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https://www.readbyqxmd.com/read/28636421/analysis-of-origins-of-admission-for-solid-tumor-oncology-inpatients-disease-severity-and-outcomes
#1
Christopher E Wee, Lindsey M Goodman, Leticia Varella, Lisa A Rybicki, Alberto J Montero, Bassam N Estfan, Carolyn H Best, James P Stevenson
PURPOSE: Hospital transfers may affect clinical outcomes. Evaluation of admission by source of transfer, time of admission, and provider type may identify opportunities to improve inpatient outcomes. METHODS: We reviewed charts of patients admitted to the solid tumor oncology service between July and December 2014 from the Cleveland Clinic Foundation (CCF) Main Campus emergency department (ED), CCF Regional EDs, outside hospital (OSH) ED, OSH inpatient services, and CCF outpatient clinics...
June 21, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28634313/-a-case-of-bilateral-traumatic-carotid-cavernous-fistula
#2
Hanae Terashima, Takashi Higa, Koichi Kato, Tadasuke Tominaga, Masanori Nakagawa, Shigeru Kadoyama, Hiroshi Ujiie, Akira Teramoto
Bilateral traumatic carotid-cavernous fistula(CCF)is rare. It is most commonly caused by a direct head or face injury involving the cavernous sinus and develops immediately after trauma. We report a case of bilateral traumatic CCF that occurred as an intracerebral hematoma(ICH)mimicking apoplexy 5 months later. We treated the patient with point occlusion of venous reflux causing an ICH using coil embolization to remove the hematoma. Three days after we performed trans-venous occlusion of the intercavernous connection and right cavernous sinus using coil embolization through the right inferior petrosal vein, it was identified that the left CCF was occluded after first embolization into the left sylvian vein...
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28582503/hugin-hi-c-unifying-genomic-interrogator
#3
Joshua S Martin, Zheng Xu, Alex P Reiner, Karen L Mohlke, Patrick Sullivan, Bing Ren, Ming Hu, Yun Li
Motivation: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability. Results: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data...
June 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28580223/carotid-cavernous-fistula-with-central-retinal-artery-occlusion-and-terson-syndrome-after-mid-facial-trauma
#4
Satya Karna, Mukesh Jain, Md Shahid Alam, Bipasha Mukherjee, Rajiv Raman
Objectives: To report a rare occurrence combination of central retinal artery occlusion (CRAO) and Terson syndrome in a Barrow's type A carotid cavernous fistula (CCF) patient. Methods: Observational case report. Results: A twenty-year-old male patient with a history of road traffic accident presented with periorbital swelling and redness in the left eye. Examination revealed a CRAO with intraretinal and preretinal hemorrhages. On imaging, type A CCF and subarachnoid hemorrhage were detected. He underwent embolization of the fistula for cosmetic blemish...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28559980/all-trans-retinoic-acid-activates-sdf-1-cxcr4-rock2-signaling-pathway-to-inhibit-chondrogenesis
#5
Qin-Xiao Hu, Xue-Dong Li, Peng Xie, Chu-Cheng Wu, Gui-Zhou Zheng, Fei-Xiang Lin, Da Xie, Qi-Hao Zhang, De-Zhong Liu, Yun-Guo Wang, Bo Chang, Shi-Xin Du
Recent studies have indicated that ATRA inhibits chondrogenesis and can lead to congenital clubfoot (CCF). The molecular mechanism of ATRA-induced chondrogenesis is not clear. As RhoA/ROCK and SDF-1/CXCR4 signaling play important molecular roles for a variety of cellular processes, we hypothesized that RhoA/ROCK2 and SDF-1/CXCR4 signaling are involved in ATRA-induced chondrogenesis in rat embryo hind limb bud mesenchymal cells (rEHBMCs). We found that ATRA dose-dependently inhibits proliferation and expression of chondrogenic transcription factors (SOX9 and COL2A1) in rEHBMCs...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28546007/development-and-validation-of-the-halt-hcc-score-to-predict-mortality-in-liver-transplant-recipients-with-hepatocellular-carcinoma-a-retrospective-cohort-analysis
#6
Kazunari Sasaki, Daniel J Firl, Koji Hashimoto, Masato Fujiki, Teresa Diago-Uso, Cristiano Quintini, Bijan Eghtesad, John J Fung, Federico N Aucejo, Charles M Miller
BACKGROUND: Tumour morphological criteria for determining the appropriateness of liver transplantation in patients with hepatocellular carcinoma poorly estimate post-transplantation mortality. The aim of this study was to develop and assess the utility of a continuous risk score in predicting overall survival following liver transplantation for hepatocellular carcinoma. METHODS: We did a retrospective cohort analysis to develop a continuous multivariable risk score for assessment of overall survival following liver transplantation for hepatocellular carcinoma...
