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Anita K Chisholm, Vicki A Anderson, Natalie A Pride, Stephanie Malarbi, Kathryn N North, Jonathan M Payne
In light of the proliferation of recent research into social function in neurofibromatosis type 1 (NF1), a systematic review and meta-analysis is required to synthesise data and place findings within the context of a theoretical framework. This paper reviews findings from research into social function and autism spectrum disorder (ASD) in children and adults with NF1 and integrates these findings with the Socio-Cognitive Integration Abilities Model (SOCIAL). It also critically appraises links between social outcomes, internal and external factors moderating social functioning, cognitive domains implicated in social functioning, and underlying neural pathology in NF1...
August 11, 2018: Neuropsychology Review
Gokhlesh Kumar, Karin Hummel, Ebrahim Razzazi-Fazeli, Mansour El-Matbouli
The head kidney and spleen are major lymphoid organs of the teleost fish. We identified proteome profiles of head kidney and spleen of rainbow trout (Oncorhynchus mykiss) using a shotgun proteomic approach. GO annotation of proteins was predicted using bioinformatic tools. This study represents detailed proteome profiles of head kidney and spleen of rainbow trout, with a total of 3241 and 2542 proteins identified, respectively. We found that lymphoid organs are equipped with a variety of functional proteins related to defense, receptor, signal transduction, antioxidant, cytoskeleton, transport, binding and metabolic processes...
August 10, 2018: Proteomics
Gianfranco Sinagra, Marco Merlo, Antonio Cannatà
No abstract text is available yet for this article.
August 9, 2018: European Journal of Heart Failure
Danka Pavliakova, Peter C Giardina, Soraya Moghazeh, Shite Sebastian, Maya Koster, Viliam Pavliak, Andrew McKeen, Roger French, Kathrin U Jansen, Michael Pride
A Luminex-based direct immunoassay (dLIA) platform has been developed to replace the standardized pneumococcal enzyme-linked immunosorbent assay platform. The multiplex dLIA simultaneously measures the concentration of serum immunoglobulin G (IgG) antibodies specific for pneumococcal capsular polysaccharide (PnPS) serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. The assay uses poly-l-lysine (PLL)-conjugated PnPS, chemically coupled to spectrally distinct Luminex microspheres. Assay validation experiments were performed using residual human serum samples obtained from 13-valent pneumococcal conjugate vaccine (13vPnC) clinical studies...
August 8, 2018: MSphere
Charles Y Tan, Fred W Immermann, Shite Sebastian, Michael W Pride, Danka Pavliakova, Kelly A Belanger, Wendy Watson, Daniel A Scott, Mohinder Sidhu, Kathrin U Jansen, Peter C Giardina
This article describes the results of a study designed to bridge the World Health Organization (WHO) pneumococcal enzyme-linked immunosorbent assay (ELISA) platform to the validated Luminex-based 13-plex direct immunoassay (dLIA) platform developed by Pfizer, Inc. Both assay platforms quantify serotype-specific serum IgG antibodies (in micrograms per milliliter) against an international reference standard serum. The primary goal of this study was to determine if the dLIA is a suitable replacement for the ELISA to support clinical vaccine studies that include the evaluation of immune responses to serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F...
August 8, 2018: MSphere
Heiko Schuster, Wenguang Shao, Tobias Weiss, Patrick G A Pedrioli, Patrick Roth, Michael Weller, David S Campbell, Eric W Deutsch, Robert L Moritz, Oliver Planz, Hans-Georg Rammensee, Ruedi Aebersold, Etienne Caron
The large array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the immune system, very little is known, in any species, about its composition across most tissues and organs in vivo. We applied mass spectrometry (MS) technologies to draft the first tissue-based atlas of the murine MHC class I immunopeptidome in health...
August 7, 2018: Scientific Data
Leigh A Bukowski, Cristian J Chandler, Stephanie L Creasy, Derrick D Matthews, M Reuel Friedman, Ronald D Stall
BACKGROUND: Although Black transgender women (BTW) experience high prevalence of HIV in the United States, no characterization of the HIV care continuum exists for this population. This study addresses this gap by (1) characterizing the HIV care continuum, and (2) exploring correlates of HIV diagnosis and viral suppression among a community based sample of BTW. METHODS: Data came from Promoting Our Worth, Equality, and Resilience (POWER). From 2014 to 2017, POWER recruited BTW who attended Black Pride events in six U...
