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https://www.readbyqxmd.com/read/28530852/long-term-risk-of-subsequent-malignant-neoplasms-after-treatment-of-childhood-cancer-in-the-dcog-later-study-cohort-role-of-chemotherapy
#1
Jop C Teepen, Flora E van Leeuwen, Wim J Tissing, Eline van Dulmen-den Broeder, Marry M van den Heuvel-Eibrink, Helena J van der Pal, Jacqueline J Loonen, Dorine Bresters, Birgitta Versluys, Sebastian J C M M Neggers, Monique W M Jaspers, Michael Hauptmann, Margriet van der Heiden-van der Loo, Otto Visser, Leontien C M Kremer, Cécile M Ronckers
Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term risk of SMNs in a well-characterized cohort of 5-year CCSs, with a particular focus on individual chemotherapeutic agents and solid cancer risk. Methods The Dutch Childhood Cancer Oncology Group-Long-Term Effects After Childhood Cancer cohort includes 6,165 5-year CCSs diagnosed between 1963 and 2001 in the Netherlands. SMNs were identified by linkages with the Netherlands Cancer Registry, the Dutch Pathology Registry, and medical chart review...
May 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28528874/animal-health-and-greenhouse-gas-intensity-the-paradox-of-periparturient-parasitism
#2
J G M Houdijk, B J Tolkamp, J A Rooke, M R Hutchings
Here we provide the first known direct measurements of pathogen challenge impacts on greenhouse gas (GHG) production, yield and intensity. Twin-rearing ewes were ad libitum fed pelleted lucerne from day -32 to 36 (day 0 is parturition), and repeatedly infected with 10,000 Teladorsagia circumcincta infective larvae (n=16), or sham-dosed with water (n=16). A third group of 16 ewes were fed at 80% of uninfected ewes' feed intake during lactation. Methane emissions were measured in respiration chambers (day 30 to 36) whilst total tract apparent nutrient digestibility around day 28 informed calculated manure methane and nitrous oxide emissions estimates...
May 18, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28528762/safety-and-immunogenicity-of-a-prototype-anti-chlamydia-pecorum-recombinant-protein-vaccine-in-lambs-and-pregnant-ewes
#3
Marion Desclozeaux, Martina Jelocnik, Katrina Whitting, Siamak Saifzadeh, Sankhya Bommana, Andrew Potter, Volker Gerdts, Peter Timms, Adam Polkinghorne
Arthritis and kerato-conjunctivitis caused by Chlamydia pecorum in lambs are difficult to diagnose and treat. We tested the ability of a prototype C. pecorum vaccine (SC-vaccine), comprised of C. pecorum major outer membrane protein (MOMP-G) and polymorphic membrane protein G (PmpG), to trigger a Chlamydia-specific humoral and cell-mediated immune response in lambs and pregnant ewes. Vaccinations with the SC-vaccine (one and two injections) were very well tolerated by all ewes and lambs. Although the overall immune responses of ewes to SC-vaccination was poor, their lambs showed stronger antigen-specific immune response than lambs from control vaccine ewes...
May 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28527806/endogenous-synthesis-of-milk-oleic-acid-in-dairy-ewes-in-vivo-measurement-using-13-c-labeled-stearic-acid
#4
P G Toral, P Frutos, D Carreño, G Hervás
The use of stable isotopes is a reliable and risk-free alternative to radioactive tracers for directly examining in vivo fatty acid (FA) metabolism. However, very limited information is available in ruminants, and none is available in sheep. Therefore, we conducted an experiment in dairy ewes to determine, for the first time in this species, the uptake, Δ(9)-desaturation, and secretion of (13)C-labeled stearic acid (SA) into milk with the aim of measuring in vivo endogenous synthesis of milk oleic acid (OA) and stearoyl-CoA desaturase activity...
