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Deniz Özel, Mehmet Cemal Erşan, Betül Duran Özel
No abstract text is available yet for this article.
August 2018: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
Yoon Gon Lee, Ungsoo Samuel Kim
PURPOSE: To evaluate the response to corticosteroid therapy as a primary treatment for ocular myasthenia gravis. METHODS: Patients diagnosed as having ocular myasthenia gravis by an acetylcholine receptor binding antibody test between January 2011 and September 2015 were included in the study and started receiving treatment with a corticosteroid. Patients with a blowout fracture, hyperthyroidism, diabetes mellitus, hypertension, cardiovascular disease, or history of strabismus surgery were excluded...
July 27, 2018: Journal of Pediatric Ophthalmology and Strabismus
Eugene A Lowry, Steven L Mansberger
PURPOSE: To determine the proportion of patients in the US population who are receiving long-term pressure lowering medication but deny having a diagnosis of glaucoma or elevated intraocular pressure. METHODS: The National Health and Nutrition Examination Survey (NHANES) is a home-based survey of a cross-sectional, representative, stratified sample of the US population every two years. Questions on prescription medication use are asked every survey cycle and patients were questioned whether they had ever been diagnosed with glaucoma or elevated intraocular pressure in the 2005-2006 and 2007-2008 surveys...
July 27, 2018: Journal of Glaucoma
G Brzan Simenc, J Ambrozic, K Prokselj, N Tul, M Cvijic, T Mirkovic, M Lucovnik
BACKGROUND: Ultrasound measurements of optic nerve sheath diameter (ONSD) and optic disc height (ODH) measured outside pregnancy correlate with intracranial hypertension. Data on the usefulness of ocular ultrasonography in preeclampsia are limited. OBJECTIVE: To determine whether ONSD and ODH are greater in patients with features of severe preeclampsia compared to healthy controls. METHODS: Consecutively admitted patients with severe preeclampsia (according to the ACOG Task Force on Hypertension in Pregnancy) and healthy term control pregnant women were included in this prospective observational study...
July 4, 2018: International Journal of Obstetric Anesthesia
Jaime E Ordóñez, Angélica Ordóñez, Urpy M Osorio
OBJECTIVE: To estimate cost-effectiveness of trabecular micro bypass stent versus laser trabeculoplasty or medications only, for patients with open-angle glaucoma in setting of Colombian System Health. METHODS: This is a cost-effectiveness analysis that based its assumptions in external data sources, used to extrapolate the quality of life related to health, survival and costs. A Markov model, with stages from 0 (ocular hypertension without glaucoma) to 5 and bilateral blindness, was developed inclusive of Colombian older than 40 years in 2018, from a societal perspective, comparing trabecular micro-bypass stents versus, laser trabeculoplasty, timolol+dorzolamide+brimonidine, timolol+dorzolamide+latanoprost, or timolol+dorzolamide+brimatoprost, in terms of clinical and economic outcomes over a lifetime horizon...
July 27, 2018: Current Medical Research and Opinion
Dan Călugăru, Mihai Călugăru, Ştefan Ţălu
AIM: To prospectively evaluate the cumulative prevalence and the management of ocular hypertension (OH) in patients with unilateral acute central/hemicentral retinal vein occlusions (C/HCRVOs) over the course of 3y. METHODS: The study included 57 patients with unilateral acute C/HCRVOs. All patients underwent a comprehensive ophthalmological examination of both eyes. OH associated with C/HCRVO in patients showing a score >5% for the risk of conversion to primary open angle glaucoma (POAG) was treated with OH medication...
2018: International Journal of Ophthalmology
Subha Nasir-Ahmad, Rachael Cordina, Gerald Liew, Peter McCluskey, David Celermajer
In recent years, there has been a rise in the number patients with CHD surviving into adulthood. Many have complications related to their CHD or its treatments, outside the heart, including ocular abnormalities. The objective of this review is to highlight the ocular abnormalities that occur in adults with CHD, either from their condition or related to the common drugs prescribed to manage it. In particular, we reviewed the effects of cyanosis, coarctation of the aorta, endocarditis, and the side effects of Sildenafil and Amiodarone...
August 2018: Cardiology in the Young
Ryan R Riahi, Philip R Cohen
The eyebrows frame the upper margin of the orbit and are an essential feature of the facial landscape. Eyebrow hypotrichosis, also known as madarosis, is characterized by a lack of growth or loss of eyebrow hair. Eyebrow loss can have cosmetic, functional, and social consequences. Eyebrow hypotrichosis can be idiopathic or related to an underlying condition. Bimatoprost 0.03% solution is a prostamide F2α analog indicated for the treatment of glaucoma and ocular hypertension that has also demonstrated efficacy for hair growth; indeed, it is currently approved by the Food and Drug Administration for the treatment of eyelash hypotrichosis...
