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https://www.readbyqxmd.com/read/29917243/sex-specific-activation-of-sk-current-by-isoproterenol-facilitates-action-potential-triangulation-and-arrhythmogenesis-in-rabbit-ventricles
#1
Mu Chen, Dechun Yin, Shuai Guo, Dong-Zhu Xu, Zhuo Wang, Zhenhui Chen, Michael Rubart-von der Lohe, Shien-Fong Lin, Thomas H Everett, James N Weiss, Peng-Sheng Chen
KEY POINTS: It is unknown if sex difference exists in cardiac apamin sensitive small conductance Ca2+ activated K+ (SK) current (IKAS ). There is no sex difference in IKAS at basal condition. However, there is larger IKAS in female rabbit ventricles than in males during isoproterenol infusion. IKAS activation by isoproterenol leads to action potential triangulation in females, indicating its abundant activation at early phases of repolarization. IKAS activation in females induces negative Ca2+ -voltage coupling and promotes electromechanical discordant phase 2 repolarization alternans...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917240/defining-lifelong-exercise-frequency-and-arterial-stiffness-changes-in-older-adults-considerations-for-sex-differences-and-exercise-dose
#2
Bonsignore Alis, Banks Laura
No abstract text is available yet for this article.
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917237/the-extracellular-matrix-glycoprotein-tenascin-x-regulates-peripheral-sensory-and-motor-neurones
#3
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo J A Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
The extracellular matrix (ECM) is not only an integral structural molecule, but is also critical for a wide range of cellular functions. The glycoprotein tenascin-X (TNX) predominates in the ECM of tissues like skin and regulates tissue structure through anti-adhesive interactions with collagen. Monogenic TNX deficiency causes painful joint hypermobility and skin hyperelasticity, symptoms characteristic of hypermobility-Ehlers Danlos Syndrome (hEDS). hEDS patients also report consistently increased visceral pain and gastrointestinal (GI) dysfunction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917233/the-effects-of-plant-sexual-system-and-latitude-on-resistance-to-herbivores
#4
L R Rivkin, Spencer C H Barrett, Marc T J Johnson
PREMISE OF THE STUDY: The strength of plant-herbivore interactions varies in space and time, but the factors that explain this variation are poorly understood. Several lines of research suggest that variation in plant reproductive systems and latitude may explain resistance against herbivores, but how these factors jointly affect plant-herbivore interactions has not been investigated in detail. We examined the effects of latitude, sexual system, and plant gender on herbivory in Sagittaria latifolia, an aquatic plant in which populations are typically monoecious (separate female and male flowers) or dioecious (separate female and male plants)...
June 19, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29917207/impact-of-patients-nutritional-status-on-major-surgery-outcome
#5
E V Mignini, E Scarpellini, E Rinninella, E Lattanzi, M V Valeri, N Clementi, L Abenavoli, A Gasbarrini, C Rasetti, P Santori
OBJECTIVE: Surgery is a major stress factor that activates several inflammatory and catabolic pathways in man. An appropriate nutritional status allows the body to react properly to this stressor and recover in a faster and more efficient manner. On the other hand, malnutrition is related to a worse surgery outcome and to a higher prevalence of comorbidities and mortality. The aims of this study were to evaluate the nutritional status of patients undergoing major surgery and investigate the potential correlation between malnutrition and surgical outcomes...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917083/sex-differences-in-reproductive-hormones-during-mini-puberty-in-infants-with-normal-and-disordered-sex-development
#6
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29917069/winter-cholecalciferol-supplementation-at-55%C3%A2-n-has-no-effect-on-markers-of-cardiometabolic-risk-in-healthy-children-aged-4-8-years
#7
Hanne Hauger, Christian Mølgaard, Charlotte Mortensen, Christian Ritz, Hanne Frøkiær, Taryn J Smith, Kathryn Hart, Susan A Lanham-New, Camilla T Damsgaard
Background: Low serum 25-hydroxyvitamin D [25(OH)D] has been associated with unfavorable cardiometabolic risk profiles in many observational studies in children, but very few randomized controlled trials have investigated this. Objective: We explored the effect of winter-time cholecalciferol (vitamin D3) supplementation on cardiometabolic risk markers in young, white, 4- to 8-y-old healthy Danish children (55°N) as part of the pan-European ODIN project. Methods: In the ODIN Junior double-blind, placebo-controlled, dose-response trial, 119 children (mean ± SD age: 6...