May 17, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28527530/intergenerational-impact-of-maternal-overnutrition-and-obesity-throughout-pregnancy-in-sheep-on-metabolic-syndrome-in-grandsons-and-granddaughters
#5
C L Pankey, M W Walton, J F Odhiambo, A M Smith, A B Ghnenis, P W Nathanielsz, S P Ford
We previously reported that maternal overnutrition and obesity (MO) throughout pregnancy and lactation in sheep (MOF0) decreases term fetal pancreatic β-cell numbers and increases perirenal adiposity producing hyperphagia, increased adiposity and insulin resistance in adult female offspring (MOF1) fed ad libitum. Pregnant female MOF1 exhibited increased blood glucose from mid to late gestation vs control F1 (CTRF1) though both groups ate only to NRC recommendations. MOF1 ewes delivered female offspring (F2) who like their MOF1 mothers exhibited increased abdominal adiposity and absent neonatal leptin surge...
April 22, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28524013/probiotic-supplementation-effects-on-milk-fatty-acid-profile-in-ewes
#6
Shahab Payandeh, Farokh Kafilzadeh, Manuela Juárez, Miguel Angel de la Fuente, Darab Ghadimi, Andrés L Martínez Marín
We hypothesised that probiotic feeding would alter the fatty acid (FA) profile of sheep's milk. Sixteen lactating ewes, kept under the same feeding and management practices, were randomly allocated to receive either a control diet or the same diet supplemented with a commercial multi-strain bacterial probiotic. Milk fat FA contents were monitored fortnightly for eight consecutive weeks from 14 d after lambing. Probiotic supplementation increased the contents of butyric and caproic acids in milk fat and had no negative effects on other relevant FA from the human's health point of view (i...
May 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28523221/reading-lines-within-the-cocaine-addicted-brain
#7
Glenn A Doyle, Tara T Doucet-O'Hare, Matthew J Hammond, Richard C Crist, Adam D Ewing, Thomas N Ferraro, Deborah C Mash, Haig H Kazazian, Wade H Berrettini
INTRODUCTION: Long interspersed element (LINE)-1 (L1) is a type of retrotransposon capable of mobilizing into new genomic locations. Often studied in Mendelian diseases or cancer, L1s may also cause somatic mutation in the developing central nervous system. Recent reports showed L1 transcription was activated in brains of cocaine-treated mice, and L1 retrotransposition was increased in cocaine-treated neuronal cell cultures. We hypothesized that the predisposition to cocaine addiction may result from inherited L1s or somatic L1 mobilization in the brain...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28522314/relationship-of-antral-follicular-blood-flow-velocity-to-superovulatory-responses-in-ewes
#8
M E F Oliveira, P M Bartlewski, N Jankowski, L C Padilha-Nakaghi, L G Oliveira, S D Bicudo, J F Fonseca, W R R Vicente
The aim of this study was to examine the association between antral follicular blood flow velocity and the response of ewes to hormonal ovarian superstimulation. Ten Santa Inês ewes were subjected to a short- (7days; Group 1) or long-term (13days; Group 2) progesterone (CIDR(®); InterAg, Hamilton, New Zealand) priming, and a superovulatory treatment with porcine follicle-stimulating hormone (pFSH; Folltropin(®)-V; Bioniche Animal Health, Belleville, ON, Canada), given twice daily for four consecutive days in decreasing doses and initiated four or ten days after CIDR insertion, respectively...
April 24, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28521819/linking-hypoxia-dna-damage-and-proliferation-in-multicellular-tumor-spheroids
#9
Stephen Riffle, Ram Naresh Pandey, Morgan Albert, Rashmi S Hegde
BACKGROUND: Multicellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DNA damage repair pathways and their correlation to developing hypoxia. METHODS: Activation of DNA damage repair markers, proliferation, cell death, glycogen accumulation and developing hypoxia were investigated using immunofluorescence, immuno-histochemistry, EdU incorporation, Western blots, COMET assays, and pharmacological agents in A673 Ewing sarcoma spheroids and monolayer cultures...
