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Peripheral blood gene expression in atherosclerosis

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https://www.readbyqxmd.com/read/29651704/hdac9-polymorphism-alters-blood-gene-expression-in-patients-with-large-vessel-atherosclerotic-stroke
#1
Natasha Shroff, Bradley P Ander, Xinhua Zhan, Boryana Stamova, DaZhi Liu, Heather Hull, Farah R Hamade, Cheryl Dykstra-Aiello, Kwan Ng, Frank R Sharp, Glen C Jickling
The histone deacetylase 9 (HDAC9) polymorphism rs2107595 is associated with an increased risk for large vessel atherosclerotic stroke (LVAS). In humans, there remains a need to better understand this HDAC9 polymorphism's contribution to large vessel stroke. In this pilot study, we evaluated whether the HDAC9 polymorphism rs2107595 is associated with differences in leukocyte gene expression in patients with LVAS. HDAC9 SNP rs2107595 was genotyped in 155 patients (43 LVAS and 112 vascular risk factor controls)...
April 13, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29596498/analyses-of-genome-wide-association-data-cytokines-and-gene-expression-in-african-americans-with-benign-ethnic-neutropenia
#2
Bashira A Charles, Matthew M Hsieh, Adebowale A Adeyemo, Daniel Shriner, Edward Ramos, Kyung Chin, Kshitij Srivastava, Neil A Zakai, Mary Cushman, Leslie A McClure, Virginia Howard, Willy A Flegel, Charles N Rotimi, Griffin P Rodgers
BACKGROUND: Benign ethnic neutropenia (BEN) is a hematologic condition associated with people of African ancestry and specific Middle Eastern ethnic groups. Prior genetic association studies in large population showed that rs2814778 in Duffy Antigen Receptor for Chemokines (DARC) gene, specifically DARC null red cell phenotype, was associated with BEN. However, the mechanism of this red cell phenotype leading to low white cell count remained elusive. METHODS: We conducted an extreme phenotype design genome-wide association study (GWAS), analyzed ~16 million single nucleotide polymorphisms (SNP) in 1,178 African-Americans individuals from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study and replicated from 819 African-American participants in the Atherosclerosis Risk in Communities (ARIC) study...
2018: PloS One
https://www.readbyqxmd.com/read/29584810/identification-of-mir-9-5p-as-direct-regulator-of-abca1-and-hdl-driven-reverse-cholesterol-transport-in-circulating-cd14-cells-of-patients-with-metabolic-syndrome
#3
Simona D'Amore, Jennifer Härdfeldt, Marica Cariello, Giusi Graziano, Massimiliano Copetti, Giuseppe Di Tullio, Marilidia Piglionica, Natasha Scialpi, Carlo Sabbà, Giuseppe Palasciano, Michele Vacca, Antonio Moschetta
Aims & Methods: metabolic syndrome is a cluster of cardio-metabolic risk factors associated to atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 miRNAs controlling inflammatory, immune and metabolic responses. In order to further elucidate the link between inflammation and the HDL cholesterol pathway in metabolic syndrome (MS), we focused on the regulation of the ATP-binding cassette transporter A1 (ABCA1), a key player in cholesterol efflux...
March 23, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29499204/alteration-in-microrna-25-expression-regulate-cardiac-function-via-renin-secretion
#4
Hongzhi Li, Yeming Xie, Yunshuang Liu, Yali Qi, Chong Tang, Xuefeng Li, Kuiyang Zuo, Dingce Sun, Yongchao Shen, Daxin Pang, Yanhhui Chu, Binghai Zhao
Heart failure arises from diverse cardiovascular diseases, including hypertension, ischemic disease and atherosclerosis, valvular insufficiency, myocarditis, and contractile protein mutations. MicroRNAs are dysregulated in heart failure, but identification of the specific microRNAs involved remains incomplete. Here, we evaluate miR-25 expression in the peripheral blood from healthy, dilated cardiomyopathy (DCM), remote infarct (OMI), hypertensive heart disease (HHD), and HHD resulting in heart failure (HHDF) using q-PCR...
