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REVIEW
Benoit J Arsenault, André C Carpentier, Paul Poirier, Jean-Pierre Després
The worldwide prevalence of individuals with an elevated body weight has increased steadily over the past five decades. Billions of research dollars have been invested to improve our understanding of the causes and consequences of having an elevated body weight. All this knowledge has, however, failed to influence populational body weight trajectories of most countries around the world. Research on the definition of "obesity" has also evolved. Body mass index (BMI), the most commonly used tool to make its diagnosis, has major limitations...
April 14, 2024: Atherosclerosis
#22
JOURNAL ARTICLE
Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Sue Kyung Park, Kyu Beck Lee, Ji Yong Jung, Jong Cheol Jeong, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND AND AIMS: High coronary artery calcification (CAC) burden is a significant risk factor for adverse cardiovascular and kidney outcomes. However, it is unknown whether changes in the coronary atherosclerotic burden can accompany changes in kidney disease progression. Here, we evaluated the relationship between CAC progression and the risk of kidney failure with replacement therapy (KFRT). METHODS: We analyzed 1173 participants with chronic kidney disease (CKD) G1 to G5 without kidney replacement therapy from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)...
April 23, 2024: Atherosclerosis
#23
JOURNAL ARTICLE
Seán R Millar, Pilar Navarro, Janas M Harrington, Ivan J Perry, Catherine M Phillips
BACKGROUND AND AIMS: Lipoprotein particle concentrations and size are associated with increased risk for atherosclerosis and premature cardiovascular disease. Certain dietary behaviours may be cardioprotective and public health strategies are needed to guide consumers' dietary choices and help prevent diet-related disease. The Food Standards Agency nutrient profiling system (FSAm-NPS) constitutes the basis of the five-colour front-of-pack Nutri-Score labelling system. No study has examined FSAm-NPS index associations with a wide range of lipoprotein particle subclasses...
April 20, 2024: Atherosclerosis
#24
JOURNAL ARTICLE
Kazushige Dobashi
No abstract text is available yet for this article.
May 2, 2024: Journal of Atherosclerosis and Thrombosis
#25
JOURNAL ARTICLE
Yasuhiro Endo, Kei Sasaki, Katsunori Ikewaki
No abstract text is available yet for this article.
May 2, 2024: Journal of Atherosclerosis and Thrombosis
#26
REVIEW
S von Stengel, M Fröhlich, O Ludwig, C Eifler, J Berger, H Kleinöder, F Micke, B Wegener, C Zinner, F C Mooren, M Teschler, A Filipovic, S Müller, K England, J Vatter, S Authenrieth, M Kohl, W Kemmler
Whole-body electromyostimulation has proven to be a highly effective alternative to conventional resistance-type exercise training. However, due to adverse effects in the past, very extensive contraindications have been put in place for the commercial, non-medical WB-EMS market. Considering recent positive innovations e.g., federal regulation, mandatory trainer education, revised guidelines, and new scientific studies on WB-EMS application, we believe that a careful revision of the very restrictive contraindications on WB-EMS is needed...
2024: Frontiers in sports and active living
#27
JOURNAL ARTICLE
Anna Pàmies, Dídac Llop, Daiana Ibarretxe, Roser Rosales, Luis Masana, Joan-Carles Vallvé, Silvia Paredes
INTRODUCTION: Patients with RA are at a higher risk of developing CV diseases than the general population. The precise mechanisms are still unknown. We evaluated the associations between 8 plasma growth factors (GFs) (angiopoietin-2, EGF, HB-EGF, PLGF, TGF-α, VEGFa, VEGFc, and VEGFd) and subclinical arteriosclerosis in RA patients. MATERIALS AND METHODS: A total of 199 patients with RA treated at the Hospital Universitari Sant Joan de Reus (Spain) between 2011 and 2015 were included in this cross-sectional study...
December 2024: Computational and Structural Biotechnology Journal
#28
EDITORIAL
Heinz Drexel, Andreas Festa
No abstract text is available yet for this article.
April 25, 2024: Atherosclerosis
#29
REVIEW
Lorenzo Luciani, Matteo Pedrelli, Paolo Parini
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, characterized by raised blood glucose levels and impaired lipid metabolism resulting from insulin resistance and relative insulin deficiency. In diabetes, the peculiar plasma lipoprotein phenotype, consisting in higher levels of apolipoprotein B-containing lipoproteins, hypertriglyceridemia, low levels of HDL cholesterol, elevated number of small, dense LDL, and increased non-HDL cholesterol, results from an increased synthesis and impaired clearance of triglyceride rich lipoproteins...
