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https://www.readbyqxmd.com/read/30537258/an-in-vitro-assessment-for-evaluating-the-efficiency-of-%C3%AE-d-mannuronic-acid-m2000-in-myelodysplastic-syndrome
#1
Tahereh Bakhtiari, Afshin Ghaderi, Sayyed Reza Safaee Nodehi, Zahra Aghazadeh, Farzaneh Tofighi Zavareh, Fahimeh Jafarnezhad-Ansariha, Anis Barati, Abbas Mirshafiey
β-d-Mannuronic acid (M2000), a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties, has been previously shown to exhibit potential therapeutic effects on autoimmune diseases. Immunosuppression therapy has been a standard approach for myelodysplastic syndrome (MDS) for many years. We evaluated the effect of M2000 on isolated peripheral blood mononuclear cells (PBMCs) from patients with MDS. The PBMCs were isolated from 13 patients with MDS and 13 normal donors. The cells were then treated with low, moderate, and high doses of M2000 and diclofenac as a control group...
December 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30537117/food-intolerance-in-dogs-and-cats
#2
REVIEW
J M Craig
Food intolerance refers to any abnormal physiological response to a food or food additive, believed not to be immunological in nature. Mechanisms include food toxicity, pharmacological reactions, metabolic reactions, dysmotility, dysbiosis, physical effects and non-specific dietary sensitivity. Food intolerance reactions are variable, typically dose-dependent, and can occur at any age. Signs may arise at any time, sometimes several hours or days after consumption of the offending food item, and can last for hours or days...
December 11, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/30536895/exosomes-as-a-novel-cell-free-therapeutic-approach-in-gastrointestinal-diseases
#3
REVIEW
Kaveh Baghaei, Samaneh Tokhanbigli, Hamid Asadzadeh, Saeed Nmaki, Mohammad Reza Zali, Seyed Mahmoud Hashemi
Cell communication through extracellular vesicles (EVs) has been defined for many years and it is not limited only to neighboring cells, but also distant ones in organisms receive these signals. These vesicles are secreted from the variety of cells and are composed of a distinctive component such as proteins, lipids, and nucleic acids. EVs have different classified subgroups regarding their cell origin, in this context, exosomes are the most appealing particles in cell biology, especially clinical in recent years and are represented as novel therapeutic agents with numerous advantages alongside and/or over cell therapy...
December 7, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30536351/efficacy-and-safety-of-rituximab-therapy-for-membranous-nephropathy-a-meta-analysis
#4
J Zhang, L Bian, F-Z Ma, Y Jia, P Lin
OBJECTIVE: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults, but the treatment of MN remains controversial. Rituximab, a possible alternative treatment option, represented a new therapeutic hope for the treatment of membranous nephropathy (MN). We performed a meta-analysis to perform the efficacy and safety of rituximab therapy. MATERIALS AND METHODS: Either randomized controlled trials (RCTs), cohort studies or case studies were eligible for review and were performed in Medline, Embase, Web of Science, Cochrane database with the computerized searches...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30536256/-registry-research-funding-of-the-german-society-of-plastic-reconstructive-and-aesthetic-surgeons-dgpr%C3%A3-c-and-research-funding-report-2017-2018
#5
R E Giunta, N Möllhoff, R E Horch, L Prantl, J P Beier, A Daigeler, A Dragu, S U Eisenhardt, P C Fuchs, G Germann, T Hirsch, M Infanger, R Jakubietz, U Kneser, S Langer, M Lehnhardt, H G Machens, P Mailänder, B Reichert, C Radtke, D J Schaefer, F Siemers, G B Stark, H U Steinau, P M Vogt
INTRODUCTION: This report serves to publicize the research of academic institutions for Plastic Surgery within our society DGPRÄC in 2017/2018 and sequels the funding report of 2015/2016. Applications to public, non-public, or industrial funding organizations were evaluated. At the same time, this paper analyses the number of approved DFG applications in Plastic, Thoracic and Vascular Surgery in the GEPRIS system. Contrary to these specialties, Plastic Surgery is not classified as an independent speciality in the subject structure of the DFG review board which results in a lack of transparency concerning Plastic Surgery research work...
