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https://www.readbyqxmd.com/read/27923754/successful-coil-embolization-of-pediatric-carotid-cavernous-fistula-due-to-ruptured-post-traumatic-giant-internal-carotid-artery-aneurysm
#1
Daisuke Wajima, Ichiro Nakagawa, Hun Soo Park, Shohei Yokoyama, Takeshi Wada, Kimihiko Kichikawa, Hiroyuki Nakase
BACKGROUND: The goal of the treatment of direct carotid cavernous fistula (CCF) is to occlude the arteriovenous shunt and to preserve the patency of the concerned internal carotid artery (ICA). However, for the ipsilateral post-traumatic fragile cerebrum, coil embolization plus parent artery occlusion for the high flow direct CCF would be better for the prevention of hyper-perfusion syndrome and the intracranial hemorrhage. We experienced such a case and managed it successfully. CASE DESCRIPTION: A 6-year-old boy was suffered from severe head trauma caused by being hit by a car...
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27901483/meta-analysis-on-the-association-of-vegfr1-genetic-variants-with-sunitinib-outcome-in-metastatic-renal-cell-carcinoma-patients
#2
Xiaoyan Liu, Jesse J Swen, Epie Boven, Daniel Castellano, Hans Gelderblom, Ron H J Mathijssen, Cristina Rodríguez-Antona, Jesus García-Donas, Brian I Rini, Henk-Jan Guchelaar
VEGFR1 rs9582036 and rs9554320 were previously reported the association with sunitinib progression-free survival (PFS) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). Hereafter, the association of both single nucleotide polymorphisms (SNPs) with PFS/OS was confirmed in two independent mRCC cohorts. The aim of the current study was to validate the associations of both SNPs with sunitinib outcome in three independent well-characterized cohorts (SUTOX, CCF and SOGUG) including 286 sunitinib-treated mRCC patients, as well as to perform a meta-analysis of current and published data combined...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27885800/sacral-neuromodulation-for-the-treatment-of-faecal-incontinence-following-proctectomy
#3
Ido Mizrahi, Sami A Chadi, Nadav Haim, Dana R Sands, Brooke Gurland, Massarat Zutshi, Steven D Wexner, Giovanna da Silva
AIM: This study assessed the effectiveness of sacral neuromodulation (SNM) for faecal incontinence (FI) following proctectomy with colorectal or coloanal anastomosis. METHODS: An IRB-approved database identified patients treated for FI following proctectomy (SNM-P) for benign or malignant disease, who were matched 1:1 by pre-operative Cleveland Clinic Florida Faecal Incontinence Scores (CCF-FIS) with patients without proctectomy (SNM-NP). Primary outcome was change in CCF-FIS...
November 25, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27878416/identification-of-large-variation-in-the-photosynthetic-induction-response-among-37-soybean-glycine-max-l-merr-genotypes-that-is-not-correlated-with-steady-state-photosynthetic-capacity
#4
M A Soleh, Y Tanaka, S Y Kim, S C Huber, K Sakoda, T Shiraiwa
Irradiance continuously fluctuates during the day in the field. The speed of the induction response of photosynthesis in high light affects the cumulative carbon gain of the plant and could impact growth and yield. The photosynthetic induction response and its relationship with the photosynthetic capacity under steady-state conditions (P max) were evaluated in 37 diverse soybean [Glycine max (L.) Merr.] genotypes. The induction response of leaf photosynthesis showed large variation among the soybean genotypes...
November 22, 2016: Photosynthesis Research
https://www.readbyqxmd.com/read/27875070/competitive-funding-strategies-for-the-conquer-cancer-foundation-of-asco
#5
Tanios Bekaii-Saab, Sanjay Goel, Adrien Dickerson, Jamie Von Roenn, Michael A Thompson, Anne S Tsao
PURPOSE: The Conquer Cancer Foundation (CCF), the philanthropic arm of ASCO, is responsible for funding innovative clinical research. CCF wants to broaden its donor base instead of relying predominantly on health-care companies. Our Leadership Development Program (LDP) group was tasked with identifying potential donor sources and making recommendations to increase funding. MATERIALS AND METHODS: We selected three sources to research: the general public, crowdsourcing/social media, and ASCO members...