April 17, 2024: Atherosclerosis
#30
REVIEW
Angela Dardano, Cristina Bianchi, Monia Garofolo, Stefano Del Prato
Despite the risk of atherosclerosis has progressively declined over the past few decades, subjects with type 2 diabetes mellitus (T2DM) continue to experience substantial excess of atherosclerotic cardiovascular disease (ASCVD)-related events. Therefore, there is urgent need to treat ASCVD disease in T2DM earlier, more intensively, and with greater precision. Many factors concur to increase the risk of atherosclerosis, and multifactorial intervention remains the basis for effective prevention or reduction of atherosclerotic events...
April 23, 2024: Atherosclerosis
#31
JOURNAL ARTICLE
Shengzhuang Yang, Gaosheng Huang, Xiangsen Liang, Yu Sun, Lei Xian
Cardiovascular diseases, particularly those involving arterial stenosis and smooth muscle cell proliferation, pose significant health risks. This study aimed to investigate the therapeutic potential of curcumol in inhibiting platelet-derived growth factor-BB (PDGF-BB)-induced human aortic smooth muscle cell (HASMC) proliferation, migration and autophagy. Using cell viability assays, 5-ethynyl-2'-deoxyuridine (EdU) incorporation assays and Western Blot analyses, we observed that curcumol effectively attenuated PDGF-BB-induced HASMC proliferation and migration in a concentration-dependent manner...
June 2024: Clinical and Experimental Pharmacology & Physiology
#32
JOURNAL ARTICLE
Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Hiroshi Sawabe, Hiroyasu Inui, Ayami Saga, Takeshi Okada, Tomoaki Higo, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Mikio Watanabe
AIM: A twin study is a valuable tool for elucidating the acquired factors against lifestyle diseases such as dyslipidemia, diabetes mellitus, and obesity. We aimed 1. to investigate the factors that affect low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in monozygotic (MZ) twins, and 2. to identify genes which expression levels changed in pairs with large differences in LDL-C or HDL-C levels. METHODS: The registered database at the Center for Twin Research, Osaka University, containing 263 pairs of MZ twins, was analyzed...
April 27, 2024: Journal of Atherosclerosis and Thrombosis
#33
JOURNAL ARTICLE
Marco Guglielmo, Marco Penso, Maria Ludovica Carerj, Carlo Maria Giacari, Alessandra Volpe, Laura Fusini, Andrea Baggiano, Saima Mushtaq, Andrea Annoni, Francesco Cannata, Francesco Cilia, Alberico Del Torto, Fabio Fazzari, Alberto Formenti, Antonio Frappampina, Paola Gripari, Daniele Junod, Maria Elisabetta Mancini, Valentina Mantegazza, Riccardo Maragna, Francesca Marchetti, Giorgio Mastroiacovo, Sergio Pirola, Luigi Tassetti, Francesca Baessato, Valentina Corino, Andrea Igoren Guaricci, Mark G Rabbat, Alexia Rossi, Chiara Rovera, Pietro Costantini, Ivo van der Bilt, Pim van der Harst, Marianna Fontana, Enrico G Caiani, Mauro Pepi, Gianluca Pontone
BACKGROUND AND AIMS: This study investigated the additional prognostic value of epicardial adipose tissue (EAT) volume for major adverse cardiovascular events (MACE) in patients undergoing stress cardiac magnetic resonance (CMR) imaging. METHODS: 730 consecutive patients [mean age: 63 ± 10 years; 616 men] who underwent stress CMR for known or suspected coronary artery disease were randomly divided into derivation (n = 365) and validation (n = 365) cohorts...
April 18, 2024: Atherosclerosis
#34
JOURNAL ARTICLE
Takahito Doi, Anne Langsted, Børge G Nordestgaard
BACKGROUND AND AIMS: The PROMINENT trial, a cardiovascular outcome trial of the triglyceride- and remnant cholesterol-lowering agent pemafibrate, has shown neutral results despite reduction in plasma triglycerides and remnant cholesterol. We tested the hypothesis that absolute mass changes in remnant cholesterol, LDL cholesterol, and apolipoprotein B explain the results of the PROMINENT trial. METHODS: Among 108,431 individuals from the Copenhagen General Population Study (CGPS), those who met the key inclusion criteria of the PROMINENT trial were analyzed to mimic the trial design...
