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Chronic pancreatitis

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https://www.readbyqxmd.com/read/29655493/hepatic-inflammatory-pseudotumor-related-with-igg4
#1
Oleksandr Legkiy, Justyna Wajda, Anna Ćwierz, Joanna Wysocka, Andrzej L Komorowski
BACKGROUND: Hepatic inflammatory pseudotumor (HIP) related to IgG4 is a poorly understood entity. It is a rare finding that can simulate malignant liver tumors. Pathogenesis has been associated with pathological inflammatory response. Corticosteroids are considered standard of care once a firm diagnosis has been established. CASE REPORT: We report a case of a 60-year-old man with chronic pancreatitis who was admitted to our hospital with suspicious liver tumor. Imaging studies were inconclusive...
April 11, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29651002/metformin-decreases-the-incidence-of-pancreatic-ductal-adenocarcinoma-promoted-by-diet-induced-obesity-in-the-conditional-krasg12d-mouse-model
#2
Hui-Hua Chang, Aune Moro, Caroline Ei Ne Chou, David W Dawson, Samuel French, Andrea I Schmidt, James Sinnett-Smith, Fang Hao, O Joe Hines, Guido Eibl, Enrique Rozengurt
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies. We aimed to characterize the chemo-preventive effects of metformin, a widely used anti-diabetic drug, on PDAC development using the KrasG12D mouse model subjected to a diet high in fats and calories (HFCD). LSL-KrasG12D/+ ;p48-Cre (KC) mice were given control diet (CD), HFCD, or HFCD with 5 mg/ml metformin in drinking water for 3 or 9 months...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643954/cost-effectiveness-of-benign-wirsung-duct-strictures-treatment-in-chronic-pancreatitis
#3
Dariusz Łaski, Stanisław Hać, Iwona Marek, Jarosław Kobiela, Justyna Kostro, Krystian Adrych, Zbigniew Śledziński
Introduction: Chronic pancreatitis (CP) is an important problem for modern medicine, the healthcare system (Poland - NFZ) and the national insurance system (Poland - ZUS). The chronic nature of the disease, the lack of targeted treatment and the low mortality rate lead to an accumulation of patients who demand expensive treatment, both conservative and invasive. Rising costs in health care are forcing the need for a more cost-effective method of treatment. Aim: The primary aim of this study was to perform a retrospective calculation of costs in both surgical and endoscopic treatment, hospital stay, healthcare, and public insurance of patients suffering from chronic pancreatitis...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29643115/chronic-at1-blockade-improves-glucose-homeostasis-in-obese-oletf-rats
#4
Ruben Rodriguez, Jacqueline N Minas, Jose Pablo Vazquez-Medina, Daisuke Nakano, David G Parkes, A Nishiyama, Rudy M Ortiz
Obesity is associated with the inappropriate activation of the renin-angiotensin-system (RAS), which increases arterial pressure, impairs insulin secretion, and decreases peripheral tissue insulin sensitivity. RAS blockade reverses these detriments; however, it is not clear whether the disease state of the organism and treatment duration determine the beneficial effects of RAS inhibition on insulin secretion and insulin sensitivity. Therefore, the objective of this study was to compare the benefits of acute vs...
April 11, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29642943/celiac-axis-stenosis-due-to-median-arcuate-ligament-compression-in-a-patient-who-underwent-pancreatoduodenectomy-intraoperative-assessment-of-hepatic-arterial-flow-using-doppler-ultrasonography-a-case-report
#5
Masateru Yamamoto, Toshiyuki Itamoto, Akihiko Oshita, Yasuhiro Matsugu
BACKGROUND: Celiac axis stenosis due to compression by the median arcuate ligament has been reported in patients undergoing pancreaticoduodenectomy; it leads to the development of major collateral pathways that feed the hepatic artery. Dividing these important collaterals during pancreaticoduodenectomy can cause ischemic complications which may lead to a high mortality rate. To prevent these complications, it is necessary to assess intrahepatic arterial flow. CASE PRESENTATION: A 71-year-old Japanese man with anorexia was referred to us for the treatment of alcoholic chronic pancreatitis...