November 22, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27869621/ponseti-treatment-of-rigid-residual-deformity-in-congenital-clubfoot-after-walking-age
#6
Massimiliano Dragoni, Pasquale Farsetti, Giuseppe Vena, Diego Bellini, Pierluigi Maglione, Ernesto Ippolito
BACKGROUND: There is no established treatment for rigid residual deformity of congenital clubfoot (CCF) after walking age. Soft-tissue procedures, osseous procedures, and external fixation have been performed with unpredictable results. We applied the Ponseti method to patients with this condition in order to improve the outcomes of treatment. METHODS: We retrospectively reviewed the cases of 44 patients (68 feet) with congenital clubfoot whose mean age (and standard deviation) at treatment was 4...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27868373/acute-myeloid-leukemia-in-baraitser-winter-cerebrofrontofacial-syndrome
#7
Paola Cianci, Grazia Fazio, Sara Casagranda, Marco Spinelli, Carmelo Rizzari, Gianni Cazzaniga, Angelo Selicorni
Baraitser-Winter malformation syndrome (BWMS), Fryns-Aftimos syndrome (FA), and craniofrontofacial syndromes (CFFs) have all been recently proposed to be part of the same phenotypic spectrum of Baraitser-Winter cerebrofrontofacial syndrome (BWCFF), which is characterized by facial dysmorphism, ocular coloboma, brain malformations, and intellectual disabilities. In addition to that, the recent discovery of missense mutations in one of the two ubiquitously expressed cytoplasmic β- and γ-acting-encoding genes ACTB (7p22...
November 21, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27867265/alpha-glucosidase-inhibitory-and-antioxidant-potential-of-antidiabetic-herb-alternanthera-sessilis-comparative-analyses-of-leaf-and-callus-solvent-fractions
#8
Tsun-Thai Chai, Chee-Siong Khoo, Chong-Siang Tee, Fai-Chu Wong
BACKGROUND: Alternanthera sessilis is a medicinal herb which is consumed as vegetable and used as traditional remedies of various ailments in Asia and Africa. OBJECTIVE: This study aimed to investigate the antiglucosidase and antioxidant activity of solvent fractions of A. sessilis leaf and callus. MATERIALS AND METHODS: Leaf and callus methanol extracts were fractionated to produce hexane, chloroform, ethyl acetate, butanol, and water fractions...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27865932/oral-helicobacter-pylori-vaccine-encapsulated-acid-resistant-hp55-plga-nanoparticles-promote-immune-protection
#9
Zhoulin Tan, Wei Liu, Hai Liu, Cheng Li, Yan Zhang, Xia Meng, Tingting Tang, Tao Xi, Yingying Xing
Oral vaccination, is notoriously weak or nonimmunogenic. One of the major reasons is the inefficient antigen uptake caused by enzymolysis and hydrolysis in the gastrointestinal tract. In this study, acid-resistant HP55/PLGA nanoparticle was developed as an oral delivery system to protect H. pylori recombinant antigen CCF against the complex gastrointestinal environment. These ∼200nm particles controlled the release of antigen in the acidic environment (pH⩽5.5). Immunized mice with HP55/PLGA-CCF nanoparticles induced high levels of urease-specific antibodies and memory T cell responses...
