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Louis J M van der Putten, Nicole C M Visser, Koen van de Vijver, Maria Santacana, Peter Bronsert, Johan Bulten, Marc Hirschfeld, Eva Colas, Antonio Gil-Moreno, Angel Garcia, Gemma Mancebo, Fransesc Alameda, Jone Trovik, Reidun K Kopperud, Jutta Huvila, Stefanie Schrauwen, Martin Koskas, Francine Walker, Vit Weinberger, Lubos Minar, Eva Jandakova, Marc P L M Snijders, Saskia van den Berg-van Erp, Xavier Matias-Guiu, Helga B Salvesen, Henrica M J Werner, Frederic Amant, Leon F A G Massuger, Johanna M A Pijnenborg
OBJECTIVES: Endometrial carcinoma mortality is mainly caused by recurrent disease, and various immunohistochemical markers to predict recurrences have been studied. Loss of the estrogen receptor (ER) and progesterone receptor (PR) and the presence of the L1 cell adhesion molecule (L1CAM) are promising markers, but their combined value has not been studied. MATERIALS AND METHODS: Expression of ER, PR, and L1CAM was immunohistochemically determined in 293 endometrial carcinomas from 11 collaborating European Network for Individualized Treatment of Endometrial Cancer centers...
January 10, 2018: International Journal of Gynecological Cancer
David Valentín, Alexandre Presas, Matias Bossio, Mònica Egusquiza, Eduard Egusquiza, Carme Valero
Nowadays, hydropower plays an essential role in the energy market. Due to their fast response and regulation capacity, hydraulic turbines operate at off-design conditions with a high number of starts and stops. In this situation, dynamic loads and stresses over the structure are high, registering some failures over time, especially in the runner. Therefore, it is important to know the dynamic response of the runner while in operation, i.e., the natural frequencies, damping and mode shapes, in order to avoid resonance and fatigue problems...
January 10, 2018: Sensors
Mario F Muñoz, Sandro Argüelles, Matias Guzman-Chozas, Remedios Guillén-Sanz, Jaime M Franco, José A Pintor-Toro, Mercedes Cano, Antonio Ayala
Adipose tissue is an important source of adipose derived stem cells (ADSCs). These cells have the potential of being used for certain therapies, in which the main objective is to recover the function of a tissue/organ affected by a disease. In order to contribute to repair of the tissue, these cells should be able to survive and carry out their functions in unfavorable conditions after being transplanted. This process requires a better understanding of the biology involved: such as the time cells remain in the implant site, how long they stay there, and whether or not they differentiate into host tissue cells...
January 10, 2018: Journal of Cellular Physiology
Antonio Guglielmetti, Matías Gompertz, Catalina Jahr, Tomas Silva, Sergio González
No abstract text is available yet for this article.
January 10, 2018: International Journal of Dermatology
César Navea, Christian von Mühlenbrock, Nicolás Cabello, Matías Echeverría, Andrea Jiménez, Jaime Poniachik
No abstract text is available yet for this article.
January 6, 2018: Gastroenterología y Hepatología
Rita Ventura Matos, Natércia Matias, Filipa Ferreira, João Santos Silva, José Saldanha Matos
Production and build-up of sulfide in wastewater systems, especially downstream of rising mains, may lead to severe odour nuisance, toxic environments and high risk of corrosion. Due to increased population migration towards cities and lower area availability for treatment facilities, rising mains for the conveyance of wastewater sludge are becoming more frequent, and research on sulfide build-up in such cases is needed. In this paper the findings of the work carried out in a full scale wastewater sludge rising main, operated during different seasons and under distinct conditions are presented (comprising both the start-up and normal operation stages of the facility)...
January 6, 2018: Journal of Environmental Management
Matías A Zúñiga, Joel B Alderete, Gonzalo A Jaña, Pedro A Fernandez, Maria J Ramos, Verónica A Jiménez
Laulimalide (LAU) and Peloruside A (PLA) are non-taxane microtubule stabilizing agents with promising antimitotic properties. These ligands promote the assembly of microtubules (MTs) by targeting a unique binding site on β-tubulin. The X-ray structure for LAU/PLA-tubulin association was recently elucidated but little information is available regarding the role of these ligands as modulators of interdimeric interactions across MTs. Herein we report the use of Molecular Dynamics (MD), Principal Component Analysis (PCA), MM/GBSA binding free energy calculations, and computational Alanine Scanning Mutagenesis (ASM) to examine effect of LAU/PLA association on lateral and longitudinal contacts between tubulin dimers in reduced MT models...
