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Colorectal Neoplasia

Carrie M Nielson, Amanda F Petrik, Lorie Jacob, William M Vollmer, Erin M Keast, Jennifer L Schneider, Jennifer S Rivelli, Tanya J Kapka, Richard T Meenan, Rajasekhara R Mummadi, Beverly B Green, Gloria D Coronado
Annual fecal immunochemical testing (FIT) is cost-effective for colorectal cancer (CRC) screening. However, FIT positivity rates and positive predictive value (PPV) can vary substantially, with false-positive (FP) results adding to colonoscopy burden without improving cancer detection. Our objective was to describe FIT PPV and the factors associated with FP results among patients undergoing CRC screening. In an ongoing pragmatic clinical trial of mailed-FIT outreach, clinics delivered one of three FIT brands (InSure, OC-Micro, and Hemosure)...
August 13, 2018: Cancer Medicine
Daniel Azuara, Susanna Aussó, Francisco Rodriguez-Moranta, Jordi Guardiola, Xavier Sanjuan, Triana Lobaton, Jaume Boadas, Marta Piqueras, David Monfort, Elisabet Guinó, Victor Moreno, Gabriel Capellá, Javier de Oca
Background: The risk of developing colorectal cancer (CRC) is increased in patients with inflammatory bowel disease (IBD) of the colon. The aim of the study was to evaluate the effectiveness of selected methylation gene panel for the early detection of CRC in high-risk IBD patients. Methods: In a discovery phase, 73 biopsies of 48 IBD patients (associated or not to CRC) were analyzed from genome-wide DNA methylation analysis using the Illumina Human Methylation 450K BeadChip...
August 7, 2018: Inflammatory Bowel Diseases
I Mizrahi, M Abu-Gazala, A S Rickles, L M Fernandez, A Petrucci, J Wolf, D R Sands, S D Wexner
BACKGROUND: Anastomotic leak (AL) after low anterior resection (LAR) is associated with increased morbidity, mortality, cost and cancer recurrence rates. The aim of this study was to evaluate the impact of fluorescence angiography (FA) on AL following LAR for low rectal cancer. METHODS: This is a single surgeon retrospective cohort study with a historical, consecutively sampled case matched control group. The institution's prospectively maintained institutional review board (IRB)-approved database was queried for all patients who underwent a laparoscopic LAR for rectal neoplasia with a colorectal or coloanal anastomosis < 5 cm from the anal verge between 2013 and 2016...
August 10, 2018: Techniques in Coloproctology
Jia-Le Song, Jung-Ho Choi, Jae-Hoon Seo, Kun-Young Park
The effects of different ganjangs (also designated as kanjang), including acid-hydrolyzed soy sauce (AHSS), fermented soy sauce (FSS), and fermented sesame sauce (FSeS), on azoxymethane (AOM, 10 mg/kg)/dextran sulfate sodium (DSS, 2%)-induced colorectal carcinogenesis in C57BL/6J mice were studied. Low doses (4 mL/kg) of both FSeS and FSS significantly increased colon length, suppressed AOM/DSS-induced increases in colon weight/length ratios, and induced colorectal neoplasia compared with AHSS-treated and control mice...
August 10, 2018: Journal of Medicinal Food
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND: Obesity and metabolic syndrome are risk factors for colorectal neoplasia (CRN). However, the association between metabolically healthy obese (MHO) or metabolically unhealthy non-obese (MUNO) status and the risk of CRN remains unclear. AIMS: We aimed to elucidate the association between MHO or MUNO status and the risk of CRN. METHODS: A total of 139,023 asymptomatic subjects who underwent a primary screening colonoscopy were categorized into 4 groups according to obesity and metabolic status: metabolically healthy non-obese (MHNO), MHO, MUNO, and metabolically unhealthy obese (MUO)...
