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https://www.readbyqxmd.com/read/29878094/tissue-type-plasminogen-activator-controlled-corticogenesis-through-a-mechanism-dependent-of-nmda-receptors-expressed-on-radial-glial-cells
#1
Nolwenn Pasquet, Sara Douceau, Mickael Naveau, Flavie Lesept, Morgane Louessard, Laurent Lebouvier, Yannick Hommet, Denis Vivien, Isabelle Bardou
Modifications of neuronal migration during development, including processes that control cortical lamination are associated with functional deficits at adult stage. Here, we report for the first time that the lack of the serine protease tissue-type Plasminogen Activator (tPA), previously characterized as a neuromodulator and a gliotransmitter, leads to an altered cortical lamination in adult. This results in a neuronal migration defect of tPA deficient neurons which are stopped in the intermediate zone at E16...
June 6, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29792475/the-alliance-in-adult-psychotherapy-a-meta-analytic-synthesis
#2
Christoph Flückiger, A C Del Re, Bruce E Wampold, Adam O Horvath
The alliance continues to be one of the most investigated variables related to success in psychotherapy irrespective of theoretical orientation. We define and illustrate the alliance (also conceptualized as therapeutic alliance, helping alliance, or working alliance) and then present a meta-analysis of 295 independent studies that covered more than 30,000 patients (published between 1978 and 2017) for face-to-face and Internet-based psychotherapy. The relation of the alliance and treatment outcome was investigated using a three-level meta-analysis with random-effects restricted maximum-likelihood estimators...
May 24, 2018: Psychotherapy
https://www.readbyqxmd.com/read/29785158/obtaining-adequate-surgical-margin-status-in-breast-conservation-therapy-intraoperative-ultrasound-guided-resection-versus-specimen-mammography
#3
Maria Mihaela Pop, Silviu Cristian, Orsolya Hanko-Bauer, Dana Valentina Ghiga, Rares Georgescu
Background and aim: The purpose of breast-conserving surgery (BCS) for women with cancer is to perform an oncological radical procedure with disease-free margins at the final histological assessment and with the best aesthetic result possible. Intraoperative resected specimen ultrasound and intraoperative resected specimen mammography may reduce the rates of positive margins and reexcision among patients undergoing conserving therapy. Our objective is to compare the two methods with the histopathological results for a preset cut off and asses which parameters can influence the positive margin status...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29712839/habitat-degradation-negatively-affects-auditory-settlement-behavior-of-coral-reef-fishes
#4
Timothy A C Gordon, Harry R Harding, Kathryn E Wong, Nathan D Merchant, Mark G Meekan, Mark I McCormick, Andrew N Radford, Stephen D Simpson
Coral reefs are increasingly degraded by climate-induced bleaching and storm damage. Reef recovery relies on recruitment of young fishes for the replenishment of functionally important taxa. Acoustic cues guide the orientation, habitat selection, and settlement of many fishes, but these processes may be impaired if degradation alters reef soundscapes. Here, we report spatiotemporally matched evidence of soundscapes altered by degradation from recordings taken before and after recent severe damage on Australia's Great Barrier Reef...
May 15, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29626325/what-to-do-with-a-second-chance-in-life-long-term-experiences-of-non-carriers-of-huntington-s-disease
#5
Elisabeth Winnberg, Ulrika Winnberg, Lilian Pohlkamp, Anette Hagberg
Little is known about how people's lives are influenced when going from a 50% risk status of Huntington's disease (HD) to no risk after performing predictive testing. In this study, 20 interviews were conducted to explore the long-term (> 5 years) experiences after receiving predictive test results as a non-carrier of HD. The results showed a broad variety of both positive and negative reactions. The most prominent positive reaction reported was feelings of relief and gratitude, of not carrying the HD mutation for themselves and for their children...
April 7, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29501072/what-accounts-for-poor-functioning-in-people-with-schizophrenia-a-re-evaluation-of-the-contributions-of-neurocognitive-v-attitudinal-and-motivational-factors
#6
Aaron T Beck, Robyn Himelstein, Keith Bredemeier, Steven M Silverstein, Paul Grant
BACKGROUND: Neurocognitive deficits are often seen as core features of schizophrenia, and as primary determinants of poor functioning. Yet, our clinical observations suggest that individuals who score within the impaired range on standardized tests can reliably perform better in complex real-world situations, especially when performance is embedded within a positive socio-affective context. METHODS: We analyzed literature on the influence of non-neurocognitive factors on test performance in order to clarify their contributions...
March 4, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29423684/small-things-micro-affirmations-and-helpful-professionals-everyday-recovery-orientated-practices-according-to-persons-with-mental-health-problems
#7
Alain Topor, Tore Dag Bøe, Inger Beate Larsen
The aim of this study is to present concrete descriptions of the content in the construction of helpful relationships with staff, according to users. Starting with the re-occurring concept of the meaning of "little things" in recovery studies, a literature review was done. A thematic analysis shows that small things play an important role in improving a person's sense of self. Small things seem to be an invisible but effective parts of a recovery-orientated practice, but they might be defined as unprofessional and their efficacy negated...
