Mei-Xuan Zhang, Hui Hong, Yun Shi, Wen-Yan Huang, Yi-Meng Xia, Lu-Lu Tan, Wei-Jiang Zhao, Chen-Meng Qiao, Jian Wu, Li-Ping Zhao, Shu-Bing Huang, Xue-Bing Jia, Yan-Qin Shen, Chun Cui
Parkinson's disease (PD) is characterized not only by motor symptoms but also by non-motor dysfunctions, such as olfactory impairment; the cause is not fully understood. Our study suggests that neuronal loss and inflammation in brain regions along the olfactory pathway, such as the olfactory bulb (OB) and the piriform cortex (PC), may contribute to olfactory dysfunction in PD mice, which might be related to the downregulation of the trace amine-associated receptor 1 (TAAR1) in these areas. In the striatum, although only a decrease in mRNA level, but not in protein level, of TAAR1 was detected, bioinformatic analyses substantiated its correlation with PD...
March 22, 2024: Brain Sciences