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Chronic pancreatitis

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https://www.readbyqxmd.com/read/29470174/antidiabetic-and-protective-effects-of-the-aqueous-extract-of-arbutus-unedo-l-in-streptozotocin-nicotinamide-induced-diabetic-mice
#1
Hanae Naceiri Mrabti, Karima Sayah, Nidal Jaradat, Faouzi Kichou, Abdelaziz Ed-Dra, Badiaa Belarj, Yahia Cherrah, My El Abbes Faouzi
Background Diabetes mellitus (DM) is currently a major health problem and the most common chronic disease worldwide. Traditional medicinal plants remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Arbutus unedo L. has been traditionally used to manage several diseases including diabetes. This study was undertaken to contribute the validation of the traditional use of Arbutus unedoL. (Ericaceae) in the treatment of diabetes. Methods In-vitro antidiabetic effect of the A...
February 21, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29468058/a-patient-with-men1-and-end-stage-chronic-kidney-disease-due-to-alport-syndrome-decision-making-on-the-eligibility-of-transplantation
#2
Antonio Matrone, Alessandro Brancatella, Piero Marchetti, Enrico Vasile, Ugo Boggi, Rossella Elisei, Filomena Cetani, Claudio Marcocci, Paolo Vitti, Francesco Latrofa
Absence of neoplastic disease in the organ-recipient is required in order to allow organ transplantation. Due to its rarity, no data regarding management of patients with Multiple endocrine neoplasia type 1 (MEN1) and end-stage renal failure candidates for kidney transplantation are available. A 36 year-old man was referred to the present hospital with MEN1, with a neuroendocrine pancreatic tumor and primary hyperparathyroidism and associated Alport syndrome with end stage renal failure. The present study aimed to establish the eligibility of the patient for a kidney transplantation...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29465601/postoperative-hemorrhage-caused-by-portal-hypertension-associated-with-autoimmune-pancreatitis-a-case-report
#3
Puzi Wang, Rongli Xie, Zhifeng Zhao, Jiajun Ren, Jian Fei
RATIONALE: Autoimmune pancreatitis is a form of chronic pancreatitis, characterized by diffused enlargement of the pancreas and irregular narrowing of the main pancreatic duct. The theory that portal hypertension is associated with autoimmune pancreatitis has not been emphasized. In addition, only a few studies report that the gastrointestinal tract hemorrhage caused by portal hypertension is associated with autoimmune pancreatitis. PATIENT CONCERNS: The patient was a 61-year-old male with pancreas occupying lesion detected in a physical examination...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464583/intestinal-involvement-in-systemic-sclerosis-a-clinical-review
#4
REVIEW
Lazaros I Sakkas, Theodora Simopoulou, Dimitrios Daoussis, Stamatis-Nick Liossis, Spyros Potamianos
Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, autoantibodies, and extensive fibrosis. Intestinal involvement is frequent in SSc and represents a significant cause of morbidity. The pathogenesis of intestinal involvement includes vascular damage, nerve dysfunction, smooth muscle atrophy, and fibrosis, causing hypomotility, which leads to small intestinal bacterial overgrowth (SIBO), malabsorption, malnutrition, diarrhea, pseudo-obstruction, constipation, pneumatosis intestinalis, and fecal incontinence...
February 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29463644/the-inositol-requiring-enzyme-1-ire1%C3%AE-rnase-inhibitor-4%C3%A2%C2%B58c-is-also-a-potent-cellular-antioxidant
#5
Stanley M H Chan, Mark P Lowe, Ashton Bernard, Alyson A Miller, Terence P Herbert
Inositol Requiring Enzyme 1 alpha (IRE1α) is an ER-transmembrane endonuclease that is activated in response to ER stress as part of the unfolded protein response (UPR). Chronic activation of the UPR has been implicated in the pathogenesis of many common disease including diabetes, cancer and neurological pathologies such as Huntington's and Alzheimer's disease. 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde (4µ8C) is widely used as a specific inhibitor of IRE1α ribonuclease activity in mechanistic studies (IC50 of 6...
February 20, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29460919/a-role-for-total-pancreatectomy-and-islet-autotransplant-in-the-treatment-of-chronic-pancreatitis
#6
Melena D Bellin
No abstract text is available yet for this article.
