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L-Carnosine

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https://www.readbyqxmd.com/read/29053168/fl-926-16-a-novel-bioavailable-carnosinase-resistant-carnosine-derivative-prevents-onset-and-stops-progression-of-diabetic-nephropathy-in-db-db-mice
#1
Carla Iacobini, Stefano Menini, Claudia Blasetti Fantauzzi, Carlo M Pesce, Andrea Giaccari, Enrica Salomone, Annunziata Lapolla, Marica Orioli, Giancarlo Aldini, Giuseppe Pugliese
BACKGROUND AND PURPOSE: The advanced glycation endproducts (AGEs) participate in the pathogenesis of diabetic nephropathy (DN) by promoting renal inflammation and injury. L-carnosine acts as a quencher of the AGE precursors reactive carbonyl species (RCS), but it is rapidly inactivated by carnosinase. This study evaluated the effect of FL-926-16, a carnosinase-resistant and bioavailable carnosine derivative, on the onset and progression of DN in db/db mice. EXPERIMENTAL APPROACH: Adult male db/db mice and coeval db/m controls were left untreated or treated with FL-926-16 (30 mg·kg(-1) body weight) from week 6 to 20 (prevention protocol) or from week 20 to 34 (regression protocol)...
October 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29027815/l-carnosine-as-an-adjunctive-therapy-to-risperidone-in-children-with-autistic-disorder-a-randomized-double-blind-placebo-controlled-trial
#2
Reihaneh Hajizadeh-Zaker, Alireza Ghajar, Bita Mesgarpour, Mohsen Afarideh, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: This study aimed at investigating the efficacy and tolerability of l-carnosine as an add-on to risperidone in the management of children with autism. METHODS: This was a 10-week, randomized, double-blind, placebo-controlled study. Seventy drug-free children aged 4-12 years old with a diagnosis of autism spectrum disorder (ASD), according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (DSM-5) who had an Aberrant Behavior Checklist-Community (ABC-C) scale irritability subscale score of ≥12, entered the study...
October 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28960829/separation-and-determination-of-peptide-metabolite-of-bacillus-licheniformis-in-a-microbial-fuel-cell-by-high-speed-capillary-micellar-electrokinetic-chromatography
#3
Wei Wang, Ruiguang Bai, Xiaoyu Cai, Ping Lin, Lihong Ma
A method using high-speed capillary micellar electrokinetic chromatography and a microbial fuel cell was applied to determine the metabolite of the peptides released by Bacillus licheniformis. Two peptides, l-carnosine and l-alanyl-l-glutamine were used as the substrate to feed Bacillus licheniformis in a microbial fuel cell. The metabolism process of the bacterium was monitored by analyzing the voltage outputs of the microbial fuel cell. A home-made spontaneous injection device was applied to perform high-speed capillary micellar electrokinetic chromatography...
September 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28932258/the-effect-for-japanese-workers-of-a-self-help-computerized-cognitive-behaviour-therapy-program-with-a-supplement-soft-drink
#4
Kentaro Shirotsuki, Yuji Nonaka, Keiichi Abe, So-Ichiro Adachi, Shohei Adachi, Tomifusa Kuboki, Mutsuhiro Nakao
BACKGROUND: Computerized cognitive behaviour therapy (CCBT) programs can provide a useful self-help approach to the treatment of psychological problems. Previous studies have shown that CCBT has moderate effects on depression, insomnia, and anxiety. The present study investigated whether a supplement drink that includes L-carnosine enhances the effect of CCBT on psychological well-being. METHODS: Eighty-seven participants were randomly allocated to a control group, CCBT, or CCBT with supplement drink...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28926352/zinc-l-carnosine-complex-polaprezinc-for-the-treatment-of-binge-eating-three-case-reports
#5
Kensaku Sakae, Hiroyuki Yanagisawa
No abstract text is available yet for this article.
