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Cristiano de Queiroz Mendonca, Marcelle Vieira Freire, Simone Santana Viana, Mayo Kayann Guerra Silva Tavares, Wallace Marcelo Almeida Silva, Rosana Cipolotti
OBJECTIVE: To characterize ocular manifestations (OM) of pediatric patients treating for acute lymphoblastic leukemia (ALL) and to evaluate whether they are associated with well-described predictive risk factors for relapse, protocol (1999 or 2009), gender and cerebrospinal fluid infiltration. METHODS: A prospective cohort study was conducted in children and adolescents with ALL from January 2013 to December 2017. The patients underwent ophthalmologic evaluations before starting treatment (D0), on the eighth day (D8), at the 28th day (D28), and at six months (D6 months)...
November 29, 2018: Leukemia Research
Hyung Bin Lim, Min Woo Lee, Jae Hyeong Park, Kyeung Min Kim, Young Joon Jo, Jung Yeul Kim
OBJECTIVE: To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. DESIGN: Retrospective, cross-sectional study. METHODS: A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2)...
November 28, 2018: American Journal of Ophthalmology
Darin Sakiyalak, Yuwared Chattagoon
Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT. Patients and methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted...
2018: Clinical Ophthalmology
Xinxiao Gao, Carl H Park, Krista Dedrick, Durga S Borkar, Anthony Obeid, Shae Reber, Jay Federman
PURPOSE: To determine the incidence of diabetic retinopathy (DR) and other ocular findings in previously diagnosed diabetes using telehealth retinal screening with nonmydriatic fundus photography (nFP) in primary care physicians' offices. METHODS: A retrospective study based on electronic chart review was performed. All diabetic patients who participated in the Wills Eye Hospital (WEH) telehealth retinal screening program from July 1, 2012 to February 20, 2017 were included...
November 27, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Ian Pitha, Ericka Oglesby, Amanda Chow, Elizabeth Kimball, Mary Ellen Pease, Julie Schaub, Harry Quigley
Purpose: We evaluated prevention of transforming growth factor β (TGFβ)-induced transdifferentiation of cultured scleral fibroblasts to myofibroblasts by rho-associated protein kinase (ROCK) inhibitors. Additionally, we tested whether local delivery of ROCK inhibitors reduced scleral fibroblast proliferation in response to chronic intraocular pressure (IOP) elevation. Methods: Primary human peripapillary sclera (PPS) fibroblasts were cultured and treated with TGFβ to induce myofibroblast transdifferentiation, as determined by immunoblot assessment of α smooth muscle actin (SMA) levels and collagen gel contraction...
November 2018: Translational Vision Science & Technology
S Lazreg, Z Merad, M T Nouri, R Garout, A Derdour, N Ghroud, R Kherroubi, M Meziane, S Belkacem, O Ouhadj, C Baudouin, M Tiar
GOALS: To assess the efficacy and safety of preservative-free timolol 0.1% gel in patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). METHODS: In this multicenter, open-label, non-controlled clinical trial in Algeria, treatment-naïve patients with intraocular pressure (IOP)>20mmHg and<31mmHg (treatment-naïve patients, group 1) and patients with IOP controlled by current ocular monotherapy but presenting with local intolerance in at least one eye (intolerant patients; group 2) were eligible...
November 23, 2018: Journal Français D'ophtalmologie
Mae O Gordon, Eve J Higginbotham, Dale K Heuer, Richard K Parrish, Alan L Robin, Patricia A Morris, Deborah A Dunn, Bradley S Wilson, Michael A Kass
PURPOSE: To assess the impact of a masked Endpoint Committee on estimates of the incidence of primary open angle glaucoma (POAG), treatment efficacy and statistical power of the Ocular Hypertension Treatment Study-Phase 1, 1994-2002 (OHTS-1). DESIGN: Retrospective inter-rater reliability analysis of endpoint attribution by the Endpoint Committee METHODS: After study closeout, we re-calculated estimates of endpoint incidence, treatment efficacy and statistical power using all-cause endpoints and POAG endpoints...
