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Yasuhide Yoshitake, Hiroaki Kanehisa, Minoru Shinohara
PURPOSE: The purpose of this study was to determine the modulation of common low-frequency oscillations in pools of motor units across antagonistic muscles due to the difference in the activation level of pools of spinal motor neurons and the presence of neuromuscular fatigue during intended co-contraction. METHODS: Ten healthy young men (21.8 ± 1.5 yr) performed intended steady co-contractions of elbow flexors and extensors at maximal and a submaximal (10% of maximal electromyogram, EMG) effort...
October 6, 2016: Medicine and Science in Sports and Exercise
Eduard Bleijenberg, Rudolph W Koster, Hendrik de Vries, Stefanie G Beesems
PURPOSE: The Guidelines place emphasis on high-quality cardiopulmonary resuscitation (CPR). This study aims to measure the impact of post-resuscitation feedback on the quality of CPR as performed by ambulance personnel. MATERIALS AND METHODS: Two ambulances are dispatched for suspected cardiac arrest. The crew (driver and paramedic) of the first arriving ambulance is responsible for the quality of CPR. The crew of the second ambulance establishes an intravenous access and supports the first crew...
October 14, 2016: Resuscitation
Sameh K Elsaidi, Mona H Mohamed, John S Loring, Bernard Peter McGrail, Praveen K Thallapally
The synthetic approaches for fine-tuning the structural properties of coordination polymers or metal organic frameworks have exponentially grown during the last decade. This is due to the control over the properties of the resulting structures such as stability, pore size, pore chemistry and surface area for myriad possible applications. Herein, we present a new class of porous materials called Covalent Coordination Frameworks (CCFs) that were designed and effectively synthesized using a two-step reticular chemistry approach...
October 13, 2016: ACS Applied Materials & Interfaces
A Nowakiewicz, G Ziółkowska, A Trościańczyk, P Zięba, S Gnat
The aim of this study was to determine the antimicrobial resistance of E. faecalis and E. faecium strains isolated from poultry and to carry out genotypic characterization thereof with the ADSRRS-fingerprinting method (amplification of DNA fragments surrounding rare restriction sites) and analysis of the genetic relatedness between the isolates with different resistance and virulence determinants. Samples were collected from 70 4-week-old chickens and tested for Enterococcus Minimum inhibitory concentrations of 11 antimicrobials were determined using the broth microdilution method...
October 4, 2016: Poultry Science
Gang Wang, Jun-Jie Wang, Li Du, Li Fei, Shing-Shun Tony To
This proposal seeks to study the potential therapeutic modality of chemoprevention and anticancer effects and mechanisms of the flavonoids from Cotinus coggygria Scop. on glioblastoma cancer. In the current study, the total flavonoids (TFs) isolated from Cotinus coggygria Scop. var. cinerea Engl. (Cotinus coggygria Scop.) and the major flavonoids of Cotinus coggygria Scop. (CCFs) were identified, and the inhibitory kinetics of TF and CCF on glioblastoma cell lines were calculated. We also investigated whether TF or CCF regulated the apoptotic mechanism in cellular models of glio-blastoma cells...
September 27, 2016: Nutrition and Cancer
Yosuke Arima, Hiroaki Shiraishi, Atsushi Saito, Kanji Yoshimoto, Akira Namera, Ryosuke Makita, Kazuhiro Murata, Kazunori Imaizumi, Masataka Nagao
Organophosphorus (OP) compounds such as sarin are toxic agents that irreversibly inhibit the enzyme acetylcholinesterase. A recent study showed that OP compounds also have multiple toxicity mechanisms, and another suggested that endoplasmic reticulum (ER) dysfunction contributes to OP toxicity. However, the signaling pathway and mechanisms involved are poorly understood. We examined whether the sarin-like OP agent bis(isopropyl methyl)phosphonate (BIMP), which exhibits toxicity similar to that of sarin, induced ER stress in human astrocytoma CCF-STTG1 cells...
2016: Journal of Toxicological Sciences
Markus Gross, Oleg Vasilyev, Andrea Gambassi, S Dietrich
Critical properties of a liquid film between two planar walls are investigated in the canonical ensemble, within which the total number of fluid particles, rather than their chemical potential, is kept constant. The effect of this constraint is analyzed within mean-field theory (MFT) based on a Ginzburg-Landau free-energy functional as well as via Monte Carlo simulations of the three-dimensional Ising model with fixed total magnetization. Within MFT and for finite adsorption strengths at the walls, the thermodynamic properties of the film in the canonical ensemble can be mapped exactly onto a grand canonical ensemble in which the corresponding chemical potential plays the role of the Lagrange multiplier associated with the constraint...
