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https://www.readbyqxmd.com/read/28506880/advanced-correlation-grid-analysis-and-visualisation-of-functional-connectivity-among-multiple-spike-trains
#1
Mohammad Shahed Masud, Roman Borisyuk, Liz Stuart
BACKGROUND: This study analyses multiple spike trains (MST) data, defines its functional connectivity and subsequently visualises an accurate diagram of connections. This is a challenging problem. For example, it is difficult to distinguish the common input and the direct functional connection of two spike trains. NEW METHOD: The new method presented in this paper is based on the traditional pairwise cross-correlation function (CCF) and a new combination of statistical techniques...
May 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28489786/bilateral-carotid-cavernous-fistula-with-spontaneous-resolution-a-case-report-and-literature-review
#2
Lan Ke, Yan-Ning Yang, Jing Yuan
RATIONALE: Bilateral carotid-cavernous fistula (CCF) is rare and serious extra-ocular disease occurring in clinical which may result in severe complication. Unique manifestations and imaging examinations are important to the diagnosis. PATIENT CONCERNS: A case of bilateral carotid-cavernous fistula in an 60-year-old healthy man caused by a head injury is reported. Further clinical symptoms and signs and imaging examinations lead to the correct diagnosis. DIAGNOSES: Computed tomography angiography of the brain aroused suspicion of bilateral CCF...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28485656/delayed-massive-epistaxis-from-traumatic-cavernous-carotid-false-aneurysms-a-report-of-two-unusual-cases
#3
Ncedile Mankahla, David LeFeuvre, Allan Taylor
Introduction Blunt head trauma can injure the cavernous segment of the internal carotid artery (ICA). This may result in a carotid cavernous fistula (CCF). Rarely, a traumatic aneurysm may bleed medially causing massive epistaxis. Case presentation We present two cases of traumatic intracavernous carotid pseudoaneurysms with delayed massive epistaxis. The patients were managed with endovascular treatment involving coil embolization with parent vessel sparing and detachable balloon occlusion with carotid sacrifice...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28484825/comparison-of-polyvinyl-alcohol-copolymer-with-detachable-balloons-for-the-embolisation-of-direct-carotid-cavernous-fistula-a-single-centre-experience
#4
Xuying He, Chuanzhi Duan, Lingfeng Lai, Xin Zhang, Zhenjun Li, Xifeng Li, Tielin Li
OBJECTIVES: To characterise the safety, efficacy and cost of direct carotid-cavernous fistula (CCF) treatment using polyvinyl alcohol copolymer or detachable balloons. METHODS: We reviewed retrospectively patients with direct CCFs treated with either a detachable balloon or polyvinyl alcohol copolymer at our hospital from 2005 to 2015 and identified 94 patients with 105 CCFs. All patients had follow-up angiograms. The CCF occlusion rate, procedure complication rate, treatment expense and operation time were recorded...
May 8, 2017: European Radiology
https://www.readbyqxmd.com/read/28476475/lower-chest-compression-fraction-associated-with-rosc-in-ohca-patients-with-longer-downtimes
#5
Milena Talikowska, Hideo Tohira, Madoka Inoue, Paul Bailey, Deon Brink, Judith Finn
AIM: To investigate the relationship between chest compression fraction (CCF) and survival outcomes in OHCA, including whether the relationship varied based upon downtime from onset of arrest to provision of cardiopulmonary resuscitation (CPR) by emergency medical services (EMS). METHODS: Data from resuscitations performed by St John Ambulance Western Australia (SJA-WA) paramedics between July 2014 and June 2016 was captured using the Q-CPR feedback device. Logistic regression analysis was used to study the relationship between CCF and return of spontaneous circulation (ROSC)...
