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MS and diet

Helena Bjermo, Marie Aune, Tatiana Cantillana, Anders Glynn, P Monica Lind, Peter Ridefelt, Per Ola Darnerud
The aim of this study was to investigate associations between serum concentrations of brominated flame retardants and personal characteristics, including diet, in adults participating in a population-based study in Sweden 2010-11. Moreover, observed concentrations were used in a health risk assessment, using published health-based reference values. Serum samples of 170 adult individuals of both sexes were analyzed for 10 PBDE congeners and HBCD by GC-MS. When including concentrations between LOD and LOQ, highest median serum concentration was observed for BDE-153 (1...
October 14, 2016: Chemosphere
Francesco Martino, Paolo Emilio Puddu, Feliciana Lamacchia, Chiara Colantoni, Cristina Zanoni, Francesco Barillà, Eliana Martino, Francesco Angelico
OBJECTIVES: The aim of this study was to assess the impact of Mediterranean diet (MD) and physical activity on metabolic syndrome (MS) prevalence in children and adolescents. MATERIAL AND METHODS: This cross-sectional study was carried out in 863 boys and 780 girls, 6-14years old, from primary and secondary schools in a 14-town Southern Italian community. We modified the KIDMED questionnaire to adapt it to the local reality. RESULTS: Poor adherence to MD was seen in 18...
October 6, 2016: International Journal of Cardiology
Natalja P Nørskov, Knud Erik Bach Knudsen
Despite the extensive literature describing the biological effects of phenolic compounds from cereals, little is known about their bioaccessibility in the food matrix. This paper describes a validated LC-MS/MS method for quantification of free and total content (free + bound) of eight plant lignans (matairesinol, hydroxymatairesinol, secoisolariciresinol, lariciresinol, isolariciresinol, syringaresinol, medioresinol and pinoresinol) and the two enterolignans (enterodiol and enterolactone) in cereal based diets/bread and feces...
October 14, 2016: Journal of Agricultural and Food Chemistry
Danyue Zhao, Nagendra P Shah
Black tea (BT) has been positively linked to improved redox status, while its efficacy is limited due to the low bioavailability of BT flavonoids. In addition to the direct antioxidant activity, flavonoids regulate redox balance via inducing endogenous antioxidants, particularly glutathione (GSH) and GSH-dependent antioxidant enzymes. This work first examined the effect of lactic acid bacteria (LAB) and BT alone or in combination on flavonoid bioavailability and metabolism; next, the effect of LAB-fermented BT diet in attenuating oxidative stress in mice and the underlying mechanisms were studied...
September 18, 2016: Journal of Nutritional Biochemistry
Eunice Molinar-Toribio, Elisabet Fuguet, Sara Ramos-Romero, Núria Taltavull, Lucía Méndez, M Rosa Nogués, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez
PURPOSE: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). METHODS: Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. RESULTS: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group...
October 12, 2016: European Journal of Nutrition
Yanshan Lv, Shaoyou Lu, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yuanxiu Zhou, Yanru Li, Qihua Pang, Ruifang Fan
Bisphenol A (BPA) is a widely used chemical in the production of many polycarbonate plastics, epoxy resin linings for food and beverage containers and thermal papers. Oral intakes from the contaminated diets were considered as the predominant source of BPA exposure for humans. However, due to the high levels of BPA on thermal receipts and their wide applications in our daily life, the amount of BPA be transferred to the skin after holding thermal paper should not be underestimated, particularly for cashiers...
October 8, 2016: Environment International
Nadia Musco, Serena Calabro, Raffaella Tudisco, Micaela Grossi, Laura Addi, Giuseppe Moniello, Pietro Lombardi, Monica Isabella Cutrignelli
In the paper the short- and long-term glycaemic response after 4 diet programmes was evaluated. Each diet programme was alternatively administered to 6 healthy cats for 30 days. At the end of each period cats were weighed and underwent blood sampling for glucose and fructosamine determination. Glycaemia was measured every 2 hours for 24 hours using an automated glucometer. Very high protein level and low starch (VHP/LS) and high protein and moderate starch level (HP/LS) diets showed glucose (Mean and Peak) and fructosamine values signi cantly lower compared to the moderate protein and high starch diets (MP/HS)...