August 2016: Physical Review. E
Fabio G Rodrigues, Sami A Chadi, Alejandro J Cracco, Dana R Sands, Massarat Zutshi, Brooke Gurland, Giovanna Da Silva, Steven D Wexner
AIM: Sphincteroplasty (SP) is used to treat faecal incontinence (FI) in patients with a sphincter defect. Sacral nerve stimulation (SNS) is now the form of interventional treatment used in most patients, but in those with a sphincter defect its outcome has not been definitively evaluated. We compared the results of SP and SNS for FI associated with a sphincter defect. METHOD: Patients treated by SNS or SP for FI with an associated sphincter defect were retrospectively identified from an IRB-approved prospective database...
September 12, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Archana Srinivasan, Nicolas G Biro, Ann P Murchison, Robert C Sergott, Mark L Moster, Pascal M Jabbour, Jurij R Bilyk
PURPOSE: To evaluate the diagnostic sensitivity and specificity of orbital color Doppler imaging (CDI) and conventional neuroimaging (CT/MRI) compared with cerebral angiography in patients with carotid-cavernous fistulas (CCFs). METHODS: The study design was a retrospective patient chart and imaging review. The authors reviewed 655 charts of all patients who underwent CDI and neuroimaging (CT/MRI) between 2006 and 2015 at one institution. Sixty patients had a presumptive diagnosis of CCF without thrombosis...
September 6, 2016: Ophthalmic Plastic and Reconstructive Surgery
Jianjia Fan, Shahab Zareyan, Wenchen Zhao, Yoko Shimizu, Tom A Pfeifer, Jun-Hyung Tak, Murray B Isman, Bernard Van den Hoven, Mark E Duggan, Michael W Wood, Cheryl L Wellington, Iva Kulic
The apolipoprotein E (APOE) gene is the most highly associated susceptibility locus for late onset Alzheimer's Disease (AD), and augmenting the beneficial physiological functions of apoE is a proposed therapeutic strategy. In a high throughput phenotypic screen for small molecules that enhance apoE secretion from human CCF-STTG1 astrocytoma cells, we show the chrysanthemic ester 82879 robustly increases expressed apoE up to 9.4-fold and secreted apoE up to 6-fold and is associated with increased total cholesterol in conditioned media...
2016: PloS One
Anil K Roy, Jonathan A Grossberg, Joshua W Osbun, Susana L Skukalek, Brian M Howard, Faiz U Ahmad, Frank Tong, Jacques E Dion, Charles M Cawley
OBJECTIVE: Carotid cavernous fistula (CCF) development after Pipeline Embolization Device (PED) treatment of cavernous carotid aneurysms (CCA) can be a challenging pathology to treat for the neurointerventionalist. METHODS: A database of all patients whose aneurysms were treated with the PED since its approval by the Food and Drug Administration in 2011 was retrospectively reviewed. Demographic information, aneurysm characteristics, treatment technique, antiplatelet regimen, and follow-up data were collected...
September 5, 2016: Journal of Neurointerventional Surgery
Francesco Acerbi, Giuseppe FARAGò, Morgan Broggi, Claudio Cavallo, Michela Ranieri, Valentina Caldiera, Elisa Ciceri, Paolo Ferroli
Backgorund Direct exposure and cannulation of superior ophthalmic vein (SOV) provides an alternative access to reach the cavernous sinus for carotid-cavernous fistula (CCF) embolization, when classic transvenous routes through inferior petrosal sinus (IPS) or facial vein are not feasible. We have used indocyanine green (ICG) videoangiography to study intraoperatively the flow inside the SOV in two cases of indirect CCF. In this paper we report the operative technique and the result of ICG videoangiographic-guided cannulation of the SOV for endovascular treatment of CCF...
July 15, 2016: Turkish Neurosurgery
Alexander Y Mitrophanov, Fania Szlam, Roman M Sniecinski, Jerrold H Levy, Jaques Reifman
BACKGROUND: The use of prothrombin complex concentrates in trauma- and surgery-induced coagulopathy is complicated by the possibility of thromboembolic events. To explore the effects of these agents on thrombin generation (TG), we investigated combinations of coagulation factors equivalent to 3- and 4-factor prothrombin complex concentrates with and without added antithrombin (AT), as well as recombinant factor VIIa (rFVIIa), in a dilutional model. These data were then used to develop a computational model to test whether such a model could predict the TG profiles of these agents used to treat dilutional coagulopathy...