May 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28521631/immunohistochemical-profile-of-myc-protein-in-pediatric-small-round-blue-cell-tumors
#10
Karen M Chisholm, Chandra Krishnan, Amy Heerema-McKenney, Yasodha Natkunam
Deregulation of MYC oncoprotein in cancers can result from multiple oncogenic mechanisms. Although MYC translocations define Burkitt lymphoma and MYC protein expression is a poor prognostic factor in undifferentiated neuroblastomas, the distribution of MYC protein (c-MYC) across other pediatric small round blue cell tumors (SRBCT) has not been well characterized. We undertook this study to assess MYC protein expression in a large cohort of pediatric lymphomas, sarcomas, and other SRBCT. Tissue microarrays containing 302 SRBCT were successfully evaluated by immunohistochemistry using anti-MYC clone Y69, with nuclear positivity scored as 0%, 1%-25%, 26%-50%, 51%-75%, or 76%-100%...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28521160/evidence-for-bisphenol-a-induced-disruption-of-maternal-thyroid-homeostasis-in-the-pregnant-ewe-at-low-level-representative-of-human-exposure
#11
Davy Guignard, Véronique Gayrard, Marlène Z Lacroix, Sylvie Puel, Nicole Picard-Hagen, Catherine Viguié
Many uncertainties remain regarding the potential of bisphenol A (BPA) as a thyroid disruptor in mammals and the relevance of experimental data to humans. The relevance of the exposure schemes used in experimental in vivo studies is also a major source of uncertainty when analysing the risk of BPA exposure for human health. In this context, the goals of our study, conducted in an ovine model relevant to human gestation and thyroid physiologies, were to: 1) determine the equivalence of subcutaneous and dietary exposures and 2) determine if environmentally relevant doses of BPA can alter gestational and newborn thyroid functions...
May 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28515956/effects-of-phosalone-consumption-via-feeding-with-or-without-sodium-bentonite-on-performance-blood-metabolites-and-its-transition-to-milk-of-iranian-baluchi-sheep
#12
Mohsen Kazemi, Ameneh Eskandary Torbaghan, Abdoul Mansour Tahmasbi, Reza Valizadeh, Abbas Ali Naserian
BACKGROUND: Transfer of pesticides from environment to animal products is inevitable, so the purpose of the present work was to evaluate phosalone consumption via feeding with or without sodium bentonite (SB) on performance, blood metabolites and its transition to milk of Iranian Baluchi sheep. METHODS: Twenty Baluchi ewes were divided into four treatments (P1 as control, P2, P3, and P4) of five animals in which phosalone, an organophosphate pesticide, was given via diet (only for P2 and P3) at a dose of 280 mg/sheep/day for 63 consecutive days...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28513108/dermatofibrosarcoma-protuberans-of-the-scalp-therapeutic-challenges
#13
Davendran Kanesen, Zaitun Zakaria, Ewe S Ch'ng, Puneet Nandrajog, Regunath Kandasamy
No abstract text is available yet for this article.
May 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28509141/primary-ewing-sarcoma-of-the-kidney-a-case-report-and-treatment-review
#14
Muhammad Sadiq, Iftikhar Ahmad, Jamila Shuja, Khushnaseeb Ahmad
Ewing sarcomas/primitive neuroectodermal tumors (ES/PNET) of the kidney are rarely found high-grade malignant tumors, offering poor prognosis. Although established treatment guidelines for ES of kidney are scarce, a multi-modality treatment approached is typically implemented. Herein, we report a 14-year-old female patient with ES of right kidney. Post-nephrectomy disease recurrence was treated with chemotherapy (i.e., vincristine, doxorubicin and cyclophosphamide); marked reduction in tumor size (i.e., from 18...
April 21, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28508996/hyalinizing-clear-cell-carcinoma-of-the-bronchus
#15
Maryam Shahi, Michelle Dolan, Paari Murugan
Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old man who presented with a 2.5 cm lung mass that was partially obstructing the right bronchus intermedius. The tumor consisted of cords and nests of clear and eosinophilic cells in a hyalinized stromal background. The neoplastic cells expressed cytokeratin (CK) 7, CK 5/6, high-molecular weight cytokeratin (34BE12), p63 and p40, while TTF-1, napsin A, CK20, S100, smooth muscle actin, synaptophysin and chromogranin were negative...