February 27, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29479887/niemann-pick-disease-type-c1-gene-expression-in-pbmcs-is-associated-with-interleukin-10-serum-concentration-a-case-control-study
#5
Fatemeh Zali, Maryam Teimouri, Parisa Shabani, Akram Vatannejad, Mahdi Najafi, Hossein Shateri, Mostafa Asadnia, Mahmood Doosti
BACKGROUND: Recent studies showed that atherosclerosis is a lysosomal storage disease (LSD) and Niemann-Pick disease type C1 (NPC1) is the most important protein of the lysosomal membrane that is involved in the removal of FC from lysosomes. Whereas several in vitro and in vivo studies have described the crosstalk between lysosomal cholesterol accumulation and increased inflammation, there is no study addressing the correlation between NPC1 gene expression and an anti-inflammatory cytokine, interleukin 10 (IL-10) serum concentration in atherosclerotic patients...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29420090/lxr%C3%AE-is-expressed-at-higher-levels-in-healthy-people-compared-to-atherosclerosis-patients-and-its-over-expression-polarizes-macrophages-towards-an-anti-inflammatory-m%C3%AE-2-phenotype
#6
Mengyuan Liu, Weijian Yang, Shuling Liu, Duncan Hock, Bohao Zhang, Ruth Ya Huo, Xiaoguang Tong, Hua Yan
OBJECTIVES: (1) To investigate the expression patterns of MΦ1 and MΦ2 phenotype markers of peripheral blood monocyte (PBMC)-derived macrophages in atherosclerosis patients and healthy controls, as well as the expression correlation among these genes. (2) To elucidate whether a high level of liver X receptor α (LXRα) expression is associated with anti-inflammatory MΦ2-type polarization. DESIGN: Peripheral blood monocytes (PBMCs) were obtained from 28 patients with carotid artery plaques and 10 normal persons, who did not have carotid artery plaques...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29366786/smad7-methylation-as-a-novel-marker-in-atherosclerosis
#7
Lihua Wei, Shimei Zhao, Gaoxing Wang, Shiming Zhang, Weibo Luo, Zhengxue Qin, Xiongjie Bi, Yimei Tan, Moke Meng, Jun'an Qin, Huiping Qin, Dan Tian, An'wen Zhang
Atherosclerosis is a complicated process comprising inflammation, accumulation of collagen matrix and aberrant DNA methylation. SMAD7 is known to play an important role in fibrosis and inflammation. In recent years, increasing research has concentrated on the connection between DNA methylation and atherosclerosis. The current study was designed to investigate methylation status of some specific gene with a focus on SMAD7 in atherosclerosis and elucidate their relationship. We found that SMAD7 expression was decreased and its promoter region was markedly methylated in atherosclerotic plaques when compared with normal artery walls...
January 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29250154/microrna-24-inhibits-the-proliferation-and-migration-of-endothelial-cells-in-patients-with-atherosclerosis-by-targeting-importin-%C3%AE-3-and-regulating-inflammatory-responses
#8
Ye Zheng, Yongxing Li, Gang Liu, Xiangqian Qi, Xufen Cao
The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. A total of 30 patients with atherosclerosis admitted to hospital between January and June 2016 were enrolled in the present study; 30 healthy subjects with a similar age range were enrolled as controls...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29234849/urbanization-in-sub-saharan-africa-declining-rates-of-chronic-and-recurrent-infection-and-their-possible-role-in-the-origins-of-non-communicable-diseases
#9
REVIEW
Stephen W Bickler, Andrew Wang, Said Amin, Jonathan Halbach, Radhames Lizardo, David M Cauvi, Antonio De Maio
BACKGROUND: Non-communicable diseases (NCDs), such as atherosclerosis and cancers, are a leading cause of death worldwide. An important, yet poorly explained epidemiological feature of NCDs is their low incidence in under developed areas of low-income countries and rising rates in urban areas. METHODS: With the goal of better understanding how urbanization increases the incidence of NCDs, we provide an overview of the urbanization process in sub-Saharan Africa, discuss gene expression differences between rural and urban populations, and review the current NCD determinant model...
