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https://www.readbyqxmd.com/read/30114727/association-of-changes-in-inflammation-with-changes-in-glycemia-insulin-resistance-and-secretion-a-direct-study-based-on-kora
#1
Tonia de Las Heras Gala, Christian Herder, Femke Rutters, Maren Carstensen-Kirberg, Cornelia Huth, Coen D A Stehouwer, Giel Nijpels, Casper Schalkwijk, Allan Flyvbjerg, Paul W Franks, Jacqueline Dekker, Christa Meisinger, Wolfgang Koenig, Michael Roden, Wolfgang Rathmann, Annette Peters, Barbara Thorand
AIMS: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro- (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycemia, insulin resistance and secretion (HbA1c , HOMA-IR, HOMA-ß)...
August 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30113217/identification-of-lncrnas-and-their-functional-network-associated-with-chemoresistance-in-sw1990-gz-pancreatic-cancer-cells-by-rna-sequencing
#2
Duguang Li, Xiaowei Qian, Peng Xu, Xiaodong Wang, Zhennan Li, Jianjun Qian, Jie Yao
Drug resistance is a major problem in the treatment of pancreatic cancer (PC). Long noncoding (lnc)RNAs modulate a variety of cellular processes. This study was carried out to identify lncRNAs that are differentially expressed in drug-resistant PC by next-generation RNA sequencing. We identified 205 differentially expressed lncRNAs (DELs) and 847 differentially expressed mRNAs (DEMs) in a comparison of gemcitabine-resistant and -sensitive SW1990 human PC cells. The expression levels of 12 randomly selected lncRNAs were confirmed by quantitative real-time PCR...
August 16, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/30113051/metabolic-and-genetic-response-to-probiotics-supplementation-in-patients-with-diabetic-nephropathy-a-randomized-double-blind-placebo-controlled-trial
#3
Alireza Mafi, Gholamreza Namazi, Alireza Soleimani, Fereshteh Bahmani, Esmat Aghadavod, Zatollah Asemi
This study was carried out to evaluate the effects of probiotics administration on the metabolic and genetic profiles in patients with diabetic nephropathy (DN). This was a randomized, placebo-controlled clinical trial with homeostasis model of assessment-estimated insulin resistance (HOMA-IR) as the primary and other metabolic profiles, and biomarkers of inflammation and oxidative stress as the secondary outcomes. This randomized, double-blind, placebo-controlled clinical trial was performed on 60 patients with DN...
August 16, 2018: Food & Function
https://www.readbyqxmd.com/read/30112875/inhibition-of-serotonin-synthesis-induces-negative-hepatic-lipid-balance
#4
Jun Namkung, Ko Eun Shong, Hyeongseok Kim, Chang Myung Oh, Sangkyu Park, Hail Kim
BACKGROUND: Hepatic steatosis is caused by metabolic stress associated with a positive lipid balance, such as insulin resistance and obesity. Previously we have shown the anti-obesity effects of inhibiting serotonin synthesis, which eventually improved insulin sensitivity and hepatic steatosis. However, it is not clear whether serotonin has direct effect on hepatic lipid accumulation. Here, we showed the possibility of direct action of serotonin on hepatic steatosis. METHODS: Mice were treated with para-chlorophenylalanine (PCPA) or LP-533401 to inhibit serotonin synthesis and fed with high fat diet (HFD) or high carbohydrate diet (HCD) to induce hepatic steatosis...
April 25, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30112874/synthesis-of-a-new-zinc-mixed-ligand-complex-and-evaluation-of-its-antidiabetic-properties-in-high-fat-diet-low-dose-streptozotocin-induced-diabetic-rats
#5
Muruganantham Koothappan, Roshana Devi Vellai, Iyyam Pillai Subramanian, Sorimuthu Pillai Subramanian
Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed-low dose streptozotocin induced T2DM in rats...
April 24, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30112689/impact-of-daily-incremental-change-in-environmental-temperature-on-beta-cell-function-and-the-risk-of-gestational-diabetes-in-pregnant-women
#6
Ravi Retnakaran, Chang Ye, Caroline K Kramer, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman
AIMS/HYPOTHESIS: The prevalence of gestational diabetes (GDM) is higher in summer months, possibly reflecting an association between ambient temperature and blood glucose levels. However, the specific exposure and mechanism by which temperature may affect glucose metabolism in pregnancy remains unclear. We systematically evaluated the relationships of environmental temperature and changes therein over varying durations of exposure time with beta cell function, insulin sensitivity and glucose tolerance in women undergoing antepartum screening for GDM...
August 15, 2018: Diabetologia
https://www.readbyqxmd.com/read/30112679/inpatient-glycemic-management-of-the-pregnant-patient
#7
REVIEW
Tiffany Yeh, Michele Yeung, Felicia A Mendelsohn Curanaj
PURPOSE OF REVIEW: There is a rising prevalence of type 1 diabetes (T1DM), type 2 diabetes (T2DM), and gestational diabetes (GDM) in pregnancy. Reaching and maintaining glycemic targets during and after this time are important for both the health of the mother and her baby. RECENT FINDINGS: Based on recently published guidelines from various societies, we review the diagnosis of diabetes in pregnancy, types of therapies available to maintain euglycemia, important keys to management of T1DM, T2DM, and GDM, and strategies for reaching inpatient glycemic targets during the peripartum period...