May 16, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28507811/adoptive-natural-killer-cell-therapy-is-effective-in-reducing-pulmonary-metastasis-of-ewing-sarcoma
#16
Alexander A Tong, Hasan Hashem, Saada Eid, Frederick Allen, Daniel Kingsley, Alex Y Huang
The survival of patients with metastatic or relapsed Ewing sarcoma (ES) remains dismal despite intensification of combination chemotherapy and radiotherapy, precipitating the need for novel alternative therapies with minimal side effects. Natural killer (NK) cells are promising additions to the field of cellular immunotherapy. Adoptive NK cell therapy has shown encouraging results in hematological malignancies. Despite these initial promising successes, however, NK cell therapy for solid tumors remains to be investigated using in vivo tumor models...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28506520/the-evolving-role-of-proton-beam-therapy-for-sarcomas
#17
S Frisch, B Timmermann
As an alternative to conventional photon-based radiotherapy, radiation with protons is recognised to offer considerable advantages. Today, central nervous system tumours, various sarcomatous tumours, childhood cancer and head and neck tumours are commonly treated with proton therapy. This review evaluates current data from clinical and dosimetric trials on the treatment of selected sarcomatous tumours like rhabdomyosarcoma, osteosarcoma, chordoma, chondrosarcoma and Ewing sarcoma. Special considerations for paediatric tumours and future prospects of proton therapy are outlined...
May 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28506298/fecx-bar-a-novel-bmp15-mutation-responsible-for-prolificacy-and-female-sterility-in-tunisian-barbarine-sheep
#18
Narjess Lassoued, Zohra Benkhlil, Florent Woloszyn, Ahmed Rejeb, Mohamed Aouina, Mourad Rekik, Stephane Fabre, Sonia Bedhiaf-Romdhani
BACKGROUND: Naturally occurring mutations in growth and differentiation factor 9 (GDF9) or bone morphogenetic protein 15 (BMP15) genes are associated with increased ovulation rate (OR) and litter size (LS) but also sterility. Observing the Tunisian Barbarine ewes of the "W" flock selected for improved prolificacy, we found prolific and infertile ewes with streaky ovaries. Blood genomic DNA was extracted from a subset of low-ovulating, prolific and infertile ewes of the "W" flock, and the entire coding sequences of GDF9 and BMP15 were sequenced...
May 15, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28504918/sheep-placenta-cotyledons-a-noninvasive-source-of-ovine-mesenchymal-stem-cells
#19
Iris Ribitsch, Souyet Chang-Rodriguez, Monika Egerbacher, Simone Gabner, Sinan Gueltekin, Johann Huber, Therese Schuster, Florien Jenner
Sheep are one of the most frequently used large animal models in stem cell research. However, minimal invasive or noninvasive sources of mesenchymal stem cells (MSCs) in sheep are scarce. In the light of the principles of the 3Rs (reduce, refine, replace), it would therefore be desirable to identify a minimally invasive or noninvasive ovine MSC source. In humans, the chorionic villi of the placenta, which can be noninvasively harvested as part of the afterbirth, have been identified as a rich source of MSCs...
May 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28504093/genetic-characterization-of-staphylococcus-aureus-isolated-from-nasal-samples-of-healthy-ewes-in-tunisia-high-prevalence-of-cc130-and-cc522-lineages
#20
Meriam Ben Said, Mohamed Salah Abbassi, Paula Gómez, Laura Ruiz-Ripa, Senda Sghaier, Oussama El Fekih, Abdennaceur Hassen, Carmen Torres
Staphylococcus aureus is a versatile bacterium, which can infect or colonize a variety of host species. The objective of this study was to characterize S. aureus isolates recovered from nasal swabs of 167 healthy ewes sampled from 12 farms in different areas of Tunisia during the period of 2014-2015. Genetic lineages, virulence factors and antibiotic resistance mechanisms were determined for recovered isolates. S. aureus was detected in 45 out of 167 tested samples (26.9%). All isolates were methicillin-susceptible (MSSA) and the majority of them were susceptible to tested antibiotics with few exceptions (% of resistance): penicillin (8...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
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