Annette Boegel, Ingo Flamme, Ralph Krebber, Terry Settje, Franziska Schmidt, Eva Kruedewagen, Sandra Mangold-Gehring, Chantal Lainesse, Andreas Moritz, Gerald Beddies
BACKGROUND: Inhibition of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) stimulates erythropoiesis in rats, dogs, monkeys, and humans. HYPOTHESIS/OBJECTIVE: Determine if molidustat, a novel HIF-PH inhibitor, stimulates erythropoiesis in healthy cats. ANIMALS: Seventeen healthy adult laboratory cats. METHODS: Randomized, placebo-controlled study. Cats were treated PO once daily with suspensions of 0 (Group 1; n = 6), 5 (Group 2; n = 6), or 10 (Group 3; n = 5) mg/kg of molidustat...
November 23, 2023: Journal of Veterinary Internal Medicine