June 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29917058/cross-sectional-association-of-frailty-and-arterial-stiffness-in-community-dwelling-older-adults-the-framingham-heart-study
#8
Ariela R Orkaby, Kathryn L Lunetta, Fangui J Sun, Jane A Driver, Emelia J Benjamin, Naomi M Hamburg, Gary F Mitchell, Ramachandran S Vasan, Joanne M Murabito
Background: Frailty is a risk factor for cardiovascular disease. Underlying mechanisms to explain the connection between frailty and cardiovascular disease are unclear. We sought to examine the association between frailty and arterial stiffness, a precursor of hypertension and cardiovascular disease. Methods: We conducted a cross-sectional analysis of community-dwelling Framingham Heart Study Offspring and Omni participants ≥60 years of age examined in 2005-2008...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29917051/combining-a-food-frequency-questionnaire-with-24-hour-recalls-to-increase-the-precision-of-estimating-usual-dietary-intakes-evidence-from-the-validation-studies-pooling-project
#9
Laurence S Freedman, Douglas Midthune, Lenore Arab, Ross L Prentice, Amy F Subar, Walter Willett, Marian L Neuhouser, Lesley F Tinker, Victor Kipnis
Improving estimates of individuals' dietary intakes is key to obtaining more reliable evidence for diet-health relationships from nutritional cohort studies. One approach to improvement is combining information from different self-report instruments. Previous work evaluated the gains obtained from combining information from a food frequency questionnaire (FFQ) and multiple 24-hour recalls (24HRs), based on assuming that 24HRs provide unbiased measures of individual intakes. Here, we evaluate the same approach of combining instruments, but based on the better assumption that recovery biomarkers provide unbiased measures of individual intakes...
June 18, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29917038/serum-untargeted-metabolomic-profile-of-the-dietary-approaches-to-stop-hypertension-dash-dietary-pattern
#10
Casey M Rebholz, Alice H Lichtenstein, Zihe Zheng, Lawrence J Appel, Josef Coresh
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjective measures and a few biomarkers from 24-h urine collections. Objective: The aim of the study was to use metabolomics to identify serum compounds that are associated with adherence to the DASH dietary pattern. Design: We conducted untargeted metabolomic profiling in serum specimens collected at the end of 8 wk following the DASH diet (n = 110), the fruit and vegetables diet (n = 111), or a control diet (n = 108) in a multicenter, randomized clinical feeding study (n = 329)...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29917037/high-plasma-apolipoprotein-b-identifies-obese-subjects-who-best-ameliorate-white-adipose-tissue-dysfunction-and-glucose-induced-hyperinsulinemia-after-a-hypocaloric-diet
#11
Simon Bissonnette, Nathalie Saint-Pierre, Valerie Lamantia, Catherine Leroux, Viviane Provost, Yannick Cyr, Remi Rabasa-Lhoret, May Faraj
Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29917009/clubfoot-etiology-a-meta-analysis-and-systematic-review-of-observational-and-randomized-trials
#12
Cynthia Chen, Neil Kaushal, David M Scher, Shevaun M Doyle, John S Blanco, Emily R Dodwell
BACKGROUND: Clubfoot is a common congenital anomaly with multiple potential risk factors. Identification of modifiable risk factors may minimize future incidence of clubfoot. The aim of this meta-analysis was to systematically review and analyze the best clinical evidence regarding risk factors associated with clubfoot. METHODS: Medline, Embase, and Cochrane databases were systematically searched from 1967 to May 11, 2016 for studies reporting risk factors for clubfoot...
June 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29917004/is-female-sex-an-independent-risk-factor-for-early-mortality-in-isolated-coronary-artery-bypass-graft-a-propensity-matched-analysis
#13
Andrea Garatti, Alessandro Parolari, Alberto Canziani, Eugenio Mossuto, Andrea Daprati, Ali Abu Farah, Daniele Brugnetti, Marco Ranucci, Lorenzo Menicanti
AIMS: Despite several studies reporting a higher mortality rate for women undergoing isolated coronary artery bypass graft (CABG) surgery, this issue has not been completely clarified. The aim of the current study was to determine if sex differences in CABG surgery affect adjusted operative results and operative mortality. METHODS: Between January 2005 and December 2012, 3756 consecutive patients (3009 men and 747 women) underwent isolated CABG at our institution...
June 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29916994/uric-acid-is-linked-to-cardiometabolic-risk-factors-in-overweight-and-obese-youths
#14
Empar Lurbe, María Isabel Torro, Julio Alvarez-Pitti, Josep Redon, Claudio Borghi, Pau Redon
OBJECTIVE: Observational studies have indicated that high levels of serum uric acid are associated with the risk of cardiovascular disease. The aim of the present study is to investigate the association of uric acid with individual cardiometabolic risk factors, as well as their degree of clustering, in overweight and moderate obese youth. METHODS: Three hundred and thirty-three Caucasians of both sexes (149 women), from 5-18 years of age from those who underwent an assessment of overweight/obesity...