September 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28777736/a-pilot-study-of-the-effect-of-human-breast-milk-on-urinary-metabolome-analysis-in-infants
#6
Hiromichi Shoji, Hikari Taka, Naoko Kaga, Naho Ikeda, Tomohiro Kitamura, Yoshiki Miura, Toshiaki Shimizu
BACKGROUND: This study aimed to examine the nutritional effect of breast feeding on healthy term infants by using urinary metabolome analysis. METHODS: Urine samples were collected from 19 and 14 infants at 1 and 6 months, respectively. Infants were separated into two groups: the breast-fed group receiving <540 mL/week of their intake from formula (n=13 at 1 month; n=9 at 6 months); and the formula-fed group receiving no breast milk (BM) (n=6 at 1 month; n=5 at 6 months)...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28752496/investigations-on-in-vitro-anti-carcinogenic-potential-of-l-carnosine-in-liver-cancer-cells
#7
Minghui Ding, Guihua Jiao, Haizhou Shi, Yanrong Chen
This study was carried out to investigate the anti-carcinogenic effect of L-carnosine in human carcinoma cells (SNU-423). The SNU-423 cancer cells were cultured at a density of 2 × 10(4) cells/well in Dulbecco modified Eagle medium. After 24 h of adherence, the cells were treated with L-carnosine (0.2 and 1 mg/mL) for 48 h. Then, cell viability was assessed by sulforhodamine assay, while mitochondrial dysfunction was measured by fluorescence microscopy using chromatin-specific dye Hoechst 33258. Intracellular levels of ROS were assayed by fluorescence spectroscopy with 2',7'-dichlorofluorescein diacetate (DCFDA)...
July 27, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28744992/the-effect-of-12-weeks-carnosine-supplementation-on-renal-functional-integrity-and-oxidative-stress-in-pediatric-patients-with-diabetic-nephropathy-a-randomized-placebo-controlled-trial
#8
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Abdel Rahman El-Naggar, Mahitab Hany Hamouda, Manal El-Hamamsy
BACKGROUND AND OBJECTIVES: Oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. Carnosine is a natural radical oxygen species scavenger. We investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion (UAE), the tubular damage marker alpha 1-microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy. METHODS: This randomized placebo-controlled trial included 90 patients with diabetic nephropathy, despite oral angiotensin-converting enzyme inhibitors (ACE-Is), who were randomly assigned to receive either 12 weeks of carnosine 1 g/day (n = 45), or matching placebo (n = 45)...
July 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28697633/zinc-l-carnosine-suppresses-inflammatory-responses-in-lipopolysaccharide-induced-raw-264-7-murine-macrophages-cell-line-via-activation-of-nrf2-ho-1-signaling-pathway
#9
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
CONTEXT: Zinc L-carnosine (ZnC) is a chelate of Zn and L-carnosine and is used clinically in the treatment of peptic ulcer. OBJECTIVE: In this study, we aim to investigate the involvement of heme oxygenase-1 (HO-1) in the anti-inflammatory effects of ZnC in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages. MATERIALS AND METHODS: We used immunoblotting analysis to evaluate the involvement of HO-1 in the anti-inflammatory effects of ZnC and the signaling pathway involved was measured using Dual luciferase reporter assay...
July 11, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28485008/l-carnosine-as-an-adjuvant-to-fluvoxamine-in-treatment-of-obsessive-compulsive-disorder-a-randomized-double-blind-study
#10
Somaye Arabzadeh, Maryam Shahhossenie, Bita Mesgarpour, Farzin Rezaei, Mohammad Reza Shalbafan, Zahra Ghiasi, Shahin Akhondzadeh
BACKGROUND: Dysregulation of glutamate is implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Consistently, glutamate-modulating agents, such as riluzole and memantine have been used in OCD treatment. Previous research has identified some neuroprotective role for L-carnosine potentially via its modulatory effect on glutamate. Here, we assessed the efficacy of L-carnosine as adjuvant to fluvoxamine in OCD treatment. METHODS: Forty-four patients diagnosed with moderate to severe OCD were recruited in a randomized double-blind trial...