August 9, 2018: Digestive Diseases and Sciences
Soon Young Kim, Tae Il Kim
In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions via the alternative serrated neoplasia pathway. Major molecular alterations of sessile serrated neoplasia include BRAF mutation, high CpG island methylator phenotype, and escape of cellular senescence and progression via methylation of tumor suppressor genes or mismatch repair genes...
July 2018: Intestinal Research
Takashi Murakami, Naoto Sakamoto, Akihito Nagahara
Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in colorectal carcinomas with BRAF mutations, methylation for DNA repair genes, a CpG island methylator phenotype, and high levels of microsatellite instability. Some of these lesions can rapidly become dysplastic or invasive carcinomas that exhibit high lymphatic invasion and lymph node metastasis potentials. Detecting serrated lesions, including SSA/Ps with and without dysplasia/carcinoma, is critical, but SSA/Ps can be difficult to detect, are inconsistently identified by endoscopists and pathologists, and are often incompletely resected...
August 7, 2018: World Journal of Gastroenterology: WJG
Joren R Ten Hove, Jonathan M K Bogaerts, Michiel T J Bak, Miangela M Laclé, Vincent Meij, Lauranne A A P Derikx, Frank Hoentjen, Nofel Mahmmod, Sebastiaan A van Tuyl, Bas Oldenburg
Background: Patients with refractory inflammatory bowel disease (IBD) might require a subtotal colectomy with construction of an ileostomy. Due to the risk of nerve damage and pelvic sepsis, the diverted rectum is often left in situ. Evidence on long-term complications of this rectal stump is limited, particularly in patients with Crohn's disease (CD). In addition to the risk of development of neoplasia, diversion proctitis is a frequently reported rectal stump associated complication...
August 1, 2018: Inflammatory Bowel Diseases
Bruna Girardi, Mariabeatrice Principi, Maria Pricci, Floriana Giorgio, Andrea Iannone, Giuseppe Losurdo, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Based on preliminary "in vitro" experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model.Study sample enclosed 110 C57BL/6J male mice. Forty underwent dietary supplement safety assessment (20 standard and 20 enriched formulation). Seventy were treated with azoxymethane (AOM)/dextran-sulfate-sodium (DSS) and divided into two groups: 35 received standard and 35 the enriched formulation (curcumin, boswellic acids, silymarin and maltodextrins)...
August 6, 2018: Carcinogenesis
Eunate Arana-Arri, Natale Imaz-Ayo, Mari Jose Fernández, Isabel Idigoras, Isabel Bilbao, Luis Bujanda, Fidencio Bao, Enrique Ojembarrena, Ines Gil, Iñaki Gutiérrez-Ibarluzea, Isabel Portillo
Background: Screening by means of biennial fecal occult blood test has provided a reduction in overall colorectal cancer mortality. Notwithstanding, we should not underestimate the harms that it can produce. Aim: The aim of this article is to identify the independent risk factors of complications after a screening colonoscopy. Methods: A six-year, nested case-control study was conducted. Mortality/complications within 30 days after colonoscopy were registered and its predictors identified through logistic regression...
June 2018: United European Gastroenterology Journal
Ana S Pires, Cláudia R Marques, João C Encarnação, Ana M Abrantes, Inês A Marques, Mafalda Laranjo, Rui Oliveira, João E Casalta-Lopes, Ana C Gonçalves, Ana B Sarmento-Ribeiro, Maria F Botelho
Colorectal cancer (CRC) is continuously classified as one of the most incidental and mortal types of cancer worldwide. The positive outcomes of the conventional chemotherapy are frequently associated with high toxicity, which often leads to the suspension of the treatment. Growing evidences consider the use of pharmacological concentrations of ascorbic acid (AA), better known as vitamin C, in the treatment of cancer. The use of AA in a clinical context is essentially related to the adoption of new therapeutic strategies based on combination regimens, where AA plays a chemosensitizing role...
