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https://www.readbyqxmd.com/read/30318741/comparison-between-90-degree-and-360-degree-selective-laser-trabeculoplasty-slt-a-2-year-follow-up
#1
Kozar Tawfique, Pardis Khademi, Laurence Quérat, Joobin Khadamy, Enping Chen
PURPOSE: To compare the effect of 90- and 360-degree selective laser trabeculoplasty (SLT) as primary or supplement therapy in patients with glaucoma and ocular hypertension (OHT). METHODS: Patients (>30 years old) with OHT, primary open-angle glaucoma (OAG), pigmentary glaucoma or pseudoexfoliative glaucoma were enrolled in a prospective randomized clinical trial. Patients were sequentially randomized to either 90- or 360-degree SLT. Their intraocular pressure (IOP) was monitored...
October 15, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30315650/metipranolol-promotes-structure-and-function-of-retinal-photoreceptors-in-the-rd10-mouse-model-of-human-retinitis-pigmentosa
#2
Yogita Kanan, Mahmood Khan, Valeria E Lorenc, Da Long, Rishi Chadha, Jason Sciamanna, Ken Green, Peter A Campochiaro
Metipranolol is a β-adrenergic receptor antagonist that is given orally for the treatment of hypertension and also applied topically to the cornea for treating glaucoma. It also inhibits nitrosative stress which has previously been shown to be the cause of cone photoreceptor death in retinitis pigmentosa (RP). In this study, we tested the hypothesis that metipranolol protects photoreceptor structure and function in the mouse model rd10. At P35, compared with vehicle-treated rd10 mice in which rod degeneration was nearly complete, rd10 mice given daily subcutaneous injections of 40 mg/kg of metipranolol had reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer (ONL) thickness, and substantially more staining for rhodopsin...
October 13, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/30315616/heterogeneity-in-arterial-hypertension-and-ocular-perfusion-pressure-definitions-towards-a-consensus-on-blood-pressure-related-parameters-for-glaucoma-studies
#3
João Barbosa-Breda, Luis Abegão-Pinto, Karel Van Keer, Danilo A Jesus, Sophie Lemmens, Evelien Vandewalle, Amândio Rocha-Sousa, Ingeborg Stalmans
PURPOSE: Glaucoma studies have long taken into account the blood pressure (BP) status of patients. This study summarizes and evaluates the impact of the different criteria that have been used for BP-related variables in glaucoma research. METHODS: Studies included in two meta-analyses that reviewed the role of BP in glaucoma were analyzed. Additional studies published after the search periods of the meta-analyses were also included. Criteria for the definition of arterial hypertension and other BP-related variables, such as mean arterial pressure (MAP) and mean ocular perfusion pressure (MOPP), were retrieved...
October 12, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30310697/normative-values-of-peripapillary-retinal-nerve-fiber-layer-thickness-in-a-middle-eastern-population
#4
Mouna M Al-Sa'ad, Amjad T Shatarat, Justin Z Amarin, Darwish H Badran
Purpose: Peripapillary retinal nerve fiber layer (pRNFL) thickness is subject to high variability. Normative values of pRNFL thickness remain undocumented in the Middle East. The aim of our study is to assess the normative values of pRNFL thickness in a Middle Eastern population. Methods: A retrospective chart review of 74 patients was conducted. Outpatients who had presented to the ophthalmology clinic at the Jordan University Hospital between January 2016 and July 2018 were consecutively sampled...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/30310137/novel-classification-of-early-stage-systemic-hypertensive-changes-in-human-retina-based-on-octa-measurement-of-choriocapillaris
#5
Kei Takayama, Hiroki Kaneko, Yasuki Ito, Keiko Kataoka, Takeshi Iwase, Tetsuhiro Yasuma, Toshiyuki Matsuura, Taichi Tsunekawa, Hideyuki Shimizu, Ayana Suzumura, Eimei Ra, Tomohiko Akahori, Hiroko Terasaki
The traditional classification of hypertensive retinopathy was based on the Keith-Wagener-Barker (KWB) grading, which is a subjective scaling system, and it is difficult to distinguish between the first and second grades. Retinal and choroidal vasculatures are affected by systemic hypertension, although retinal vasculature changes with age, axial length, intraocular pressure, and retinal diseases. It is necessary to establish a new objective method to assess hypertensive vascular changes. In the present study, we have examined the vasculature of the macular choriocapillaris in order to establish a new objective method to assess hypertensive vascular changes using optical coherence tomography angiography (OCTA)...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30308563/incidence-and-risk-factors-for-hypotony-after-25-gauge-pars-plana-vitrectomy-with-nonexpansile-endotamponade
#6
Michael Mimouni, Hamza Abualhasan, Laura Derman, Assaf Feldman, Fares Mazzawi, Yoreh Barak
PURPOSE: The purpose of this study was to assess the incidence and risk factors for early postoperative hypotony after 25-gauge pars plana vitrectomy with nonexpansile endotamponade. METHODS: A retrospective study of consecutive patients who underwent 25-G pars plana vitrectomy. Hypotony was defined as an intraocular pressure of 5 mmHg or less after surgery and ocular hypertension as an intraocular pressure greater than 21 mmHg. RESULTS: Overall, 307 eyes of 307 patients with a mean age of 61...