May 8, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28245346/n-acetylcarnosine-nac-drops-for-age-related-cataract
#11
REVIEW
Vincent Dj-P Dubois, Andrew Bastawrous
BACKGROUND: Cataract is the leading cause of world blindness. The only available treatment for cataract is surgery. Surgery requires highly-trained individuals with expensive operating facilities. Where these are not available, patients go untreated. A form of treatment that did not involve surgery would be a useful alternative for people with symptomatic cataract who are unable or unwilling to undergo surgery. If an eye drop existed that could reverse or even prevent progression of cataract, then this would be a useful additional treatment option...
February 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28094570/antioxidant-anti-inflammatory-and-genomic-stability-enhancement-effects-of-zinc-l-carnosine-a-potential-cancer-chemopreventive-agent
#12
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
Cancer is one of the major causes of death worldwide, and the incidence and mortality rates of cancer are expected to rise tremendously in the near future. Despite a better understanding of cancer biology and advancement in cancer management, current strategies in cancer treatment remain costly and ineffective. Hence, instead of putting more efforts to search for new cancer cures, attention has now been shifted to the development of cancer chemopreventive agents as a preventive measure for cancer formation...
February 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27822337/on-the-anticataractogenic-effects-of-l-carnosine-is-it-best-described-as-an-antioxidant-metal-chelating-agent-or-glycation-inhibitor
#13
Hamdy Abdelkader, Michael Longman, Raid G Alany, Barbara Pierscionek
Purpose. L-Carnosine is a naturally occurring dipeptide which recently gained popularity as an anticataractogenic agent due to its purported antioxidant activities. There is a paucity of research and conclusive evidence to support such claims. This work offers compelling data that help clarify the mechanism(s) behind the anticataract properties of L-carnosine. Methods. Direct in vitro antioxidant free radical scavenging properties were assayed using three different antioxidant (TEAC, CUPRAC, and DPPH) assays...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27801825/a-clinical-trial-about-a-food-supplement-containing-%C3%AE-lipoic-acid-on-oxidative-stress-markers-in-type-2-diabetic-patients
#14
RANDOMIZED CONTROLLED TRIAL
Giuseppe Derosa, Angela D'Angelo, Davide Romano, Pamela Maffioli
The aim of this study was to evaluate the effect of a food supplement containing α-lipoic acid and of a placebo on glyco-metabolic control and on oxidative stress markers in type 2 diabetics. We randomized 105 diabetics to either a supplementation containing 600 mg of α-lipoic acid, 165 mg of L-carnosin, 7.5 mg of zinc, and vitamins of group B, or a placebo, for three months. We evaluated body mass index, fasting plasma glucose (FPG), post-prandial-glucose (PPG), glycated hemoglobin (HbA1c), fasting plasma insulin (FPI), HOMA-index (HOMA-IR), lipid profile, high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA)...
October 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27584013/computational-approaches-in-the-rational-design-of-improved-carbonyl-quenchers-focus-on-histidine-containing-dipeptides
#15
Giulio Vistoli, Mara Colzani, Angelica Mazzolari, Danilo De Maddis, Giovanni Grazioso, Alessandro Pedretti, Marina Carini, Giancarlo Aldini
AIM: The inhibition of protein carbonylation can play therapeutic roles in several oxidative-based diseases and direct carbonyl quenching appears the most effective inhibition strategies. l-carnosine derivatives are effective and selective quenchers toward 4-hydroxy-2-nonenal even though their activity was never investigated in a fully comparable way. RESULTS: The reported results revealed that anserine, homocarnosine and carnosinamide retain a remarkable quenching activity combined with a satisfactory selectivity...