November 16, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27847780/recurrent-carotid-cavernous-fistula-originating-from-a-giant-cerebral-aneurysm-after-placement-of-a-covered-stent
#10
Jung Wook Baek, Sung Tae Kim, Young Seo Lee, Young-Gyun Jeong, Hae Woong Jeong, Jin Wook Baek, Jung Hwa Seo
We report the case of a recurrent carotid cavernous fistula (CCF) originating from a giant cerebral aneurysm (GCA) after placement of a covered stent. A 47-year-old woman presented with sudden onset of severe headache, and left-sided exophthalmos and ptosis. Cerebral angiography revealed a CCF caused by rupture of a GCA in the cavernous segment of the left internal carotid artery. Two covered stents were placed at the neck of the aneurysm. The neurological symptoms improved at first, but were aggravated in the 6 months following the treatment...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27847763/preliminary-experience-with-vascular-plugs-for-parent-artery-occlusion-of-the-carotid-or-vertebral-arteries
#11
Woosung Lee, Yong Sam Shin, Kyung Hyun Kim, Yong Bae Kim, Chang-Ki Hong, Joonho Chung
OBJECTIVE: The purpose of this study was to report the authors' preliminary experience using the Amplatzer Vascular Plug (AVP) (St. Jude Medical, Plymouth, MN, USA) for parent artery occlusion of the internal carotid artery (ICA) or vertebral artery (VA). MATERIALS AND METHODS: Between September 2008 and December 2015, we performed 52 therapeutic parent artery occlusions (PAOs) by an endovascular technique. Among them, 10 patients underwent PAO of the carotid or vertebral arteries using AVPs...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27837319/functional-outcomes-after-tem-in-patients-with-complete-clinical-response-after-neoadjuvant-chemoradiotherapy
#12
Roberto Ghiselli, Monica Ortenzi, Luca Cardinali, Edlira Skrami, Rosaria Gesuita, Mario Guerrieri
BACKGROUND: In patients who exhibit a complete clinical response after radio-chemotherapy for rectal cancer, the standard surgical approach might constitute overtreatment. The aim of this study is to analyse the outcomes of anorectal function and quality of life after transanal endoscopic microsurgery (TEM) in irradiated patients with complete clinical response. PATIENTS AND METHODS: Between 2007 and 2014, 84 patients who were diagnosed with stage T2-T3-T4 N0 rectal cancer before chemoradiotherapy showed a complete clinical response to neoadjuvant therapy and underwent TEM...
November 11, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27809745/phenolic-profile-and-antioxidant-activity-of-centaurea-choulettiana-pomel-asteraceae-extracts
#13
Djihane Azzouzi, Kenza Bioud, Ibrahim Demirtas, Fatih Gül, Djamel Sarri, Samir Benayache, Fadila Benayache, Ratiba Mekkiou
This study aimed to quantify phenolic acids from Centaurea choulettiana Pomel (Asteraceae) leaves (CcL) and flowers (CcF); compare the antioxidant activity of their extracts. The identification and quantification of phenolic acids from ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts of CcL and CcF carried out using HPLC-TOF/MS analysis system which revealed the presence of several phenolic acids. The antioxidant activity of both organs extracts investigated using total phenolics (TP), flavonoids (TF) contents, DPPH radical scavenging and lipid peroxidation inhibition...
November 1, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27784057/use-of-sex-specific-clinical-and-exercise-risk-scores-to-identify-patients-at-increased-risk-for-all-cause-mortality
#14
Paul C Cremer, Yuping Wu, Haitham M Ahmed, Lee M Pierson, Danielle M Brennan, Mouaz H Al-Mallah, Clinton A Brawner, Jonathan K Ehrman, Steven J Keteyian, Roger S Blumenthal, Michael J Blaha, Leslie Cho
Importance: Risk assessment tools for exercise treadmill testing may have limited external validity. Cardiovascular mortality has decreased in recent decades, and women have been underrepresented in prior cohorts. Objectives: To determine whether exercise and clinical variables are associated with differential mortality outcomes in men and women and to assess whether sex-specific risk scores better estimate all-cause mortality. Design, Setting, and Participants: This retrospective cohort study included 59 877 patients seen at the Cleveland Clinic Foundation (CCF cohort) from January 1, 2000, through December 31, 2010, and 49 278 patients seen at the Henry Ford Hospital (FIT cohort) from January 1, 1991, through December 31, 2009...
October 26, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27753740/correlated-emg-oscillations-between-antagonists-during-co-contraction-in-men
#15
Yasuhide Yoshitake, Hiroaki Kanehisa, Minoru Shinohara
PURPOSE: The purpose of this study was to determine the modulation of common low-frequency oscillations in pools of motor units across antagonistic muscles due to the difference in the activation level of pools of spinal motor neurons and the presence of neuromuscular fatigue during intended co-contraction. METHODS: Ten healthy young men (21.8 ± 1.5 yr) performed intended steady co-contractions of elbow flexors and extensors at maximal and a submaximal (10% of maximal electromyogram, EMG) effort...
