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Dynamic fusion cage

Bong Jin Hong, Aysenur Iscen, Anthony J Chipre, Mei Mei Li, One-Sun Lee, Joshua N Leonard, George C Schatz, SonBinh T Nguyen
Highly stable and stimuli/pH-responsive ultra-small polymer-grafted nanobins (usPGNs) have been developed by grafting a small amount (10 mol %) of short (4.3 kDa) cholesterol-terminated poly(acrylic acid) (Chol-PAA) into an ultra-small unilamellar vesicle (uSUV). The usPGNs are stable against fusion and aggregation over several weeks and exhibit over 10-fold enhanced cargo retention in biologically relevant media at pH 7.4 in comparison with the parent uSUV template. Coarse-grained molecular dynamics (CGMD) simulations show that the presence of the cholesterol moiety can greatly stabilize the lipid bilayer...
February 1, 2018: Journal of Physical Chemistry Letters
Junfeng Zeng, Yuchen Duan, Yi Yang, Beiyu Wang, Ying Hong, Jigang Lou, Ning Ning, Hao Liu
Anterior cervical corpectomy and fusion (ACCF) is an effective surgical technique for cervical spondylotic myelopathy (CSM). However, no data exist regarding long-term outcomes after ACCF with the dynamic cervical plate for CSM. This study aimed to provide minimum 5-year clinical and radiographic outcomes of anterior corpectomy and reconstruction using dynamic cervical plate and titanium mesh cage (TMC) for CSM.Thirty-five patients who underwent single- or 2-level ACCF with dynamic cervical plate and TMC for the treatment of CSM were retrospectively investigated...
February 2018: Medicine (Baltimore)
Parmenion P Tsitsopoulos, Leonard I Voronov, Michael R Zindrick, Gerard Carandang, Robert M Havey, Alexander J Ghanayem, Avinash G Patwardhan
OBJECTIVE: To test the following hypotheses: (i) anterior cervical discetomy and fusion (ACDF) using stand-alone interbody spacers will significantly reduce the range of motion from intact spine; and (ii) the use of a static or a rotational-dynamic plate will significantly augment the stability of stand-alone interbody spacers, with similar beneficial effect when compared to each other. METHODS: Eleven human cadaveric subaxial cervical spines (age: 48.2 ± 5.4 years) were tested under the following sequence: (i) intact spine; (ii) ACDF at C4 -C5 using a stand-alone interbody spacer; (iii) ACDF at C5 -C6 and insertion of an interbody spacer (two-level construct); and (iv) randomized placement of either a two-level locking static plate or a rotational-dynamic plate...
August 2017: Orthopaedic Surgery
Zhao Zhang, Yang Yang, Frederic Pincet, Marc C Llaguno, Chenxiang Lin
The diverse structure and regulated deformation of lipid bilayer membranes are among a cell's most fascinating features. Artificial membrane-bound vesicles, known as liposomes, are versatile tools for modelling biological membranes and delivering foreign objects to cells. To fully mimic the complexity of cell membranes and optimize the efficiency of delivery vesicles, controlling liposome shape (both statically and dynamically) is of utmost importance. Here we report the assembly, arrangement and remodelling of liposomes with designer geometry: all of which are exquisitely controlled by a set of modular, reconfigurable DNA nanocages...
June 23, 2017: Nature Chemistry
Félix Tomé-Bermejo, Julián A Morales-Valencia, Javier Moreno-Pérez, Juan Marfil-Pérez, Elena Díaz-Dominguez, Angel R Piñera, Luis Alvarez
STUDY DESIGN: A retrospective, observational study of prospectively collected outcomes. OBJECTIVE: To investigate the long-term clinical course of anterior cervical discectomy and fusion with interbody fusion cages (ACDF-IFC) with lordotic tantalum implants and to correlate the radiologic findings with the clinical outcomes, with special emphasis on the significance and the influence of implant subsidence. SUMMARY OF BACKGROUND DATA: Cage subsidence is the most frequently reported complication after ACDF-IFC...