February 8, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29336695/-ghosts-from-the-past-the-re-emergence-of-internalized-religious-stigma-following-diagnosis-of-hiv-among-northern-irish-gay-men
#8
Keith Kerrigan, Gill Green
This article explores how previous exposure to religious homonegativity features in the sense-making process following HIV diagnosis in a homogenous sample of six gay men living in Northern Ireland. Interpretive phenomenological analysis was used to identify two key overarching themes: Negotiating authenticity in unsafe space, which relates to the experience of negotiating same-sex attraction within religious environments, and Re-emergence of religious shame in diagnosis, which relates to the way in which the men made sense of diagnosis from the position of having been exposed to religious homonegativity earlier in their lives...
January 16, 2018: Journal of Homosexuality
https://www.readbyqxmd.com/read/29188754/-it-s-sort-of-reaffirmed-to-me-that-i-m-not-a-monster-i-m-not-a-terrible-person-sex-offenders-movements-toward-desistance-via-peer-support-roles-in-prison
#9
Christian Perrin, Nicholas Blagden, Belinda Winder, Gayle Dillon
Individuals incarcerated in prisons across the United Kingdom and abroad are able to volunteer for a variety of peer-support roles, which are characterized by prisoner-to-prisoner helping. Some research has found that such roles can represent turning points in the lives of those who have offended and encourage movements toward desistance. This proposed redemptive influence is argued to result from the prosocial behaviors that such roles appear to elicit in their holders. The present study aims to explore the mechanics of this claimed influence...
March 1, 2017: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/29067981/coping-in-residual-schizophrenia-re-analysis-of-ways-of-coping-checklist
#10
Ruchita Shah, Sandeep Grover, Parmanand Kulhara
BACKGROUND & OBJECTIVES: Persons with schizophrenia use various coping strategies to adapt to distressing symptoms as well as to deal with daily stressors. Efforts have been made to explore alternative frameworks of coping using Ways of Coping Checklist (WCC) in persons with schizophrenia. This study aimed to re-analyze (factor analysis) the revised-WCC in Indian patients with residual schizophrenia. The secondary aim of the study was to evaluate the relationship of new framework of coping with psychopathology, disability and quality of life (QOL)...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29032205/binding-and-hydrolysis-of-a-single-atp-is-sufficient-for-n-gate-closure-and-dna-supercoiling-by-gyrase
#11
Simon Hartmann, Airat Gubaev, Dagmar Klostermeier
Topoisomerases catalyze the relaxation, supercoiling, catenation, and decatenation of DNA. Gyrase is a bacterial topoisomerase that introduces negative supercoils into DNA in an ATP-dependent reaction. The enzyme consists of two GyrB subunits, containing the ATPase domains, and two GyrA subunits. Nucleotide binding to gyrase B GyrB causes closing of the N-gate in gyrase, which orients bound DNA for supercoiling. N-gate re-opening after ATP hydrolysis, at the end of the supercoiling reaction, resets the enzyme for subsequent catalytic cycles...
November 24, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28697882/the-emotional-and-professional-wellbeing-of-australian-midwives-a-comparison-between-those-providing-continuity-of-midwifery-care-and-those-not-providing-continuity
#12
Jennifer Fenwick, Mary Sidebotham, Jenny Gamble, Debra K Creedy
BACKGROUND: Continuity of midwifery care contributes to significant positive outcomes for women and babies. There is a perception that providing continuity of care may negatively impact on the wellbeing and professional lives of midwives. AIM: To compare the emotional and professional wellbeing as well as satisfaction with time off and work-life balance of midwives providing continuity of care with midwives not providing continuity. METHOD: Online survey...
February 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28602075/a-synthetic-recombinase-based-feedback-loop-results-in-robust-expression
#13
Thomas Folliard, Harrison Steel, Thomas P Prescott, George Wadhams, Lynn J Rothschild, Antonis Papachristodoulou
Accurate control of a biological process is essential for many critical functions in biology, from the cell cycle to proteome regulation. To achieve this, negative feedback is frequently employed to provide a highly robust and reliable output. Feedback is found throughout biology and technology, but due to challenges posed by its implementation, it is yet to be widely adopted in synthetic biology. In this paper we design a synthetic feedback network using a class of recombinase proteins called integrases, which can be re-engineered to flip the orientation of DNA segments in a digital manner...