January 6, 2018: Chemical Biology & Drug Design
Matías Castells, Carlos Schild, Darío Caffarena, Marina Bok, Federico Giannitti, Joaquín Armendano, Franklin Riet-Correa, Matías Victoria, Viviana Parreño, Rodney Colina
AIM: To analyze group A rotavirus (RVA) environmental contamination in waters used for calves' consumption and to assess viral viability in dairy farm water sources. METHODS AND RESULTS: We analyzed 202 samples of water used for calves' consumption and RVA was detected by RT-qPCR in 35.1% (95%CI: 28.9-42.0%). A marked pattern of seasonality was observed with higher frequency of detection in colder than warmer months (p=0.002). There was no association between viral load and season or between the number of milking cows in the herd and the detection of RVA in the farm...
January 9, 2018: Journal of Applied Microbiology
Vikram Wadhera, Norifumi Harimoto, Nir Lubezky, Ilias Gomatos, Matias Facciuto, David Gonzalez, Ashley Stueck, M Isabel Fiel, Thomas Schiano, Marcelo Facciuto
BACKGROUND: The utilization of extended criteria liver allografts (ECD) shortens time to transplantation. OBJECTIVE: To characterize the effect of liver allograft fibrosis on graft and patient survival after LT, with particular attention to fibrosis progression. METHODS: Retrospective database search of donor and recipient liver allograft histology of liver transplants performed between 2007 and 2011. Donor and patient characteristics were analyzed...
January 3, 2018: Clinical Transplantation
José P Morgado, Cristina P Monteiro, Catarina N Matias, Joana F Reis, Júlia Teles, Maria José Laires, Francisco Alves
PURPOSE: Long-term training influence on athletes' immune cell response to acute exercise has been poorly studied, despite the complexity of both chronic and acute adaptations induced by training. The purpose of the study is to study the influence of a 4-month swimming training cycle on the immune cell response to a high-intensity training session, during 24 h of recovery, considering sex, maturity, and age group. METHODS: Forty-three swimmers (16 females, 14.4 ± 1...
January 8, 2018: European Journal of Applied Physiology
Núria Eritja, Mariona Jové, Kristine Eldevik Fasmer, Sònia Gatius, Manuel Portero-Otin, Jone Trovik, Camilla Krakstad, Joaquim Sol, Reinald Pamplona, Ingfrid S Haldorsen, Xavier Matias-Guiu
Purpose: We aimed to study the potential influence of tumour blood flow -obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours. Methods: Liquid chromatography coupled to mass spectrometry established the metabolomic profile of endometrial cancer lesions exhibiting high (n=12) or low (n=14) tumour blood flow at DCE-MRI. Univariate and multivariate statistics (ortho-PLS-DA, a random forest (RF) classifier and hierarchical clustering) and receiver operating characteristic (ROC) curves were used to establish a panel for potentially discriminating tumours with high versus low blood flow...
December 12, 2017: Oncotarget
Mariano S Picchio, Vanesa R Sánchez, Nadia Arcon, Ariadna S Soto, Matías Perrone Sibilia, María de Los Angeles Aldirico, Mariela Urrutia, Moretta Rosalía, Ignacio M Fenoy, Alejandra Goldman, Valentina Martin
The development of an effective and safe vaccine to prevent Toxoplasma gondii infection is an important aim due to the great clinical and economic impact of this parasitosis. We have previously demonstrated that immunization with the serine protease inhibitor-1 (TgPI-1) confers partial protection to C3H/HeN and C57BL/6 mice. In order to improve the level of protection, in this work, we combined this novel antigen with ROP2 and/or GRA4 recombinant proteins (rTgPI-1+rROP2, rTgPI-1+rGRA4, rTgPI-1+rROP2+rGRA4) to explore the best combination against chronic toxoplasmosis in C3H/HeN mice...
January 5, 2018: Experimental Parasitology
Marina O Fernandez, Nadia S Bourguignon, Paula Arocena, Matías Rosa, Carlos Libertun, Victoria Lux-Lantos
Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500 μg 50 μl-1 oil (B500), or 50 μg 50 μl-1 (B50), or 5 μg 50 μl-1 (B5). Controls were injected with 50 μl vehicle during the same period...
