. Disruption of TGFβ signaling has been implicated in many cancers, including ovarian cancer...
July 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28755900/assessment-of-urinary-tweak-levels-in-mexican-patients-with-untreated-lupus-nephritis-an-exploratory-study
#19
Fabiola Reyes-Martínez, Monserrat Pérez-Navarro, Adrián Rodríguez-Matías, Virgilia Soto-Abraham, Gabriela Gutierrez-Reyes, Zaira Medina-Avila, Rafael Valdez-Ortiz
OBJECTIVES: Urinary levels of TWEAK (uTWEAK) may be correlated with the degree of lupus nephritis (LN) activity. Our objective was to determine the sensitivity and specificity of uTWEAK in Mexican patients with untreated active lupus nephritis. METHODS: An exploratory study was performed; four groups of patients were analyzed as follows: 1) patients with systemic lupus erythematosus (SLE) without renal activity (SLE-LN), 2) patients with SLE with renal activity (SLE+LN), 3) patients with other types of glomerulopathy (glomerulonephritis, GMN), 4) and healthy patients (controls)...
July 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28755848/the-use-of-brazilian-propolis-for-discovery-and-development-of-novel-anti-inflammatory-drugs
#20
REVIEW
Marcelo Franchin, Irlan Almeida Freires, Josy Goldoni Lazarini, Bruno Dias Nani, Marcos Guilherme da Cunha, David Fernando Colón, Severino Matias de Alencar, Pedro Luiz Rosalen
Anti-Inflammatory drugs have been routinely used in the management of acute and chronic inflammatory conditions. Nevertheless, their undesirable side and adverse effects have encouraged the development of more selective, tolerable and efficacious drugs able to modulate the inflammatory process through distinct mechanisms than those of drugs currently available in the market, for instance, inhibition of leukocyte recruitment (chemotaxis, rolling, adhesion and transmigration). Natural products, including Brazilian propolis, have been considered a rich source of anti-inflammatory molecules due to a very complex phytochemical diversity...
June 27, 2017: European Journal of Medicinal Chemistry
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