October 6, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27751861/the-impact-of-post-resuscitation-feedback-for-paramedics-on-the-quality-of-cardiopulmonary-resuscitation
#16
Eduard Bleijenberg, Rudolph W Koster, Hendrik de Vries, Stefanie G Beesems
PURPOSE: The Guidelines place emphasis on high-quality cardiopulmonary resuscitation (CPR). This study aims to measure the impact of post-resuscitation feedback on the quality of CPR as performed by ambulance personnel. MATERIALS AND METHODS: Two ambulances are dispatched for suspected cardiac arrest. The crew (driver and paramedic) of the first arriving ambulance is responsible for the quality of CPR. The crew of the second ambulance establishes an intravenous access and supports the first crew...
October 14, 2016: Resuscitation
https://www.readbyqxmd.com/read/27736096/covalent-coordination-frameworks-a-new-route-for-synthesis-and-expansion-of-functional-porous-materials
#17
Sameh K Elsaidi, Mona H Mohamed, John S Loring, Bernard Peter McGrail, Praveen K Thallapally
The synthetic approaches for fine-tuning the structural properties of coordination polymers or metal organic frameworks have exponentially grown during the last decade. This is due to the control over the properties of the resulting structures such as stability, pore size, pore chemistry and surface area for myriad possible applications. Herein, we present a new class of porous materials called Covalent Coordination Frameworks (CCFs) that were designed and effectively synthesized using a two-step reticular chemistry approach...
October 13, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27702915/determination-of-resistance-and-virulence-genes-in-enterococcus-faecalis-and-e-faecium-strains-isolated-from-poultry-and-their-genotypic-characterization-by-adsrrs-fingerprinting
#18
A Nowakiewicz, G Ziółkowska, A Trościańczyk, P Zięba, S Gnat
The aim of this study was to determine the antimicrobial resistance of E. faecalis and E. faecium strains isolated from poultry and to carry out genotypic characterization thereof with the ADSRRS-fingerprinting method (amplification of DNA fragments surrounding rare restriction sites) and analysis of the genetic relatedness between the isolates with different resistance and virulence determinants. Samples were collected from 70 4-week-old chickens and tested for Enterococcus Minimum inhibitory concentrations of 11 antimicrobials were determined using the broth microdilution method...
October 4, 2016: Poultry Science
https://www.readbyqxmd.com/read/27673410/inhibitory-kinetics-and-mechanism-of-flavonoids-extracted-from-cotinus-coggygria-scop-against-glioblastoma-cancer
#19
Gang Wang, Jun-Jie Wang, Li Du, Li Fei, Shing-Shun Tony To
This proposal seeks to study the potential therapeutic modality of chemoprevention and anticancer effects and mechanisms of the flavonoids from Cotinus coggygria Scop. on glioblastoma cancer. In the current study, the total flavonoids (TFs) isolated from Cotinus coggygria Scop. var. cinerea Engl. (Cotinus coggygria Scop.) and the major flavonoids of Cotinus coggygria Scop. (CCFs) were identified, and the inhibitory kinetics of TF and CCF on glioblastoma cell lines were calculated. We also investigated whether TF or CCF regulated the apoptotic mechanism in cellular models of glio-blastoma cells...
September 27, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27665771/the-sarin-like-organophosphorus-agent-bis-isopropyl-methyl-phosphonate-induces-er-stress-in-human-astrocytoma-cells
#20
Yosuke Arima, Hiroaki Shiraishi, Atsushi Saito, Kanji Yoshimoto, Akira Namera, Ryosuke Makita, Kazuhiro Murata, Kazunori Imaizumi, Masataka Nagao
Organophosphorus (OP) compounds such as sarin are toxic agents that irreversibly inhibit the enzyme acetylcholinesterase. A recent study showed that OP compounds also have multiple toxicity mechanisms, and another suggested that endoplasmic reticulum (ER) dysfunction contributes to OP toxicity. However, the signaling pathway and mechanisms involved are poorly understood. We examined whether the sarin-like OP agent bis(isopropyl methyl)phosphonate (BIMP), which exhibits toxicity similar to that of sarin, induced ER stress in human astrocytoma CCF-STTG1 cells...
2016: Journal of Toxicological Sciences
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