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29460880/-outcomes-of-cardiac-achalasia-grade-ii-iii-management
#7
A P Koshel, S S Klokov, V A Alekseev, T V Dibina, N S Rudaya, K M Popov
AIM: To analyze early and remote results of the new method of cardiac achalasia grade II-III management. MATERIAL AND METHODS: Original surgical approach was applied in 21 patients with cardiac achalasia grade II-III. RESULTS: There were no any specific postoperative complications and deaths. Exacerbation of chronic pancreatitis, acute stomach ulcer and biliary peritonitis were observed in 3 cases respectively. All patients were followed-up within the period from 1...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29460878/-laparoscopic-pancreatic-head-resection
#8
R E Izrailov, V V Tsvirkun, R B Alikhanov, A V Andrianov
AIM: To analyze the features and efficacy of laparoscopic Frey procedure. MATERIAL AND METHODS: For the period from August 2012 to May 2017 Frey procedure was carried out in 31 patients with chronic calculous pancreatitis Buchler type C. There were 20 men and 11 women aged 48.6±9 years. Mean pancreatic head dimension was 35.5±14 mm, diameter of the main pancreatic duct - 9.6±2.7 mm. RESULTS: Completely laparoscopic procedure was made in 28 (90...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29456124/a-multicenter-study-of-total-pancreatectomy-with-islet-autotransplantation-tpiat-post-prospective-observational-study-of-tpiat
#9
Melena D Bellin, Maisam Abu-El-Haija, Katherine Morgan, David Adams, Gregory J Beilman, Srinath Chinnakotla, Darwin L Conwell, Ty B Dunn, Martin L Freeman, Timothy Gardner, Varvara A Kirchner, Luis F Lara, Leslie Long-Simpson, Jaimie D Nathan, Bashoo Naziruddin, John A Nyman, Timothy L Pruett, Sarah J Schwarzenberg, Vikesh K Singh, Kerrington Smith, Jennifer L Steel, Martin Wijkstrom, Piotr Witkowski, James S Hodges
BACKGROUND/OBJECTIVES: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. METHODS: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients...
February 6, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29453786/long-term-outcomes-of-6-mm-diameter-of-fully-covered-self-expandable-metal-stents-in-benign-refractory-pancreatic-ductal-stricture
#10
Dongwook Oh, Jae Hoon Lee, Tae Jun Song, Do Hyun Park, Sung Koo Lee, Myung-Hwan Kim, Sang Soo Lee
OBJECTIVES: Fully covered self-expandable metal stents (FCSEMSs) placement has been tried for pancreatic ductal strictures in chronic pancreatitis. However, the long-term outcome of this procedure remains unknown. This study aimed to investigate the procedural and long-term outcomes of FCSEMS placement in patients with benign refractory pancreatic ductal strictures. METHODS: Between August 2011 and September 2015, 18 patients underwent endoscopic treatment with FCSEMSs for a benign refractory pancreatic ductal stricture...
February 17, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29452961/dipeptidyl-peptidase-4-inhibitors-dpp-4i-combined-with-vitamin-d3-an-exploration-to-treat-new-onset-type-1-diabetes-mellitus-and-latent-autoimmune-diabetes-in-adults-in-the-future
#11
Marcelo Maia Pinheiro, Felipe Moura Maia Pinheiro, Maria Luisa Trabachin
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic beta cells through cell injury caused primarily by cytotoxic T lymphocytes (CD8 + ). The pathophysiological basis of T1DM seems to be an imbalance between a reduced function of T regulatory lymphocytes and an increased inflammatory activity of Th17 lymphocytes caused by increased production of inflammatory cytokines, as IL-1β, IL-6, IL-17 and IFN-gamma due to environmental factors and genetic predisposition...
February 13, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29451525/-chronic-pancreatitis-new-definition-and-perspectives
#12
Maria Cristina Conti Bellocchi, Nicolò De Pretis, Antonio Amodio, Alessandro Zerbi, Luca Frulloni
Chronic pancreatitis has been considered over the past years as a single disease, alcohol-induced and different from acute pancreatitis, in terms of etiology and prognosis. Actually, the introduction of a new concept of chronic pancreatitis, now considered as a fibroinflammatory process caused by multiple factors (toxic-metabolic, genetic, immunologic, obstructive), allow to better understand the pathogenesis of this complex disease. Furthermore, the discover of peculiar forms of chronic pancreatitis (autoimmune, paraduodenal, associated to gene mutations), different in term of clinical aspects, findings at imaging, prognosis and therapy, radically changed the concept of the disease...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29447028/elastase-as-a-potential-biomarker-for-radiation-induced-gut-wall-injury-of-the-distal-bowel-in-an-experimental-mouse-model
#13
Fei Sjöberg, Dilip Kumar Malipatlolla, Piyush Patel, Ulrica Wilderäng, Marie Kalm, Gunnar Steineck, Cecilia Bull
BACKGROUND AND PURPOSE: Traditionally, elastase has been used to study exocrine activity of the pancreas in patients with chronic pancreatitis and cystic fibrosis, and calprotectin as a marker for gut-wall inflammation in patients with inflammatory bowel disease. The aim of the study was to find out whether elastase and calprotectin could be used as inflammatory markers for radiation-induced gut wall injury of the distal bowel. MATERIAL AND METHODS: Adult male mice were exposed to two, three, or four fractions of 6 Gy or 8 Gy irradiation to the sigmoid and rectum of the large bowel, using a linear accelerator...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29444760/risk-factors-for-persistent-aspergillus-respiratory-isolation-in-cystic-fibrosis
#14
Gina Hong, Kevin J Psoter, Mark T Jennings, Christian A Merlo, Michael P Boyle, Denis Hadjiliadis, Steven M Kawut, Noah Lechtzin
BACKGROUND: Aspergillus species are increasingly detected in the respiratory tracts of individuals with cystic fibrosis (CF), and chronic Aspergillus fumigatus is associated with more frequent hospitalizations for pulmonary exacerbations. However, patient and clinical factors that may contribute to the acquisition of persistent Aspergillus infection have yet to be identified. The objective of this study was to identify risk factors for development of Aspergillus respiratory isolation in CF...