2018: Frontiers in Physiology
Daisuke Hojo, Toshiaki Tanaka, Miwako Takahashi, Koji Murono, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Keisuke Hata, Kazushige Kawai, Toshimitsu Momose, Hiroaki Nozawa
Identification of secondary colonic neoplasia proximal to obstructing colorectal cancer is essential for determining the range of colorectal resection.We examined the accuracy of 18-fluoro deoxy glucose-positron emission tomography (FDG-PET) for detection of colonic neoplasia.We recruited patients with obstructing colorectal cancer from our registry. Preoperative FDG-PET was performed, and the detection rate for colonic neoplasia was estimated. Preoperative colonoscopy or postoperative colonoscopy within a year after operation was employed as the indexed standard...
August 2018: Medicine (Baltimore)
Daniel Rodríguez-Alcalde, Sabela Carballal, Leticia Moreira, Luis Hernández, Lorena Rodríguez-Alonso, Francisco Rodríguez-Moranta, Victoria Gonzalo, Luis Bujanda, Xavier Bessa, Carmen Poves, Joaquín Cubiella, Inés Castro, Mariano González, Eloísa Moya, Susana Oquiñena, Joan Clofent, Enrique Quintero, Pilar Esteban, Virginia Piñol, Francisco Javier Fernández, Rodrigo Jover, Lucía Cid, Esteve Saperas, María López-Cerón, Miriam Cuatrecasas, Jorge López-Vicente, Liseth Rivero-Sánchez, Gerhard Jung, María Vila-Casadesús, Ariadna Sánchez, Antoni Castells, María Pellisé, Francesc Balaguer
BACKGROUND:  Serrated polyposis syndrome (SPS) has been associated with an increased risk of colorectal cancer (CRC). Accordingly, intensive surveillance with annual colonoscopy is advised. The aim of this multicenter study was to describe the risk of advanced lesions in SPS patients undergoing surveillance, and to identify risk factors that could guide the prevention strategy. METHODS:  From March 2013 to April 2015, 296 patients who fulfilled criteria I and/or III for SPS were retrospectively recruited at 18 centers...
August 1, 2018: Endoscopy
Jade E Jones, Susheel Bhanu Busi, Jonathan B Mitchem, James M Amos-Landgraf, Michael R Lewis
The goal of these studies was to use a tumor-targeting, near-infrared (NIR) fluorescent peptide to evaluate early detection and to guide surgical removal of polyps in a genetically engineered rat model of spontaneous colorectal cancer. This peptide, LS301, was conjugated to Cy7.5 and applied topically to the colon of adenoma-bearing Pirc rats. Ten minutes after administration, rats underwent targeted NIR laser colonoscopy. Rats were also evaluated by white light colonoscopy and narrow-band imaging, for comparison to the NIR technique...
January 2018: Molecular Imaging
Christoph Engel, Hans F Vasen, Toni Seppälä, Stefan Aretz, Marloes Bigirwamungu-Bargeman, Sybrand Y de Boer, Karolin Bucksch, Reinhard Büttner, Elke Holinski Feder, Stefanie Holzapfel, Robert Hüneburg, Maarten A J M Jacobs, Heikki Järvinen, Matthias Kloor, Magnus von Knebel Doeberitz, Jan J Koornstra, Mariette van Kouwen, Alexandra M Langers, Paul C van de Meeberg, Monika Morak, Gabriela Möslein, Fokko M Nagengast, Kirsi Pylvanainen, Nils Rahner, Laura Renkonen-Sinisalo, Silvia Sanduleanu, Hans K Schackert, Wolff Schmiegel, Karsten Schulmann, Verena Steinke-Lange, Christian P Strassburg, Juda Vecht, Marie-Louise Verhulst, Wouter de Vos Tot Nederveen Cappel, Silke Zachariae, Jukka-Pekka Mecklin, Markus Loeffler
BACKGROUND & AIMS: Patients with Lynch syndrome are at high risk for developing colorectal cancer (CRC). Regular colonoscopic surveillance is recommended, but there is no international consensus on the appropriate interval. We investigated whether shorter intervals are associated with lower CRC incidence and detection at earlier stages by comparing the surveillance policies in Germany, which evaluates patients by colonoscopy annually, in the Netherlands (patients evaluated at 1-2-year intervals), and Finland (patients evaluated at 2-3-year intervals)...