December 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29207167/prazosin-protects-myocardial-cells-against-anoxia-reoxygenation-injury-via-the-extracellular-signal%C3%A2-regulated-kinase-signaling-pathway
#10
Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui
Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms underlying the effects of prazosin have not been fully elucidated. The aim of the present study was to investigate the protective effects of prazosin on myocardial cells against anoxia‑reoxygenation injury in a mouse model...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29176764/interleukin-27-is-increased-in-carotid-atherosclerosis-and-promotes-nlrp3-inflammasome-activation
#11
Ida Gregersen, Øystein Sandanger, Erik T Askevold, Ellen Lund Sagen, Kuan Yang, Sverre Holm, Turid M Pedersen, Mona Skjelland, Kirsten Krohg-Sørensen, Trond Vidar Hansen, Tuva Børresdatter Dahl, Kari Otterdal, Terje Espevik, Pål Aukrust, Arne Yndestad, Bente Halvorsen
AIM: Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid atherosclerosis and if IL-27 could modulate the inflammatory effects of the NLRP3 inflammasome in vitro. METHODS: Plasma IL-27 was measured by enzyme immunoassay in patients with carotid stenosis (n = 140) and in healthy controls (n = 19). Expression of IL-27 and IL-27R was analyzed by quantitative PCR and immunohistochemistry in plaques from patients and in non-atherosclerotic vessels...
2017: PloS One
https://www.readbyqxmd.com/read/29153655/clinical-evidence-supports-a-protective-role-for-cxcl5-in-coronary-artery-disease
#12
Saranya Ravi, Robert N Schuck, Eleanor Hilliard, Craig R Lee, Xuming Dai, Kaitlin Lenhart, Monte S Willis, Brian C Jensen, George A Stouffer, Cam Patterson, Jonathan C Schisler
Our goal was to measure the association of CXCL5 and molecular phenotypes associated with coronary atherosclerosis severity in patients at least 65 years old. CXCL5 is classically defined as a proinflammatory chemokine, but its role in chronic inflammatory diseases, such as coronary atherosclerosis, is not well defined. We enrolled individuals who were at least 65 years old and undergoing diagnostic cardiac catheterization. Coronary artery disease (CAD) severity was quantified in each subject via coronary angiography by calculating a CAD score...
December 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29151033/induction-of-dendritic-cell-mediated-activation-of-t-cells-from-atherosclerotic-plaques-by-human-heat-shock-protein-60
#13
Mizanur Rahman, Johnny Steuer, Peter Gillgren, Assim Hayderi, Anquan Liu, Johan Frostegård
BACKGROUND: Atherosclerosis is characterized by the presence of activated immune-competent cells including dendritic cells (DCs) and T cells, dead cells, and oxidized low-density lipoprotein. HSP60 (Heat shock protein 60) has been implicated in atherosclerosis. A plasma protein, Annexin A5, has atheroprotective properties. METHODS AND RESULTS: Human DCs differentiated from peripheral blood monocytes were treated with human HSP60 or HSP90 and autologous T cells were cocultured with these pretreated DCs (mDCs)...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29096828/analysis-of-circulating-mirnas-in-patients-with-familial-hypercholesterolaemia-treated-by-ldl-lp-a-apheresis
#14
Dana Dlouha, Milan Blaha, Vladimir Blaha, Ilona Fatorova, Jaroslav A Hubacek, Petr Stavek, Vera Lanska, Alena Parikova, Jan Pitha
BACKGROUND: LDL/Lp(a) apheresis therapy is a well-established method of aggressively lowering LDL and Lp(a). Recently, miRNAs have been discussed as markers of vascular status including atherosclerosis. MiRNAs inhibit post-transcriptional processes through RNA duplex formation resulting in gene silencing or regulation of gene expression. MATERIALS AND METHODS: We measured a profile of 175 plasma-circulating miRNAs using pre-defined Serum/Plasma Focus Human microRNA PCR Panels in pooled samples of 11 subjects with familial hypercholesterolaemia under long-term apheresis treatment...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29017439/the-expression-of-pdcd4-in-patients-with-missed-abortion-and-its-clinical-significance
#15
Yue Li, Xihong Liu, Yingshun Sun, Yanping Liu, Lu Wan, Lining Zhang, Zhenghui Fang, Zengtao Wei, Xiaoyan Wang
Missed abortion is a special form of spontaneous abortion and its incidence shows a rising trend. Immunological factor is one of the most common reasons. Tumor suppressor gene programmed cell death 4 ( PDCD4) also participates in some immune-mediated inflammation, such as atherosclerosis, and so on, but the role of PDCD4 in missed abortion remains unclear. Here, the expression of PDCD4 was detected in decidual and chorionic tissues, as well as peripheral blood mononuclear cells from patients with missed abortion and healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemistry...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28777829/identification-of-an-early-transcriptomic-signature-of-insulin-resistance-and-related-diseases-in-lymphomonocytes-of-healthy-subjects
#16
Alice Matone, Eleonora Derlindati, Luca Marchetti, Valentina Spigoni, Alessandra Dei Cas, Barbara Montanini, Diego Ardigò, Ivana Zavaroni, Corrado Priami, Riccardo C Bonadonna
Insulin resistance is considered to be a pathogenetic mechanism in several and diverse diseases (e.g. type 2 diabetes, atherosclerosis) often antedating them in apparently healthy subjects. The aim of this study is to investigate with a microarray based approach whether IR per se is characterized by a specific pattern of gene expression. For this purpose we analyzed the transcriptomic profile of peripheral blood mononuclear cells in two groups (10 subjects each) of healthy individuals, with extreme insulin resistance or sensitivity, matched for BMI, age and gender, selected within the MultiKnowledge Study cohort (n = 148)...