October 9, 2018: Retina
https://www.readbyqxmd.com/read/30308561/ocular-hypertension-after-intravitreal-injection-of-2-mg-triamcinolone
#7
Philip P Storey, Anthony Obeid, Maitri Pancholy, Jake Goodman, Durga Borkar, Daniel Su, Carl Regillo
PURPOSE: To report the incidence and course of ocular hypertension after intravitreal injection of 2-mg triamcinolone acetonide (IVT). METHODS: In a retrospective, consecutive series, all patients receiving 2-mg IVT at a single institution between March 1, 2012, and March 1, 2017, with a minimum of 3-month follow-up were reviewed. Ocular hypertension was defined as an intraocular pressure (IOP) measurement over 24 mmHg at any follow-up visit after IVT. Patients receiving topical, periocular, or intravitreal corticosteroid other than 2-mg IVT were excluded...
October 9, 2018: Retina
https://www.readbyqxmd.com/read/30305959/retrospective-comparison-of-27-gauge-and-25-gauge-microincision-vitrectomy-surgery-with-silicone-oil-for-the-treatment-of-primary-rhegmatogenous-retinal-detachment
#8
Jie Li, Bo Zhao, Sanmei Liu, Fang Li, Wentao Dong, Jie Zhong
Aim: To retrospectively compare the safety and effectiveness of 27-gauge (27G) microincision vitrectomy surgery (MIVS) with 25-guage (25G) MIVS for the treatment of primary rhegmatogenous retinal detachment (RRD) with silicone oil tamponade. Methods: Ninety-two patients with RRD who underwent MIVS from May 1, 2015, to June 30, 2017, were included in this study. Fifty-eight eyes underwent 25G MIVS and 34 eyes underwent 27G MIVS. We analyzed the characteristics of the patients, surgical time, main clinical outcomes, and rate of complications...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/30302411/lifespan-reduction-due-to-neoplasia-is-nullified-by-pseudoexfoliation-syndrome
#9
Jon Klokk Slettedal, Leiv Sandvik, Amund Ringvold
Background: Pseudoexfoliation syndrome (PES) is a common eye condition, indicating a risk of various eye diseases. Whether or not PES has extra-ocular physiological or even pathophysiological implications has been a matter of controversy for years. Methods: In total 1888 persons were examined for PES in 1985-86. Of these, 1864 (98·7%) had died and were therefore available for analysis by 01.01.2016. Age and cause(s) of death were recorded. 9 diagnostic groups (cardiovascular disease, cerebrovascular disease, neoplasms, systemic hypertension, diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), Parkinson's disease, aortic aneurysm (AA), and amyloidosis) based on ICD-coding were analyzed for both a possible association between PES and lifespan, as well as PES and specific systemic diseases...