April 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29629907/incidence-admission-rates-and-predictors-and-economic-burden-of-adult-emergency-visits-for-acute-pancreatitis-data-from-the-national-emergency-department-sample-2006-to-2012
#6
Sushil K Garg, Shashank Sarvepalli, James P Campbell, Itegbemie Obaitan, Dupinder Singh, Fateh Bazerbachi, Rajeshwar Singh, Madhusudhan R Sanaka
INTRODUCTION: Acute pancreatitis (AP) is the most common gastroenterology-related reason for hospital admission, and a major source of morbidity and mortality in the United States. This study examines the National Emergency Database Sample, a large national database, to analyze trends in emergency department (ED) utilization and costs, risk factors for hospital admission, and associated hospital costs and length of stay (LOS) in patients presenting with AP. METHODS: The National Emergency Database Sample (2006 to 2012) was evaluated for trends in ED visits, ED charges, hospitalization rates, hospital charges, and hospital LOS in patients with primary diagnosis of AP (further subcategorized by age and etiology)...
April 6, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29627328/toxoplasma-gondii-as-a-possible-causative-pathogen-of-type-1-diabetes-mellitus-evidence-from-case-control-and-experimental-studies
#7
Engy Victor Nassief Beshay, Samar A El-Refai, Mohamed A Helwa, Amany Fawzy Atia, Marwa Mohammed Dawoud
Toxoplasma gondii is the causative parasite of an important worldwide disease. This obligate intracellular parasite can infect and replicate inside any nucleated cells including those of pancreas. Insulin is a hormone secreted by the pancreas and is responsible for controlling blood glucose concentration. Deficiency of insulin production accounts for the occurrence of type-1 diabetes mellitus (T1D). Thus, theoretically, toxoplasmosis could play a possible role in the development of T1D. However, the studies on this theory are still insufficient; therefore, this work was designed...
April 5, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29626466/substance-p-preserves-pancreatic-%C3%AE-cells-in-type-1-and-type-2-diabetic-mice
#8
Jihyun Um, Neunggum Jung, Dongjin Kim, Sanghyuk Choi, Sang-Ho Lee, Youngsook Son, Ki-Sook Park
Preservation of pancreatic β-cells is required for the development of therapies for type 1 and type 2 diabetes (T1D and T2D, respectively). Our previous study demonstrated that substance P (SP) preserves β-cell populations in mice with streptozotocin-induced T1D. Here, we demonstrated that chronic systemic treatment with SP restored the mass of β-cells both in nonobese diabetic (NOD) mice with T1D or db/db mice with T2D. SP delayed the onset of T1D in NOD mice via immune modulation. SP inhibited immune infiltration into islets and the salivary glands of NOD mice...
April 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29626085/correction-metabolic-biomarker-signature-to-differentiate-pancreatic-ductal-adenocarcinoma-from-chronic-pancreatitis
#9
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Gut
https://www.readbyqxmd.com/read/29624168/age-related-islet-inflammation-marks-the-proliferative-decline-of-pancreatic-beta-cells-in-zebrafish
#10
Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, Neda Mousavy-Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy Rutter, Gavin Bewick, Nikolay N Ninov
The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from younger and older zebrafish, here we show that the aging islets exhibit signs of chronic inflammation. These include recruitment of tnfα -expressing macrophages and the activation of NF-kB signaling in beta-cells. Using a transgenic reporter, we show that NF-kB activity is undetectable in juvenile beta-cells, whereas cells from older fish exhibit heterogeneous NF-kB activity...