2017: PloS One
https://www.readbyqxmd.com/read/28683362/promoter-hypomethylation-of-microrna223-gene-is-associated-with-atherosclerotic-cerebral-infarction
#17
Zhibin Li, Fang Yu, Xiaoqing Zhou, Sian Zeng, Qiong Zhan, Mei Yuan, Qidong Yang, Yunhai Liu, Jian Xia
BACKGROUND AND AIMS: microRNA223 (miR-223) plays an important role in the development of atherosclerosis and ischemic stroke. It is involved in regulation of multiple physiological and pathophysiological processes such as cholesterol metabolism, endothelial cell (EC) function, and thrombosis. Here we investigated the role of methylation regulation of MIR-223 promoter region in atherosclerotic cerebral infarction (ACI) patients. METHODS: A total of 23 patients with ACI and 32 healthy individuals were recruited...
June 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28636844/clonal-hematopoiesis-and-risk-of-atherosclerotic-cardiovascular-disease
#18
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular disease, but the nature of this association was unclear. METHODS: We used whole-exome sequencing to detect the presence of CHIP in peripheral-blood cells and associated such presence with coronary heart disease using samples from four case-control studies that together enrolled 4726 participants with coronary heart disease and 3529 controls...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28633641/expression-levels-of-atherosclerosis-associated-mir-143-and-mir-145-in-the-plasma-of-patients-with-hyperhomocysteinaemia
#19
Kejian Liu, Saiyare Xuekelati, Yue Zhang, Yin Yin, Yue Li, Rui Chai, Xinwei Li, Yi Peng, Jiangdong Wu, Xiaomei Guo
BACKGROUND: An elevated level of homocysteine (Hcy) in the blood is designated hyperhomocysteinaemia (Hhcy) and is regarded as a strong risk factor for the development of atherosclerosis (ATH), although the association remains controversial. Considered to be essential gene expression regulators, micro-RNAs (miRNAs) modulate cardiovascular disease development and thus can be regarded as potential biomarkers and therapeutic targets in atherosclerosis. The aim of the current study is to investigate the expression levels of atherosclerosis-associated miR-143 and miR-145 in Hhcy patients and predict the progress of atherosclerosis in Hhcy patients...
June 20, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28433861/c-reactive-protein-and-enzymatically-modified-ldl-cooperatively-promote-dendritic-cell-mediated-t-cell-activation
#20
Wei He, Yong Ren, Xiao Wang, Qiao Chen, Shifang Ding
BACKGROUND: Enzymatically modified low density lipoprotein (eLDL), C reactive protein (CRP), dendritic cells (DCs), and T cells were shown to be involved in the pathogenesis of atherosclerosis. This study aimed to investigate whether eLDL and CRP could cooperatively promote DC-mediated T cell activation and proliferation. METHOD: Low density lipoprotein was isolated from healthy human plasma and treated with proteases and cholesterol esterase. CD14(+) monocytes were isolated from human peripheral blood by gradient centrifugation and enriched with CD14 Microbeads, which were then induced with recombinant human IL-4 and granulocyte-macrophage colony-stimulating factor before treated with eLDL and/or CRP...
April 7, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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