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Neurophysiology

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https://www.readbyqxmd.com/read/29458203/precision-pharmacology-for-alzheimer-s-disease
#1
REVIEW
Harald Hampel, Andrea Vergallo, Lisi Flores Aguilar, Norbert Benda, Karl Broich, A Claudio Cuello, Jeffrey Cummings, Bruno Dubois, Howard J Federoff, Massimo Fiandaca, Remy Genthon, Marion Haberkamp, Eric Karran, Mark Mapstone, George Perry, Lon S Schneider, Lindsay A Welikovitch, Janet Woodcock, Filippo Baldacci, Simone Lista
The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant challenges for drug development. AD pathophysiology is progressing in a non-linear dynamic fashion across multiple systems levels - from molecules to organ systems - and through adaptation, to compensation, and decompensation to systems failure. Adaptation and compensation maintain homeostasis: a dynamic equilibrium resulting from the dynamic non-linear interaction between genome, epigenome, and environment. An individual vulnerability to stressors exists on the basis of individual triggers, drivers, and thresholds accounting for the initiation and failure of adaptive and compensatory responses...
February 16, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29457912/decreased-resting-gamma-activity-in-adult-attention-deficit-hyperactivity-disorder
#2
László Tombor, Brigitta Kakuszi, Szilvia Papp, János Réthelyi, István Bitter, Pál Czobor
OBJECTIVES: To delineate task-free gamma activity in adult ADHD and healthy control subjects based on high-density EEG recordings. Relationship of gamma activity with symptom severity was also examined, since gamma activity is considered as an index of network functions in the brain that underlie higher-order cognitive processes. METHODS: Spontaneous-EEG was recorded in adult ADHD subjects (N = 42;25 methylphenidate-naïve and 17 on methylphenidate treatment) and controls (N = 59) with eyes open...
February 19, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29456496/how-do-acquired-political-identities-influence-our-neural-processing-toward-others-within-the-context-of-a-trust-game
#3
Chien-Te Wu, Yang-Teng Fan, Ye-Rong Du, Tien-Tun Yang, Ho-Ling Liu, Nai-Shing Yen, Shu-Heng Chen, Ray-May Hsung
Trust is essential for mutually beneficial human interactions in economic exchange and politics and people's social identities notably have dramatic effects on trust behaviors toward others. Previous literature concerning social identities generally suggests that people tend to show in-group favoritism toward members who share the same identity. However, how our brains process signals of identity while facing uncertain situations in interpersonal interactions remains largely unclear. To address this issue, we performed an fMRI experiment with 54 healthy adults who belonged to two identity groups of opposing political orientations...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29455369/intradural-spinal-tumors-in-adults-update-on-management-and-outcome
#4
REVIEW
Malte Ottenhausen, Georgios Ntoulias, Imithri Bodhinayake, Finn-Hannes Ruppert, Stefan Schreiber, Annette Förschler, John A Boockvar, Andreas Jödicke
Among spinal tumors that occur intradurally, meningiomas, nerve sheath tumors, ependymomas, and astrocytomas are the most common. While a spinal MRI is the state of the art to diagnose intradural spinal tumors, in some cases CT scans, angiography, CSF analyses, and neurophysiological examination can be valuable. The management of these lesions depends not only on the histopathological diagnosis but also on the clinical presentation and the anatomical location, allowing either radical resection as with most extramedullary lesions or less invasive strategies as with intramedullary lesions...
February 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29454657/monitoring-brain-neuronal-activity-with-manipulation-of-cardiac-events-in-a-freely-moving-rat
#5
Yu Shikano, Yuji Ikegaya, Takuya Sasaki
Behavioral and cognitive studies have demonstrated that brain functions are affected by the activity states of the peripheral organs, such as the cardiac and respiratory systems. However, detailed neurophysiological mechanisms underlying the body-brain interactions remain unknown. In this study, we developed a method for manipulating activity levels of the heart using direct cardiac stimulation and vagus nerve stimulation that can be combined with recording cerebral local field potentials using a microdrive system, electrocardiograms, electromyograms, in a freely moving rat...
February 15, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29454224/the-consonant-vowel-pattern-determines-the-structure-of-orthographic-representations-in-the-left-fusiform-gyrus
#6
Fabienne Chetail, Mariagrazia Ranzini, Xavier De Tiège, Vincent Wens, Alain Content
Recent findings demonstrated readers' sensitivity to the distinction between consonant and vowel letters. Especially, the way consonants and vowels are organised within written words determines their perceptual structure. The present work attempted to overcome two limitations of previous studies by examining the neurophysiological correlates of this perceptual structure through magnetoencephalography (MEG). One aim was to establish that the extraction of vowel-centred units takes place during early stages of processing...