April 6, 2018: ELife
https://www.readbyqxmd.com/read/29623673/the-relationship-between-age-and-chronic-kidney-disease-in-patients-undergoing-pancreatic-resection
#11
Derrick Antoniak, Chandrakanth Are, Chad Vokoun, Kaeli Samson, Lynette Smith, Jason Shiffermiller
BACKGROUND: Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65. METHODS: Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Primary outcomes were all-cause mortality and major complication, defined as myocardial infarction, cardiac arrest, stroke, venous thromboembolism, respiratory failure, deep surgical site infection, pneumonia, acute kidney injury, coma > 24 h, or re-operation occurring within 30 days of surgery...
April 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29620654/successful-endoscopic-removal-of-a-rare-large-impacted-pancreatic-duct-stone-using-grasping-forceps-a-case-report-with-video
#12
Qin Liu, Yiping Wang, Hongze Zeng, Bing Hu
RATIONALE: As a main complication of chronic pancreatitis (CP), pancreatic duct stones (PDSs) are often associated with ductal obstruction resulting in increasing intraductal and parenchymal pressure and long-lasting pain. There are many methods for removing PDSs. However, for large stones, it is technically difficult to remove them entirely by endoscopic retrograde cholangiopancreatography (ERCP). PATIENT CONCERNS: A 57-year-old man presented with a chief complaint of severe epigastric pain radiating to his back 3 or 4 times annually for 2 years...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29615311/mr-imaging-of-hemorrhage-associated-with-acute-pancreatitis
#13
Meng Yue Tang, Tian Wu Chen, Thomas L Bollen, Yi Xiang Wang, Hua Dan Xue, Zheng Yu Jin, Xiao Hua Huang, Bo Xiao, Xing Hui Li, Yi Fan Ji, Xiao Ming Zhang
PURPOSE: To study MRI findings of hemorrhage in acute pancreatitis (AP) and correlate the presence and extent of hemorrhage with the MR severity index (MRSI), Acute Physiology And Chronic Health Evaluation (APACHE) II scores, and clinical outcome. MATERIALS AND METHODS: This retrospective study included 539 patients with AP. Hemorrhage was defined as areas of hyperintensity in or outside the pancreas on liver imaging with volume acceleration flexible (LAVA-Flex)...
March 27, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29610171/autoimmune-pancreatitis-and-ulcerative-rectocolitis-in-an-adolescent
#14
Elie Cousin, Ianis Cousin, Karim Aziz, Pascal Chailloux, Estelle Breton
Autoimmune pancreatitis (AIP) is rare in teenagers and difficult to diagnose. There are no clear and established diagnostic criteria in the pediatric population to distinguish subtype 1 and subtype 2. Here, we report the case of a 16-year-old white French teenager admitted to the pediatric emergency service with more than 1 year's history of pain originating from the epigastric and the right hypochondriac regions, with bloody diarrhea. After exclusion of pancreatic cancer and other common causes of acute pancreatitis, the diagnosis of AIP was suspected...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29607537/gastrointestinal-unusual-cause-of-acute-cholangitis-in-a-chronic-pancreatitis-patient
#15
J W Choe, J J Lee, J J Hyun
No abstract text is available yet for this article.
April 1, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29604293/immune-cell-production-of-interleukin-17-induces-stem-cell-features-of-pancreatic-intraepithelial-neoplasia-cells
#16
Yu Zhang, Michelle Zoltan, Erick Riquelme, Hanwen Xu, Ismet Sahin, Susana Castro-Pando, Maria Fernanda Montiel, Kyle Chang, Zhengyu Jiang, Jianhua Ling, Sonal Gupta, William Horne, Melissa Pruski, Huamin Wang, Shao-Cong Sun, Guillermina Lozano, Paul Chiao, Anirban Maitra, Steven D Leach, Jay K Kolls, Eduardo Vilar Sanchez, Timothy C Wang, Jennifer M Bailey, Florencia McAllister
BACKGROUND & AIMS: Little is known about how the immune system affects stem cell features of pancreatic cancer cells. Immune cells that produce interleukin 17 A (IL17A) in the chronically inflamed pancreas (chronic pancreatitis) contribute to PanIN initiation and progression. We investigated the effects of IL17A signaling exerts on pancreatic cancer progenitor cells and the clinical relevance of this phenomena. METHODS: We performed studies with Mist1Cre;LSLKras;Rosa26mTmG (KCiMist ;G) and Kras(G12D); Trp53(R172H); Pdx1-Cre (KPC) mice (which upon tamoxifen induction spontaneously develop pancreatic intraepithelial neoplasias, PanINs) and control littermates...