October 2018: Heliyon
https://www.readbyqxmd.com/read/30301370/objective-ocular-surface-tolerance-in-patients-with-glaucoma-treated-with-topical-preserved-or-unpreserved-prostaglandin-analogues
#10
Ammar El Ameen, Guillaume Vandermeer, Raoul K Khanna, Pierre-Jean Pisella
PURPOSE: Preservatives in glaucoma medications have been associated with ocular toxicity. We compared ocular signs and symptoms in patients with open-angle glaucoma or ocular hypertension treated in monotherapy with preserved or preservative-free prostaglandin analogues. METHODS: Observational cross-sectional clinical study in real life. 82 patients treated for at least 6 months with prostaglandin analogue were assessed for intraocular pressure, ocular symptoms and ocular signs including conjunctival hyperaemia, tear break-up time and tear meniscus height measured using objective and non-invasive methods (OCULUS Keratograph 5M)...
October 10, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/30298705/outcomes-of-intraocular-lens-scleral-fixation-with-the-friction-knot-technique
#11
Petri Aaltonen, Pertti Oskala, Ilkka Immonen
PURPOSE: To examine the clinical outcomes of intraocular lens (IOL) scleral fixation with the friction knot technique. METHODS: Retrospective case series of 152 eyes of 152 patients with inadequate capsular bag support operated with the friction knot IOL scleral fixation technique by a single surgeon. The fixated IOLs were one-piece or three-piece models all with open loop haptics. Main outcome measures were change in corrected distance visual acuity (CDVA) and postoperative complications...
October 8, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30295543/efficacy-of-the-combination-of-carteolol-hydrochloride-latanoprost-in-the-treatment-of-glaucoma-and-ocular-hypertension
#12
Rebecca Russ Soares, M Reza Razeghinejad
The only evidence-based mechanism for prevention and treatment of glaucomatous optic neuropathy is decreasing the intraocular pressure (IOP). Prescribing multiple ocular hypotensive agents, such as the combination of carteolol and latanoprost, may synergistically improve IOP; however, doing so may increase the complexity of a medication regimen, in turn, impairing patient adherence. Fixed-combination glaucoma medications offer convenience and effectiveness. New to this class of glaucoma medication is fixed combination carteolol-latanoprost (FCCL)...
October 8, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30293851/-arterial-hypertension-with-multiple-organ-damage-a-new-entity
#13
Sophie Kuntz, Romain Boulestreau, Sébastien Rubin, Antoine Cremer, Philippe Gosse
Hypertensive emergency. Stable incidence for several decades or even increasing (under diagnosed). Early and specific management improves prognosis. Absence of eye damage or lack of access to fundus should not delay or prevent the diagnosis. Multi Organ Damage Hypertension: new definition for an old entity: unusual, sudden and persistent blood pressure rise without threshold and ocular involvement or involvement of at least 3 target organs among brain, heart, kidney or endothelial disease.
October 4, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/30291364/magnetic-resonance-spectroscopy-features-of-the-visual-pathways-in-patients-with-glaucoma
#14
Direnç Özlem Aksoy, Jülide Canan Umurhan Akkan, Alpay Alkan, Ayşe Aralaşmak, Hafize Otçu Temur, İsmail Yurtsever
PURPOSE: The aim of the study was to investigate any metabolic changes on magnetic resonance spectroscopy (MRS) throughout the visual pathway of the brain in patients with glaucoma and a control group and correlate the results with clinical findings. MATERIAL AND METHODS: A total of 87 patients were enrolled in the study, 30 healthy controls, 25 glaucoma, 16 suspected glaucoma (GS) and 16 ocular hypertension (OHT) patients. A single voxel MRS on TE 30 ms was performed by placing the volume of interest (VOI) on the corpus geniculatum laterale (CGL) and primary visual cortex (VC)...
October 5, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/30286250/lower-body-negative-pressure-to-safely-reduce-intracranial-pressure
#15
Lonnie G Petersen, Justin S Lawley, Alexander Lilja-Cyron, Johan Cg Petersen, Erin J Howden, Satyam Sarma, William K Cornwell, Rong Zhang, Louis A Whitworth, Michael A Williams, Marianne Juhler, Benjamin D Levine
KEY POINTS: During long-term missions, some astronauts experience structural and functional changes of the eyes and brain which resemble signs/symptoms experienced by patients with intracranial hypertension. Weightlessness prevents the normal cerebral volume and pressure "unloading" associated with upright postures on Earth, which may be part of the cerebral and ocular pathophysiology. By placing the lower body in a negative pressure device (LBNP) that pulls fluid away from cranial compartments, we simulated effects of gravity and significantly lowered pressure within the brain parenchyma and ventricle compartments...
