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https://www.readbyqxmd.com/read/30341898/mir-128-3p-accelerates-cardiovascular-calcification-and-insulin-resistance-through-isl1-dependent-wnt-pathway-in-type-2-diabetes-mellitus-rats
#1
Xin-Yong Wang, Xian-Zhao Zhang, Feng Li, Qing-Rong Ji
Vascular calcification is highly prevalent in patients with type 2 diabetes mellitus (T2DM), one of the most common chronic diseases with high morbidity and mortality. In recent years, microRNAs have been widely reported as potential biomarkers for the diagnosis and treatment of T2DM. We hypothesized that miR-128-3p is associated with cardiovascular calcification and insulin resistance (IR) in rats with T2DM by targeting ISL1 via the Wnt pathway. Microarray analysis was adopted to identify differentially expressed genes related to T2DM...
October 20, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30341867/the-influence-of-metformin-on-serum-carbohydrate-antigen-19-9-ca-19-9-levels-in-type-2-diabetes-mellitus-patients
#2
B S Ankit, Ritvik Agrawal, Ajeet Gadhwal, Chitresh Chahar, R P Agrawal
Objectives: Diabetes mellitus has been claimed to be a risk factor for the development of pancreatic carcinoma. CA 19-9 has a great sensitivity in detection of pancreatic adenocarcinoma. Metformin exhibits a strong and consistent antiproliferative action on several cancer cell lines including pancreatic cancer. We aim to determine the influence of metformin on CA 19-9 levels in type 2 diabetes mellitus patients. Methods: Total 193 patients with type 2 diabetes mellitus were registered for a single centre, cross-sectional study...
March 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30340496/the-effect-of-cinnamon-on-polycystic-ovary-syndrome-in-a-mouse-model
#3
Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu, Yi Guo
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in PCOS. The use of insulin-sensitizing drugs has been shown to improve both the reproductive and the metabolic aspects of PCOS. Cinnamon has been found to have insulin sensitizing effect and improve menstrual cyclicity in women with PCOS. The aim of this study was to determine the effect and mechanism of cinnamon on PCOS using a dehydroepiandrosterone (DHEA) induced PCOS mouse model...
October 19, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30339787/a-potential-novel-pathological-implication-of-serum-soluble-triggering-receptor-expressed-on-myeloid-cell-2-in-insulin-resistance-in-a-general-japanese-population-the-hisayama-study
#4
Masashi Tanaka, Takanori Honda, Hajime Yamakage, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Mao Shibata, Takayuki Inoue, Toru Kusakabe, Noriko Satoh-Asahara, Toshiharu Ninomiya
AIMS: No cohort study has examined the pathological significance of triggering receptor expressed on myeloid cell 2 (TREM2), a cell surface receptor expressed on myeloid lineage cells, and its soluble form, sTREM2, in insulin resistance in a general population. METHODS: A total of 2,742 community-dwelling Japanese individuals aged ≥40 years were divided into 4 groups according to the serum sTREM2 concentration quartiles. We examined the cross-sectional association of sTREM2 levels with anthropometric parameters and the homeostasis model assessment of insulin resistance (HOMA-IR)...
October 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30339765/zinc-supplementation-reduces-diet-induced-obesity-and-improves-insulin-sensitivity-in-rats
#5
Rutiane Ullmann Thoen, Nathaniele Nebel Barter, Elizângela Schemitt, Silvia Bona, Sabrina Fernandes, Gabriela Coral, Norma Possa Marroni, Cristiane Tovo, Renata Padilha Guedes, Marilene Porawski
Rates of obesity have been growing at alarming rates, compromising the health of the world population. Thus, the search for interventions that address the metabolic repercussions of obesity are necessary. Here we evaluated the metabolic and antioxidant effects of zinc and branched-chain amino acid (BCAA) supplementation on obese rats. Male Wistar rats were fed with high-fat/high-fructose diet (HFD) or standard diet (SD) for 19 weeks. From the 15th week until the end of the experiment, HFD and SD-fed rats received zinc (6mg/kg) or BCAA (750mg/kg) supplementation...