June 18, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29916957/regional-differences-in-diffuse-idiopathic-skeletal-hyperostosis-a-retrospective-cohort-study-from-sweden-and-japan
#15
Atsuhiko Hirasawa, Yohan Robinson, Claes Olerud, Norimitsu Wakao, Mitsuhiro Kamiya, Kenta Murotani, Masataka Deie
STUDY DESIGN: We retrospectively reviewed computed tomography (CT) records of patients in Japan and Sweden, which are both aging populations. OBJECTIVE: To researche the influence of ethnicity and region on diffuse idiopathic skeletal hyperostosis (DISH) prevalence. SUMMARY OF BACKGROUND DATA: DISH can complicate non-surgical treatment of spinal fractures and often requires surgical intervention. We previously reported a prevalence of DISH in Japan that was higher than that reported in other studies...
June 18, 2018: Spine
https://www.readbyqxmd.com/read/29916952/bioimpedance-spectroscopy-imprecisely-assesses-lean-body-mass-in-pediatric-dialysis-patients
#16
Gregorio P Milani, Jaap W Groothoff, Federica A Vianello, Emilio F Fossali, Fabio Paglialonga, Sivia Consolo, Alberto Edefonti, Dario Consonni, Dewi van Harskamp, Johannes B van Goudoever, Henk Schierbeek, Carlo Agostoni, Michiel J S Oosterveld
OBJECTIVES: Alterations in body compositions are strongly associated with poor outcomes in end-stage renal disease patients. Hence, assessment of lean body mass is crucial for clinically monitoring these patients. The use of multi-frequency bioimpedance spectroscopy measurements have also been advocated, but their usefulness in children is questioned. We investigated whether their application is appropriate for lean body mass measurement in pediatric patients receiving chronic dialysis...
June 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29916929/intravenous-versus-topical-tranexamic-acid-in-total-knee-arthroplasty-both-effective-in-a-randomized-clinical-trial-of-640-patients
#17
Matthew P Abdel, Brian P Chalmers, Michael J Taunton, Mark W Pagnano, Robert T Trousdale, Rafael J Sierra, Yuo-Yu Lee, Friedrich Boettner, Edwin P Su, Steven B Haas, Mark P Figgie, David J Mayman
BACKGROUND: Tranexamic acid (TXA) reduces bleeding and the need for transfusion after total knee arthroplasty. Most literature has focused on intravenous (IV) administration of TXA, with less data available on the efficacy of topically administered TXA. This multicenter randomized clinical trial specifically assessed the efficacy of topical TXA compared with IV TXA as measured by calculated blood loss, drain output, and transfusion rates. Complications, including venous thromboembolism (VTE), were reported...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916928/linking-a-total-ankle-arthroplasty-registry-to-medicare-inpatient-claims-without-unique-identifiers
#18
Sudha R Raman, Bradley G Hammill, Robin M Queen, Samuel B Adams, Lesley H Curtis
BACKGROUND: Linking clinical registries to administrative claims data enables researchers to capitalize on the specific strengths of each data source with respect to the depth, breadth, and completeness of information. The objectives of this study were to link a health-system-based orthopaedic surgery registry to U.S. Medicare claims data without the use of unique identifiers and to assess the representativeness of the linked records. METHODS: The registry included clinical data for patients ≥65 years of age who underwent elective, inpatient total ankle arthroplasty (TAA) in a single health system during the period of 2007 through 2012...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916897/lncrna-malat1-promotes-migration-and-invasion-of-non-small-cell-lung-cancer-by-targeting-mir-206-and-activating-akt-mtor-signaling
#19
Yi Tang, GaoMing Xiao, YueJun Chen, Yu Deng
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in lung cancer. The aim of this study is to unravel the underlying mechanisms of lncRNA MALAT1 in non-small-cell lung cancer (NSCLC). A cohort of 36 NSCLC tumor tissues and adjacent normal tissues was collected postoperatively from patients with NSCLC. qRT-PCR was performed to detect the expression of MALAT1 in both NSCLC tissues and cell lines. Cell migration and invasion were monitored by wound healing assay and transwell invasion assay...
June 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29916890/aesthetic-refinement-in-the-creation-of-the-clitoris-its-preputial-hood-and-labia-minora-in-male-to-female-transsexual-patients
#20
Iván Mañero Vazquez, Oihane García-Senosiain, Trinidad Labanca, Esther Gómez Gil
BACKGROUND: In male-to-female genital sex reassignment surgery, the clitoris, its prepuce, and the labia minora remain among the most difficult structures to construct. We describe the authors' clitoroplasty and vulvoplasty technique. METHODS: All patients who underwent male-to-female sex reassignment surgery at a single center, between June 2012 and June 2016, were prospectively included. The standard pedicled island neurovascular flap of the glans penis was harvested in a letter M fashion with attached preputial skin...
June 19, 2018: Annals of Plastic Surgery
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