February 2, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29453522/structural-disconnection-is-responsible-for-increased-functional-connectivity-in-multiple-sclerosis
#7
Kevin R Patel, Sean Tobyne, Daria Porter, John Daniel Bireley, Victoria Smith, Eric Klawiter
Increased synchrony within neuroanatomical networks is often observed in neurophysiologic studies of human brain disease. Most often, this phenomenon is ascribed to a compensatory process in the face of injury, though evidence supporting such accounts is limited. Given the known dependence of resting-state functional connectivity (rsFC) on underlying structural connectivity (SC), we examine an alternative hypothesis: that topographical changes in SC, specifically particular patterns of disconnection, contribute to increased network rsFC...
February 16, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29452324/microsurgical-clipping-of-intracranial-aneurysms-assisted-by-neurophysiological-monitoring-microvascular-flow-probe-and-icg-va-outcomes-and-intraoperative-data-on-a-multimodal-strategy
#8
Alessandro Della Puppa, Marta Rossetto, Francesco Volpin, Oriela Rustemi, Alberto Grego, Alessandra Gherardi, Riccardo Ortolan, Francesco Causin, Marina Munari, Renato Scienza
OBJECTVE: The aim of this study is to report data on a multimodal monitoring strategy based on the intraoperative use of neurophysiological monitoring, flowmetry by microflow probe and intraoperative indocyanine green-videoangiography (ICG-VA) during microsurgical clipping of intracranial aneurysms. METHODS: This retrospective analysis was performed on 85 consecutive patients undergoing clipping of 96 intracranial aneurysms with the present monitoring strategy. Patient outcomes were evaluated by assessing rate of aneurysm exclusion and post-operative occurrence of ischemic injury...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451125/reduced-integration-and-improved-segregation-of-functional-brain-networks-in-alzheimer-s-disease
#9
A Kabbara, H Eid, W El Falou, M Khalil, F Wendling, M Hassan
OBJECTIVE: Emerging evidence shows that cognitive deficits in Alzheimer's disease (AD) are associated with disruptions in brain functional connectivity. Thus, the identification of alterations in AD functional networks has become a topic of increasing interest. However, to what extent AD induces disruption of the balance of local and global information processing in the human brain remains elusive. The main objective of this study is to explore the dynamic topological changes of AD networks in terms of brain network segregation and integration...
February 16, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29451058/developmental-differences-in-stress-responding-after-repeated-underwater-trauma-exposures-in-rats
#10
Daniel E Altman, Laurence P Simmons, Chau T Vuong, Rachel M Taylor, Jason C Sousa, Sean R Marcsisin, Victor E Zottig, Nicole L T Moore
Adolescence is a distinct developmental period characterized by behavioral and physiological maturation. Rapid ongoing changes during neurodevelopment in particular present potential opportunities for stress to have lasting effects on longitudinal outcomes of behavioral and neuroendocrine function. While adult stress effects on outcomes during adulthood have been characterized, little is known about the lasting effects of adolescent repeated stressor exposure on outcomes during adolescence. We have previously reported different stress responses in adolescent rats relative to adult rats, including a blunted fear response outcome in adulthood in rats stressed during adolescence...
February 16, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29449828/understanding-spreading-depression-from-headache-to-sudden-unexpected-death
#11
REVIEW
Olga Cozzolino, Maria Marchese, Francesco Trovato, Enrico Pracucci, Gian Michele Ratto, Maria Gabriella Buzzi, Federico Sicca, Filippo M Santorelli
Spreading depression (SD) is a neurophysiological phenomenon characterized by abrupt changes in intracellular ion gradients and sustained depolarization of neurons. It leads to loss of electrical activity, changes in the synaptic architecture, and an altered vascular response. Although SD is often described as a unique phenomenon with homogeneous characteristics, it may be strongly affected by the particular triggering event and by genetic background. Furthermore, SD may contribute differently to the pathogenesis of widely heterogeneous clinical conditions...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29449064/pain-related-psychological-issues-in-hand-therapy
#12
Tokiko Hamasaki, René Pelletier, Daniel Bourbonnais, Patrick Harris, Manon Choinière
STUDY DESIGN: Literature review. INTRODUCTION: Pain is a subjective experience that results from the modulation of nociception conveyed to the brain via the nervous system. Perception of pain takes place when potential or actual noxious stimuli are appraised as threats of injury. This appraisal is influenced by one's cognitions and emotions based on her/his pain-related experiences, which are processed in the forebrain and limbic areas of the brain. Unarguably, patients' psychological factors such as cognitions (eg, pain catastrophizing), emotions (eg, depression), and pain-related behaviors (eg, avoidance) can influence perceived pain intensity, disability, and treatment outcomes...
February 12, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29447999/late-heartbeat-evoked-potentials-are-associated-with-survival-after-cardiac-arrest
#13
André Schulz, Pascal Stammet, Angelika M Dierolf, Claus Vögele, Stefan Beyenburg, Christophe Werer, Yvan Devaux
RATIONALE: Cardiac arrest (CA) is a serious condition characterized by high mortality rates, even after initial successful resuscitation, mainly due to neurological damage. Whether brain-heart communication is associated with outcome after CA is unknown. Heartbeat-evoked brain potentials (HEPs) represent neurophysiological indicators of brain-heart communication. The aim of this study was to address the association between HEPs and survival after CA. METHODS: HEPs were calculated from resting EEG/ECG in 55 CA patients 24 hours after resuscitation...