May 22, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28544216/a-structurally-characterized-fluoroalkyne
#7
Lewis M Hall, David P Tew, Natalie E Pridmore, Adrian C Whitwood, Jason M Lynam, John M Slattery
The facile synthesis of a stable and isolable compound with a fluoroalkynyl group, M-C≡CF, is reported. Reaction of [Ru(C≡CH)(η(5) -C5 Me5 )(dppe)] with an electrophilic fluorinating agent (NFSI) results in the formation of the fluorovinylidene complex [Ru(=C=CHF)(η(5) -C5 Me5 )(dppe)][N(SO2 Ph)2 ]. Subsequent deprotonation with LiN(SiMe3 )2 affords the fluoroalkynyl complex [Ru(C≡CF)(η(5) -C5 Me5 )(dppe)]. In marked contrast to the rare and highly reactive examples of fluoroalkynes that have been reported previously, this compound can be readily isolated and structurally characterized...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543885/dce-mri-prediction-of-survival-time-for-patients-with-glioblastoma-multiforme-using-an-adaptive-neuro-fuzzy-based-model-and-nested-model-selection-technique
#8
Azimeh N V Dehkordi, Alireza Kamali-Asl, Ning Wen, Tom Mikkelsen, Indrin J Chetty, Hassan Bagher-Ebadian
This pilot study investigates the construction of an Adaptive Neuro-Fuzzy Inference System (ANFIS) for the prediction of the survival time of patients with glioblastoma multiforme (GBM). ANFIS is trained by the pharmacokinetic (PK) parameters estimated by the model selection (MS) technique in dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data analysis, and patient age. DCE-MRI investigations of 33 treatment-naïve patients with GBM were studied. Using the modified Tofts model and MS technique, the following physiologically nested models were constructed: Model 1, no vascular leakage (normal tissue); Model 2, leakage without efflux; Model 3, leakage with bidirectional exchange (influx and efflux)...
May 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28539723/antimicrobial-and-anti-inflammatory-effects-of-ethanol-extract-of-corylopsis-coreana-uyeki-flos
#9
Da-Eon Park, In-Soo Yoon, Jung-Eun Kim, Ji-Hye Seo, Jin-Cheol Yoo, Chun-Sik Bae, Chang-Dai Lee, Dae-Hun Park, Seung-Sik Cho
BACKGROUND: Corylopsis coreana Uyeki (Hamamelidaceae) is a medicinal plant cultivated in Northeast Asia. Previously, we have reported that an ethanol extract of Corylopsis coreana Uyeki flos (ECCF) contains four active compounds with antioxidant activity. OBJECTIVE: The aim of this study was to investigate the antimicrobial spectrum against infectious bacteria and anti-inflammatory effect of ECCF in a mouse model of acute local inflammation. MATERIALS AND METHODS: In vitro antimicrobial susceptibility was evaluated using standard plate assay technique...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28534769/a-systematic-investigation-of-lateral-estimation-using-various-interpolation-approaches-in-conventional-ultrasound-imaging
#10
Zhi Liu, Chengwu Huang, Jianwen Luo
Accurate lateral displacement and strain estimat- ion is critical for some applications of elasticity imaging. Typically, motion estimation in the lateral direction is challenging because of low sampling frequency and lack of phase information in conventional ultrasound imaging. Several approaches have been proposed to improve the performance of lateral estimation, such as lateral interpolation on the RF signals (Interp_RF), lateral interpolation on the cross-correlation function (Interp_CCF) and lateral interpolation on both the RF signals and cross-correlation function (Interp_Both)...