June 2017: Clinical Spine Surgery
Timothy A Peppers, Dennis E Bullard, Jed S Vanichkachorn, Scott K Stanley, Paul M Arnold, Erik I Waldorff, Rebekah Hahn, Brent L Atkinson, James T Ryaby, Raymond J Linovitz
BACKGROUND: Trinity Evolution® (TE), a viable cellular bone allograft, previously demonstrated high fusion rates and no safety-related concerns after single-level anterior cervical discectomy and fusion (ACDF) procedures. This prospective multicenter clinical study was performed to assess the radiographic and clinical outcomes of TE in subjects undergoing two-level ACDF procedures. METHODS: In a prospective, multicenter study, 40 subjects that presented with symptomatic cervical degeneration at two adjacent vertebral levels underwent instrumented ACDF using TE autograft substitute in a polyetherethereketone (PEEK) cage...
April 26, 2017: Journal of Orthopaedic Surgery and Research
Mark P Arts, Jasper F C Wolfs, Terry P Corbin
PURPOSE: Anterior cervical discectomy with fusion is a common procedure for treating radicular arm pain. Polyetheretherketone (PEEK) plastic is a frequently used material in cages for interbody fusion. Silicon nitride is a new alternative with desirable bone compatibility and imaging characteristics. The aim of the present study is to compare silicon nitride implants with PEEK cages filled with autograft harvested from osteophytes. METHODS: The study is a prospective, randomized, blinded study of 100 patients with 2 years follow-up...
April 5, 2017: European Spine Journal
Giuseppe M Barbagallo, Francesco Certo
BACKGROUND: Posterior dynamic stabilization of the lumbar spine is spreading as a viable alternative to spinal fusion, aiming to achieve an equally satisfactory clinical outcome without making the spine completely rigid. We describe the feasibility of a minimally invasive surgical technique used to implant a hybrid system and perform a mini-open (m-open) transforaminal lumbar interbody fusion (TLIF) in patients suffering from degenerative spondylolistesis and adjacent level's degenerative disc disease (DDD)...
January 26, 2017: Journal of Neurosurgical Sciences
Majid R Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized-controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral disks. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiological disk height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteointegration and stability, has not been identified yet...
February 2017: Clinical Spine Surgery
Gregory D Schroeder, Christopher K Kepler, Douglas A Hollern, Ricardo Rodrigues-Pinto, Mark F Kurd, Jefferson R Wilson, Mitchell G Maltenfort, Jonathan T Paul, Andrew N Fleischman, Kathryn Dwight, Paul W Millhouse, Alexander R Vaccaro
STUDY DESIGN: A systematic review. OBJECTIVE: To determine the effect of plate design on fusion rates in patients undergoing a 1- and 2-level anterior cervical discectomy and fusion (ACDF). METHODS: Articles published between January 1, 2002 and January 1, 2015 were systematically reviewed to determine the fusion rate of 1- and 2-level ACDFs using either a fully constrained or semiconstrained locking plate. Additional variables that were collected included the number of levels, the type of graft/cage used, the study design, the method for determining fusion, and complications...
February 2017: Clinical Spine Surgery
Man Kyu Choi, Sung Bum Kim, Chang Kyu Park, Sung Ho Lee, Dae Jean Jo
OBJECTIVE: In the cervical spine, deep paraspinal muscles (DPMs) function to preserve spinal stability and mobility. However, the relationship between DPMs and bone union after cervical fusion surgery has not yet been investigated. The objective of this study is to evaluate the relationship between the cross-sectional area (CSA) of DPMs and bone union after cage alone anterior cervical decompression and fusion (ACDF). METHODS: A total of 243 patients who underwent cage alone ACDF at the C5-6 or C6-7 segments were enrolled...
December 2016: World Neurosurgery
Sanket A Deshmukh, Lee A Solomon, Ganesh Kamath, H Christopher Fry, Subramanian K R S Sankaranarayanan
Understanding the role of water in governing the kinetics of the self-assembly processes of amphiphilic peptides remains elusive. Here, we use a multistage atomistic-coarse-grained approach, complemented by circular dichroism/infrared spectroscopy and dynamic light scattering experiments to highlight the dual nature of water in driving the self-assembly of peptide amphiphiles (PAs). We show computationally that water cage formation and breakage near the hydrophobic groups control the fusion dynamics and aggregation of PAs in the micellar stage...