August 3, 2016: Veterinaria Italiana
Tolulope Morawo, Henry Fadamiro
Herbivores emit plant-associated volatile organic compounds (VOCs) after feeding on plants. These plant-associated VOCs can be used by parasitoids to locate their hosts. It is hypothesized that certain compounds play key roles in the attractiveness of host-associated odor blends. The larval parasitoid, Microplitis croceipes (Hymenoptera: Braconidae) and its herbivore host, Heliothis virescens (Lepidoptera: Noctuidae), a major pest of cotton plant were used as model species to identify key compounds mediating attraction of parasitoids to hosts...
October 8, 2016: Journal of Chemical Ecology
José de Jesús Guerrero-García, Lucrecia Carrera-Quintanar, Rocío Ivette López-Roa, Ana Laura Márquez-Aguirre, Argelia Esperanza Rojas-Mayorquín, Daniel Ortuño-Sahagún
Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue. Once MS is initiated, obesity can contribute to increased disease severity by negatively influencing disease progress and treatment response, but, also, obesity in early life is highly relevant as a susceptibility factor and causally related risk for late MS development...
2016: Mediators of Inflammation
Weifeng Shen, Wei Han, Yunong Li, Zhiqi Meng, Leiming Cai, Liang Li
Silkworm (Bombyx mori) is a very useful target insect for evaluation of endocrine disruptor chemicals (EDCs) due to mature breeding techniques, complete endocrine system and broad basic knowledge on developmental biology. Comparative metabolomics of silkworms with and without EDC exposure offers another dimension of studying EDCs. In this work, we report a workflow on metabolomic profiling of silkworm hemolymph based on high-performance chemical isotope labeling (CIL) liquid chromatography mass spectrometry (LC-MS) and demonstrate its application in studying the metabolic changes associated with the pesticide dichlorodiphenyltrichloroethane (DDT) exposure in silkworm...
October 26, 2016: Analytica Chimica Acta
Yu-Hong Lin, James A Brown, Carmine DiMartino, Irina Dahms, Norman Salem, Joseph R Hibbeln
Human studies and some animal work have shown more docosahexaenoic acid (DHA) and arachidonic acid (ARA) was accumulated or converted from precursors in females compared to males. This study explored in-depth the effect of gender on fatty acid composition and polyunsaturated fatty acid metabolism in rats fed one of two well-defined diets containing 10% total fat. One diet contained 15% of linoleic acid (LA) and 3% of α-linolenic acid (ALA) of the total fatty acids (LA+ALA diet), while the other diet contained 15% LA and 0...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Stine Krogh Steffensen, Hans Albert Pedersen, Khem B Adhikari, Bente Birgitte Laursen, Elena-Claudia Jensen, Søren Høyer, Michael Borre, Helene Holm Pedersen, Mette Borre, David Edwards, Inge S Fomsgaard
Rye bread contains high amounts of benzoxazinoids and in vitro studies have shown suppressive effects of selected benzoxazinoids on prostate cancer cells. Thus research into benzoxazinoids as possible suppressors of prostate cancer is demanded. A pilot study was performed in which ten prostate cancer patients received a rye-enriched diet one week prior to prostatectomy. Plasma and urine samples were collected pre- and post-intervention. Ten prostate biopsies were obtained from each patient and histologically evaluated...
