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https://www.readbyqxmd.com/read/29341947/spontaneous-direct-carotid-cavernous-fistula-in-an-elderly-patient
#1
Stanimir S Sirakov, Borislav D Kitov, Kristina S Sirakova, Ivo I Kehayov
We describe the case of an 83-year-old woman with left-sided ophthalmoplegia. She had no family history of connective tissue disease. The computed tomography study found a dilated left cavernous sinus. The conventional cerebral panangiography confirmed the diagnosis - a direct carotid-cavernous fistula (CCF), with no evidence of ruptured aneurysm. The woman underwent endovascular treatment with coiling of the cavernous sinus in combination with application of the Onyx embolic agent in the fistula. During the first 48 hours after the embolization the local pain, exophthalmos and conjunctival injection of the left eye were significantly ameliorated...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29338236/detection-of-the-cytotoxic-penitrems-a-f-in-cheese-from-the-european-single-market-eu-by-hplc-ms-ms
#2
Svetlana Kalinina, Annika Jagels, Sebastian Hickert, Lucas Maciel Mauriz Marques, Benedikt Cramer, Hans-Ulrich Humpf
Penitrems are fungal indole diterpene derived tremorgenic secondary metabolites, which are mainly produced by Penicillium spp. Several cases of intoxications with penitrems and subsequent occurrences of penitrem A in foodstuff underline the need for reliable quantitation methods for the detection of these mycotoxins in food. In this study, a simple and fast HPLC-MS/MS method for the quantitative analysis of penitrems A-F in cheese was developed. Therefore, penitrems A-F were isolated from Penicillium crustosum as analytical reference standards...
January 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29326418/a-case-of-right-sided-direct-carotid-cavernous-fistula-a-diagnostic-challenge
#3
Htun Latt, Kyaw Kyaw, Htwe Htwe Yin, Deepak Kapoor, Sammy San Myint Aung, Raheel Islam
BACKGROUND Carotid cavernous fistulas (CCFs) are rare potentially sight-threatening abnormal connections between carotid artery and cavernous sinus. CASE REPORT We report a case of CCF in an 83-year-old female, who presented with swollen and painful right eye. The patient was initially treated with empiric antibiotics for suspected peri-orbital cellulitis, as noted clinically and in computed tomography (CT) orbits. However, lack of clinical improvement, physical finding of orbital bruit/thrill, and enlarged superior ophthalmic vein in magnetic resonance (MR) orbits suggest alternate diagnoses...
January 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29322505/impact-of-bistrand-abasic-sites-and-proximate-orientation-on-dna-global-structure-and-duplex-energetics
#4
Conceição A Minetti, Jeffrey Y Sun, Daniel P Jacobs, Inkoo Kang, David P Remeta, Kenneth J Breslauer
Bistrand lesions embedded within a single helical turn of tridecameric deoxyoligonucleotide duplexes represent a model system for exploring the impact of clustered lesions that occur in vivo and pose a significant challenge to cellular repair machineries. Such investigations are essential for understanding the forces that dictate lesion-induced mutagenesis, carcinogenesis, and cytotoxicity within a context that mimics local helical perturbations caused by an ionizing radiation event. This study characterizes the structural and energy profiles of DNA duplexes harboring synthetic abasic sites (tetrahydrofuran, F) as models of clustered bistrand abasic (AP) lesions...
January 11, 2018: Biopolymers
https://www.readbyqxmd.com/read/29318450/the-utility-of-noninvasive-scores-in-assessing-the-prevalence-of-nonalcoholic-fatty-liver-disease-and-advanced-fibrosis-in-type-1-diabetic-patients
#5
Amandeep Singh, Phuc Le, Rocio Lopez, Naim Alkhouri
GOALS: The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND: There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanced disease in NAFLD patients. STUDY: Using ICD-9 codes, all patients with the diagnosis of T1D were reviewed and a retrospective chart analysis was carried out on 23,314 patients between the ages of 18 and 80...