February 12, 2018: Resuscitation
https://www.readbyqxmd.com/read/29447711/no-355-physiologic-basis-of-pain-in-labour-and-delivery-an-evidence-based-approach-to-its-management
#14
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
OBJECTIVE: To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. OPTIONS: Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. EVIDENCE: PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29446711/neurophysiological-adaptations-in-the-untrained-side-in-conjunction-with-cross-education-of-muscle-strength-a-systematic-review-and-meta-analysis
#15
Andrea Manca, Tibor Hortobagyi, John C Rothwell, Franca Deriu
We reviewed the evidence from randomized controlled trials (RCTs) focusing on the neurophysiological adaptations in the untrained side associated with cross-education of strength (CE) and pooled data into definite effect estimates for neurophysiological variables assessed in chronic CE studies. Furthermore, scoping directions for future research were provided to enhance the homogeneity and comparability of studies investigating the neural responses to CE. The magnitude of CE was 21.1{plus minus}18.2% (p<0...
February 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29446312/interactive-laboratory-classes-enhance-neurophysiological-knowledge-in-thai-medical-students
#16
Nicha Wongjarupong, Danai Niyomnaitham, Pitchamol Vilaisaktipakorn, Tanawin Suksiriworaboot, Shaun Peter Qureshi, Saknan Bongsebandhu-Phubhakdi
Interactive laboratory class (ILC) is a two-way communication teaching method that encourages students to correlate laboratory findings with materials from lectures. In Thai medical education, active learning methods are uncommon. This paper aims to establish 1) if ILCs would effectively promote physiology learning; 2) if effectiveness would be found in both previously academically high-performing and low-performing students; and 3) the acceptability of ILCs to Thai medical students as a novel learning method...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29445333/sleep-dependent-memory-consolidation-and-incremental-sentence-comprehension-computational-dependencies-during-language-learning-as-revealed-by-neuronal-oscillations
#17
Zachariah R Cross, Mark J Kohler, Matthias Schlesewsky, M G Gaskell, Ina Bornkessel-Schlesewsky
We hypothesize a beneficial influence of sleep on the consolidation of the combinatorial mechanisms underlying incremental sentence comprehension. These predictions are grounded in recent work examining the effect of sleep on the consolidation of linguistic information, which demonstrate that sleep-dependent neurophysiological activity consolidates the meaning of novel words and simple grammatical rules. However, the sleep-dependent consolidation of sentence-level combinatorics has not been studied to date...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29444973/eight-hours-adaptive-deep-brain-stimulation-in-patients-with-parkinson-disease
#18
Mattia Arlotti, Sara Marceglia, Guglielmo Foffani, Jens Volkmann, Andres M Lozano, Elena Moro, Filippo Cogiamanian, Marco Prenassi, Tommaso Bocci, Francesca Cortese, Paolo Rampini, Sergio Barbieri, Alberto Priori
OBJECTIVES: To assess the feasibility and clinical efficacy of local field potentials (LFPs)-based adaptive deep brain stimulation (aDBS) in patients with advanced Parkinson disease (PD) during daily activities in an open-label, nonblinded study. METHODS: We monitored neurophysiologic and clinical fluctuations during 2 perioperative experimental sessions lasting for up to 8 hours. On the first day, the patient took his/her daily medication, while on the second, he/she additionally underwent subthalamic nucleus aDBS driven by LFPs beta band power...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29443723/neurophysiological-pain-education-for-patients-with-chronic-low-back-pain-a-systematic-review-and-meta-analysis
#19
Heidi Tegner, Pernille Frederiksen, Bente Appel Esbensen, Carsten Juhl
OBJECTIVE: To evaluate the effect of Neurophysiological Pain-Education (NPE) for patients with Chronic Low Back Pain (CLBP). METHODS: A systematic search was performed in six electronic databases. Eligible RCTs were those with at least 50 % of patients with CLBP and in which NPE was compared with no intervention or usual care. Methodological quality was assessed independently by two of the authors using the Cochrane Collaboration Risk of Bias Tool. The effect of NPE was summarized in a random effect meta-analysis for pain, disability and behavioral attitudes...
February 13, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29442559/neural-mechanisms-of-navigation-involving-interactions-of-cortical-and-subcortical-structures
#20
James R Hinman, Holger Dannenberg, Andrew Alexander, Michael E Hasselmo
Animals must perform spatial navigation for a range of different behaviors, including selection of trajectories toward goal locations and foraging for food sources. To serve this function, a number of different brain regions play a role in coding different dimensions of sensory input important for spatial behavior, including the entorhinal cortex, the retrosplenial cortex, the hippocampus and the medial septum. This article will review data concerning the coding of the spatial aspects of animal behavior, including location of the animal within an environment, the speed of movement, the trajectory of movement, the direction of the head in the environment, and the position of barriers and objects both relative to the animal's head direction (egocentric) and relative to the layout of the environment (allocentric)...
February 14, 2018: Journal of Neurophysiology
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