May 21, 2018: Curēus
Kevin M Miller, Alan Kuo, Michael D Olson, Samuel Masket
PURPOSE: To assess the safety and efficacy of Morcher 67B black iris diaphragm intraocular lens (IOL) implantation for managing large iris defects and aphakia. SETTING: Stein Eye Institute, UCLA, Los Angeles, California, USA. DESIGN: Prospective case series. METHODS: The demographic, preoperative, and postoperative data on patients implanted with a black iris diaphragm IOL and followed to 1 year were reviewed. Safety measures included loss of corrected distance visual acuity (CDVA), perioperative complications, adverse events, and secondary surgical interventions...
June 2018: Journal of Cataract and Refractive Surgery
Nitin Nema, Sonam Verma, Ravindra Kumar
PURPOSE: Thromboembolic phenomenon is one of the causes of retinal vein occlusion (RVO) which is in fact a multifactorial disease. Therefore, we aimed to study methylenetetrahydrofolate reductase gene polymorphism (MTHFR C677T) and factor V Leiden as genetic risk factors of RVO. MATERIALS AND METHODS: A total of 50 (19 males and 31 females) cases of RVO were compared with 50 age- and sex-matched (21 males and 29 females) controls. Complete ocular examination was done for all samples...
April 2018: Taiwan Journal of Ophthalmology
Benjamin M Davis, Milena Pahlitzsch, Li Guo, Shiama Balendra, Parth Shah, Nivedita Ravindran, Giulia Malaguarnera, Claudia Sisa, Ehtesham Shamsher, Hisham Hamze, Abdinasir Noor, Acom Sornsute, Satyanarayana Somavarapu, M Francesca Cordeiro
Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione) is a polyphenol extracted from turmeric that has long been advocated for the treatment of a variety of conditions including neurodegenerative and inflammatory disorders. Despite this promise, the clinical use of curcumin has been limited by the poor solubility and low bioavailability of this molecule. In this article, we describe a novel nanocarrier formulation comprising Pluronic-F127 stabilised D-α-Tocopherol polyethene glycol 1000 succinate nanoparticles, which were used to successfully solubilize high concentrations (4...
July 23, 2018: Scientific Reports
Reiko Yamagishi-Kimura, Megumi Honjo, Makoto Aihara
We explored the involvement of FP receptor and endogenous prostaglandins (PGs) in transient ocular hypertension (OH) induced by PGE2 or PGF2α in mouse eyes. PGE2 and PGF2α were topically applied to induce transient OH in Wild-type (WT) and FP-, EP1-, EP2-, and EP3-deficient (knockout [KO]) mice. To suppress endogenous PG production, the non-steroidal anti-inflammatory drug nepafenac was applied topically before treatment. PGE2 and PGF2α induced significant OH in the WT, FPKO, and EP1-3KO mice compared to the control 30 min after instillation, and the increase in IOP at 30 or 60 min after instillation in FPKO mice was significantly higher than that in the WT mice...
July 23, 2018: Scientific Reports
Elyse Jabbour, Georges Azar, Joelle Antoun, Hampig Raphael Kourie, Youssef Abdelmassih, Alexandre Jalkh
PURPOSE: To evaluate the risk factors for elevated intraocular pressure (IOP) after pars plana vitrectomy (PPV) with silicone oil injection (SOI). PROCEDURES: This prospective interventional study included 254 consecutive eyes receiving PPV with SOI. RESULTS: Elevated IOP developed in 48% of the eyes postoperatively. The onset of IOP elevation was early (≤1 week) in 61.5% of the eyes, intermediate (1-6 weeks) in 28.7%, and late (> 6 weeks) in 9...
July 23, 2018: Ophthalmologica. Journal International D'ophtalmologie
Vallinayagam Muthu Krishnan, Pandian Datta Gulnar, Rao Vasudev Anand, Chellappa Vijayakumar, Gopal Balasubramaniyan
Background Normal tension glaucoma (NTG) is a clinical entity that poses a diagnostic and therapeutic challenge. The study elaborates ocular and systemic risk factors of NTG in the South Indian population. It determines the correlation between risk factors and severity of glaucomatous damage. Methods This descriptive study was done on 81 eyes of 41 patients. A brief history of hypertension, heart disease, migraine, and family history of glaucoma were noted. The parameters measured include blood pressure, lipid profile, visual acuity, refraction, intraocular pressure (IOP) by applanation tonometry, diurnal variation, slit lamp biomicroscopy, central corneal thickness (CCT), and perimetry (Humphrey 24-2)...