January 9, 2018: Hepatology International
https://www.readbyqxmd.com/read/29308959/choroidal-thickening-in-a-case-of-carotid-cavernous-fistula
#6
Julio González Martín-Moro, Marco Sales-Sanz, Noelia Oblanca-Llamazares, Angel Bustos-García, Jose Carlos Méndez-Cendón, Eduardo Fandiño
A 47-year-old woman was diagnosed with dural carotid cavernous fistula (CCF) in her right eye (RE). Scans of the choroid using Spectralis optic coherence tomography (OCT) demonstrated significant asymmetry in subfoveal choroidal thickness (RE 451 μm, left eye (LE) 367 μm). This asymmetry disappeared after the fistula was embolizated through the ophthalmic artery (RE 341 μm; LE 340 μm). This case suggests that OCT should be considered as an ancillary test in the diagnosis of CCF.
January 8, 2018: Orbit
https://www.readbyqxmd.com/read/29308277/fibromyalgia-has-a-high-prevalence-and-impact-in-cardiac-failure-patients
#7
Anthea C Gist, Emma K Guymer, Andrew E Ajani, Geoffrey O Littlejohn
Objective: Chronic cardiac failure (CCF) shares several clinical features with fibromyalgia (FM), a syndrome of increased central sensitivity and musculoskeletal pain. FM frequently coexists with other chronic illness. Musculoskeletal pain is reported in patients with CCF; however, the prevalence and impact of FM in patients with CCF is not known. This research aims to assess the prevalence and effects of concurrent FM in patients with CCF and to identify other coexisting central sensitivity syndromes...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29296184/integrin-%C3%AE-5-triggers-the-metastatic-potential-in-renal-cell-carcinoma
#8
Ines Breuksch, Franz Prosinger, Fabian Baehr, Franz-Peter Engelhardt, Heide-Katharina Bauer, Joachim W Thüroff, Anne-Sophie Heimes, Annette Hasenburg, Dirk Prawitt, Walburgis Brenner
The therapy of advanced renal cell carcinoma (RCC) is still a major challenge. To intervene therapeutically a deeper comprehension of the particular steps of metastasis is necessary. In this context membrane bound receptors like integrins play a decisive role. We analyzed the integrin α5 expression in 141 clear cell RCC patients by Western blot. Patients with RCC expressed a significant higher level of integrin α5 in tumor than in normal tissue. The integrin α5 expression correlated with tumor grade, the development of distant metastases within five years after tumor nephrectomy and reduced survival...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29287280/rotational-study-on-the-van-der-waals-complex-1-chloro-1-1-difluoroethane-argon
#9
Juan Wang, Junhua Chen, Gang Feng, Zhining Xia, Qian Gou
The rotational spectrum of the van der Waals complex formed between 1-chloro-1,1-difluoroethane and argon has been investigated by using a pulsed jet Fourier transform microwave spectrometer. Only one set of rotational transitions belonging to the lowest energy conformer has been observed and assigned, although theoretical calculations suggest six stable conformers that might be observed. The observed conformer, according to the experimental evidence from two isotopologues (35Cl and 37Cl), adopts a configuration in which the argon atom is located, close to the CF2Cl top, between the CCF and CCCl planes (the dihedral angle ∠ArCCCl is 65...
December 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29246439/development-of-solidified-self-microemulsifying-drug-delivery-systems-containing-l-tetrahydropalmatine-design-of-experiment-approach-and-bioavailability-comparison
#10
Nguyen-Thach Tung, Cao-Son Tran, Thi-Minh-Hue Pham, Hoang-Anh Nguyen, Tran-Linh Nguyen, Sang-Cheol Chi, Dinh-Duc Nguyen, Thi-Bich-Huong Bui
The study first aimed to apply a design of experiment (DoE) approach to investigate the influences of excipients on the properties of liquid self-microemulsifying drug delivery system (SMEDDS) and SMEDDS loaded in the pellet (pellet-SMEDDS) containing l-tetrahydropalmatine (l-THP). Another aim of the study was to compare the bioavailability of l-THP suspension, liquid SMEDDS and pellet-SMEDDS in the rabbit model. By using Central Composite Face design (CCF), the optimum ratio of Capryol 90, and Smix `(Cremophor RH 40: Transcutol HP) in the formulation of SMEDDS was determined...