October 4, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/30282966/novel-engineered-membrane-localized-variants-of-vascular-endothelial-growth-factor-vegf-protect-retinal-ganglion-cells-a-proof-of-concept-study
#16
Junhui Shen, Ru Xiao, Jeffrey Bair, Fang Wang, Luk H Vandenberghe, Darlene Dartt, Petr Baranov, Yin Shan Eric Ng
Endogenous vascular endothelial growth factor (VEGF-A) can protect retinal ganglion cells (RGC) from stress-induced cell death in ocular hypertensive glaucoma. To exploit the neuroprotective function of VEGF-A for therapeutic application in ocular disorders such as glaucoma while minimizing unwanted vascular side effects, we engineered two novel VEGF variants, eVEGF-38 and eVEGF-53. These variants of the diffusible VEGF-A isoform VEGF121 are expressed as dimeric concatamers and remain tethered to the cell membrane, thus restricting the effects of the engineered VEGF to the cells expressing the protein...
October 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30281031/ocular-manifestations-of-cytomegalovirus-in-immunocompetent-hosts
#17
Ashlin Joye, John A Gonzales
PURPOSE OF REVIEW: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts. RECENT FINDINGS: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium...
November 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/30268108/cytomegalovirus-related-uncontrolled-glaucoma-in-an-immunocompetent-patient-a-case-report-and-systematic-review
#18
Lei Xi, Liang Zhang, Wenlei Fei
BACKGROUND: Cytomegalovirus can cause ocular anterior uveitis with ocular hypertension. Basis on the therapy, ocular pressure usually can be controlled. We report a case of a man who had unilateral cytomegalovirus anterior uveitis with refractory glaucoma during the process of treatment. CASE PRESENTATION: A 57-year-old man who was diagnosed Posner-Schlossman syndrome and was admitted for repeatly attacks of raised IOP in left eye for 4 months. We found the cytomegalovirus -DNA was high (1800 copies/ml) in his aqueous...
September 29, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/30267046/myocilin-gene-gln368ter-variant-penetrance-and-association-with-glaucoma-in-population-based-and-registry-based-studies
#19
Xikun Han, Emmanuelle Souzeau, Jue-Sheng Ong, Jiyuan An, Owen M Siggs, Kathryn P Burdon, Stephen Best, Ivan Goldberg, Paul R Healey, Stuart L Graham, Jonathan B Ruddle, Richard A Mills, John Landers, Anna Galanopoulos, Andrew J R White, Robert Casson, David A Mackey, Alex W Hewitt, Puya Gharahkhani, Jamie E Craig, Stuart MacGregor
Importance: The p.Gln368Ter (rs74315329) risk allele in the myocilin gene (MYOC) was initially reported to have high penetrance in glaucoma registry-based studies, but much lower estimates were recently obtained from population-based studies. We investigated this disparity using data from Australia and the United Kingdom. Objectives: To examine the penetrance and effect size of the MYOC p.Gln368Ter variant with glaucoma and ocular hypertension (OHT). Design, Setting, and Participants: This cross-sectional study within the UK Biobank (UKBB) included participants of white British ancestry...
September 27, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/30266279/phaco-non-penetrating-deep-sclerectomy-in-ocular-hypertension-secondary-to-dexamethasone-intravitreal-implant
#20
A Pérez-Sarriegui, P Casas-Llera, L Díez-Álvarez, I Contreras, M Moreno-López, M S Figueroa, J González-Martín-Moro, F J Muñoz-Negrete, G Rebolleda
PURPOSE: To evaluate the characteristics and progression of patients treated with a 0.7mg dexamethasone intravitreal implant (Ozurdex® ) and required glaucoma filtering surgery (phaco-non-penetrating deep sclerectomy) to control ocular hypertension (OHT). METHODS: A retrospective observational study including patients treated with Ozurdex® in a tertiary-care university hospital from May 2011 to April 2016. RESULTS: In five years of follow-up, 1...
September 25, 2018: Archivos de la Sociedad Española de Oftalmología
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