October 10, 2016: Journal of Agricultural and Food Chemistry
Елена В Хмиль, Лилия И Ляшенко, Наталия В Янко, Дмитрий А Хмиль, Людмила Ф Каськова
INTRODUCTION: one of the peroxidation stress mechanisms is inducible NO synthase (iNOS) expression involved in the pathogenesis of periodontitis. AIM: to access the influence of isoform NO synthase (NOS) on alteration mechanisms of oxidative stress at periodontal tissues of 50 mature rats in a simulated periodontitis (SP). MATERIALS AND METHODS: a SP at rats was induced by a high-carbohydrate, high-fat (HCHF) diet. Тreated SP rat groups were intragastrically administered with selective neuronal NOS (nNOS) inhibitor 7-nitroindazole, selective inducible NOS (iNOS) inhibitor aminoguanidine, and nitric oxide synthase substrate L-arginine...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Veronica Sanda Chedea, Rodica Stefania Pelmus, Cristina Lazar, Gina Cecilia Pistol, Loredana Georgeta Calin, Smaranda Mariana Toma, Catalin Dragomir, Ionelia Taranu
BACKGROUND: The effect of a diet containing 15% grape pomace (GP) on the general health status and milk quality of dairy cows was assessed by plasma biochemistry and total polyphenols (TP) content, milk polyphenols, composition and protein fractions. RESULTS: Among the polyphenols, measured by LC-MS, in GP, in feed containing GP (GP+) or not (GP-), gallic acid and epicatechin were present in the highest concentration (67.58 µg/mL and 19.23 µg/mL, respectively)...
October 6, 2016: Journal of the Science of Food and Agriculture
Jeevan K Prasain, Rajani Rajbhandari, Adam B Keeton, Gary A Piazza, Stephen Barnes
In the present study, anti-proliferative activities of cranberry derived flavonoids and some of their in vivo metabolites were evaluated using a panel of human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC). Among the compounds tested, quercetin 3-O-glucoside, isorhamnetin (3'-O-methylquercetin), myricetin and quercetin showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM...
September 14, 2016: Food & Function
Veit Rothhammer, Francisco J Quintana
Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disorder of the central nervous system (CNS), which causes severe disability and requires extensive medical attention and treatment. While the infiltration of pathogenic immune cells into the CNS leads to the formation of inflammatory lesions in its initial relapsing-remitting stage, late stages of MS are characterized by progressive neuronal loss and demyelination even without continued interaction with the peripheral immune compartment...
October 3, 2016: Current Opinion in Immunology
Yang Xia, Yeqing Gu, Fei Yu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Huanmin Du, Hongbin Shi, Xiaoyan Guo, Xing Liu, Chunlei Li, Peipei Han, Renwei Dong, Xiuyang Wang, Xue Bao, Qian Su, Liyun Fang, Fangfang Liu, Huijun Yang, Li Kang, Yixuan Ma, Bin Yu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Qi Guo, Yuntang Wu, Kun Song, Guowei Huang, Guolin Wang, Kaijun Niu
Previous studies indicated that dietary patterns were associated with metabolic syndrome (MS), but little is known in Chinese. We design this case-control study to evaluate the associations between dietary patterns and MS in Chinese adults. In this study, 1492 participants with MS were matched with 1492 controls using the 1:1 ratio propensity score matching methods. Dietary intake was assessed using a valid self-administered food frequency questionnaire, and MS was defined in accordance with the criteria of the American Heart Association scientific statement of 2009...
October 6, 2016: Scientific Reports
Asmaa I Owis, Amira M Abo-Youssef, Ahmed H Osman
Cordia boissieri A. DC. (Boraginaceae) is traditionally used as an herbal remedy for diabetes by Hispanic women in Southwestern USA. A recent investigation showed the significant protective effect of ethyl acetate extract against metabolic syndrome (MS). However, the corresponding active principles responsible for this effect and relations between their structure and biological actions remain unclear. Thus, ethyl acetate extract was subjected to column chromatography, which yielded seven compounds identified on the basis of spectroscopic data as rutin, hesperidin, kaempferol-3-O-β-d-glucopyranoside, rosmarinic acid, β-sitosterol-3-O-β-d-glucopyranoside, quercetin, and kaempferol...
October 4, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Ahmad Abu-Awwad, Tawfiq Arafat, Oliver J Schmitz
Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink...
September 28, 2016: Journal of Pharmaceutical and Biomedical Analysis
S K Lengger, J Fromont, K Grice
Over 8600 species are currently recorded in the phylum Porifera (sponges). They produce a large diversity of biochemical compounds including sterols, with more than 250 different sterols identified. Some of these sterols are of great interest, due to their use for fingerprinting in ecological and biomarker (molecular fossil) studies. As a large number of identified extant species from biodiversity surveys are housed in museum collections, preserved in ethanol, these present a potentially rich source of identified specimens for comparative lipid analyses...
September 29, 2016: Geobiology
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