July 28, 2018: Gastroenterology
Natalia Strzelczyk, Sebastian Kwiatek, Wojciech Latos, Aleksander Sieroń, Agata Stanek
BACKGROUND: White light endoscopy (WLE) is the gold standard for detection of colorectal cancer. Autofluorescence endoscopy (AFE) is among the novel methods expected to increase the sensitivity and specificity of endoscopic diagnosis. The main objective of the study was to determine the diagnostic efficacy of AFE for the detection of preneoplastic and neoplastic colorectal lesions and to identify high-grade neoplasia using Numerical Colour Value (NCV). METHODS: This retrospective study included 188 patients with colorectal mucosal lesions diagnosed on WLE and assessed using AFE; they were included in the study if a complete patient record was available (description of visualized colorectal lesions, NCV and histopathology report)...
July 25, 2018: Photodiagnosis and Photodynamic Therapy
Els Wieten, Clasine M de Klerk, Annemieke van der Steen, Christian R Ramakers, Ernst J Kuipers, Bettina E Hansen, Iris Lansdorp-Vogelaar, Patrick M Bossuyt, Evelien Dekker, Manon Cw Spaander
BACKGROUND AND AIMS: Although different brands of fecal immunochemical tests (FITs) are used for colorectal cancer (CRC) screening, few studies have compared their accuracy in detecting advanced neoplasia. METHODS: We performed a large prospective cohort study within the Dutch national CRC screening program to evaluate 2 quantitative FITs: FOB-Gold (Sentinel, Italy) and OC-Sensor (Eiken, Japan, reference standard), from May 2016 through March 2017. We randomly selected 42,179 screening-naïve individuals (55-75 years old), who were asked to perform both FITs themselves using the same bowel movement...
July 25, 2018: Gastroenterology
David Cm Yeung, Alexander C Vlantis, Eddy Wy Wong, Michael Cf Tong, Jason Yk Chan
Background : Narrow band imaging (NBI), an endoscopic technique featuring an augmented definition of microvasculature and mucosal patterns. NBI is increasingly advocated as a tool to characterize neoplasia and intestinal metaplasia in endoscopic standards, such as for colorectal polyps and tumors. Recently NBI has also been studied in the detection of Nasopharyngeal Carcinoma (NPC). Here we aimed to assess the diagnostic utility of NBI for the diagnosis of NPC. Methods: A meta-analysis of studies comparing narrow-band imaging and white light endoscopy in the diagnosis of primary nasopharyngeal carcinoma was performed...
2018: F1000Research
Takeshi Nagasaka, Yoshiyuki Yamaguchi
To screen colorectal cancers, fecal occult blood test(FOBT), conducted to detect occult blood present in the feces, has been shown to reduce colorectal cancer mortality in many large-scale colorectal cancer screening programs. However, the sensitivities of FOBT for early-stage colon cancer, colon cancer located at the right colon and colorectal adenoma tend to be low. Additionally, some colorectal cancers which could not detect by repeated FOBT screening are actually existed. Beyond those disadvantages, FOBT is the most promised colorectal cancer screening tool for large-scale cohort...
June 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND & AIMS: The incidence of colorectal cancer is increasing among persons 50 years old or younger. However, data on the epidemiology of young-onset colorectal neoplasia (CRN) are limited. Although some studies have investigated the epidemiology of CRN in persons younger than 50 years, most have focused on persons 40 years or older. We evaluated the prevalence of and risk factors for CRN in adults younger than 40 years. METHODS: We performed a cross-sectional analysis of 72,356 asymptomatic individuals, 20-39 years old, who underwent colonoscopies as participants in the Kangbuk Samsung Health Study in South Korea, from August 2004 through December 2015...
July 17, 2018: Clinical Gastroenterology and Hepatology
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