May 17, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28506880/advanced-correlation-grid-analysis-and-visualisation-of-functional-connectivity-among-multiple-spike-trains
#11
Mohammad Shahed Masud, Roman Borisyuk, Liz Stuart
BACKGROUND: This study analyses multiple spike trains (MST) data, defines its functional connectivity and subsequently visualises an accurate diagram of connections. This is a challenging problem. For example, it is difficult to distinguish the common input and the direct functional connection of two spike trains. NEW METHOD: The new method presented in this paper is based on the traditional pairwise cross-correlation function (CCF) and a new combination of statistical techniques...
May 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28489786/bilateral-carotid-cavernous-fistula-with-spontaneous-resolution-a-case-report-and-literature-review
#12
REVIEW
Lan Ke, Yan-Ning Yang, Jing Yuan
RATIONALE: Bilateral carotid-cavernous fistula (CCF) is rare and serious extra-ocular disease occurring in clinical which may result in severe complication. Unique manifestations and imaging examinations are important to the diagnosis. PATIENT CONCERNS: A case of bilateral carotid-cavernous fistula in an 60-year-old healthy man caused by a head injury is reported. Further clinical symptoms and signs and imaging examinations lead to the correct diagnosis. DIAGNOSES: Computed tomography angiography of the brain aroused suspicion of bilateral CCF...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28485656/delayed-massive-epistaxis-from-traumatic-cavernous-carotid-false-aneurysms-a-report-of-two-unusual-cases
#13
Ncedile Mankahla, David LeFeuvre, Allan Taylor
Introduction Blunt head trauma can injure the cavernous segment of the internal carotid artery (ICA). This may result in a carotid cavernous fistula (CCF). Rarely, a traumatic aneurysm may bleed medially causing massive epistaxis. Case presentation We present two cases of traumatic intracavernous carotid pseudoaneurysms with delayed massive epistaxis. The patients were managed with endovascular treatment involving coil embolization with parent vessel sparing and detachable balloon occlusion with carotid sacrifice...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28484825/comparison-of-polyvinyl-alcohol-copolymer-with-detachable-balloons-for-the-embolisation-of-direct-carotid-cavernous-fistula-a-single-centre-experience
#14
Xuying He, Chuanzhi Duan, Lingfeng Lai, Xin Zhang, Zhenjun Li, Xifeng Li, Tielin Li
OBJECTIVES: To characterise the safety, efficacy and cost of direct carotid-cavernous fistula (CCF) treatment using polyvinyl alcohol copolymer or detachable balloons. METHODS: We reviewed retrospectively patients with direct CCFs treated with either a detachable balloon or polyvinyl alcohol copolymer at our hospital from 2005 to 2015 and identified 94 patients with 105 CCFs. All patients had follow-up angiograms. The CCF occlusion rate, procedure complication rate, treatment expense and operation time were recorded...
May 8, 2017: European Radiology
https://www.readbyqxmd.com/read/28476475/lower-chest-compression-fraction-associated-with-rosc-in-ohca-patients-with-longer-downtimes
#15
Milena Talikowska, Hideo Tohira, Madoka Inoue, Paul Bailey, Deon Brink, Judith Finn
AIM: To investigate the relationship between chest compression fraction (CCF) and survival outcomes in OHCA, including whether the relationship varied based upon downtime from onset of arrest to provision of cardiopulmonary resuscitation (CPR) by emergency medical services (EMS). METHODS: Data from resuscitations performed by St John Ambulance Western Australia (SJA-WA) paramedics between July 2014 and June 2016 was captured using the Q-CPR feedback device. Logistic regression analysis was used to study the relationship between CCF and return of spontaneous circulation (ROSC)...
