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Re-orienting negativity

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https://www.readbyqxmd.com/read/28383620/-integrated-project-of-personalisation-school-curricula-and-training
#1
A Zanon, R Tomassoni, N Santangelo, M Gargano, E Treglia, M G Granai, A Incagnoli
OBJECTIVES: To strengthen the motivation to study, promote awareness of their attitudes and actions of orientation / re-orientation to the profession, making the learning experience more stimulating and training in order to staunch the sharp drop-out affecting the school. MATERIALS AND METHODS: The project, coordinated by psychologists, involved the administration of AMOS Test as a tool to detect the variables of interest (self-image, ambitions and motivations, concerns for the future, soft skills etc...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28325716/coproporphyrin-i-a-fluorescent-endogenous-optimal-probe-substrate-for-abcc2-mrp2-that-is-suitable-for-vesicle-based-mrp2-inhibition-assay
#2
Ravindranath Reddy Gilibili, Sagnik Chatterjee, Pravin Bagul, Kthleen W Mosure, Bokka Venkata Murali, T Thanga Mariappan, Sandhya Mandlekar, Yurong Lai
Inside-out-oriented membrane vesicles are useful tools to investigate whether a compound can be an inhibitor of efflux transporters such as multidrug-resistance associated protein 2 (MRP2). However, because of technical limitations of substrate diffusion and low dynamic uptake windows for interacting drugs used in clinic, estradiol-17β-glucuronide (E17βG) remains the probe substrate frequently used in MRP2 inhibition assays. Here we re-capitulated the sigmoidal kinetics of MRP2 mediated uptake of E17βG, with apparent Km and Vmax values 170 ±17 μM and 1447 ± 137 pmol/mg protein/min, respectively...
March 21, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28273132/re-conceptualizing-stress-shifting-views-on-the-consequences-of-stress-and-its-effects-on-stress-reactivity
#3
Jenny J W Liu, Kristin Vickers, Maureen Reed, Marilyn Hadad
BACKGROUND: The consequences of stress are typically regarded from a deficit-oriented approach, conceptualizing stress to be entirely negative in its outcomes. This approach is unbalanced, and may further hinder individuals from engaging in adaptive coping. In the current study, we explored whether negative views and beliefs regarding stress interacted with a stress framing manipulation (positive, neutral and negative) on measures of stress reactivity for both psychosocial and physiological stressors...
2017: PloS One
https://www.readbyqxmd.com/read/28243776/intergenerational-conflicts-cultural-restraints-and-suicide-experiences-of-young-african-people-in-adelaide-south-australia
#4
Lillian Mwanri, Eunice Okyere, Mariastella Pulvirenti
This study aimed to explore determinants of increased suicide deaths among African youth in South Australia. The paper reports on the intersectionality between intergenerational conflicts and fatal suicides in the target population. The study employed a qualitative inquiry approach, studying 31 young people in the African community in Adelaide. Intergenerational conflicts were identified as pervasive, with negative implications for the affected individuals, their families, and the entire African community. These led to turmoil in the community, youth isolation, reduced social interactions, stress and fatal suicides...
February 27, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28228249/a-computerised-test-of-perceptual-ability-for-learning-endoscopic-and-laparoscopic-surgery-and-other-image-guided-procedures-score-norms-for-picsor
#5
Patrick Henn, Anthony G Gallagher, Emmeline Nugent, Roddy Cowie, Neal E Seymour, Randy S Haluck, Hazem Hseino, Oscar Traynor, Paul C Neary
BACKGROUND: The aptitude to infer the shape of 3-D structures, such as internal organs from 2-D monitor displays, in image guided endoscopic and laparoscopic procedures varies. We sought both to validate a computer-generated task Pictorial Surface Orientation (PicSOr), which assesses this aptitude, and to identify norm referenced scores. METHODS: 400 subjects (339 surgeons and 61 controls) completed the PicSOr test. 50 subjects completed it again one year afterwards...