December 10, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/30535098/recovery-after-stroke-not-so-proportional-after-all
#6
Thomas M H Hope, Karl Friston, Cathy J Price, Alex P Leff, Pia Rotshtein, Howard Bowman
The proportional recovery rule asserts that most stroke survivors recover a fixed proportion of lost function. To the extent that this is true, recovery from stroke can be predicted accurately from baseline measures of acute post-stroke impairment alone. Reports that baseline scores explain more than 80%, and sometimes more than 90%, of the variance in the patients' recoveries, are rapidly accumulating. Here, we show that these headline effect sizes are likely inflated. The key effects in this literature are typically expressed as, or reducible to, correlation coefficients between baseline scores and recovery (outcome scores minus baseline scores)...
December 7, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30535024/what-if-all-children-achieved-who-recommendations-on-physical-activity-estimating-the-impact-on-socioeconomic-inequalities-in-childhood-overweight-in-the-uk-millennium-cohort-study
#7
Anna Pearce, Steven Hope, Lucy Griffiths, Mario Cortina-Borja, Catherine Chittleborough, Catherine Law
Background: The World Health organization (WHO) recommends that children engage in 60 min daily moderate-to-vigorous physical activity (dMVPA). Just half of children in the UK achieve these levels (with similarly low levels in other high-income countries). Thus, the dMVPA target is a focus of national obesity strategies. However, the potential impact of increased physical activity on prevalence and inequalities in childhood overweight is unknown. Using objective data from the Millennium Cohort Study (∼18 000 children born 2000-02) we simulated a series of hypothetical physical activity intervention scenarios: achievement of the target, and more realistic increases demonstrated in trials...
December 7, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/30534857/cecum-perforation-associated-with-a-calcium-polystyrene-sulfonate-bezoar-a-rare-entity
#8
David Carvalho Fiel, Iolanda Santos, Joana Eugénio Santos, Rita Vicente, Susana Ribeiro, Artur Silva, Beatriz Malvar, Carlos Pires
Hyperkalemia is one of the most common electrolyte disorders, responsible for a high number of adverse outcomes, including life-threatening arrhythmias. Potassium binders are largely prescribed drugs used for hyperkalemia treatment but unfortunately, there are many adverse events associated with its use, mostly gastrointestinal. Identification of patients at highest risk for the serious complications associated with the current potassium binders, such as colon necrosis and perforation, could prevent fatal outcomes...
December 6, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30534619/panoramic-azimuthal-schlumberger-vertical-electrical-sounding-for-fracture-orientation-and-anisotropy-quantification
#9
Jide Nosakare Ogunbo, Emmanuel Abiodun Mamukuyomi, Wahab Stephens Adepoju, Harrison Adebowale, Olamide Akinro, Chukwuebuka Richard Ukaegbu
Vertical electrical sounding (VES) data acquired with the Schlumberger configuration is popularly used to image the electrical resistivity variation with depth at a single azimuth. Apart from the random subjective choice of the single azimuthal direction by the field geophysicists, important hydrological information such as fracture orientation and anisotropic coefficients needed for understanding resultant groundwater flow direction are by design lost in the process. Panoramic (0°-360°) azimuthal VES data were acquired at two data points at the Federal University of Technology, Akure (FUTA) at angular step of 15°, making a total of 24 data sets per data point...
