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https://www.readbyqxmd.com/read/28089576/conditional-deletion-of-pejvakin-in-adult-outer-hair-cells-causes-progressive-hearing-loss-in-mice
#1
Suzan L Harris, Marcin Kazmierczak, Tina Pangršič, Prahar Shah, Nadiya Chuchvara, Alonso Barrantes-Freer, Tobias Moser, Martin Schwander
Mutations in the Pejvakin (Pjvk) gene cause autosomal recessive hearing loss DFNB59 with audiological features of auditory neuropathy spectrum disorder (ANSD) or cochlear dysfunction. The precise mechanisms underlying the variable clinical phenotypes of DFNB59 remain unclear. Here, we demonstrate that mice with conditional ablation of the Pjvk gene in all sensory hair cells or only in outer hair cells (OHCs) show similar auditory phenotypes with early-onset profound hearing loss. By contrast, loss of Pjvk in adult OHCs causes a slowly progressive hearing loss associated with OHC degeneration and delayed loss of inner hair cells (IHCs), indicating a primary role for pejvakin in regulating OHC function and survival...
January 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28087093/audiologic-and-radiologic-findings-in-cochlear-hypoplasia
#2
Betul Cicek Cinar, Merve Ozbal Batuk, Emel Tahir, Gonca Sennaroglu, Levent Sennaroglu
OBJECTIVE: The aim of the current study is to evaluate audiologic and radiologic findings of cochlear hypoplasia which is a subgroup of inner ear malformations. METHODS: This study was a prospective clinical study and based on voluntary participation from cases with cochlear hypoplasia diagnosis. The study was conducted at Hacettepe University, Department of Otolaryngology, Head and Neck Surgery and Department of Audiology. Subjects were selected from an inner ear malformations database...
January 10, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28072811/evaluation-of-the-ototoxicity-potential-of-once-daily-single-entity-hydrocodone-in-patients-with-chronic-pain-results-of-two-phase-3-clinical-studies
#3
Kathleen Campbell, J Walter Kutz, Angela Shoup, Warren Wen, Shau Yu Lynch, Ellie He, Steven R Ripa
BACKGROUND: Use/misuse of the opioid combination hydrocodone-acetaminophen has been associated with permanent hearing loss. Although reports have been rare, this potential effect can have significant detrimental effect on patients' overall quality of life. To date, the ototoxic effect of hydrocodone alone has not been systematically investigated. OBJECTIVE: In this report, we aimed to evaluate the potential ototoxicity of a novel, single-entity, once-daily, extended-release hydrocodone tablet (Hysingla® ER; HYD)...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28054914/detailed-audiological-evaluation-of-a-patient-with-xeroderma-pigmentosum-with-neural-degeneration
#4
Danielle Mercer, Annette Hurley, Fern Tsien
BACKGROUND: Xeroderma pigmentosum (XP) is a rare autosomal recessive condition characterized by extreme sensitivity to ultraviolet light. Individuals with XP lack the ability to repair DNA (deoxyribonucleic acid) damage caused by ultraviolet radiation, leading to sunburn and increased susceptibility to skin cancers. Approximately 25% of patients also exhibit neural degeneration, which includes progressive mental deterioration, cortical thinning, and sensorineural hearing loss. PURPOSE: Herein, we describe the audiological and genetic findings in a patient with XP subtype D with neural degeneration and hearing loss...