February 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28110546/social-cultural-factors-of-hiv-related-stigma-among-the-chinese-general-population-in-hong-kong
#6
Tien Ee Dominic Yeo, Tsz Hang Chu
HIV-related stigma in the wider community compounds the suffering of people living with HIV (PLWH) and hampers effective HIV prevention and care. This study examines the level of public stigma toward PLWH in Hong Kong and associated social-cultural factors. A telephone survey was conducted in June-July 2016 with 1080 Chinese adults aged 18-94 randomly selected from the general population. The results indicate substantial degree of public stigma toward PLWH. Overall, 58.1% of the participants endorsed at least one statement indicating negative social judgment of PLWH...
January 23, 2017: AIDS Care
https://www.readbyqxmd.com/read/28110454/tackling-the-salinity-pollution-nexus-in-coastal-aquifers-from-arid-regions-using-nitrate-and-boron-isotopes
#7
V Re, E Sacchi
Salinization and nitrate pollution are generally ascertained as the main issues affecting coastal aquifers worldwide. In arid zones, where agricultural activities also result in soil salinization, both phenomena tend to co-exist and synergically contribute to alter groundwater quality, with severe negative impacts on human populations and natural ecosystems' wellbeing. It becomes therefore necessary to understand if and to what extent integrated hydrogeochemical tools can help in distinguishing among possible different salinization and nitrate contamination origins, in order to provide adequate science-based support to local development and environmental protection...
January 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28100024/evaluation-of-cast-re-orientation-on-a-dental-surveyor-using-three-tripod-techniques-a-survey-and-in-vitro-study
#8
Mohammed E Sayed, Idris A Busaily, Rana J Nahari, Ruaa O Hakami, Sami M Maashi, Naveen R Ramireddy
PURPOSE: To survey different educational levels (i.e., students, interns, technicians, and prosthodontic faculty) with regard to their opinions, attitudes, and adoption of three selected tripod techniques. The study will also investigate the accuracy of these techniques to reposition casts on the dental surveyor in anterio-posterior (AP) and lateral directions at both technique and educational levels. MATERIALS AND METHODS: Tripod points, scored lines, and cemented post tripod techniques were used in this study...
January 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28089535/farmer-attitudes-and-perceptions-to-the-re-use-of-fertiliser-products-from-resource-oriented-sanitation-systems-the-case-of-vellore-south-india
#9
Prithvi Simha, Cecilia Lalander, Björn Vinnerås, M Ganesapillai
Relatively little research has been conducted to date on farmer attitudes towards the use of fertilisers from resource-oriented sanitation systems. This study employed a psycho-sociological approach to identify factors that encourage, or discourage, negative and positive attitudes to human waste recycling among farmers in southern India. A survey involving face-to-face interviews was performed with 120 randomly sampled farmers, taking into account the following factors: gender, age, religion, caste, type of farming, farm size, annual income and farming history...
January 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27942251/the-effects-of-radical-prostatectomy-on-gay-and-bisexual-men-s-mental-health-sexual-identity-and-relationships-qualitative-results-from-the-restore-study
#10
B R Simon Rosser, Benjamin Capistrant, Beatriz Torres, Badrinath Konety, Enyinnaya Merengwa, Darryl Mitteldorf, William West
The effect of prostate cancer treatment in gay and bisexual men is an under-researched area. In 2015, we conducted in-depth telephone interviews with 19 gay and bisexual men who had undergone radical prostatectomies. Across the respondents' five emotional themes emerged: (1) shock at the diagnosis, (2) a reactive, self-reported "depression", (3) sex-specific situational anxiety, (4) a sense of grief, and, (5) an enduring loss of sexual confidence. Identity challenges included loss of a sense of maleness and manhood, changes in strength of sexual orientation, role-in-sex identity, and immersion into sexual sub-cultures...
2016: Sexual and Relationship Therapy: Journal of the British Association for Sexual and Relationship Therapy
https://www.readbyqxmd.com/read/27891686/implementation-of-a-real-time-reference-and-calibration-grid-platform-for-improved-screening-mapping-in-pap-test-slides
#11
Evangelos Tsiambas, Christos Riziotis
Cervical cancer screening based on the Papanicolaou (Pap) test is a widely applied but not always efficient practice for detecting Human Papillomavirus (HPV) mediated lesions, partially due to a non-systematic and inadequate screening process. Our aim was to introduce an inexpensive easy-to-use direct screening platform for improved detection of abnormal cells indicative of underlying cervical neoplasia as well as persisting HPV infection. By employing a novel, efficient technique of laser-based micromachining, we achieved the fabrication of spatial grids on commercially available coverslips allowing visual segmentation of the slide for efficient screening...