December 2018: Heliyon
https://www.readbyqxmd.com/read/30534357/extraskeletal-myxoid-chondrosarcoma-with-massive-pulmonary-metastases
#10
Luca Paoluzzi, Munir Ghesani
Background: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant mesenchymal neoplasm of uncertain differentiation characterized by rearrangements of the NR4A3 gene. EMC often affects adults around the age of 50 and arise in the deep tissues of the proximal extremities and limb girdles. EMC is characterized by indolent growth rate but strong tendency to local recurrence and metastatic spread. No systemic treatment is specifically approved by the FDA for this disease and surgery has been traditionally the only potentially curative strategy...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/30534055/an-integrated-cytoskeletal-model-of-neurite-outgrowth
#11
REVIEW
Kyle E Miller, Daniel M Suter
Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative contributions of individual cytoskeletal processes to neurite growth are controversial. Here, we review the structural organization and biophysical properties of neurons to make a semi-quantitative comparison of the relative contributions of different processes to neurite growth...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30533970/how-to-read-a-research-paper-an-exercise-using-a-study-on-continuation-vs-discontinuation-of-antidepressants-during-pregnancy
#12
Chittaranjan Andrade
The ability to critically read a research paper is a skill that all postgraduate students and academicians require because the findings of a study must be interpreted in the context of its strengths and limitations. This article summarizes a recent study on continuation vs. discontinuation of antidepressants during pregnancy; preterm birth and low-birth weight were the outcomes of interest. The strengths and limitations of the study are considered, as are the best and worst case scenarios related to antidepressant use during pregnancy...
November 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/30533701/genome-sequences-of-nine-erwinia-amylovora-bacteriophages
#13
Ruchira Sharma, Jordan A Berg, Nolan J Beatty, Minsey C Choi, Ashlin E Cowger, Brooke J R Cozzens, Steven G Duncan, Christopher P Fajardo, Hannah P Ferguson, Trevon Galbraith, Jacob A Herring, Taalin R Hoj, Jill L Durrant, Jonathan R Hyde, Garrett L Jensen, Si Yang Ke, Shalee Killpack, Jared L Kruger, Eliza E K Lawrence, Ifeanyichukwu O Nwosu, Tsz Ching Tam, Daniel W Thompson, Josie A Tueller, Megan E H Ward, Charles J Webb, Madison E Wood, Edward L Yeates, David A Baltrus, Donald P Breakwell, Sandra Hope, Julianne H Grose
Erwinia amylovora is a plant pathogen belonging to the Enterobacteriaceae family, a family containing many plant and animal pathogens. Herein, we announce nine genome sequences of E. amylovora bacteriophages isolated from infected apple trees along the Wasatch Front in Utah.
October 2018: Microbiology resource announcements
https://www.readbyqxmd.com/read/30533693/complete-genome-sequences-of-18-paenibacillus-larvae-phages-from-the-western-united-states
#14
Bryan D Merrill, Christopher P Fajardo, Jared A Hilton, Ashley M Payne, Andy T Ward, Jamison K Walker, Aziza Dhalai, Cameron Imahara, James Mangohig, Josh Monk, Cristian Pascacio, Padmani Rai, Alicia Salisbury, Kathie Velez, Travis J Bloomfield, Brett Buhler, Steven G Duncan, David A Fuhriman, Josil George, Kiel Graves, Karli Heaton, Hunter L Hill, Michelle Kim, Bradley K Knabe, Devin B Ririe, Spencer L Rogers, Casey Stamereilers, Michael B Stephenson, Brittian K Usher, Colton S Ward, Jacob M Withers, Cole K Wright, Donald P Breakwell, Julianne H Grose, Sandra Hope, Philippos K Tsourkas
We present here the complete genomes of 18 phages that infect Paenibacillus larvae, the causative agent of American foulbrood in honeybees. The phages were isolated between 2014 and 2016 as part of an undergraduate phage discovery course at Brigham Young University. The phages were isolated primarily from bee debris and lysogens.
October 2018: Microbiology resource announcements
https://www.readbyqxmd.com/read/30533554/a-comprehensive-review-of-biodegradable-synthetic-polymer-ceramic-composites-and-their-manufacture-for-biomedical-applications
#15
REVIEW
Mona Alizadeh-Osgouei, Yuncang Li, Cuie Wen
The application of various materials in biomedical procedures has recently experienced rapid growth. One area that is currently receiving significant attention from the scientific community is the treatment of a number of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites. Biomaterials, the most common materials used to repair or replace damaged parts of the human body, can be categorized into three major groups: metals, ceramics, and polymers. Composites can be manufactured by combining two or more materials to achieve enhanced biocompatibility and biomechanical properties for specific applications...