January 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28051029/a-pou3f4-mutation-causes-nonsyndromic-hearing-loss-in-a-chinese-x-linked-recessive-family
#5
Wan Du, Ming-Kun Han, Da-Yong Wang, Bing Han, Liang Zong, Lan Lan, Ju Yang, Qi Shen, Lin-Yi Xie, Lan Yu, Jing Guan, Qiu-Ju Wang
BACKGROUND: The molecular genetic research showed the association between X-linked hearing loss and mutations in POU3F4. This research aimed to identify a POU3F4 mutation in a nonsyndromic X-linked recessive hearing loss family. METHODS: A series of clinical evaluations including medical history, otologic examinations, family history, audiologic testing, and a high-resolution computed tomography scan were performed for each patient. Bidirectional sequencing was carried out for all polymerase chain reaction products of the samples...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28049114/a-targeted-approach-for-congenital-cytomegalovirus-screening-within-newborn-hearing-screening
#6
Karen B Fowler, Faye P McCollister, Diane L Sabo, Angela G Shoup, Kris E Owen, Julie L Woodruff, Edith Cox, Lisa S Mohamed, Daniel I Choo, Suresh B Boppana
BACKGROUND AND OBJECTIVE: Congenital cytomegalovirus (cCMV) infection remains a leading cause of childhood hearing loss. Currently universal CMV screening at birth does not exist in the United States. An alternative approach could be testing infants who do not pass their newborn hearing screening (NHS) for cCMV. This study was undertaken to evaluate whether a targeted approach will identify infants with CMV-related sensorineural hearing loss (SNHL). METHODS: Infants born at 7 US medical centers received NHS and were also screened for cCMV while in the newborn nursery...
January 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28034533/audiological-features-in-congenital-bony-atresia-of-external-auditory-canal-with-temporal-mandibular-joint-retroposition
#7
Ran Ren, Shouqin Zhao, Danni Wang, Lin Yang, Zhonglin Liu, Ying Li, Chenyi Wei
OBJECTIVES: To facilitate the diagnosis, treatment and surgical options for congenital bony atresia of external auditory canal (EAC) with temporal-mandibular joint (TMJ) retroposition by analyzing its audiological features and the morphology of temporal bone on CT scan. MATERIALS AND METHODS: Two cohorts of patients with congenital EAC bony atresia with (n=23) or without (n=21) TMJ retroposition were recruited from September 2012 to July 2014 at Beijing Tongren Hospital, Capital Medical University...
October 3, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28031155/an-implantable-hearing-system-as-rehabilitation-for-hearing-loss-due-to-bilateral-aural-atresia-surgical-technique-and-audiological-results
#8
Rubens de Brito, Luzia Maria Pozzobom Ventura, José Carlos Jorge, Eduardo Boaventura Oliveira, Luiz Fernando Manzoni Lourencone
OBJECTIVE: To demonstrate the surgical technique and audiological results of a middle ear implant for restoring hearing in patients with bilateral aural atresia and microtia with conductive or mixed hearing loss. MATERIALS AND METHODS: In this prospective study, 12 subjects aged 12 years and older presenting with hearing loss and bilateral congenital aural atresia underwent surgical insertion of a middle ear implant. The patients underwent tympanomastoidectomy with a wide opening of the attic and preservation of the roof of the atresic tympanic bone to expose the middle ear and position the floating mass transducer of the implant...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28028976/evaluating-the-hearing-of-patients-with-pseudoexfoliation-syndrome
#9
Hanna Temporale, Anna Karasińska-Kłodowska, Anna Turno-Kręcicka, Monika Morawska-Kochman, Karolina Dorobisz, Krzysztof Dudek, Marta Misiuk-Hojło, Tomasz Kręcicki
BACKGROUND: It is estimated that pseudoexfoliation syndrome (PEX) occurs in 10-20% of the general population over 60 years of age, and its morbidity increases with age. Some research indicates that PEX may be a systemic disease. Some experts state that it can also lead to ear dysfunction. OBJECTIVES: The aim of the study was to evaluate the incidence and type of hearing disorders in patients with PEX. MATERIAL AND METHODS: The study included 51 patients (102 eyes) hospitalized in Wroclaw Medical University Hospital's Department of Ophthalmology and scheduled for cataract surgery in 2012-2014...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028329/the-future-of-private-practice-in-audiology
#10
REVIEW
David A Fabry
Although private practice in audiology has evolved during the past 40 years, hearing aids have remained as a central component to success. This article will discuss present and future trends for the next 40 years, including parallels to other professions and the need to innovate beyond technology.