March 28, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29603910/insulin-secretion-kinetics-from-single-islets-reveals-distinct-sub-populations
#17
Rajesh Guruswamy Damodaran, Alexandre Poussard, Benoît Côté, Parker L Andersen, Patrick Vermette
Type II diabetes progresses with inadequate insulin secretion and prolonged elevated circulating glucose levels. Also, pancreatic islets isolated for transplantation or tissue engineering can be exposed to glucose over extended timeframe. We hypothesized that isolated pancreatic islets can secrete insulin over a prolonged period of time when incubated in glucose solution and that not all islets release insulin in unison. Insulin secretion kinetics was examined and modeled from single mouse islets in response to chronic glucose exposure (2...
March 31, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29602940/morphological-and-crystal-chemical-characteristic-of-pan%C3%B1-reatic-lithiasis
#18
Oleksandr V Kravets, Ihor A Danilenko, Olga M Smorodska, Artem M Piddubnyi, Inna-Margaryta S Zakorko, Sergei N Danilchenko, Roman A Moskalenko, Mykola G Kononenko, Anatolii M Romaniuk
OBJECTIVE: Introduction: Information on chemical and phase composition of pancreoliths is limited and discrepant. There are reports, that pancreoliths are composed by calcium, phosphate, calcium carbonate or combination of calcium with fatty acids The aim of the work is studying of structural characteristics of pancreatoliths in 5 clinical cases. PATIENTS AND METHODS: Materials and methods: Morphological and crystal-chemical study of five cases of pathological biomineralization in the pancreas were conducted in the work...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29602793/effects-of-smoking-versus-nonsmoking-on-postprandial-glucose-metabolism-in-heavy-smokers-compared-with-nonsmokers
#19
Magnus F Grøndahl, Jonatan I Bagger, Asger Lund, Annesofie Faurschou, Jens F Rehfeld, Jens J Holst, Tina Vilsbøll, Filip K Knop
OBJECTIVE: Epidemiological studies suggest that smoking increases the risk of type 2 diabetes. We hypothesized that smoking-derived nicotine and ensuing activation of nicotinic cholinergic receptors in the gastrointestinal tract and the autonomic nervous system would have a detrimental effect on postprandial glucose metabolism and, thus, potentially constitute a link between smoking and the development of type 2 diabetes. RESEARCH DESIGN AND METHODS: We subjected 11 male heavy smokers to two identical 4-h liquid mixed-meal tests: one with concomitant cigarette smoking (immediately before and after meal intake) and one without smoking...
March 30, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29599810/the-aqueous-extract-of-gynura-divaricata-l-dc-improves-glucose-and-lipid-metabolism-and-ameliorates-type-2-diabetes-mellitus
#20
Jinnan Li, Jinlei Feng, Hong Wei, Qunying Liu, Ting Yang, Shengpan Hou, Ying Zhao, Bo Zhang, Cheng Yang
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia and dyslipidemia caused by impaired insulin secretion and resistance of the peripheral tissues. A major pathogenesis of T2DM is obesity-associated insulin resistance. Gynura divaricata (L.) DC. (GD) is a natural plant and has been reported to have numerous health-promoting effects on both animals and humans. In this study, we aimed to elucidate the regulatory mechanism of GD improving glucose and lipid metabolism in an obesity animal model induced by high-fat and high-sugar diet in combination with low dose of streptozocin and an insulin-resistant HepG2 cell model induced by dexamethasone...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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