January 2, 2018: Toxicology Letters
A Matías Gámez, Rodolfo Bernal-Gamboa
The study of post-extinction recovery effects in humans has received significant attention. For instance, research on reinstatement has increased in the last decade. However, most of the studies focus on the return of fear responses. In the present experiments, we used a videogame task to explore the reinstatement of operant behavior in human participants. In Experiment 1, after participants learned to shoot at enemies, they received an extinction procedure that eliminated the shooting behavior. However, the mere reintroduction of the outcome reinstated the original response...
January 2, 2018: Acta Psychologica
J Carola Pérez, Soledad Coo, Matías Irarrázaval
While adolescent-parent disagreements about family functioning are common, they may also be indicative of family members' health problems and may compromise adolescent adjustment. This study examines the association between maternal depressive symptoms and family functioning perceptions, considering both the adolescents' and their mothers' points of view. A sample of 943 Chilean dyads of adolescents (69% female, Mage = 14.43 years old) and their mothers (Mage = 43.20 years) reported their perceptions of family cohesion and adaptability...
January 2, 2018: Journal of Adolescence
Paul Maurice Conway, Annie Høgh, Kirsten Nabe-Nielsen, Matias Brødsgaard Grynderup, Eva Gemzøe Mikkelsen, Roger Persson, Reiner Rugulies, Jens Peter Ellekilde Bonde, Laura Francioli, Åse Marie Hansen
Objectives: The behavioural experience method has been extensively used in the literature for the measurement of potential bullying behaviours at work. However, this approach presents limitations when used to classify respondents as targets or non-targets of workplace bullying. Therefore, the present study aimed to: (i) identify optimal cut-off points, reflecting a possible subjectively experienced exposure to occasional and frequent workplace bullying, for the 9-item Short Negative Act Questionnaire (S-NAQ), and (ii) examine the criterion validity of these cut-off points in relation to depressive symptoms and diagnosis of depression...
January 3, 2018: Annals of Work Exposures and Health
Matías Salvo, Andrés Lizasoain, Matías Castells, Viviana Bortagaray, Sebastián Castro, Rodney Colina, Fernando Lopez Tort, Matías Victoria
Human bocavirus (HBoV) infections are related to respiratory and gastroenteric diseases. The aim of this study was to investigate the presence of HBoV in both sewage and surface waters in Uruguay. Sixty-eight sewage samples from the cities of Salto, Paysandú, Bella Unión, Fray Bentos, Treinta y Tres and Melo and 36 surface water samples from the cities of Salto, Florida and Santa Lucía were studied. HBoV was screened by multiplex qPCR for the detection of the four subtypes, followed by monoplex qPCRs for the independent quantification of each subtype...
January 3, 2018: Food and Environmental Virology
Matías S Pellegrino, Ignacio D Frola, Berardo Natanael, Dino Gobelli, María E F Nader-Macias, Cristina I Bogni
Bovine mastitis causes economic losses on dairy farms worldwide. Lactic acid bacteria (LAB) in animal health are an alternative tool to avoid antibiotic therapy on the prevention of bovine mastitis. In previous studies, 12 LAB isolated from bovine milk were selected taking into account some of the following characteristics: hydrophobicity, auto aggregative capability, inhibition of indicator pathogens, hydrogen peroxide, and capsular polysaccharide production. These LAB were considered because of their beneficial properties...
January 2, 2018: Probiotics and Antimicrobial Proteins
Pau Matias-Guiu, Juan José Rodríguez-Bencomo, José R Pérez-Correa, Francisco López
Developing new distillation strategies can help the spirits industry to improve quality, safety and process efficiency. Batch stills equipped with a packed column and an internal partial condenser are an innovative experimental system, allowing a fast and flexible management of the rectification. In this study, the impact of four factors (heart-cut volume, head-cut volume, pH and cooling flow rate of the internal partial condenser during the head-cut fraction) on 18 major volatile compounds of Muscat spirits was optimized using response surface methodology and desirability function approaches...
April 15, 2018: Food Chemistry
María F Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A Rivas, Rosalía Cordo-Russo, Cecilia J Proietti, Elmer A Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G Gercovich, Eduardo Cortese, Matías Amasino, Pablo Guzmán, Juan C Roa, Patricia V Elizalde, Roxana Schillaci
BACKGROUND: Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement. IMPC is an aggressive tumor with poor clinical outcome. In addition, this histological subtype usually expresses human epidermal growth factor receptor 2 (HER2) which also correlates with a more aggressive tumor. In this work we studied the clinical significance of IMPC in HER2-positive breast cancer patients treated with adjuvant trastuzumab...
December 28, 2017: BMC Cancer
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