November 2016: Seminars in Hearing
https://www.readbyqxmd.com/read/28025610/evidence-gaps-in-ent-surgery-a-qualitative-survey
#11
REVIEW
Jan Löhler, B Akcicek, F Müller, G Dreier, J J Meerpohl, W Vach, J A Werner
Introduction: As in other disciplines, the burgeoning knowledge in ENT medicine long ago surpassed our ability to adequately absorb it and maintain a proper overview. This can give rise to actual or assumed evidence gaps that can impede the progress of the discipline and evidence-based treatment of patients. Clinics and medical practices also hold to traditional doctrines that shape day-to-day medicine, without these schools being challenged based on evidence. Methods: Between February and June 2015, 160 ENT clinics, including 34 university hospitals, and 2,670 ENT practices took part in a two-arm online survey on existing or perceived evidentiary gaps in ENT medicine using a previously developed questionnaire...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28018209/speech-comprehension-difficulties-in-chronic-tinnitus-and-its-relation-to-hyperacusis
#12
Veronika Vielsmeier, Peter M Kreuzer, Frank Haubner, Thomas Steffens, Philipp R O Semmler, Tobias Kleinjung, Winfried Schlee, Berthold Langguth, Martin Schecklmann
Objective: Many tinnitus patients complain about difficulties regarding speech comprehension. In spite of the high clinical relevance little is known about underlying mechanisms and predisposing factors. Here, we performed an exploratory investigation in a large sample of tinnitus patients to (1) estimate the prevalence of speech comprehension difficulties among tinnitus patients, to (2) compare subjective reports of speech comprehension difficulties with behavioral measurements in a standardized speech comprehension test and to (3) explore underlying mechanisms by analyzing the relationship between speech comprehension difficulties and peripheral hearing function (pure tone audiogram), as well as with co-morbid hyperacusis as a central auditory processing disorder...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28012542/audiological-findings-in-children-with-ataxia-telangiectasia-a-t-syndrome
#13
Pretty O Afifi, Hanaa Hussein Elsanadiky
AIM: To assess peripheral and central hearing in children with A-T. METHOD: 3 children diagnosed with A-T according to the diagnostic criteria for A-T of the European Society for Immunodeficiencies. Involuntary movements were seen in the form of chorea-athetosis together with tremors. They were examined to assess both peripheral and central hearing was assessed (hearing thresholds). Sound-field testing, tympanometry, acoustic reflexes, Otoacoustic Emissions (OAEs) and Auditory Brainstem Responses (ABR) were done for all of them...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28012514/school-entry-level-tele-hearing-screening-in-a-town-in-south-india-lessons-learnt
#14
Saleth D Monica, Vidya Ramkumar, Mark Krumm, Nitya Raman, Roopa Nagarajan, Lakshmi Venkatesh
INTRODUCTION: School screening is warranted in developing countries that do not have newborn hearing screening as schools provide access to a large number of young children between 3 and 5 years of age. Due to scarcity of technical manpower and equipment, hearing screening programs are not often conducted in developing countries. In these circumstances, telehealth services appear to be a reasonable solution. Consequently, the purpose of this study was to assess the feasibility of school hearing screening using telehealth technology operated by a practitioner located 400 kms away at a distant hospital...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27999999/cartilage-island-on-stapes-autologous-porp-in-the-hypoventilated-middle-ear
#15
Jeanette Hess-Erga, Bart Lambertus Henricus Jozef Engelen, Flemming Slinning Vassbotn
The most common technique in sound restoration of the middle ear is prosthetic surgery. Hypoventilation of the middle ear may cause adhesive otitis or atelectasis resulting in a higher risk of prosthetic extrusion rate and recurrence of the underlying cholesteatoma. We report long-term results using an island of tragal cartilage as an autologous PORP in selected patients with poor middle ear ventilation. Retrospective chart reviews were performed for procedures involving 52 patients between year 2000 and 2009...