October 19, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/30339734/adipose-tissue-expression-of-ccl19-is-positively-associated-with-insulin-resistance
#6
Shihab Kochumon, Fatema Al-Rashed, Mohamed Abu-Farha, Sriraman Devarajan, Jaakko Tuomilehto, Rasheed Ahmad
BACKGROUND: Chemokines produced by adipose tissue (AT) are involved in the development of chronic low-grade inflammation in obese humans and rodents. AT CCL19 expression in obesity and its association with metabolic inflammation and insulin resistance is poorly understood. This study aimed to investigate the effects of CCL19 gene expression on inflammatory markers in subcutaneous AT and insulin resistance. METHODS: Subcutaneous adipose samples were collected from 56 non-diabetic (26-obese, 21-overweight, and 9-lean) individuals...
October 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30339034/psychological-factors-and-cardiovascular-disease-risk-factors-as-mediators-of-the-relationship-between-overweight-obesity-and-cognitive-function-among-school-children-in-kuala-lumpur-malaysia
#7
Serene En Hui Tung, Mohd Taib Mohd Nasir, Yit Siew Chin, Mohd Shariff Zalilah, Jamil Osman Zubaidah, Hip Seng Yim
BACKGROUND: Recent research suggests that a negative relationship exists between adiposity and cognitive function in children. However, limited information is known on how they are related. This study aimed to examine the mediators of the relationship between overweight/obesity and cognitive function among school children in Kuala Lumpur, Malaysia. METHODS: This is a cross-sectional comparison study whereby 225 overweight/obese children matched for age, sex, and ethnicity with 225 normal weight children participated in this study...
October 19, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/30338914/mir-17-family-mediated-regulation-of-pknox1-influences-hepatic-steatosis-and-insulin-signaling
#8
Dan Ye, Guohua Lou, Tianbao Zhang, Fengqin Dong, Yanning Liu
The aberrant expression of Pknox1 is associated with hepatic glucose and lipid dysmetabolism status of type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanism causing Pknox1 overexpression in this pathological status remains unclear. By using miRNA target prediction programs, we found that the 3'-UTR of the Pknox1 mRNA sequence contains highly conserved target sites of miR-17 family. In a rat model of streptozotocin and high-fat diet-induced T2DM and NAFLD complication, the increased hepatic expression of Pknox1 was consistent with decreased expressions of miR-17 family, especially miR-17 and miR-20a...
October 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30338362/purinergic-receptor-y-2-p2y-2-dependent-vcam-1-expression-promotes-immune-cell-infiltration-in-metabolic-syndrome
#9
Julian Merz, Philipp Albrecht, Sunaina von Garlen, Ibrahim Ahmed, Daniel Dimanski, Dennis Wolf, Ingo Hilgendorf, Carmen Härdtner, Katja Grotius, Florian Willecke, Timo Heidt, Heiko Bugger, Natalie Hoppe, Ulrich Kintscher, Constantin von Zur Mühlen, Marco Idzko, Christoph Bode, Andreas Zirlik, Peter Stachon
Sterile inflammation of visceral fat, provoked by dying adipocytes, links the metabolic syndrome to cardiovascular disease. Danger-associated molecular patterns, such as adenosine triphosphate (ATP), are released by activated or dying cells and orchestrate leukocyte infiltration and inflammation via the purinergic receptor P2Y2 . The gene expression of ATP receptor P2Y2 did not change in several tissues in the course of obesity, but was increased within epididymal fat. Adipose tissue from P2Y 2 -/- mice consuming high-fat diet (HFD) contained less crown-like structures with a reduced frequency of adipose tissue macrophages (ATMs)...
October 18, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/30338116/effect-of-exercise-modality-on-markers-of-insulin-sensitivity-and-blood-glucose-control-in-pregnancies-complicated-with-gestational-diabetes-mellitus-a-systematic-review
#10
REVIEW
A Cremona, C O'Gorman, A Cotter, J Saunders, A Donnelly
Background/aim: Exercise can be used as a strategy to attenuate hyperglycaemia experienced during gestational diabetes mellitus (GDM). To maximize its use for clinical management, the most effective modality should be identified. The purpose of this review is to elucidate the most effective modality of exercise on insulin sensitivity and blood glucose control in pregnant women with or at risk of GDM. Methods: A search was undertaken in MEDLINE, PubMed, Scopus, CINAHL, the Cochrane Library, Embase and the Maternity & Infant Healthcare Database...