December 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29245336/amelioration-of-acute-orbital-compartment-syndrome-following-transvenous-embolization-for-an-indirect-carotid-cavernous-fistula-a-case-report
#11
Yun-Hsiu Hsieh, Tzu-Heng Weng, Ming-Cheng Tai, Ke-Hung Chien
RATIONALE: Orbital compartment syndrome (OCS) is a rare occurrence after transvenous embolization of indirect carotid-cavernous fistula (CCF). A lateral canthotomy and cantholysis are the most commonly performed surgical interventions. In our case, as the acute OCS occurred immediately after an uneventful transvenous embolization, an orbital floor orbitectomy was performed. PATIENT CONCERNS: Here, we present a rare case of a 59-year-old patient who required a transvenous embolization of an indirect CCF and subsequently immediately developed an acute OCS...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29227793/bilateral-traumatic-caroticocavernous-fistulas-a-case-report-and-review-of-the-literature
#12
Lorna Leandro, Giovanni Dolci, Satheesh Prabhu, Rufus Corkill
A traumatic caroticocavernous fistula (CCF) is an acquired, abnormal communication between the internal carotid artery and the cavernous sinus, secondary to trauma. This rare condition can initially be misdiagnosed, because its presentation shares features common to those of facial trauma, which can result in serious complications. We describe a case of bilateral CCF in an adult patient after a road traffic accident.
November 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29224893/external-validation-of-equations-to-estimate-resting-energy-expenditure-in-14952-adults-with-overweight-and-obesity-and-1948-adults-with-normal-weight-from-italy
#13
Giorgio Bedogni, Simona Bertoli, Alessandro Leone, Ramona De Amicis, Elisa Lucchetti, Fiorenza Agosti, Nicoletta Marazzi, Alberto Battezzati, Alessandro Sartorio
BACKGROUND & AIMS: We cross-validated 28 equations to estimate resting energy expenditure (REE) in a very large sample of adults with overweight or obesity. METHODS: 14952 Caucasian men and women with overweight or obesity and 1498 with normal weight were studied. REE was measured using indirect calorimetry and estimated using two meta-regression equations and 26 other equations. The correct classification fraction (CCF) was defined as the fraction of subjects whose estimated REE was within 10% of measured REE...
November 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29207796/clinico-aetiological-study-of-severe-and-very-severe-pneumonia-in-two-months-to-five-years-children-in-a-tertiary-health-care-centre-in-odisha-india
#14
Jyotiranjan Champatiray, Jyotiranjan Satapathy, Baikunthanath Kashyap, Dipankar Mondal
Introduction: Pneumonia is a major cause of mortality under five-year-old children. In spite of recent advances in management, there is paucity of data on clinical, aetiological profile of severe and very severe pneumonia among under five-year-old children in developing countries. Aim: To determine the clinico-aetiological factors of severe and very severe pneumonia and its outcome in children aged two -months to five-years in a tertiary health care centre in Odisha, India...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205798/carotid-cavernous-fistula-after-endovascular-intervention-for-chronic-carotid-artery-total-occlusion
#15
Chih-Fan Yeh, Yin-Hsien Chen, Mao-Shin Lin, Ching-Chang Huang, Chi-Sheng Hung, Shih-Wei Meng, Chih-Kuo Lee, Hsien-Li Kao
BACKGROUND AND PURPOSE: In addition to head trauma and cranial surgery, endovascular intervention for chronic carotid artery occlusion (CAO) may also result in carotid-cavernous fistula (CCF). The management and prognosis of iatrogenic CCF during CAO recanalization have never been well described and discussed in the literature. MATERIALS AND METHODS: We conducted a retrospective analysis for CAO recanalization attempts in National Taiwan University Hospital and affiliated hospitals...