April 20, 2024: Atherosclerosis
#35
REVIEW
Andrea Caddeo, Samantha Maurotti, Lohitesh Kovooru, Stefano Romeo
Steatotic liver disease (SLD) refers to a spectrum of diseases caused by hepatic lipid accumulation. SLD has emerged as the leading cause of chronic liver disease worldwide. Despite this burden and many years, understanding the pathophysiology of this disease is challenging due to the inaccessibility to human liver specimens. Therefore, cell-based in vitro systems are widely used as models to investigate the pathophysiology of SLD. Culturing hepatic cells in monolayers causes the loss of their hepatocyte-specific phenotype and, consequently, tissue-specific function and architecture...
April 15, 2024: Atherosclerosis
#36
JOURNAL ARTICLE
Lauren E Hendy, Lisa P Spees, Casey Tak, Delesha M Carpenter, Kathleen C Thomas, Megan C Roberts
BACKGROUND AND AIMS: Familial hypercholesterolemia is an underdiagnosed genetic metabolic condition limiting the clearance of low-density lipoprotein cholesterol and increasing lifetime risk of cardiovascular disease. Population genetic screening in unselected individuals could quickly identify cases of familial hypercholesterolemia and enable early prevention, but the economic impact of widespread screening on patients has not been studied. METHODS: We assessed the cost-effectiveness of population genetic screening for familial hypercholesterolemia in 20 and 35-year-old adults in the United States from the perspective of patients...
April 16, 2024: Atherosclerosis
#37
JOURNAL ARTICLE
Christian Roth, Rosa Yavuz, Carolin Maschita, Andreas Ferbert, Johannes Matthaei
BACKGROUND: Acute basilar artery occlusion is a life-threatening medical emergency with a highly elevated mortality rate when left untreated. Little is known about symptoms and clinical progression of chronic occlusions. The aim of this study was to systematically analyze the clinical presentation of patients with chronic basilar artery occlusion (CBAO). METHODS: Monocentric retrospective analysis of adult patients with CBAO was treated between 2015 and 2023 in the Department of Neurology, Klinikum Kassel...
April 27, 2024: Journal of Neurology
#38
REVIEW
Murrium I Sadaf, Usman Ali Akbar, Khurram Nasir, Bashir Hanif, Salim S Virani, Kershaw V Patel, Safi U Khan
PURPOSE OF REVIEW: This narrative review seeks to elucidate clinical and social factors influencing cardiovascular health, explore the challenges and potential solutions for enhancing cardiovascular health, and identify areas where further research is needed to better understand cardiovascular issues in native and American Pakistani populations. RECENT FINDINGS: The prevalence of cardiometabolic disease is high not only in Pakistan but also among its global diaspora...
April 26, 2024: Current Atherosclerosis Reports
#39
JOURNAL ARTICLE
Torunn Melnes, Martin P Bogsrud, Jacob J Christensen, Amanda Rundblad, Ingunn Narverud, Kjetil Retterstøl, Pål Aukrust, Bente Halvorsen, Stine M Ulven, Kirsten B Holven
BACKGROUND AND AIMS: Elderly familial hypercholesterolemia (FH) patients are at high risk of coronary heart disease (CHD) due to high cholesterol burden and late onset of effective cholesterol-lowering therapies. A subset of these individuals remains free from any CHD event, indicating the potential presence of protective factors. Identifying possible cardioprotective gene expression profiles could contribute to our understanding of CHD prevention and future preventive treatment. Therefore, this study aimed to investigate gene expression profiles in elderly event-free FH patients...
March 11, 2024: Atherosclerosis
#40
JOURNAL ARTICLE
Ping LYu, Hangyu Pan, Kexin Hu, Yazhi Xue, Qinxian Li, Rongzhan Lin, Shaoyi Zheng, Zhigang Guo, Kai Guo
BACKGROUND AND AIMS: Long noncoding RNAs (lncRNAs) play important roles in the progression of atherosclerosis. In this study, we identified an uncharacterized lncRNA, Liver Expressions by PSRC1 Induced Specifically (LEPIS). This study aimed to clarify the mechanism though which LEPIS affects atherosclerosis (AS). METHODS: The expression of LEPIS and its potential target, tropomodulin 4 (TMOD4), was increased in the livers of ApoE-/- mice fed a high-fat diet (HFD)...
April 16, 2024: Atherosclerosis
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