September 2016: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/27488081/minocycline-combination-therapy-with-fluvoxamine-in-moderate-to-severe-obsessive-compulsive-disorder-a-placebo-controlled-double-blind-randomized-trial
#16
RANDOMIZED CONTROLLED TRIAL
Sophia Esalatmanesh, Zoha Abrishami, Atefeh Zeinoddini, Fatemeh Rahiminejad, Majid Sadeghi, Mohammad-Reza Najarzadegan, Mohammad-Reza Shalbafan, Shahin Akhondzadeh
AIM: Several lines of evidence implicate glutamatergic dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD), presenting this neurotransmitter as a target for the development of novel pharmacotherapy. The objective of this study was to assess the efficacy of minocycline as an augmentative agent to fluvoxamine in the treatment of patients with OCD. METHODS: One hundred and two patients with the diagnosis of moderate-to-severe OCD were recruited to this study...
November 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27455800/-zinc-and-gastrointestinal-disorders
#17
Yasuki Higashimura, Tomohisa Takagi, Yuji Naito
Zinc, an essential trace element, affects immune responses, skin metabolism, hormone composition, and some sensory function, so that the deficiency presents various symptoms such as immunodeficiency and taste obstacle. Further, the zinc deficiency also considers as a risk of various diseases. Recent reports demonstrated that -20% of the Japanese population was marginally zinc deficiency, and over 25% of the global population is at high risk of zinc deficiency. In gastrointestinal disorders, zinc plays an important role in the healing of mucosal and epithelial damage...
July 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27433836/identification-of-telomerase-activating-blends-from-naturally-occurring-compounds
#18
Ghania Ait-Ghezala, Samira Hassan, Miles Tweed, Daniel Paris, Gogce Crynen, Zuchra Zakirova, Stefan Crynen, Fiona Crawford
Context • Telomeres are repeated deoxyribonucleic acid (DNA) sequences (TTAGGG) that are located on the 5' ends of chromosomes, and they control the life span of eukaryotic cells. Compelling evidence has shown that the length of a person's life is dictated by the limited number of times that a human cell can divide. The enzyme telomerase has been shown to bind to and extend the length of telomeres. Thus, strategies for activating telomerase may help maintain telomere length and, thus, may lead to improved health during aging...
June 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27418192/preparation-and-clinical-evaluation-of-a-novel-lozenge-containing-polaprezinc-a-zinc-l-carnosine-for-prevention-of-oral-mucositis-in-patients-with-hematological-cancer-who-received-high-dose-chemotherapy
#19
Hiroko Hayashi, Ryo Kobayashi, Akio Suzuki, Yuto Yamada, Masayuki Ishida, Toshinobu Shakui, Junichi Kitagawa, Hideki Hayashi, Tadashi Sugiyama, Hirofumi Takeuchi, Hisashi Tsurumi, Yoshinori Itoh
We previously reported that oral ingestion of polaprezinc, a zinc-L-carnosine, suspended in sodium alginate solution prevents oral mucositis in patients receiving radiotherapy or high-dose chemotherapy. In the present study, we developed a novel preparation of polaprezinc and evaluated clinical effect of the lozenge preparation in patients receiving high-dose chemotherapy for hematopoietic stem cell transplantation. The preparation contained 18.75 mg polaprezinc in a tablet and showed an excellent uniformity and stability up to 24 weeks after storage under room temperature...
August 2016: Medical Oncology
https://www.readbyqxmd.com/read/27413694/generation-of-reactive-oxygen-species-in-the-anterior-eye-segment-synergistic-codrugs-of-n-acetylcarnosine-lubricant-eye-drops-and-mitochondria-targeted-antioxidant-act-as-a-powerful-therapeutic-platform-for-the-treatment-of-cataracts-and-primary-open-angle
#20
REVIEW
Mark A Babizhayev
Senile cataract is a clouding of the lens in the aging eye leading to a decrease in vision. Symptoms may include faded colors, blurry vision, halos around light, trouble with bright lights, and trouble seeing at night. This may result in trouble driving, reading, or recognizing faces. Cataracts are the cause of half of blindness and 33% of visual impairment worldwide. Cataracts result from the deposition of aggregated proteins in the eye lens and lens fiber cells plasma membrane damage which causes clouding of the lens, light scattering, and obstruction of vision...
December 2016: BBA Clinical
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