December 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29201856/complete-reversal-of-diffusion-restriction-after-treatment-of-traumatic-carotid-cavernous-fistula
#16
Jeong Hyun Shim, Inbo Han
A 15-year-old man presented with stupor following a motorcycle traffic accident. The patient was diagnosed with a traumatic left carotid cavernous fistula (CCF) with pseudoaneurysm of the left internal carotid artery. Brain magnetic resonance imaging (MRI) showed transiently restricted diffusion in the left centrum semiovale white matter and lower temporo-occipital area extending to the splenium of the corpus callosum, with high signal intensity on diffusion-weighted imaging. On the 35th day of admission, the patient had complete neurological recovery and a follow-up brain MRI revealed complete resolution of the lesions in the left centrum semiovale and splenium of the corpus callosum...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29174523/transvenous-coil-embolization-for-the-treatment-of-carotid-cavernous-fistula-after-pipeline-placement-a-case-report
#17
Ryuta Nakae, Masaya Nagaishi, Issei Takano, Yoshihiro Tanaka, Akio Hyodo, Kensuke Suzuki
The Pipeline embolization device (PED), a type of flow diverter, has become an appealing alternative treatment option for large or giant and wide-necked intracranial aneurysms. Carotid cavernous fistula (CCF) resulting from delayed aneurysmal rupture is a rare complication of PED placement with unknown pathophysiology. Here, we describe a case of CCF resulting from aneurysmal rupture following PED placement, and present the details of treatment by transvenous coil embolization. An 81-year-old woman was referred to our hospital for treatment of an 18...
November 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29173125/time-series-analysis-variation-of-anti-acetylcholine-receptor-antibody-titer-in-myasthenia-gravis-is-related-to-incidence-of-mycoplasma-pneumoniae-and-influenza-virus-infections
#18
Kazuo Iwasa, Hiroaki Yoshikawa, Tsuyoshi Hamaguchi, Kenji Sakai, Moeko Shinohara-Noguchi, Miharu Samuraki, Kazuya Takahashi, Daisuke Yanase, Kenjiro Ono, Chiho Ishida, Mitsuhiro Yoshita, Hiroyuki Nakamura, Masahito Yamada
Objectives The exacerbating factors of myasthenia gravis (MG) are unknown. However, it has been speculated that infections may play a role in disease progression. Methods We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0-1) in 58 MG patients between 2006 and 2012. We determined the relationship between Adj-AChR-Ab titer and infection incidence. Results A cross-correlation function (CCF) analysis of Adj-AChR-Ab titer and incidence of Mycoplasma pneumoniae (M. pneumoniae) (r = 0...
November 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/29172753/design-and-characterization-of-calcium-free-in-situ-gel-formulation-based-on-sodium-alginate-and-chitosan
#19
Linda Belhadji, Abdelkader HadjSadok, Nadji Moulai-Mostefa
The aim of this study was to prepare and evaluate calcium-free sustained release drug delivery systems, based on the in-situ gelation of oral suspensions containing chitosan, sodium alginate and Ranitidine as drug model. The combined effects of polymer concentrations and their interactions on the rheological characteristics of both gels and suspensions and, on the kinetics of drug release were evaluated by using a central composite face-centered (CCF) design. Rheological analysis showed that suspensions were potentially stable, with a viscosity increased by 1000 times compared to that of water...
November 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29170837/post-traumatic-carotid-cavernous-fistula-in-a-pediatric-patient-a-case-based-literature-review
#20
Barbara Albuquerque Morais, Vitor Nagai Yamaki, Jose Guilherme Mendes Pereira Caldas, Wellingson Silva Paiva, Hamilton Matushita, Manoel Jacobsen Teixeira
BACKGROUND: Carotid-cavernous fistula (CCF) is a shunt between the carotid artery and the cavernous sinus. Traumatic CCFs are diagnosed in 0.2% of head traumas being only 4.6% of the pediatric population. Classified by Barrow in 1985, type A CCF is the most frequent, occurring in 75% of cases. Type A is characterized by direct and high-flow CCF that generally can occur as a result of traumatic injury or rupture of an intracavernous aneurysm. CASE PRESENTATION: The subject was an 8-year-old boy with penetrating trauma to his left eye...
November 23, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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