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https://www.readbyqxmd.com/read/27926510/genetic-and-epigenetic-characterization-of-the-brca1-gene-in-brazilian-women-at-risk-for-hereditary-breast-cancer
#1
Paula Silva Felicio, Matias Eliseo Melendez, Lidia Maria Rebolho Batista Arantes, Ligia Maria Kerr, Dirce Maria Carraro, Rebeca Silveira Grasel, Natalia Campacci, Cristovam Scapulatempo-Neto, Gabriela Carvalho Fernandes, Ana Carolina de Carvalho, Edenir Inêz Palmero
This study aimed to characterize women at-risk for hereditary BC regarding their clinical and molecular characteristics (mutation and methylation in the BRCA1 gene) and correlate the gene expression levels with histopathological, clinical and family history information. BRCA1 real time qPCR was performed to evaluate methylation status and gene expression. The study included 88 women grouped according to the BRCA1 mutational status: 23 BRCA1 mutated, 22 with a Variant of Unknown Significance (VUS) in BRCA1 and 43 BRCA1 WT...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925054/prone-position-in-patients-with-acute-respiratory-distress-syndrome
#2
Mariano Setten, Gustavo Adrián Plotnikow, Matías Accoce
Acute respiratory distress syndrome occupies a great deal of attention in intensive care units. Despite ample knowledge of the physiopathology of this syndrome, the focus in intensive care units consists mostly of life-supporting treatment and avoidance of the side effects of invasive treatments. Although great advances in mechanical ventilation have occurred in the past 20 years, with a significant impact on mortality, the incidence continues to be high. Patients with acute respiratory distress syndrome, especially the most severe cases, often present with refractory hypoxemia due to shunt, which can require additional treatments beyond mechanical ventilation, among which is mechanical ventilation in the prone position...
December 1, 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27923813/the-chemical-basis-of-thiol-addition-to-nitro-conjugated-linoleic-acid-a-protective-cell-signaling-lipid
#3
Lucia Turell, Dario A Vitturi, E Laura Coitiño, Lourdes Lebrato, Matias N Moller, Camila Sagasti, Sonia R Salvatore, Steven R Woodcock, Beatriz Alvarez, Francisco J Schopfer
Nitroalkene fatty acids are formed in vivo and exert protective and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key signaling pathways. Nitro-conjugated linoleic acid (NO2-CLA) is preferentially formed, constitutes the most abundant nitrated fatty acid in humans and contains two carbons that could potentially react with thiols, modulating signaling actions and levels. In this work, we examined the reactions of NO2-CLA with low molecular weight thiols (glutathione, cysteine, homocysteine, cysteinylglycine and β mercaptoethanol) and human serum albumin (HSA)...
December 6, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27923464/news-in-multiple-sclerosis-remyelination-as-a-therapeutic-target
#4
Jorge Matías-Guiu, Ulises Gomez-Pinedo, Jordi A Matias-Guiu
No abstract text is available yet for this article.
December 3, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27920944/comparing-obesity-related-health-disparities-among-native-hawaiians-pacific-islanders-asians-and-whites-in-california-reinforcing-the-need-for-data-disaggregation-and-operationalization
#5
Adrian Matias Bacong, Christina Holub, Liki Porotesano
Since the 2000 Census, Asians and Pacific Islanders have been categorized as separate races. Government initiatives have called for greater study of Asian, Native Hawaiian, and other Pacific Islander (NHPI) health outcomes. NHPI often have worse health outcomes than Asians and Whites. Despite this, the lack of operationalization of racial definitions may affect the magnitude of health disparities. This analysis examined how utilizing different sociological race definitions could influence NHPI health outcomes when compared to Asians and Whites...
November 2016: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/27919993/laryngo-esophageal-dysfunction-free-survival-in-a-preservation-protocol-for-t3-laryngeal-squamous-cell-carcinoma
#6
Philippe Gorphe, Margarida Matias, Caroline Even, Charles Ferte, François Bidault, Gabriel Garcia, Stéphane Temam, France Nguyen, Pierre Blanchard, Yungan Tao, François Janot
BACKGROUND: We reviewed the outcomes of patients with T3 laryngeal neoplasms with a fixed hemilarynx, a large gross tumor volume or a subglottic extension (SGE), treated with a laryngeal-preservation protocol with induction chemotherapy. PATIENTS AND METHODS: The study end-points were laryngo-esophageal dysfunction-free survival (LEDFS), laryngectomy-free survival (LFS), overall survival (OS), and disease-free survival (DFS). RESULTS: A total of 104 patients were included...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27918141/structure-and-fluxionality-of-b13-probed-by-infrared-photodissociation-spectroscopy
#7
Matias R Fagiani, Xiaowei Song, Petko Petkov, Sreekanta Debnath, Sandy Gewinner, Wieland Schöllkopf, Thomas Heine, André Fielicke, Knut R Asmis
We use cryogenic ion vibrational spectroscopy to characterize the structure and fluxionality of the magic number boron cluster B13(+) . The infrared photodissociation (IRPD) spectrum of the D2 -tagged all-(11) B isotopologue of B13(+) is reported in the spectral range from 435 to 1790 cm(-1) and unambiguously assigned to a planar boron double wheel structure based on a comparison to simulated IR spectra of low energy isomers from density-functional-theory (DFT) computations. Born-Oppenheimer DFT molecular dynamics simulations show that B13(+) exhibits internal quasi-rotation already at 100 K...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27915409/does-adolescent-motherhood-affect-education-and-labor-market-outcomes-of-mothers-a-study-on-young-adult-women-in-chile-during-1990-2013
#8
Matias Berthelon, Diana I Kruger
OBJECTIVES: We analyze the impact of adolescent motherhood on several education and labor market outcomes in Chile over the 1990-2013 period. We explore whether effects are different across income levels, timing of adolescent births, and three sub-periods. METHODS: Using the CASEN national household survey, we applied propensity score-matching methods on two samples of women aged 24: one for women in the 2009-2013 period and another sample of 24-year-old women living with their mother between 1990-2013...