August 2, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Yanan Gao, Songli Li, Xiaoyu Bao, Chaochao Luo, Huaigu Yang, Jiaqi Wang, Shengguo Zhao, Nan Zheng
Aflatoxin M1 (AFM1) is a common mycotoxin in dairy milk and it is typically concurrently present with other mycotoxins that may represent a threat for food safety. However, knowledge on how AFM1, alone or in combination with other mycotoxins may affect human intestinal epithelial integrity remain to be established. We employed transcriptome and proteome analysis integrated with biological validation to reveal the molecular basis underlining the effect AFM1 and/or ochratoxin A (OTA) exposure on intestinal epithelial integrity of differentiated Caco-2 cells...
August 6, 2018: Journal of Proteome Research
Willem J Verbeke, Frank Belschak, Tsachi Ein-Dor, Richard P Bagozzi, Michaéla Schippers
A person's ability to form relationships and seek and attain social status affects their chances of survival. We study how anxious and avoidant-attachment styles and subsequent winning or losing affects the testosterone (T) levels of team members playing two status contests. The first is a management game played by teams striving to earn the most profits. Winners and losers emerge due to the cognitive endeavor of the players, which provokes intense status dynamics. Avoidant-attached winners do not show higher T levels whereas anxious-attached winners do...
2018: Frontiers in Psychology
Lisa A Eaton, Derrick D Matthews, Leigh A Bukowski, M Reuel Friedman, Cristian J Chandler, Darren L Whitfield, Jordan M Sang, Ron D Stall
BACKGROUND: The HIV epidemic among Black men who have sex with men (BMSM) demands urgent public health attention. Pre-Exposure Prophylaxis (PrEP) is a highly efficacious option for preventing HIV, but characteristics of PrEP use among community samples of BMSM are not well-understood. METHODS: A serial cross-sectional survey assessment (N=4,184 BMSM reporting HIV negative/unsure status) and HIV testing were conducted at Black Gay Pride events in six US cities in 2014, 2015, 2016, and 2017...
July 25, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ingrid Tjoflåt, Theodotha John Melissa, Estomih Mduma, Britt S Hansen, Bjørg Karlsen, Eldar Søreide
Aim: To describe the experiences of Tanzanian nurses, how they perceive their role as a professional nurse and their experience with nursing care in a general hospital. Design: This study is explorative, descriptive and qualitative. Methods: The data were collected in 2015 by means of 10 semi-structured interviews and was analysed using qualitative content analysis. Results: The data analysis revealed two themes with corresponding sub-themes related to Tanzanian nurses' perception with their professional role and experiences with nursing care: (1) Feeling professional pride; (2) Experiencing limitations and inadequacy...
July 2018: Nursing Open
Anirban Basu, Carmela Benson, Larry Alphs
BACKGROUND: Once-monthly and once-every-3-months long-acting injectable (LAI) formulations of paliperidone palmitate (PP1M and PP3M, respectively) are available for the treatment of patients with schizophrenia. However, information on the comparative effectiveness and costs of using these LAIs versus oral antipsychotics (OAs) is not available. The population effectiveness of using these treatments is also not known. OBJECTIVE: To project the effect of using PP1M and PP3M LAIs on psychiatric (Psych) and all-cause (AC) hospitalization rates over 18 months in patients with schizophrenia receiving Medicaid and treated with OAs...
August 2018: Journal of Managed Care & Specialty Pharmacy
Ursula Moffitt, Linda P Juang, Moin Syed
Recent discursive research has built on Michael Billig's theory of banal nationalism, arguing that minoritized individuals who explicitly claim adherence to a national group may be further marginalized from a perceived majority who view such acts as socially undesirable. In Germany, a master narrative of muted national pride precludes hot nationalism, while a narrative of integration calls for overt national allegiance from anyone perceived as Other. Integration is demanded not only of recent immigrants, but also of the second generation and beyond, bolstering a related narrative of unquestioned Germanness as ethnically based...