January 2017: Pathology International
https://www.readbyqxmd.com/read/27847496/revising-the-intolerance-of-uncertainty-model-of-generalized-anxiety-disorder-evidence-from-uk-and-italian-undergraduate-samples
#12
Gioia Bottesi, Marta Ghisi, Eleonora Carraro, Nicola Barclay, Rebecca Payne, Mark H Freeston
The Intolerance of Uncertainty Model (IUM) of Generalized Anxiety Disorder (GAD) attributes a key role to Intolerance of Uncertainty (IU), and additional roles to Positive Beliefs about Worry (PBW), Negative Problem Orientation (NPO), and Cognitive Avoidance (CA), in the development and maintenance of worry, the core feature of GAD. Despite the role of the IUM components in worry and GAD has been considerably demonstrated, to date no studies have explicitly assessed whether and how PBW, NPO, and CA might turn IU into worry and somatic anxiety...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27801544/short-term-psychodynamic-psychotherapy-with-mentalization-based-techniques-in-major-depressive-disorder-patients-relationship-among-alexithymia-reflective-functioning-and-outcome-variables-a-pilot-study
#13
Cinzia Bressi, Silvia Fronza, Eleonora Minacapelli, Emanuela Paola Nocito, Elisabetta Dipasquale, Lorenzo Magri, Francesca Lionetti, Lavinia Barone
OBJECTIVES: In depressed patients, recent advances have highlighted impairment in mentalizing: identifying and interpreting one's own or other's mental states. Short-Term Psychodynamic Psychotherapy (STPP) has proven to be effective in reducing symptoms and improving relational/functional abilities in these subjects. Therefore, the first aim of our study was to evaluate effectiveness of STPP with Mentalization-Based Techniques (STMBP) on their clinical outcomes and the second, to investigate Reflective Functioning and alexithymia concerning treatment outcomes in depressed subjects...
November 1, 2016: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/27799586/modified-test-protocol-improves-sensitivity-of-the-stereo-fly-test
#14
Angie De La Cruz, Sarah E Morale, Reed M Jost, Krista R Kelly, Eileen E Birch
BACKGROUND AND PURPOSE: Stereoacuity measurement is a common element of pediatric ophthalmic examinations. Although the Stereo Fly Test is routinely used to establish the presence of coarse stereopsis (3000 arcsecs), it often yields a false negative "pass" due to learned responses and non-stereoscopic cues. We developed and evaluated a modified Stereo Fly Test protocol aimed at increasing sensitivity, thus reducing false negatives. PATIENTS AND METHODS: The Stereo Fly Test was administered according to manufacturer instructions to 321 children aged 3-12 years...
January 2016: American Orthoptic Journal
https://www.readbyqxmd.com/read/27793989/the-role-of-sialylated-glycans-in-human-platelet-endothelial-cell-adhesion-molecule-1-pecam-1-mediated-trans-homophilic-interactions-and-endothelial-cell-barrier-function
#15
Panida Lertkiatmongkol, Cathy Paddock, Debra K Newman, Jieqing Zhu, Michael J Thomas, Peter J Newman
Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) is a major component of the endothelial cell intercellular junction. Previous studies have shown that PECAM-1 homophilic interactions, mediated by amino-terminal immunoglobulin homology domain 1, contribute to maintenance of the vascular permeability barrier and to its re-establishment following inflammatory or thrombotic insult. PECAM-1 glycans account for ∼30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions...