March 2019: Bioactive Materials
https://www.readbyqxmd.com/read/30533534/demystifying-probabilistic-linkage-common-myths-and-misconceptions
#16
J C Doidge, K Harron
Many of the distinctions made between probabilistic and deterministic linkage are misleading. While these two approaches to record linkage operate in different ways and can produce different outputs, the distinctions between them are more a result of how they are implemented than because of any intrinsic differences. In the way they are generally applied, probabilistic and deterministic procedures can be little more than alternative means to similar ends-or they can arrive at very different ends depending on choices that are made during implementation...
January 10, 2018: Int J Popul Data Sci
https://www.readbyqxmd.com/read/30533475/a-case-of-primary-cervical-lymphoma-in-a-patient-with-abnormal-uterine-bleeding
#17
Maureen E Roberts, Hope M Cottrill
Primary lymphoma of the uterine cervix is a rare site of extranodal lymphoma. Many gynecologic oncologists may go their entire career without encountering one. Patients may present with symptoms of abnormal or postmenopausal bleeding, and diagnosis may be challenging as typical office tests such as the pap smear may not detect the abnormal cells. Once a diagnosis is made, management may be debated due to the rarity of the condition and lack of accepted standard treatment. However, most patients respond well to some version of chemotherapy and radiation typically used for standard lymphomas...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30533222/emerging-evidence-concerning-the-role-of-sirtuins-in-sepsis
#18
REVIEW
Lulan Li, Zhongqing Chen, Weijun Fu, Shumin Cai, Zhenhua Zeng
Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis. Notably, downstream mechanisms of sirtuins are not fully understood...
2018: Critical Care Research and Practice
https://www.readbyqxmd.com/read/30532992/evaluating-barriers-and-opportunities-in-delivering-high-quality-oncology-care-in-a-resource-limited-setting-using-a-comprehensive-needs-assessment-tool
#19
Chika R Nwachukwu, Omobola Mudasiru, Lynn Million, Shruti Sheth, Hope Qamoos, Joseph O Onah, Anita Okemini, Mojisola Rhodes, Michele Barry, Adekunbiola A Banjo, Muhameed Habeebu, Tajudeen A Olasinde, Ami S Bhatt
PURPOSE: Despite recognition of both the growing cancer burden in low- and middle-income countries and the disproportionately high mortality rates in these settings, delivery of high-quality cancer care remains a challenge. The disparities in cancer care outcomes for many geographic regions result from barriers that are likely complex and understudied. This study describes the development and use of a streamlined needs assessment questionnaire (NAQ) to understand the barriers to providing quality cancer care, identifies areas for improvement, and formulates recommendations for implementation...
December 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30532734/integration-of-proteomics-and-metabolomics-revealed-metabolite-protein-networks-in-acth-secreting-pituitary-adenoma
#20
Jie Feng, Qi Zhang, Yang Zhou, Shenyuan Yu, Lichuan Hong, Sida Zhao, Jingjing Yang, Hong Wan, Guowang Xu, Yazhuo Zhang, Chuzhong Li
An effective treatment for the management of adrenocorticotropic hormone-secreting pituitary adenomas (ACTH-PA) is currently lacking, although surgery is a treatment option. We have integrated information obtained at the metabolomic and proteomic levels to identify critical networks and signaling pathways that may play important roles in the metabolic regulation of ACTH-PA and therefore hopefully represent potential therapeutic targets. Six ACTH-PAs and seven normal pituitary glands were investigated via gas chromatography-mass spectrometry (GC-MS) analysis for metabolomics...
2018: Frontiers in Endocrinology
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