October 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/30337653/a-low-visceral-fat-proportion-independent-of-total-body-fat-mass-protects-obese-adolescent-girls-against-fatty-liver-and-glucose-dysregulation-a-longitudinal-study
#11
Giuseppina R Umano, Veronika Shabanova, Bridget Pierpont, Mariana Mata, Jessica Nouws, Domenico Tricò, Alfonso Galderisi, Nicola Santoro, Sonia Caprio
BACKGROUND: The relative proportion of visceral fat (VAT) to subcutaneous fat (SAT) has been described as a major determinant of insulin resistance (IR). Our study sought to evaluate the effect of body fat distribution on glucose metabolism and intrahepatic fat content over time in a multiethnic cohort of obese adolescents. SUBJECTS/METHODS: We examined markers of glucose metabolism by oral glucose tolerance test, and body fat distribution by abdominal MRI at baseline and after 19...
October 18, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/30337217/decreased-serum-levels-of-ctrp12-adipolin-in-patients-with-coronary-artery-disease-in-relation-to-inflammatory-cytokines-and-insulin-resistance
#12
Reza Fadaei, Nariman Moradi, Tooba Kazemi, Elham Chamani, Nahid Azdaki, Sayed Ali Moezibady, Shiva Shahmohamadnejad, Soudabeh Fallah
Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis as the main underlying mechanism of CAD is associated with inflammation and adipose tissue dysfunction. C1q/TNF-related protein12 (CTRP12) is a newly discovered adipokine which is a paralog of adiponectin. CTRP12 has anti-inflammatory and insulin sensitizing effects. Circulating levels of this adipokine have been reported to be lower in patients with type 2 diabetes and women with polycystic ovarian syndrome. The present study was undertaken for the first time to evaluate serum levels of CTRP12 in CAD patients and its association with anthropometric and biochemical parameters...
October 15, 2018: Cytokine
https://www.readbyqxmd.com/read/30336601/associations-of-physical-behaviours-and-behavioural-reallocations-with-markers-of-metabolic-health-a-compositional-data-analysis
#13
Gregory J H Biddle, Charlotte L Edwardson, Joseph Henson, Melanie J Davies, Kamlesh Khunti, Alex V Rowlands, Thomas Yates
Standard statistical modelling has shown that the reallocation of sitting time to either standing or stepping may be beneficial for metabolic health. However, this overlooks the inherent dependency of time spent in all behaviours. The aim is to examine the associations between physical behaviours and markers of metabolic health (fasting glucose, fasting insulin, 2-h glucose, 2-h insulin, Homeostasis Model Assessment of Insulin Sensitivity (HOMA-IS), Matsuda Insulin Sensitivity Index (Matsuda-ISI) while quantifying the associations of reallocating time from one physical behaviour to another using compositional analysis...
October 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30336580/apoe4-genotype-exerts-greater-benefit-in-lowering-plasma-cholesterol-and-apolipoprotein-b-than-wild-type-e3-e3-after-replacement-of-dietary-saturated-fats-with-low-glycaemic-index-carbohydrates
#14
Bruce A Griffin, Celia G Walker, Susan A Jebb, Carmel Moore, Gary S Frost, Louise Goff, Tom A B Sanders, Fiona Lewis, Margaret Griffin, Rachel Gitau, Julie A Lovegrove
We examined the impact of APOE genotype on plasma lipids and glucose in a secondary analysis of data from a five-arm, randomised controlled, parallel dietary intervention trial ('RISCK' study), to investigate the impact of replacing saturated fatty acids (SFA) with either monounsaturated fat (MUFA) or carbohydrate of high or low glycaemic index (GI) on CVD risk factors and insulin sensitivity. We tested the impact of APOE genotype (carriage of E2 and E4 alleles versus E3/E3), determined retrospectively, on plasma lipids, lipoproteins and glucose homeostasis at baseline ( n = 469), and on the change in these variables after 24 weeks of dietary intervention ( n = 389)...
October 17, 2018: Nutrients
https://www.readbyqxmd.com/read/30335939/dual-mode-electrochemical-immunoassay-for-insulin-based-on-cu7s4-au-as-a-double-signal-indicator
#15
Yueyuan Li, Wenjuan Zhu, Qing Kang, Lei Yang, Yong Zhang, Yaoguang Wang, Qin Wei
The detection of insulin by electrochemical (EC) immunoassay is desirable but highly challenged due to the obstacle of improving accuracy, especially in single response system. In this work, based on Cu7S4-Au as a dual signal indicator, we fabricated a dual mode electrochemical immunoassay for insulin. Especially, Cu7S4 presents a strong differential pulse voltammetry (DPV) signal for the electron transfer between the Cu2+ and Cu+, without the addition of K3[Fe(CN)6] or other electron transfer mediators. Furthermore, Cu7S4 displays high sensitivity and high electrocatalytic activity towards the reduction of H2O2 through chronoamperometry (CA)...