May 2, 2017: Resuscitation
https://www.readbyqxmd.com/read/28476474/the-association-between-aha-cpr-quality-guideline-compliance-and-clinical-outcomes-from-out-of-hospital-cardiac-arrest
#6
Sheldon Cheskes, Robert H Schmicker, Tom Rea, Laurie J Morrison, Brian Grunau, Ian R Drennan, Brian Leroux, Christian Vaillancourt, Terri A Schmidt, Allison C Koller, Peter Kudenchuk, Tom P Aufderheide, Heather Herren, Katharyn H Flickinger, Mark Charleston, Ron Straight, Jim Christenson
BACKGROUND: Measures of chest compression fraction (CCF), compression rate, compression depth and pre-shock pause have all been independently associated with improved outcomes from out-of-hospital (OHCA) cardiac arrest. However, it is unknown whether compliance with American Heart Association (AHA) guidelines incorporating all the aforementioned metrics, is associated with improved survival from OHCA. METHODS: We performed a secondary analysis of prospectively collected data from the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest database...
May 2, 2017: Resuscitation
https://www.readbyqxmd.com/read/28467138/chest-compression-fraction-between-mechanical-compressions-on-a-reducible-stretcher-and-manual-compressions-on-a-standard-stretcher-during-transport-in-out-of-hospital-cardiac-arrests-the-ambulance-stretcher-innovation-of-asian-cardiopulmonary-resuscitation
#7
Tae Han Kim, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, Young Sun Ro, Sung Wook Song, Chu Hyun Kim
BACKGROUND: Cardiopulmonary resuscitation (CPR) with the use of mechanical devices is recommended during ambulance transport. However, the CPR quality en route and while in transfer to the emergency department (ED) for out-of-hospital cardiac arrests (OHCAs) remains uncertain. We developed a mechanical CPR device outfitted on a reducible stretcher (M-CPR) and compared with standard manual CPR on a standard stretcher (S-CPR) to evaluate CPR quality. METHODS: Adult OHCAs transported by five ambulances in a metropolitan area with a population of 3...
May 3, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28459305/advanced-airway-type-and-its-association-with-chest-compression-interruptions-during-out-of-hospital-cardiac-arrest-resuscitation-attempts
#8
Angela F Jarman, Christy L Hopkins, J Nicholas Hansen, Jonathan R Brown, Christopher Burk, Scott T Youngquist
OBJECTIVE: To assess interruptions in chest compressions associated with advanced airway placement during cardiopulmonary resuscitation (CPR) of out-of-hospital cardiac arrest (OHCA) victims. METHODS: The method used was observational analysis of prospectively collected clinical and defibrillator data from 339 adult OHCA victims, excluding victims with <5 minutes of CPR. Interruptions in CPR, summarized by chest compression fraction (CCF), longest pause, and the number of pauses greater than 10 seconds, were compared between patients receiving bag valve mask (BVM), supraglottic airway (SGA), endotracheal intubation (ETI) via direct laryngoscopy (DL), and ETI via video laryngoscopy (VL)...
May 1, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28459133/airflow-obstruction-cognitive-function-and-mortality-in-a-us-national-cohort-nhanes-iii
#9
Yewande E Odeyemi, Edris Meda, Funmilola Ogundipe, Alem Mehari, Thomas Obisesan, Richard F Gillum
OBJECTIVE: To test the hypothesis that cognitive impairment increases mortality independent of airflow obstruction. MATERIALS AND METHODS: In 1988-1994 the Third National Health and Nutrition Examination Survey (NHANES III) measured forced expiratory volume in the first second (FEV1) and the forced vital capacity (FVC) and selected items on cognitive function with mortality follow-up. For this survival analysis 4,365 persons aged 60 and over with complete data formed the analytic sample...
April 29, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28450171/optimization-of-critical-quality-attributes-in-continuous-twin-screw-wet-granulation-via-design-space-validated-with-pilot-scale-experimental-data
#10
Huolong Liu, S C Galbraith, Brendon Ricart, Courtney Stanton, Brandye Smith-Goettler, Luke Verdi, Thomas O'Connor, Sau Lee, Seongkyu Yoon
In this study, the influence of key process variables (screw speed, throughput and liquid to solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using a central composite face-centered (CCF) experimental design method. Regression models were developed to predict the process responses (motor torque, granule residence time), granule properties (size distribution, volume average diameter, yield, relative width, flowability) and tablet properties (tensile strength). The effects of the three key process variables were analyzed via contour and interaction plots...