December 3, 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/27914672/superficial-basal-cell-carcinoma
#9
Roberto Cullen, Paula Hasbún, Matías Campos-Villenas
No abstract text is available yet for this article.
November 30, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27910068/endometrial-carcinoma-specific-targeted-pathways
#10
Nuria Eritja, Andree Yeramian, Bo-Juen Chen, David Llobet-Navas, Eugenia Ortega, Eva Colas, Miguel Abal, Xavier Dolcet, Jaume Reventos, Xavier Matias-Guiu
Endometrial cancer (EC) is the most common gynecologic malignancy in the western world with more than 280,000 cases per year worldwide. Prognosis for EC at early stages, when primary surgical resection is the most common initial treatment, is excellent. Five-year survival rate is around 70 %.Several molecular alterations have been described in the different types of EC. They occur in genes involved in important signaling pathways. In this chapter, we will review the most relevant altered pathways in EC, including PI3K/AKT/mTOR, RAS-RAF-MEK-ERK, Tyrosine kinase, WNT/β-Catenin, cell cycle, and TGF-β signaling pathways...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27905097/novel-biomarkers-in-primary-breast-core-biopsies-to-predict-poor-response-to-neoadjuvant-chemotherapy-and-appearance-of-metastases
#11
Anna Novell, Serafin Morales, Joan Valls, Maria José Panadés, Antonieta Salud, Edelmiro Iglesias, Felip Vilardell, Xavier Matias-Guiu, Antonio Llombart-Cussac
Drug resistance has been one of the major obstacles limiting the success of cancer chemotherapy. In two thirds of breast cancer patients, large (>1cm) residual tumors are present after neoadjuvant chemotherapy (NCT). The residual tumor and involved nodes have been indicators of relapse and survival very important in breast cancer. The goal of this preliminary study was to assess the predictive significance of a panel of molecular biomarkers, related with the response to treatment or drug resistance to NCT, as determined on the diagnostic tumor...
December 1, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27903647/the-production-and-utilization-of-gdp-glucose-in-the-biosynthesis-of-trehalose-6-phosphate-by-streptomyces-venezuelae
#12
Matías D Asencion Diez, Farzana Miah, Clare E M Stevenson, David M Lawson, Alberto A Iglesias, Stephen Bornemann
Trehalose-6-phosphate synthase OtsA from streptomycetes is unusual in that it uses GDP-glucose as the donor substrate rather than the more commonly used UDP-glucose. We now confirm that OtsA from Streptomyces venezuelae has such a preference for GDP-glucose and can utilise ADP-glucose to some extent too. A crystal structure of the enzyme shows that it shares twin Rossmann-like domains with the UDP-glucose-specific OtsA from Escherichia coli However, it is structurally more similar to Streptomyces hygroscopicus VldE, a GDP-valienol-dependent pseudo-glycosyltransferase enzyme...
November 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27902301/isolation-of-vibrio-tapetis-from-two-native-fish-species-genypterus-chilensis-and-paralichthys-adspersus-reared-in-chile-and-description-of-vibrio-tapetis-subsp-quintayensis-subsp-nov
#13
Arturo Levican, Aide Lasa, Rute Irgang, Jesús L Romalde, Matías Poblete-Morales, Ruben Avendaño-Herrera
Seven isolates recovered from diseased fine flounders (Paralichthys adspersus) and red conger eel (Genypterus chilensis) experimentally reared in Quintay (Chile) were confirmed as V. tapetis on the basis of the MALDI-TOF MS, 16S rRNA gene, DNA-DNA hybridization values and G+C content. The ERIC-PCR and REP-PCR patterns were homogeneous among those isolates recovered from a same host, but distinct to the type strains V. tapetis subsp. tapetis CECT 4600T and V. tapetis subsp. britannicus CECT 8161T. On the basis of atpA, rpoA, rpoD, recA and pyrH gene similarities (99...