December 9, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27732884/the-transcriptomic-analytical-level-determines-the-human-monocyte-derived-macrophage-response-toward-either-the-infectious-agent-or-the-host
#16
Philippe Holzmuller, Philippe Nirdé, Frédéric Vezilier, Paul Chuchana
Macrophages exhibit multifunctional activity and play a central role in the response to infectious agents. It is commonly accepted that the plasticity of the response of macrophages depends on the type of stimuli. Here we re-evaluate whether the macrophage response is only dependent on the stimulus. We analyzed the transcriptomic profile of monocyte-derived macrophages (MDMs) that were activated with several pathogens and multiple in vitro-stimulations. The transcriptomic data were normalized using matched-pair analysis...
October 11, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27434874/two-binding-geometries-for-risperidone-in-dopamine-d3-re-ceptors-insights-on-the-fast-off-mechanism-through-docking-quantum-biochemistry-and-molecular-dynamics-simulations
#17
Geancarlo Zanatta, Gustavo Della Flora Nunes, Eveline Matias Bezerra, Roner F da Costa, Alice Maria Martins, Ewerton Wagner Santos Caetano, Valder Nogueira Freire, Carmem Gottfried
Risperidone is an atypical antipsychotic used in the treatment of schizophrenia and of symptoms of irritability associated with autism spectrum disorder (ASD). Its main action mechanism is the blockade of D2-like receptors acting over positive and negative symptoms of schizophrenia with small risk of extrapyramidal symptoms (EPS) at doses corresponding to low/moderate D2 occupancy. Such decrease in the side effect incidence can be associated to its fast unbinding from D2 receptors in the nigrostriatal region allowing the recovery of dopamine signaling pathways...
July 19, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27313542/responses-of-in-vitro-grown-plantlets-vitis-vinifera-to-grapevine-leafroll-associated-virus-3-and-peg-induced-drought-stress
#18
Zhen-Hua Cui, Wen-Lu Bi, Xin-Yi Hao, Yan Xu, Peng-Min Li, M Andrew Walker, Qiao-Chun Wang
Stresses caused by viral diseases and drought have long threatened sustainable production of grapevine. These two stresses frequently occur simultaneously in many of grapevine growing regions of the world. We studied responses of in vitro-grown plantlets (Vitis vinifera) to Grapevine leafroll associated virus-3 (GLRaV-3) and PEG-induced drought stress. Results showed that stress induced by either virus infection or drought had negative effects on vegetative growth, caused significant decreases and increases in total soluble protein and free proline, respectively, induced obvious cell membrane damage and cell death, and markedly increased accumulations of [Formula: see text] and H2O2...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27294941/gyro-drift-correction-for-an-indirect-kalman-filter-based-sensor-fusion-driver
#19
Chan-Gun Lee, Nhu-Ngoc Dao, Seonmin Jang, Deokhwan Kim, Yonghun Kim, Sungrae Cho
Sensor fusion techniques have made a significant contribution to the success of the recently emerging mobile applications era because a variety of mobile applications operate based on multi-sensing information from the surrounding environment, such as navigation systems, fitness trackers, interactive virtual reality games, etc. For these applications, the accuracy of sensing information plays an important role to improve the user experience (UX) quality, especially with gyroscopes and accelerometers. Therefore, in this paper, we proposed a novel mechanism to resolve the gyro drift problem, which negatively affects the accuracy of orientation computations in the indirect Kalman filter based sensor fusion...
2016: Sensors
https://www.readbyqxmd.com/read/27267703/does-a-methionine-to-norleucine-substitution-in-pgla-influence-peptide-membrane-interactions
#20
Dmytro S Radchenko, Saskia Kattge, Sezgin Kara, Anne S Ulrich, Sergii Afonin
Yes. To understand the molecular mechanisms of amphiphilic membrane-active peptides, it is essential to study their interactions with lipid bilayers under near-native conditions. Amino acid composition largely determines the non-specific properties of peptides, on the basis of the physicochemical properties of the side chains. The resultant effects on peptides' functional properties include influences on the conformation, structural dynamics and binding affinities within the peptide interactome. Here, we studied the effect of substituting oxidation-prone methionine (Met) with non-oxidizable norleucine (Nle) in the model α-helical antimicrobial peptide PGLa, through systematic comparison of PGLa with the (2)Met/(2)Nle mutant...
September 2016: Biochimica et Biophysica Acta
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