April 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28444728/circulating-cell-free-braf-v600e-as-a-biomarker-in-children-with-langerhans-cell-histiocytosis
#11
Sébastien Héritier, Zofia Hélias-Rodzewicz, Hélène Lapillonne, Nathalie Terrones, Sonia Garrigou, Corinne Normand, Mohamed-Aziz Barkaoui, Jean Miron, Geneviève Plat, Nathalie Aladjidi, Anne Pagnier, Anne Deville, Marion Gillibert-Yvert, Despina Moshous, Alain Lefèvre-Utile, Anne Lutun, Catherine Paillard, Caroline Thomas, Eric Jeziorski, Philippe Nizard, Valérie Taly, Jean-François Emile, Jean Donadieu
The BRAF(V600E) mutation is reported in half of patients with Langerhans cell histiocytosis (LCH). This study investigated the detection of the BRAF(V600E) allele in circulating cell-free (ccf) DNA in a paediatric LCH cohort. Children with BRAF(V600E) -mutated LCH were investigated to detect ccf BRAF(V600E) at diagnosis (n = 48) and during follow-up (n = 17) using a picolitre-droplet digital PCR assay. At diagnosis, ccf BRAF(V600E) was positive in 15/15 (100%) patients with risk-organ positive multisystem (RO+ MS) LCH, 5/12 (42%) of patients with RO- MS LCH and 3/21 (14%) patients with single-system (SS) LCH (P < 0·001, Fisher's exact test)...
April 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28417651/laparoscopic-management-of-cholecystoenteric-fistula-a-single-center-experience
#12
Xiang-Yang Li, Xin Zhao, Peng Zheng, Xiao-Ming Kao, Xiao-Song Xiang, Wu Ji
Aim To report our experience regarding management of cholecystoenteric fistula (CEF) and identify the most effective diagnostic methods and surgical treatment. Methods In total, 10,588 patients underwent laparoscopic cholecystectomy for cholecystolithiasis from January 2000 to December 2014 at the Research Institute of General Surgery, Jinling Hospital (Nanjing, China). Twenty-nine patients were diagnosed with CEF preoperatively or intraoperatively. Data were retrospectively collected on demographics, preoperative diagnostics, intraoperative findings, laparoscopic procedures, complications, and follow-up...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28399962/time-lag-between-immigration-and-tuberculosis-rates-in-immigrants-in-the-netherlands-a-time-series-analysis
#13
C van Aart, H Boshuizen, A Dekkers, H Korthals Altes
SETTING AND OBJECTIVE: In low-incidence countries, most tuberculosis (TB) cases are foreign-born. We explored the temporal relationship between immigration and TB in first-generation immigrants between 1995 and 2012 to assess whether immigration can be a predictor for TB in immigrants from high-incidence countries. DESIGN: We obtained monthly data on immigrant TB cases and immigration for the three countries of origin most frequently represented among TB cases in the Netherlands: Morocco, Somalia and Turkey...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28323084/integration-of-in-hospital-cardiac-arrest-contextual-curriculum-into-a-basic-life-support-course-a-randomized-controlled-simulation-study
#14
Elizabeth A Hunt, Jordan M Duval-Arnould, Nnenna O Chime, Kareen Jones, Michael Rosen, Merona Hollingsworth, Deborah Aksamit, Marida Twilley, Cheryl Camacho, Daniel P Nogee, Julianna Jung, Kristen Nelson-McMillan, Nicole Shilkofski, Julianne S Perretta
OBJECTIVE: The objective was to compare resuscitation performance on simulated in-hospital cardiac arrests after traditional American Heart Association (AHA) Healthcare Provider Basic Life Support course (TradBLS) versus revised course including in-hospital skills (HospBLS). DESIGN: This study is a prospective, randomized, controlled curriculum evaluation. SETTING: Johns Hopkins Medicine Simulation Center. SUBJECTS: One hundred twenty-two first year medical students were divided into fifty-nine teams...