July 2017: Resuscitation
https://www.readbyqxmd.com/read/28476474/the-association-between-aha-cpr-quality-guideline-compliance-and-clinical-outcomes-from-out-of-hospital-cardiac-arrest
#16
Sheldon Cheskes, Robert H Schmicker, Tom Rea, Laurie J Morrison, Brian Grunau, Ian R Drennan, Brian Leroux, Christian Vaillancourt, Terri A Schmidt, Allison C Koller, Peter Kudenchuk, Tom P Aufderheide, Heather Herren, Katharyn H Flickinger, Mark Charleston, Ron Straight, Jim Christenson
BACKGROUND: Measures of chest compression fraction (CCF), compression rate, compression depth and pre-shock pause have all been independently associated with improved outcomes from out-of-hospital (OHCA) cardiac arrest. However, it is unknown whether compliance with American Heart Association (AHA) guidelines incorporating all the aforementioned metrics, is associated with improved survival from OHCA. METHODS: We performed a secondary analysis of prospectively collected data from the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest database...
July 2017: Resuscitation
https://www.readbyqxmd.com/read/28467138/chest-compression-fraction-between-mechanical-compressions-on-a-reducible-stretcher-and-manual-compressions-on-a-standard-stretcher-during-transport-in-out-of-hospital-cardiac-arrests-the-ambulance-stretcher-innovation-of-asian-cardiopulmonary-resuscitation
#17
Tae Han Kim, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, Young Sun Ro, Sung Wook Song, Chu Hyun Kim
BACKGROUND: Cardiopulmonary resuscitation (CPR) with the use of mechanical devices is recommended during ambulance transport. However, the CPR quality en route and while in transfer to the emergency department (ED) for out-of-hospital cardiac arrests (OHCAs) remains uncertain. We developed a mechanical CPR device outfitted on a reducible stretcher (M-CPR) and compared with standard manual CPR on a standard stretcher (S-CPR) to evaluate CPR quality. METHODS: Adult OHCAs transported by five ambulances in a metropolitan area with a population of 3...
May 3, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28459305/advanced-airway-type-and-its-association-with-chest-compression-interruptions-during-out-of-hospital-cardiac-arrest-resuscitation-attempts
#18
Angela F Jarman, Christy L Hopkins, J Nicholas Hansen, Jonathan R Brown, Christopher Burk, Scott T Youngquist
OBJECTIVE: To assess interruptions in chest compressions associated with advanced airway placement during cardiopulmonary resuscitation (CPR) of out-of-hospital cardiac arrest (OHCA) victims. METHODS: The method used was observational analysis of prospectively collected clinical and defibrillator data from 339 adult OHCA victims, excluding victims with <5 minutes of CPR. Interruptions in CPR, summarized by chest compression fraction (CCF), longest pause, and the number of pauses greater than 10 seconds, were compared between patients receiving bag valve mask (BVM), supraglottic airway (SGA), endotracheal intubation (ETI) via direct laryngoscopy (DL), and ETI via video laryngoscopy (VL)...
May 1, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28459133/airflow-obstruction-cognitive-function-and-mortality-in-a-us-national-cohort-nhanes-iii
#19
Yewande E Odeyemi, Edris Meda, Funmilola Ogundipe, Alem Mehari, Thomas Obisesan, Richard F Gillum
OBJECTIVE: To test the hypothesis that cognitive impairment increases mortality independent of airflow obstruction. MATERIALS AND METHODS: In 1988-1994 the Third National Health and Nutrition Examination Survey (NHANES III) measured forced expiratory volume in the first second (FEV1) and the forced vital capacity (FVC) and selected items on cognitive function with mortality follow-up. For this survival analysis 4,365 persons aged 60 and over with complete data formed the analytic sample...
April 29, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28450171/optimization-of-critical-quality-attributes-in-continuous-twin-screw-wet-granulation-via-design-space-validated-with-pilot-scale-experimental-data
#20
Huolong Liu, S C Galbraith, Brendon Ricart, Courtney Stanton, Brandye Smith-Goettler, Luke Verdi, Thomas O'Connor, Sau Lee, Seongkyu Yoon
In this study, the influence of key process variables (screw speed, throughput and liquid to solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using a central composite face-centered (CCF) experimental design method. Regression models were developed to predict the process responses (motor torque, granule residence time), granule properties (size distribution, volume average diameter, yield, relative width, flowability) and tablet properties (tensile strength). The effects of the three key process variables were analyzed via contour and interaction plots...
April 24, 2017: International Journal of Pharmaceutics
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