Rongbin Wang, Benjamin Nji Wandi, Nora Schwartz, Jacob Hecht, Larissa Ponomareva, Kendall Paige, Alexis West, Kathryn Desanti, Jennifer Nguyen, Jarmo Niemi, Jon S Thorson, Khaled A Shaaban, Mikko Metsä-Ketelä, S Eric Nybo
Streptomyces spp. are "nature's antibiotic factories" that produce valuable bioactive metabolites, such as the cytotoxic anthracycline polyketides. While the anthracyclines have hundreds of natural and chemically synthesized analogues, much of the chemical diversity stems from enzymatic modifications to the saccharide chains and, to a lesser extent, from alterations to the core scaffold. Previous work has resulted in the generation of a BioBricks synthetic biology toolbox in Streptomyces coelicolor M1152Δ matAB that could produce aklavinone, 9- epi -aklavinone, auramycinone, and nogalamycinone...
April 25, 2024: ACS Synthetic Biology