February 12, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29443735/identification-of-gene-expression-models-for-laryngeal-squamous-cell-carcinoma-using-co-expression-network-analysis
#15
Chun-Wei Yang, Shu-Fang Wang, Xiang-Li Yang, Lin Wang, Lin Niu, Ji-Xiang Liu
One of the most common head and neck cancers is laryngeal squamous cell carcinoma (LSCC). LSCC exhibits high mortality rates and has a poor prognosis. The molecular mechanisms leading to the development and progression of LSCC are not entirely clear despite genetic and therapeutic advances and increased survival rates. In this study, a total of 116 differentially expressed genes (DEGs), including 11 upregulated genes and 105 downregulated genes, were screened from LSCC samples and compared with adjacent noncancerous...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443733/serial-evaluation-of-the-sofa-score-is-reliable-for-predicting-mortality-in-acute-severe-pancreatitis
#16
Yu-San Tee, Hsin-Yueh Fang, I-Ming Kuo, Yann-Sheng Lin, Song-Fong Huang, Ming-Chin Yu
Acute severe pancreatitis caused high mortality, and several scoring systems for predicting mortality are available. We evaluated the effectiveness of serial measurement of several scoring systems in patients with acute severe pancreatitis.We retrospectively obtained serial measurements of Ranson, Acute Physiology and Chronic Health Assessment (APACHE) II, and Sequential Organ Failure Assessment (SOFA) scores of 159 patients with acute severe pancreatitis.The overall mortality rate was 20%, and early mortality (in the first 2 weeks) occurred in 10 (7...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442719/nanoliposomal-resveratrol-as-a-novel-approach-to-treatment-of-diabetes-mellitus
#17
Çiğdem Yücel, Gökçe Şeker Karatoprak, Yeşim Aktaş
Diabetes mellitus (DM) is a chronic metabolic disease and the subgroup of DM is called type II which is the most common form. The incidence of type II is increasing worldwide and it focuses on several new approaches to efficiently treatment of diabetes. Resveratrol (RSV) is known to be strong antioxidant and has an insulin-like effect in streptozotocin (STZ)-induced diabetic cells. It plays an active role at treatment of diabetes with reducing the oxidative stress, lowering glucose levels and protection of beta cells which are responsible for insulin secretion...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442468/the-role-of-pancreatic-polypeptide-in-pancreatic-diseases
#18
REVIEW
Mariola Śliwińska-Mossoń, Grzegorz Marek, Halina Milnerowicz
The aim of this study was to review the diagnostic significance of pancreatic polypeptide (PP) in pancreatic diseases. PP may play a significant role in monitoring the development of the disease and the patient's healing process, particularly after the removal of a portion of the pancreas. Determining PP in acute pancreatitis is quite controversial. At the 1st stage of severe pancreatic damage, there is excessive PP release followed by its fall. In patients with chronic pancreatitis, a significant decrease in PP secretion was found in the presence of a food stimulant...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29439461/early-diagnosis-to-improve-the-poor-prognosis-of-pancreatic-cancer
#19
REVIEW
Masataka Kikuyama, Terumi Kamisawa, Sawako Kuruma, Kazuro Chiba, Shinya Kawaguchi, Shuzo Terada, Tatsunori Satoh
Pancreatic cancer (PC) has a poor prognosis due to delayed diagnosis. Early diagnosis is the most important factor for improving prognosis. For early diagnosis of PC, patients with clinical manifestations suggestive of PC and high risk for developing PC need to be selected for examinations for PC. Signs suggestive of PC (e.g., symptoms, diabetes mellitus, acute pancreatitis, or abnormal results of blood examinations) should not be missed, and the details of risks for PC (e.g., familial history of PC, intraductal mucin producing neoplasm, chronic pancreatitis, hereditary pancreatitis, or life habit) should be understood...
February 11, 2018: Cancers
https://www.readbyqxmd.com/read/29434076/differences-in-gut-microbiota-profiles-between-autoimmune-pancreatitis-and-chronic-pancreatitis
#20
Shin Hamada, Atsushi Masamune, Tatsuhide Nabeshima, Tooru Shimosegawa
Host-derived factors alter gut microenvironment, and changes in gut microbiota also affect biological functions of host. Alterations of gut microbiota have been reported in a wide variety of diseases, but the whole picture of alterations in pancreatic diseases remains to be clarified. In particular, the gut microbiota may be affected by malnutrition or impaired exocrine pancreas function that is associated with pancreatic diseases. We here conducted comprehensive analysis of gut microbiota in patients with type 1 autoimmune pancreatitis (AIP), a pancreatic manifestation of the systemic IgG4-related disease, and chronic pancreatitis (CP)...
2018: Tohoku Journal of Experimental Medicine
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