Ligia Petrica, Elena Hogea, Florica Gadalean, Adrian Vlad, Mihaela Vlad, Victor Dumitrascu, Silvia Velciov, Cristina Gluhovschi, Flaviu Bob, Sorin Ursoniu, Dragos Catalin Jianu, Petru Matusz, Agneta-Maria Pusztai, Andrei Motoc, Octavian M Cretu, Dana Radu, Oana Milas, Alina Golea-Secara, Anca Simulescu, Maria Mogos-Stefan, Mihaela Patruica, Lavinia Balint, Silvia Ienciu, Daliborca Vlad, Roxana Popescu
Aims: Long noncoding RNAs (lncRNAs) play key roles in the pathophysiology of DKD involving actions of microRNAs (miRNAs). The aims of the study were to establish the involvement of selected lncRNAs in the epigenetic mechanisms of podocyte damage and tubular injury in DKD of type 2 diabetes mellitus (DM) patients in relation to a particular miRNAs profile. Methods: A total of 136 patients with type 2 DM and 25 healthy subjects were assessed in a cross-sectional study concerning urinary albumin: creatinine ratio (UACR), eGFR, biomarkers of podocyte damage (synaptopodin, podocalyxin) and of proximal tubule (PT) dysfunction (Kidney injury molecule-1-KIM-1, N-acetyl-D-glucosaminidase-NAG), urinary lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), nuclear-enriched abundant transcript 1 (NEAT1), myocardial infarction-associated transcript (MIAT), taurine-upregulated gene 1 (TUG1), urinary miRNA21, 124, 93, 29a...
2021: International Journal of Medical Sciences