May 2017: Resuscitation
https://www.readbyqxmd.com/read/28317442/application-of-response-surface-methodology-and-semi-mechanistic-model-to-optimize-fluoride-removal-using-crushed-concrete-in-a-fixed-bed-column
#15
Bon-Wun Gu, Chang-Gu Lee, Seong-Jik Park
The aim of this study was to investigate the removal of fluoride from aqueous solutions by using crushed concrete fines (CCF) as a filter medium. Column experiments were performed in step injection mode under varying conditions of influent solution including pH 3-7, flow rate of 0.3-0.7 mL/min, and filter depth of 10-20 cm. The performance of fixed-bed columns was evaluated on the basis of the removal ratio (Re), uptake capacity (qe), degree of sorbent used (DoSU), and sorbent usage rate (SUR) obtained from breakthrough curves (BTC)...
March 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28298038/surgical-removal-of-embolic-material-after-its-unexpected-migration-through-extracranial-intracranial-anastomosis-in-the-treatment-of-barrow-type-d-carotid-cavernous-fistula-case-report
#16
Jae-Sang Oh, Dong-Sung Kim, Jai-Joon Shim, Seok-Mann Yoon
Endovascular occlusion via the transvenous route is the favored treatment for indirect carotid-cavernous fistulas (CCFs). However, transarterial embolization can be used as an alternative method in patients with an inaccessible venous route. The authors present the case of a 49-year-old woman with a 2-month history of chemosis and proptosis in her right eye. Angiography demonstrated a Barrow Type D CCF. Transarterial Onyx embolization through the accessory meningeal artery was performed after an unsuccessful transvenous approach...
March 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28274780/analysis-of-heart-rate-and-oxygen-uptake-kinetics-studied-by-two-different-pseudo-random-binary-sequence-work-rate-amplitudes
#17
U Drescher, J Koschate, T Schiffer, S Schneider, U Hoffmann
PURPOSE: The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O2pulm) and predicted muscular (V˙O2musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. METHODS: Eight healthy individuals performed two PRBS WR protocols implying changes between 30W and 80W and between 30W and 110W. HR and V˙O2pulm were measured beat-to-beat and breath-by-breath, respectively...
June 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28274168/resting-state-effective-connectivity-allows-auditory-hallucination-discrimination
#18
Manuel Graña, Leire Ozaeta, Darya Chyzhyk
Hallucinations are elusive phenomena that have been associated with psychotic behavior, but that have a high prevalence in healthy population. Some generative mechanisms of Auditory Hallucinations (AH) have been proposed in the literature, but so far empirical evidence is scarce. The most widely accepted generative mechanism hypothesis nowadays consists in the faulty workings of a network of brain areas including the emotional control, the audio and language processing, and the inhibition and self-attribution of the signals in the auditive cortex...
August 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28248197/calibration-of-the-125-i-induced-x-ray-fluorescence-spectrometry-based-system-of-in-vivo-bone-strontium-determinations-using-hydroxyapatite-as-a-phantom-material-a-simulation-study
#19
Eric Da Silva, Ana Pejović-Milić
OBJECTIVE: The calibration of in vivo x-ray fluorescence systems of bone strontium quantification, based on (125)I excitation, is dependent on a coherent normalization procedure. Application of this procedure with the use of plaster of Paris (poP) as a phantom material requires the application of a coherent conversion factor (CCF) to make the calibration functions transferable between the phantom material and human bone. In this work we evaluate, with the use of Monte Carlo simulation, the potential benefit of employing a newly developed hydroxyapatite phantom material into the calibration protocol...
March 1, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28242210/cpr-quality-during-out-of-hospital-cardiac-arrest-transport
#20
Sheldon Cheskes, Adam Byers, Cathy Zhan, P Richard Verbeek, Dennis Ko, Ian R Drennan, Jason E Buick, Steven C Brooks, Steve Lin, Ahmed Taher, Laurie J Morrison
BACKGROUND: Previous studies have demonstrated significant associations between cardiopulmonary resuscitation (CPR) quality metrics and survival to hospital discharge. No adequately powered study has explored the relationship between location of resuscitation (scene vs. transport) and CPR quality. METHODS: We analyzed CPR quality data from treated adult OHCA occurring over a 40 month period beginning January 1, 2013 from the Rescu Epistry-cardiac arrest database...
May 2017: Resuscitation
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