July 24, 2018: British Journal of Social Psychology
Zahir Vally, Caroline G D'Souza, Hiba Habeeb, Basma M Bensumaidea
PURPOSE: The conduct of body image studies with Arab populations is hindered by a lack of psychometrically sound assessment measures. We examined the psychometric properties of an Arabic translation of the most frequently employed measure of body appreciation, the Body Appreciation Scale-2 (BAS-2). DESIGN AND METHODS: A sample of college-aged women from the United Arab Emirates (UAE) (n = 256) completed the Arabic BAS-2, and measures of aesthetic and functional body image, authentic body pride, and self-reported body mass index (BMI)...
July 18, 2018: Perspectives in Psychiatric Care
Revathi N Krishna, Kevin R Ronan, Eva Alisic
Little is known about children's experiences and involvement in disaster preparation and recovery, in particular in low- and middle-income countries. Eliciting community members' perspectives on the 2015 floods in Tamil Nadu, India, may generate useful insights for improving services in low-resource settings. This qualitative study aimed to understand how children in Chennai experienced the floods, as reported by the adults in their community, and to explore children's involvement in disaster preparedness, response and recovery efforts as reported from the adults' perspective...
2018: European Journal of Psychotraumatology
Ian Peate
No abstract text is available yet for this article.
July 12, 2018: British Journal of Nursing: BJN
Danielle R Blazek, Jason T Siegel
BACKGROUND: The current studies examined how positive affect (i.e. the blend of several positive feelings over time) and discrete positive emotions (i.e. a specific set of momentary thoughts and feelings) influence organ donor registration outcomes. METHODS: In Study 1, participants were randomly assigned to a writing task intended to elicit positive or negative affect. In Study 2, participants received a discrete positively valenced emotion induction (i.e. elevation, humor, hubristic pride), or were in a control condition...
July 10, 2018: Applied Psychology. Health and Well-being
Halie A Sonnenschein, Kenneth F Lawrence, Karli A Wittenberg, Frank A Slykas, Emerald L Dohleman, Jilan B Knoublauch, Sean M Fahey, Timothy M Marshall, James D Marion, Jessica K Bell
Suppressor of IKKepsilon (SIKE) is associated with the type I interferon response of the innate immune system through TANK-binding kinase 1 (TBK1). Originally characterized as an endogenous inhibitor of TBK1 when overexpressed in viral infection and pathological cardiac hypertrophic models, a mechanistic study revealed that SIKE acts as a high-affinity substrate of TBK1, but its function remains unknown. In this work, we report that scratch assay analysis of parental and SIKE CRISPR/Cas9 knockout HAP1 cells showed an ~ 20% decrease in cell migration...
July 2018: FEBS Open Bio
Luis Felipe Clemente, María Luisa Hernáez, Antonio Ramos-Fernández, Gertrudis Ligero, Concha Gil, Fernando José Corrales, Miguel Marcilla
Currently, 14% of the human proteome is made up of proteins whose existence is not confirmed by mass spectrometry. We performed a proteomic profiling of human mesenchymal stem cells derived from adipose tissue or umbilical cord (PRIDE accession number: PXD009893) and identified peptides derived from 13 of such missing proteins. Remarkably, we found compelling evidence of the expression of hyaluronan synthase 1 (NX_Q92839-1) and confirmed its identification by the fragmentation of four heavy-labeled peptides that coeluted with their endogenous light counterparts...
July 6, 2018: Journal of Proteome Research
Tanya J Kerr, Sonja Matthee, Danny Govender, Gerard Tromp, Susan Engelbrecht, Conrad A Matthee
Measuring contemporary dispersal in highly mobile terrestrial species is challenging, especially when species are characterized by low levels of population differentiation. Directly transmitted viruses can be used as a surrogate for traditional methods of tracking host movement. Feline immunodeficiency virus (FIV) is a species-specific lentivirus, which has an exceptionally high mutation rate and circulates naturally in wild felids. Using samples derived from 35 lion (Panthera leo) prides, we tested the prediction that FIV in lions (FIVP le ) can be used to track the dispersal of individuals between prides...
July 2, 2018: Journal of Evolutionary Biology
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