May 16, 2018: Curēus
Alexander C Barnes, Careen Y Lowder, Angela P Bessette, Kimberly Baynes, Sunil K Srivastava
BACKGROUND AND OBJECTIVE: To report on the use of intravitreal steroids in the management of acute zonal occult outer retinopathy (AZOOR), a rare disorder affecting the outer retina. PATIENTS AND METHODS: Retrospective case series of nine eyes of five patients with AZOOR who received intravitreal triamcinolone acetonide (IVTA), dexamethasone intravitreal implant, and/or fluocinolone acetonide implant. Treatment response was determined by reported symptoms and multimodal imaging findings...
July 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Wesley Chan, Si Xi Zhao, Aaron Winter, Hesham Lakosha, R Rishi Gupta
Purpose: Hypertensive emergency usually presents to ophthalmologists in the form of hypertensive retinopathy. We present a case of hypertensive emergency that presented as bilateral transient myopic shift due to ciliary body detachment in the absence of any retinal pathology. The purpose of this paper is to showcase another ocular manifestation of hypertensive emergency. Observations: A 35 year-old female with a blood pressure of 192/114 mmHg presented to the emergency department with headache and acute onset blurry vision...
September 2018: American Journal of Ophthalmology Case Reports
Angelo P Tanna, Mark Johnson
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow pathway actively regulate conventional outflow resistance was proposed in the 1990s and systematically pursued, exposing novel cellular and molecular mechanisms of intraocular pressure (IOP) regulation. The critical discovery that pharmacologic manipulation of the cytoskeleton of outflow pathway cells decreased outflow resistance placed a spotlight on the Rho kinase pathway that was known to regulate the cytoskeleton...
July 11, 2018: Ophthalmology
Janusz Skrzypecki, Tymoteusz Żera, Marcin Ufnal
BACKGROUND: Accumulating evidence supports a role of gut bacterial metabolites in arterial blood pressure (BP) regulation. Since the mechanisms controlling intraocular pressure (IOP) and BP overlap, we hypothesized that butyrate, a bacterial metabolite, might affect both IOP and BP. METHODS: IOP, BP and heart rate (HR) were measured at baseline and after the intraperitoneal administration of either butyrate or a vehicle (0.9% NaCl) in anaesthetized normotensive Wistar-Kyoto rats (WKY) and Spontaneously Hypertensive rats (SHR)...
July 11, 2018: Journal of Glaucoma
Marta Misiuk-Hojlo, Maria Pomorska, Malgorzata Mulak, Marek Rekas, Joanna Wierzbowska, Marek Prost, Jaromir Wasyluk, Wojciech Lubinski, Karolina Podboraczynska-Jodko, Wanda Romaniuk, Renata Kinasz, Renata Ortyl-Markiewicz, Lucyna Mocko, Anna Zaleska-Zmijewska, Dariusz Rokicki, Christophe Baudouin
PURPOSE: To assess tolerability and efficacy following a switch from benzalkonium chloride-latanoprost to preservative-free latanoprost in patients with glaucoma or ocular hypertension. METHODS: A total of 140 patients with glaucoma or ocular hypertension controlled with benzalkonium chloride-latanoprost for at least 3 months were switched to treatment with preservative-free latanoprost. Assessments were made on days 15, 45, and 90 (D15, D45, and D90) and included best-corrected visual acuity, intraocular pressure, slit lamp examination, fluorescein staining, tear film break-up time, patient symptom evaluation, and subjective estimation of tolerability...
July 1, 2018: European Journal of Ophthalmology
Fiona Costello, Lasse Malmqvist, Steffen Hamann
An elevated optic nerve head can be an ominous sign, sometimes signifying an underlying basis for raised intracranial pressure. Alternatively, patients may harbor a different mechanism for this optic nerve head appearance, including optic disc drusen (ODD), which does not confer any life-threatening implications. It is important to refine the approach to distinguishing ODD from papilledema because this is a relatively common, and important, conundrum encountered in clinical practice. Optical coherence tomography (OCT) is a noninvasive, readily accessible, and cost-effective ocular imaging technique that can improve the diagnostic accuracy for detecting ODD; or, instead, increase the index of suspicion for papilledema, thus prompting additional investigations needed to identify (or exclude) potential causes of raised intracranial pressure...
July 12, 2018: Asia-Pacific Journal of Ophthalmology
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