November 21, 2018: American Journal of Ophthalmology
L Agbahoungba, S Alamou, C Abouki, A Djossou-Doutetien, R Lawani, S Tchabi
INTRODUCTION: Intravitreal injections of medication are designed to obtain a high concentration in the posterior segment. We conducted a retrospective study of our practice of intravitreal injections to assess safety of the technique and short- and medium-term tolerability, and to analyze indications and the complications. PATIENTS AND METHODS: This analytic retrospective study focused on consecutive patients treated with intravitreal injections for the period of January 2015 to June 2016 in the "Lumière" ohthalmology clinic in Cotonou, with incidents or accidents during the injection procedure as a measure of safety...
November 20, 2018: Journal Français D'ophtalmologie
Lee J Holland, Ken Mitchell Ranzcr, John D Harrison, Damien Brauchli, Yun Wong, Timothy J Sullivan
PURPOSE: The main objective was to report the epidemiology, clinical manifestations, angiography features, treatment modality and post-treatment outcomes in patients diagnosed with carotid cavernous fistulas (CCF). METHODS: A retrospective review of the medical imaging database in conjunction with medical records from 2004 to 2017 at the Royal Brisbane and Women's Hospital (RBWH) was conducted.We identified 39 patients with CCF (16 direct, 23 indirect). A total of 37 diagnoses were confirmed by direct catheter angiography...
November 22, 2018: Orbit
Sean Duggan
Omidenepag isopropyl ophthalmic solution 0.002% (EYBELIS® ) is a selective prostaglandin E2 receptor 2 agonist with a non-prostaglandin structure that is being developed by Ube Industries and Santen Pharmaceutical in Japan, Singapore and the USA for the treatment of glaucoma and ocular hypertension. Based on results from phase III trials, omidenepag isopropyl ophthalmic solution 0.002% received approval in Japan in September 2018 for this indication. This article summarizes the milestones in the development of omidenepag isopropyl ophthalmic solution 0...
November 21, 2018: Drugs
James R Tribble, Pete A Williams, Bruce Caterson, Frank Sengpiel, James E Morgan
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma. Retinal ganglion cell neurites are surrounded by a specialised glycosaminoglycan extracellular matrix which inhibits dendritic plasticity. Since digestion of the extracellular matrix by chondroitinase ABC has been reported to have neuro-regenerative and neuro-plastic effects within the central nervous system, we explored its potential for dendritic recovery in a rat model of ocular hypertension...
November 21, 2018: Molecular Brain
Xiang-Yuan Song, Zhen Puyang, Ai-Hua Chen, Jin Zhao, Xiao-Jiao Li, Ya-Ying Chen, Wei-Jun Tang, Yu-Yan Zhang
Ocular hypertension (OHT), the common situation in adult patients in the outpatients, occurs ∼5% worldwide. However, there are still some practical problems in differentiation of OHT with early primary open-angle glaucoma (POAG) using current standard methods. Application of high resolution diffusion tensor imaging (DTI) enables us to the differentiate axonal architecture of visual pathway between POAG and OHT subjects. Among 32 POAG patients recruited (15 OHT and 14 control subjects), 62.5% of glaucoma were in early stage for the current study...
2018: Frontiers in Human Neuroscience
Ben Mead, Zubair Ahmed, Stanislav Tomarev
Purpose: To determine if bone marrow-derived stem cell (BMSC) small extracellular vesicles (sEV) promote retinal ganglion cell (RGC) neuroprotection in the genetic DBA/2J mouse model of glaucoma for 12 months. Methods: BMSC sEV and control fibroblast-derived sEV were intravitreally injected into 3-month-old DBA/2J mice once a month for 9 months. IOP and positive scotopic threshold responses were measured from 3 months: IOP was measured monthly and positive scotopic threshold responses were measured every 3 months...
November 1, 2018: Investigative Ophthalmology & Visual Science
Lisa Hark, Megan Acito, Jennifer Adeghate, Jeffrey Henderer, Joseph Okudolo, Kunal Malik, Jeanne Molineaux, Rita Eburuoh, Tingting Zhan, L Jay Katz
Blindness from glaucoma can be prevented by early detection and treatment. Telemedicine improves access to treatment in high-risk populations that face barriers to receiving adequate ophthalmic care. We used a practice-based telemedicine screening model at two health centers. Telemedicine imaging of the fundus and optic nerve, followed by a complete eye exam at the same location for participants with abnormal findings, unreadable images, or ocular hypertension (OHTN), was performed. A total of 182 participants were screened, of whom 108 qualified for a complete eye exam...