November 30, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27895947/subacute-bacterial-endocarditis-with-leptotrichia-goodfellowii-in-a-patient-with-a-valvular-allograft-a-case-report-and-review-of-the-literature
#14
Wilfredo R Matias, Daniel L Bourque, Tomoko Niwano, Andrew B Onderdonk, Joel T Katz
Leptotrichia species are normal constituents of the oral cavity and the genitourinary tract microbiota that are known to provoke disease in immunocompromised patients and rarely in immunocompetent individuals. Following the description of Leptotrichia goodfellowii sp. nov., two cases of endocarditis by this species have been reported. Here, we report a case of Leptotrichia goodfellowii endocarditis in an immunocompetent patient with a valvular allograft. The isolation and identification of Leptotrichia can be challenging, and it is likely that infection with this pathogen is significantly underdiagnosed...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27895324/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#15
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
No abstract text is available yet for this article.
December 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27893763/the-role-of-morbid-obesity-in-the-promotion-of-metabolic-disruptions-and-non-alcoholic-steatohepatitis-by-helicobacter-pylori
#16
Albert Lecube, Silvia Valladares, Carolina López-Cano, Liliana Gutiérrez, Andreea Ciudin, José Manuel Fort, Josep Maria Reñé, Xavier Matias-Guiu, Inés de Torres, Marta Bueno, Judit Pallarés, Juan Antonio Baena
BACKGROUND: Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant and no studies exist in morbidly obese patients, in which both insulin resistance and inflammation coexist. MATERIAL AND METHODS: Cross-sectional study to evaluate the relationship between HP infection and alterations in carbohydrate metabolism, lipid profile, inflammation markers, and liver disease in patients awaiting for bariatric surgery...
2016: PloS One
https://www.readbyqxmd.com/read/27890462/radiation-pneumonitis-following-hepatic-yttrium-90-radioembolization
#17
Horacio Matías Castro, Esteban Javier Wainstein, Joaquin Maritano Furcada
No abstract text is available yet for this article.
November 24, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27889416/reducing-spontaneous-recovery-and-reinstatement-of-operant-performance-through-extinction-cues
#18
Rodolfo Bernal-Gamboa, A Matías Gámez, Javier Nieto
It has been argued that the response recovery effects share a common mechanism. A possible way to test it is evaluating whether the techniques that impaired renewal would impair the other recovery effects as well. Two experiments with rats used a free operant procedure to explore whether an extinction-cue could prevent the spontaneous recovery and reinstatement of an extinguished lever-pressing. Both experiments consisted of four phases: Acquisition, Extinction and Test 1 and Test 2. First, all rats were trained to perform one instrumental response (R1) for food in context A, and a different instrumental response (R2) for food in context B...
November 23, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27888692/mitochondrial-gsh-replenishment-as-a-potential-therapeutic-approach-for-niemann-pick-type-c-disease
#19
Sandra Torres, Nuria Matías, Anna Baulies, Susana Nuñez, Cristina Alarcon-Vila, Laura Martinez, Natalia Nuño, Anna Fernandez, Joan Caballeria, Thierry Levade, Alba Gonzalez-Franquesa, Pablo Garcia-Rovés, Elisa Balboa, Silvana Zanlungo, Gemma Fabrías, Josefina Casas, Carlos Enrich, Carmen Garcia-Ruiz, José C Fernández-Checa
Niemann Pick type C (NPC) disease is a progressive lysosomal storage disorder caused by mutations in genes encoding NPC1/NPC2 proteins, characterized by neurological defects, hepatosplenomegaly and premature death. While the primary biochemical feature of NPC disease is the intracellular accumulation of cholesterol and gangliosides, predominantly in endolysosomes, mitochondrial cholesterol accumulation has also been reported. As accumulation of cholesterol in mitochondria is known to impair the transport of GSH into mitochondria, resulting in mitochondrial GSH (mGSH) depletion, we investigated the impact of mGSH recovery in NPC disease...
November 20, 2016: Redox Biology
https://www.readbyqxmd.com/read/27888508/outcomes-following-laryngectomy-refusal-after-insufficient-response-to-induction-chemotherapy
#20
Philippe Gorphe, Margarida Matias, Pierre Blanchard, Caroline Even, Charles Ferte, Yungan Tao, Stéphane Temam, François Bidault, François Janot
OBJECTIVE: To review patients who refused a total laryngectomy and were treated with radiotherapy (RT) after insufficient response to induction chemotherapy in a larynx preservation protocol for advanced-stage cancer of the larynx and to compare their outcomes with good responders. STUDY DESIGN: Retrospective cohort study. METHODS: Eighty-six patients treated with induction chemotherapy followed by RT were included in the analysis: 75 good responders and 11 insufficient responders who refused surgery...
November 26, 2016: Laryngoscope
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