August 15, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30112394/improvement-of-adipose-macrophage-polarization-in-high-fat-diet-induced-obese-ghsr-knockout-mice
#8
Fang Yuan, Jian Ma, Xinxin Xiang, He Lan, Yanhui Xu, Jing Zhao, Yin Li, Weizhen Zhang
Purpose: Adipose tissue inflammation is the key linking obesity to insulin resistance. Over 50% of the interstitial cells in adipose tissue are macrophages, which produce inflammatory cytokines and therefore play an important role in the progression of insulin resistance. Within this classification view, macrophage biology is driven by two polarization phenotypes, M1 (proinflammatory) and M2 (anti-inflammatory). The unique functional receptor of ghrelin, growth hormone secretagogue receptor (GHSR), is a classic seven-transmembrane G protein-coupled receptor that is linked to multiple intracellular signaling pathways...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30112307/a-randomized-controlled-trial-comparing-the-metformin-oral-contraceptive-pills-and-their-combination-in-patients-with-polycystic-ovarian-syndrome
#9
Yogesh Kumar, Narendra Kotwal, Yashpal Singh, Vimal Upreti, Shrikant Somani, K V S Hari Kumar
Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by insulin resistance (IR) and hormonal dysfunction. We conducted a randomized, controlled trial comparing the effects of metformin, oral contraceptive pills (OCP) and their combination in PCOS. Materials and Methods: We randomized 90 newly diagnosed PCOS (age 18-40 year, symptom duration >6 months) patients into three groups (Group 1-Metformin, Group 2-OCP, and Group 3- Metformin + OCP) in this prospective study...
May 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/30111834/the-ire1%C3%AE-xbp1s-pathway-promotes-insulin-stimulated-glucose-uptake-in-adipocytes-by-increasing-ppar%C3%AE-activity
#10
Yoon Mi Cho, Dong Hee Kim, Kyung Hye Lee, Seong-Whan Jeong, Oh-Joo Kwon
The peroxisome proliferator-activated receptor-γ (PPARγ) improves whole-body insulin sensitivity by regulating the adipogenic and metabolic functions of mature adipocytes. We have previously demonstrated that an active splice variant of X-box binding protein 1 (XBP1s) enhances PPARγ expression during adipogenesis. In this study, we investigated the role of XBP1s, particularly with respect to PPARγ, in the mechanisms underlying insulin sensitivity in mature adipocytes. Insulin was able to stimulate XBP1s generation by activating inositol-requiring enzyme 1 (IRE1) α and was also able to increase its transcriptional activity by inducing nuclear translocation...
August 15, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/30111678/dietary-sparassis-crispa-reduces-body-fat-mass-and-hepatic-lipid-levels-by-enhancing-energy-expenditure-and-suppressing-lipogenesis-in-rats
#11
Ai Takeyama, Yasuo Nagata, Bungo Shirouchi, Chika Nonaka, Hiromu Aoki, Tsubasa Haraguchi, Masao Sato, Kei Tamaya, Hideto Yamamoto, Kazunari Tanaka
Accumulation of abdominal fat triggers metabolic syndrome, which is a cluster of metabolic abnormalities, such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, that leads to the development of diabetes and cardiovascular disease. Mushrooms have been used as a foodstuff and folk medicine worldwide. Among these mushrooms, Sparassis crispa (SC) is a relatively newly cultivated edible and medicinal mushroom, which has been reported to have anti-diabetic and anti-hypertensive properties...
August 14, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/30111469/-effect-of-intrauterine-growth-retardation-on-insulin-sensitivity-and-plasma-adiponectin-level-in-neonates
#12
Qun Wang, Xu-Dong Wang, Xin Liu, Yun Xiang, Han-Chu Liu, Ling-Kong Zeng
OBJECTIVE: To explore the effect of intrauterine growth retardation (IUGR) on insulin sensitivity in neonates and the relationship between insulin sensitivity and plasma adiponectin level. METHODS: Eighty-two term neonates with IUGR and 90 term neonates born appropriate for gestational age (AGA) were enrolled. Weight, height, head circumference and abdomen circumference of the neonates were measured within 24 hours after birth. Fasting serum glucose (FG), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), plasma insulin and adiponectin were detected in two groups on the 7th day after birth...
August 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30111365/the-multivariate-physical-activity-signature-associated-with-metabolic-health-in-children
#13
Eivind Aadland, Olav Martin Kvalheim, Sigmund Alfred Anderssen, Geir Kåre Resaland, Lars Bo Andersen
BACKGROUND: Physical activity is a cornerstone for promoting good metabolic health in children, but it is heavily debated which intensities (including sedentary time) are most influential. A fundamental limitation to current evidence for this relationship is the reliance on analytic approaches that cannot handle collinear variables. The aim of the present study was to determine the physical activity signature related to metabolic health in children, by investigating the association pattern for the whole spectrum of physical activity intensities using multivariate pattern analysis...