September 15, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28383620/-integrated-project-of-personalisation-school-curricula-and-training
#14
A Zanon, R Tomassoni, N Santangelo, M Gargano, E Treglia, M G Granai, A Incagnoli
OBJECTIVES: To strengthen the motivation to study, promote awareness of their attitudes and actions of orientation / re-orientation to the profession, making the learning experience more stimulating and training in order to staunch the sharp drop-out affecting the school. MATERIALS AND METHODS: The project, coordinated by psychologists, involved the administration of AMOS Test as a tool to detect the variables of interest (self-image, ambitions and motivations, concerns for the future, soft skills etc...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28325716/coproporphyrin-i-a-fluorescent-endogenous-optimal-probe-substrate-for-abcc2-mrp2-suitable-for-vesicle-based-mrp2-inhibition-assay
#15
Ravindranath Reddy Gilibili, Sagnik Chatterjee, Pravin Bagul, Kathleen W Mosure, Bokka Venkata Murali, T Thanga Mariappan, Sandhya Mandlekar, Yurong Lai
Inside-out-oriented membrane vesicles are useful tools to investigate whether a compound can be an inhibitor of efflux transporters such as multidrug resistance-associated protein 2 (MRP2). However, because of technical limitations of substrate diffusion and low dynamic uptake windows for interacting drugs used in the clinic, estradiol-17 β -glucuronide (E17 β G) remains the probe substrate that is frequently used in MRP2 inhibition assays. Here we recapitulated the sigmoidal kinetics of MRP2-mediated transport of E17 β G, with apparent Michaelis-Menten constant ( K m ) and V max values of 170 ±17 µ M and 1447 ± 137 pmol/mg protein/min, respectively...
June 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28273132/re-conceptualizing-stress-shifting-views-on-the-consequences-of-stress-and-its-effects-on-stress-reactivity
#16
Jenny J W Liu, Kristin Vickers, Maureen Reed, Marilyn Hadad
BACKGROUND: The consequences of stress are typically regarded from a deficit-oriented approach, conceptualizing stress to be entirely negative in its outcomes. This approach is unbalanced, and may further hinder individuals from engaging in adaptive coping. In the current study, we explored whether negative views and beliefs regarding stress interacted with a stress framing manipulation (positive, neutral and negative) on measures of stress reactivity for both psychosocial and physiological stressors...
2017: PloS One
https://www.readbyqxmd.com/read/28243776/intergenerational-conflicts-cultural-restraints-and-suicide-experiences-of-young-african-people-in-adelaide-south-australia
#17
Lillian Mwanri, Eunice Okyere, Mariastella Pulvirenti
This study aimed to explore determinants of increased suicide deaths among African youth in South Australia. The paper reports on the intersectionality between intergenerational conflicts and fatal suicides in the target population. The study employed a qualitative inquiry approach, studying 31 young people in the African community in Adelaide. Intergenerational conflicts were identified as pervasive, with negative implications for the affected individuals, their families, and the entire African community. These led to turmoil in the community, youth isolation, reduced social interactions, stress and fatal suicides...
April 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28228249/a-computerised-test-of-perceptual-ability-for-learning-endoscopic-and-laparoscopic-surgery-and-other-image-guided-procedures-score-norms-for-picsor
#18
Patrick Henn, Anthony G Gallagher, Emmeline Nugent, Roddy Cowie, Neal E Seymour, Randy S Haluck, Hazem Hseino, Oscar Traynor, Paul C Neary
BACKGROUND: The aptitude to infer the shape of 3-D structures, such as internal organs from 2-D monitor displays, in image guided endoscopic and laparoscopic procedures varies. We sought both to validate a computer-generated task Pictorial Surface Orientation (PicSOr), which assesses this aptitude, and to identify norm referenced scores. METHODS: 400 subjects (339 surgeons and 61 controls) completed the PicSOr test. 50 subjects completed it again one year afterwards...
November 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28110546/social-cultural-factors-of-hiv-related-stigma-among-the-chinese-general-population-in-hong-kong
#19
Tien Ee Dominic Yeo, Tsz Hang Chu
HIV-related stigma in the wider community compounds the suffering of people living with HIV (PLWH) and hampers effective HIV prevention and care. This study examines the level of public stigma toward PLWH in Hong Kong and associated social-cultural factors. A telephone survey was conducted in June-July 2016 with 1080 Chinese adults aged 18-94 randomly selected from the general population. The results indicate substantial degree of public stigma toward PLWH. Overall, 58.1% of the participants endorsed at least one statement indicating negative social judgment of PLWH...
October 2017: AIDS Care
https://www.readbyqxmd.com/read/28110454/tackling-the-salinity-pollution-nexus-in-coastal-aquifers-from-arid-regions-using-nitrate-and-boron-isotopes
#20
V Re, E Sacchi
Salinization and nitrate pollution are generally ascertained as the main issues affecting coastal aquifers worldwide. In arid zones, where agricultural activities also result in soil salinization, both phenomena tend to co-exist and synergically contribute to alter groundwater quality, with severe negative impacts on human populations and natural ecosystems' wellbeing. It becomes therefore necessary to understand if and to what extent integrated hydrogeochemical tools can help in distinguishing among possible different salinization and nitrate contamination origins, in order to provide adequate science-based support to local development and environmental protection...
May 2017: Environmental Science and Pollution Research International
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