October 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30335579/the-acute-and-chronic-effects-of-hot-water-immersion-on-inflammation-and-metabolism-in-sedentary-overweight-adults
#16
Sven P Hoekstra, Nicolette C Bishop, Steve H Faulkner, Stephen J Bailey, Christof Andreas Leicht
Regular exercise-induced acute inflammatory responses are suggested to improve the inflammatory profile and insulin sensitivity. As body temperature elevations partly mediate this response, passive heating might be a viable tool to improve the inflammatory profile. This study investigated the acute, and chronic effects of hot water immersion on inflammatory and metabolic markers. Ten sedentary, overweight males (BMI: 31.0±4.2 kg/m2 ) were immersed in water set at 39°C for 1 h (HWI) or rested for 1 h at ambient temperature (AMB)...
October 18, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30334404/cross-talk-between-apelin-and-vasopressin-in-response-to-different-osmotic-stimuli-in-type-2-diabetic-rats
#17
A F Dawood, M M Sabry, S A Estaphan, E A Mohamed, S F Younes, L A Rashed, A W Elzainy
Apelin, a peptide hormone that has been linked to insulin resistance, obesity and glucose metabolism, coexists with arginine vasopressin (AVP) in hypothalamic magnocellular neurons that control body fluid homeostasis. The significant correlation between serum glucose and serum osmolarity in uncontrolled DM indicates the need for adequate compensation, but how apelin and AVP contribute to this is still unsettled. This study aims to investigate the interaction between apelin and AVP in osmotic regulation in type 2 diabetes mellitus (T2DM), and to explore the underlying mechanism...
September 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/30334082/non-traditional-biomarkers-and-incident-diabetes-in-the-diabetes-prevention-program-comparative-effects-of-lifestyle-and-metformin-interventions
#18
Ronald B Goldberg, George A Bray, Santica M Marcovina, Kieren J Mather, Trevor J Orchard, Leigh Perreault, Marinella Temprosa
AIMS/HYPOTHESIS: We compared the associations of circulating biomarkers of inflammation, endothelial and adipocyte dysfunction and coagulation with incident diabetes in the placebo, lifestyle and metformin intervention arms of the Diabetes Prevention Program, a randomised clinical trial, to determine whether reported associations in general populations are reproduced in individuals with impaired glucose tolerance, and whether these associations are independent of traditional diabetes risk factors...
October 17, 2018: Diabetologia
https://www.readbyqxmd.com/read/30333571/imatinib-reduces-non-alcoholic-fatty-liver-disease-in-obese-mice-by-targeting-inflammatory-and-lipogenic-pathways-in-macrophages-and-liver
#19
Shefaa AlAsfoor, Theresa V Rohm, Angela J T Bosch, Thomas Dervos, Diego Calabrese, Matthias S Matter, Achim Weber, Claudia Cavelti-Weder
Macrophages have been recognized as key players in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether pharmacological attenuation of macrophages can be achieved by imatinib, an anti-leukemia drug with known anti-inflammatory and anti-diabetic properties, and how this impacts on NAFLD. We analyzed the pro- and anti-inflammatory gene expression of murine macrophages and human monocytes in vitro in the presence or absence of imatinib. In a time-resolved study, we characterized metabolic disease manifestations such as hepatic steatosis, systemic and adipose tissue inflammation as well as lipid and glucose metabolism in obese mice at one and three months of imatinib treatment...
October 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30333276/effect-of-uric-acid-on-blood-glucose-levels
#20
Wardhana Wardhana, Achmad Rudijanto
Uric acid as the final result of purine bases metabolism. In high level condition, uric acid enters the cell and act as oxidant, and acts as independent risk factor and predicts the incident of type 2 diabetes mellitus (T2DM). It may directly inactivate or through oxidative reaction that lower the nitric oxide (NO) level. Lower NO level will reduce insulin uptake in tissues and reduce in GLUT4 translocation in cell that will effect the blood glucose level. The High level of uric acid or hyperuricemia makes oxidative stress by inducing the production of reactive oxygen species (ROS) which interferes the insulin signalling pathway,creates inflammatory  state that reduced the insulin sensitivity,blood glucose uptake and metabolism, also reducing the insulin production from pancreatic islet cells...
July 2018: Acta Medica Indonesiana
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