August 15, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/30110707/prepubertal-children-exposed-to-maternal-gestational-diabetes-have-latent-low-grade-inflammation
#14
Leena Antikainen, Jarmo Jääskeläinen, Henrikki Nordman, Raimo Voutilainen, Hanna Huopio
BACKGROUND: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children's height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. METHODS: A cohort of 135 prepubertal Caucasian children (age range 4.4-9.7 years) was studied in a controlled cross-sectional study...
August 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/30110341/altered-hepatic-glucose-homeostasis-in-anxa6-ko-mice-fed-a-high-fat-diet
#15
Rose Cairns, Alexander W Fischer, Patricia Blanco-Munoz, Anna Alvarez-Guaita, Elsa Meneses-Salas, Antonia Egert, Christa Buechler, Andrew J Hoy, Joerg Heeren, Carlos Enrich, Carles Rentero, Thomas Grewal
Annexin A6 (AnxA6) controls cholesterol and membrane transport in endo- and exocytosis, and modulates triglyceride accumulation and storage. In addition, AnxA6 acts as a scaffolding protein for negative regulators of growth factor receptors and their effector pathways in many different cell types. Here we investigated the role of AnxA6 in the regulation of whole body lipid metabolism and insulin-regulated glucose homeostasis. Therefore, wildtype (WT) and AnxA6-knockout (KO) mice were fed a high-fat diet (HFD) for 17 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/30110267/homeostasis-model-assessment-insulin-resistance-and-sensitivity-homa-ir-and-is-index-in-overweight-children-born-small-for-gestational-age-sga
#16
Aleksandra Janchevska, Zoran Gucev, Velibor Tasic, Momir Polenakovic
No abstract text is available yet for this article.
July 1, 2018: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/30109419/metabolic-alterations-associated-with-maternal-undernutrition-during-the-first-half-of-gestation-lead-to-a-diabetogenic-state-in-the-rat
#17
María Limones, Julio Sevillano, María G Sánchez-Alonso, Emilio Herrera, María Del Pilar Ramos-Álvarez
BACKGROUND: Although recent studies have investigated the effect of maternal nutrition on metabolic programming of the offspring, the question whether a nutritional insult during early gestation favours an altered metabolic state of the mother that persists during the remainder period of pregnancy, when foetal growth is maximal, remains to be answered. METHODS: To address this issue, we analysed the effect of 40% food restriction during the first 12 days of gestation on glucose tolerance, as well as on liver and adipose tissue metabolism, in Sprague-Dawley pregnant rats...
August 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/30107041/energy-metabolism-of-white-adipose-tissue-and-insulin-resistance-in-humans
#18
REVIEW
Kálmán Bódis, Michael Roden
BACKGROUND: Insulin resistance occurs in obesity, but also in lipodystrophy. Although adipose tissue controls metabolic fluxes and participates in inter-organ crosstalk, the role of energy metabolism within white adipose tissue for insulin resistance is less clear. MATERIALS AND METHODS: A Medline search identified in vivo studies in humans on energy and lipid metabolism in subcutaneous (SAT) and visceral adipose tissue (VAT). Studies in adipocyte cultures and transgenic animal models were included for the better understanding of the link between abnormal energy metabolism in adipose tissue and insulin resistance...
August 14, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30105804/crossing-family-histories-of-diabetes-and-cardiovascular-disease-leads-to-unexpected-outcomes-in-diabetic-offspring
#19
Michel Hermans, Sylvie Ahn, Michel Rousseau
BACKGROUND: To establish the isolated and crossed impacts of familial histories (FH) of early-onset coronary heart disease (EOCHD) and type 2 diabetes mellitus (T2DM) on their diabetic offsprings. METHODS: The cardiometabolic phenotype of 1098 T2DM patients was analysed according to FHs of DM and/or EOCHD, including body composition, fasting insulinemia, insulin sensitivity, β-cell function (BCF), lipids, lipoprotein(a), high-density lipoprotein (HDL) number/functionality, and micro-/macrovascular complications...
August 13, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/30104982/effects-of-hypoxia-and-bed-rest-on-markers-of-cardiometabolic-risk-compensatory-changes-in-circulating-trail-and-glutathione-redox-capacity
#20
Gianni Biolo, Filippo G Di Girolamo, Adam McDonnell, Nicola Fiotti, Filippo Mearelli, Roberta Situlin, Arianna Gonelli, Barbara Dapas, Mauro Giordano, Mitja Lainscak, Gabriele Grassi, Giorgio Zauli, Paola Secchiero, Igor Mekjavic
In chronic diseases, hypoxia and physical inactivity are associated with atherosclerosis progression. In contrast, a lower mortality from coronary artery disease and stroke is observed in healthy humans residing at high altitude in hypoxic environments. Eleven young, male volunteers completed the following 10-day campaigns in a randomized order: hypoxic ambulatory, hypoxic bed rest and normoxic bed rest. Before intervention, subjects were evaluated in normoxic ambulatory condition. Normobaric hypoxia was achieved in a hypoxic facility simulating 4000 m of altitude...
2018: Frontiers in Physiology
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