2018: Journal of Health Care for the Poor and Underserved
L M Hassman, M M Chung, M Gonzalez, A P Bessette
PURPOSE: To describe an uncommon presentation of ocular infection caused by human herpes simplex virus 2 (HSV-2). METHODS: Case report. RESULTS: A 32-year-old female with no prior history of mucocutaneous herpesvirus infection presented with a minimally painful hypertensive granulomatous panophthalmitis and optic neuropathy that was initially suspected to be orbital cellulitis. Her disease progressed despite antibiotic and steroid treatment, and HSV-2 was ultimately identified in the vitreous...
November 16, 2018: Ocular Immunology and Inflammation
M H Pei, C Zhao, F Gao, M F Zhang
Objective: To investigate the clinical features of glucocorticoid eye drops induced ocular hypertension in pediatric and adult uveitic eyes. Methods: Retrospective survey of consecutive uveitic patients attending referral service at Peking Union Medical College Hospital from March 2013 to August 2017. Incidences of glucocorticoid eye drops induced ocular hypertension were compared between the pediatric and adult uveitic groups. The clinical patterns of 1% prednisolone acetate eye drops induced ocular hypertension in pediatric and adult uveitic eyes were also investigated...
November 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Nimesh A Patel, Parth Shah, Nicolas A Yannuzzi, Zubair Ansari, Jill S Zaveri, Nidhi Relhan, Basil K Williams, Ajay E Kuriyan, Christopher R Henry, Jayanth Sridhar, Luis Haddock, Jorge A Fortun, Thomas A Albini, Janet L Davis, Harry W Flynn
Purpose: To report the visual outcomes and complications of scleral fixated intraocular lenses (IOLs) using Gore-Tex suture. Methods: The current study is a retrospective noncomparative case series including patients who underwent scleral fixation of IOL (Akreos AO60) using Gore-Tex suture from August 2015 to March 2017 at a university teaching center. Primary outcome measures were visual acuity and complications at last follow-up. Results: The current study included 49 eyes of 48 patients...
2018: Clinical Ophthalmology
Daniel J Oh, Judy L Chen, Thasarat S Vajaranant, Mark S Dikopf
Brimonidine tartrate is a commonly used eyedrop for short- and long-term lowering of intraocular pressure. Its use has been popularized due to its effects on aqueous suppression and uveoscleral outflow, as well as the suggestion of neuroprotection. Although available with alternative preservative vehicles, brimonidine is associated with high rates of local allergy and is contraindicated in breastfeeding women, neonates, young children, and the elderly due to risk of central nervous system depression. Other topical agents with differing advantages have challenged brimonidine's role in the treatment algorithm of ocular hypertension and glaucoma...
November 8, 2018: Expert Opinion on Pharmacotherapy
Robert N Weinreb, Jason Bacharach, Robert D Fechtner, Malik Y Kahook, David Wirta, Steve Burmaster, Xiangyi Meng, Douglas A Hubatsch
PURPOSE: To determine the intraocular pressure (IOP)-lowering effect of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) over a 24-hour period. DESIGN: Prospective, multicenter, double-masked, parallel-group clinical trial conducted at 16 academic and non-academic sites in the USA. PARTICIPANTS: Subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT) aged ≥18 years, with mean baseline IOP measurements in at least one eye of ≥21 and <28 mmHg...
November 4, 2018: Ophthalmology
Isabeau Houben, Julie De Zaeytijd, Catherine Deghislage, N Andrew Frost, Ivo Nijs, Joachim Van Calster
PURPOSE: To evaluate the efficacy of dexamethasone intravitreal implants (DEX implant) in patients with treatment-resistant macular edema (ME) owing to branch and central retinal vein occlusion (BRVO/CRVO), and the influence of prior vitrectomy on this treatment. METHODS: Multicenter retrospective chart review was performed on 40 CRVO and 32 BRVO eyes with persistent ME despite intravitreal anti-vascular endothelial growth factor agents and/or intravitreal triamcinolone, and/or laser therapy...
November 7, 2018: Journal of Ocular Pharmacology and Therapeutics
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