December 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27991459/early-indication-of-noise-induced-hearing-loss-from-pmp-use-in-adolescents-a-cross-sectional-analysis
#16
Diana C Colon, Ulla Verdugo-Raab, Carmelo P Alvarez, Thomas Steffens, Steven C Marcrum, Stefanie Kolb, Caroline Herr, Dorothee Twardella
CONTEXT: Distortion product otoacoustic emissions (DPOAEs) may indicate preclinical noise-induced hearing loss (NIHL) in adolescents from unsafe personal music player (PMP) use. AIMS: The objective, therefore, was to observe preclinical signs of NIHL in 9th grade adolescents with clinically normal hearing by comparing DPOAE signals between different levels of A-weighted equivalent PMP exposure. SETTINGS AND DESIGN: Subjects were recruited from all secondary-level schools located in the city of Regensburg, Germany during two academic years 2009/2010 and 2010/2011...
November 2016: Noise & Health
https://www.readbyqxmd.com/read/27990602/endoscopic-tympanoplasty-learning-curve-for-a-surgeon-already-trained-in-microscopic-tympanoplasty
#17
Sedat Doğan, Cem Bayraktar
The aim of this study was to evaluate the learning curve of endoscopic tympanoplasty for a surgeon already trained in microscopic tympanoplasty. We analyzed the clinical records of 81 patients who underwent transcanal endoscopic type 1 tympanoplasty and 30 control patients who underwent microscopic tympanoplasty between 2013 and 2015 in a tertiary hospital. All operations were performed by a single surgeon already trained in microscopic tympanoplasty. Patients were divided into four groups according to the date of surgery chronologically (group 1 early stage, group 2 intermediate stage, group 3 advanced stage and group 4 control)...
December 18, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27984593/capd-is-classified-in-icd-10-as-h93-25-and-hearing-evaluation-not-screening-should-be-implemented-in-children-with-verified-communication-and-or-listening-deficits
#18
Vasiliki Vivian Iliadou, Tony Sirimanna, Doris-Eva Bamiou
The article "It Is Time to Rethink Central Auditory Processing Disorder Protocols for School-Aged Children" (DeBonis, 2015) appeared in the American Journal of Audiology as a tutorial. The author used the argument made by Cowan, Rosen, and Moore (2009), referring to central auditory processing disorder (CAPD), that "such impairments have not been shown to uniquely contribute to a clearly defined condition that would warrant its inclusion in any of the major disease classification systems" (emphasis added; p...
December 1, 2016: American Journal of Audiology
https://www.readbyqxmd.com/read/27982254/electrophysiological-characterization-of-hearing-in-individuals-with-down-syndrome
#19
Hellen Medeiros Kazan, Alessandra Giannella Samelli, Ivone Ferreira Neves-Lobo, Fernanda Cristina Leite Magliaro, Suelly Cecília Olivan Limongi, Carla Gentile Matas
Introduction: Few studies have performed Brainstem (BAEP) and P300 Auditory Evoked Potentials simultaneously to assess central auditory pathways in normal hearing individuals with Down syndrome (DS), mainly because of the difficulty in applying these procedures to this population. Previous studies have suggested that individuals with DS might present different patterns of response compared with those of individuals with typical development; nevertheless, the identification of these potentials would be crucial for the establishment of an accurate audiological diagnosis...
November 2016: CoDAS
https://www.readbyqxmd.com/read/27981872/french-canadian-translation-and-validation-of-four-questionnaires-assessing-hearing-impairment-and-handicap
#20
Claude Vincent, Jean-Pierre Gagné, Tony Leroux, Audrey Clothier, Marianne Larivière, Frédéric S Dumont, Martine Gendron
OBJECTIVE: Questionnaires evaluating hearing impairment are available in English but there is a need for French standardised questionnaires for researchers as well as for audiologists and other clinicians. The objective of this study is to describe the translation and validation of four questionnaires that assess different aspects of hearing impairment and handicap among elders with hearing loss, by comparing the main score and psychometric evaluation of original and French-Canadian (FC) versions of the World Health Organization Disability Assessment Scale II (WHO-DAS II), the Screening Test for Hearing Problems (STHP), the Abbreviated Profile of Hearing Aid Benefit (APHAB) and the Measure of Audiologic Rehabilitation Self-Efficacy for Hearing Aids (MARS-HA)...
December 16, 2016: International Journal of Audiology
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