September 2016: Anesthesia and Analgesia
Srinidhi Nagaraja, Vivek Palepu
Synthetic polyurethane foams are frequently used in biomechanical testing of spinal medical devices. However, it is unclear what types of foam are most representative of human vertebral trabecular bone behavior, particularly for testing the bone-implant interface. Therefore, a study was conducted to compare polyurethane foam microstructure and screw pullout properties to human vertebrae. Cadaveric thoracolumbar vertebrae underwent microcomputed tomography to assess trabecular bone microstructure. Spine plate screws were implanted into the vertebral body and pullout testing was performed...
October 1, 2016: Journal of Biomechanical Engineering
Ian S Armstrong, Sandra A Hoffmann
The interest in quantitative single photon emission computer tomography (SPECT) shows potential in a number of clinical applications and now several vendors are providing software and hardware solutions to allow 'SUV-SPECT' to mirror metrics used in PET imaging. This brief technical report assesses the accuracy of activity concentration measurements using a new algorithm 'xSPECT' from Siemens Healthcare. SPECT/CT data were acquired from a uniform cylinder with 5, 10, 15 and 20 s/projection and NEMA image quality phantom with 25 s/projection...
November 2016: Nuclear Medicine Communications
Chien-Lun Tang, Chih-Hsiang Liao, Wen-Hsien Chen, Shih-Chieh Shen, Chung-Hsin Lee, Hsu-Tung Lee, Yuang-Seng Tsuei
Endovascular embolization is the treatment of choice for carotid-cavernous fistulas (CCFs), but failure to catheterize the cavernous sinus may occur as a result of vessel tortuosity, hypoplasia, or stenosis. In addition to conventional transvenous or transarterial routes, alternative approaches should be considered. The authors present a case in which a straightforward route to the CCF was accessed via transsphenoidal puncture of the cavernous sinus in a neurosurgical hybrid operating suite. This 82-year-old man presented with severe chemosis and proptosis of the right eye...
August 5, 2016: Journal of Neurosurgery
Deolino J Ibiapina, Paula V Oltramari-Navarro, Ricardo L Navarro, Marcio R Almeida, Daniela L Mendonça, Ana Ccf Conti
AIMS: To evaluate changes in transverse dimensions of upper arch and thickness of the buccal bone plate in patients undergoing orthodontic treatment during the leveling phase. MATERIALS AND METHODS: Sixteen patients aged between 11 and 30 years, presenting with class I and II malocclusion, with minimum of 2 mm crowding treated without extraction, were divided into two groups: GI (n = 8), self-ligating brackets (Easyclip Aditek), and GII (n = 8), conventional preadjusted brackets (3M Unitek)...
2016: Journal of Contemporary Dental Practice
Xiaohu Wu, Shubao Hou, Quanwei Zhang, Youji Ma, Yong Zhang, Wei Kan, Xingxu Zhao
The prevalence of enterococci was examined in 280 milk samples collected from dairy cattle diagnosed with mastitis in three provinces of western China. Sixty strains of enterococci were isolated and the species were determined based on their biochemical characters and 16S rRNA sequences. Resistance to seven antibiotic agents, frequency of seven virulence genes, and pathogenicity in Kunming mice were tested to evaluate biological risks. The correlation between the number of virulence genes and pathogenicity in Kunming mice was also evaluated...
August 1, 2016: Journal of Veterinary Medical Science
Dr Krishna Chaitanya Joshi, Dr Daljit Singh, Dr Deepali Garg, Dr Hukum Singh, Dr Monica S Tandon
OBJECTIVES: We attempt to find key points in endovascular coiling which can help us predict degree of clinical recovery, in an attempt to make the treatment of CCF safe and effective. PATIENTS AND METHODS: We analyzed a series of 15 patients with traumatic CCFs undergoing coiling by performing clinical, angiographical and radiological assessment before and at regular time periods after the procedure till 6 months. The findings were analyzed to find critical points predicting clinical outcome in each of the patients...
October 2016: Clinical Neurology and Neurosurgery
Silvia Calafiore, Andrea Perdicchi, Gianluca Scuderi, Maria Teresa Contestabile, Solmaz Abdolrahimzadeh, Santi Maria Recupero
Carotid cavernous fistulas (CCF) are vascular communications between the carotid artery and the cavernous sinus. Ophthalmologists are called to diagnose and manage the condition in cases that present with ocular features. A 73-year-old female was referred to our glaucoma center clinic. Eight years before, she had started receiving medication for glaucoma and had undergone laser iridotomy, but a satisfactory management of intraocular pressure (IOP) had not been achieved. The patient was complaining of intermittent diplopia, bilateral proptosis, and conjunctival chemosis over the past 6 months...
May 2016: Case Reports in Ophthalmology
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