Francisco Altamirano, Gustavo Ortiz-Morales, Mario A O'Connor-Cordova, Juan Pablo Sancén-Herrera, Judith Zavala, Jorge E Valdez-Garcia
PURPOSE: The present review will summarize FECD-associated genes and pathophysiology, diagnosis, current therapeutic approaches, and future treatment perspectives. METHODS: Literature review. RESULTS: Fuchs' endothelial corneal dystrophy (FECD) is the most common bilateral corneal dystrophy and accounts for one-third of all corneal transplants performed in the US. FECD is caused by a combination of genetic and non-heritable factors, and there are two types: early-onset FECD, which affects individuals from an early age and is usually more severe, and late-onset FECD, which is more common and typically manifests around the age of 40...
February 12, 2024: International Ophthalmology