2016: Nature Communications
Jae Hyup Lee, Chang-Bae Kong, Jae Jun Yang, Hee-Jong Shim, Ki-Hyoung Koo, Jeehyoung Kim, Choon-Ki Lee, Bong-Soon Chang
BACKGROUND CONTEXT: The CaO-SiO2-P2O5-B2O3 glass ceramics spacer generates chemical bonding to adjacent bones with high mechanical stability to produce a union with the end plate, and ultimately stability. PURPOSE: The authors aimed to compare the clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass ceramics with a titanium cage that is widely used for posterior lumbar interbody fusion (PLIF) surgery in the clinical field. STUDY DESIGN/SETTING: This is a prospective, stratified randomized, multicenter, single-blinded, comparator-controlled non-inferiority trial...
November 2016: Spine Journal: Official Journal of the North American Spine Society
Majid Reza Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral discs. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiologic disc height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteo-integration and stability, has not been identified yet...
June 28, 2016: Clinical Spine Surgery
Man Kyu Choi, Sung Bum Kim, Bong Jin Park, Chang Kyu Park, Sung Min Kim
OBJECTIVE: Although trunk muscles in the lumbar spine preserve spinal stability and motility, little is known about the relationship between trunk muscles and spinal fusion rate. The aim of the present study is to evaluate the correlation between trunk muscles cross sectional area (MCSA) and fusion rate after posterior lumbar interbody fusion (PLIF) using stand-alone cages. METHODS: A total of 89 adult patients with degenerative lumbar disease who were performed PLIF using stand-alone cages at L4-5 were included in this study...
May 2016: Journal of Korean Neurosurgical Society
Yan Zhao
Surfactant micelles are dynamic entities with a rapid exchange of monomers. By "clicking" tripropargylammonium-containing surfactants with diazide cross-linkers, we obtained surface-cross-linked micelles (SCMs) that could be multifunctionalized for different applications. They triggered membrane fusion through tunable electrostatic interactions with lipid bilayers. Antenna chromophores could be installed on them to create artificial light-harvesting complexes with efficient energy migration among tens to hundreds of chromophores...
June 14, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Elisabetta Falvo, Elisa Tremante, Alessandro Arcovito, Massimiliano Papi, Nadav Elad, Alberto Boffi, Veronica Morea, Giamaica Conti, Giuseppe Toffoli, Giulio Fracasso, Patrizio Giacomini, Pierpaolo Ceci
A novel human ferritin-based nanocarrier, composed of 24 modified monomers able to auto-assemble into a modified protein cage, was produced and used as selective carrier of anti-tumor payloads. Each modified monomer derives from the genetic fusion of two distinct modules, namely the heavy chain of human ferritin (HFt) and a stabilizing/protective PAS polypeptide sequence rich in proline (P), serine (S), and alanine (A) residues. Two genetically fused protein constructs containing PAS polymers with 40- and 75-residue lengths, respectively, were compared...
February 8, 2016: Biomacromolecules
Bastian Welke, Michael Schwarze, Christof Hurschler, Thorsten Book, Stephan Magdu, Dorothea Daentzer
PURPOSE AND METHODS: For the treatment of degenerative disc diseases of the cervical spine, anterior cervical discectomy and fusion (ACDF) still represents the standard procedure. However, long term clinical studies have shown a higher incidence of pathologies in the adjacent segments. As an alternative to spinal fusion, cervical total disc replacement (cTDR) or dynamically implants were increasingly used. This in vitro study analyzed the kinematics and intradiscal pressures in seven multi-segmental human cervical spine using hybrid multidirectional test method...
July 2016: European Spine Journal
Davut Ceylan, Can Yaldiz, Kiyasettin Asil, Tibet Kaçira, Necati Tatarli, Aytaç Can
Spinal fusion surgery techniques develop together with technologic advancements. New complications are seen as the result of new techniques and these may be very severe due to spinal cord and vascular structures in the lumbar region. The posterior lumbar interbody fusion cage (PLIFC) was shown to enhance spinal fusion and to prevent pseudoarthrosis due to its basic dynamic characteristics. PLIFC migrations are usually observed during the postoperative period, just after the mobilization of the patient and usually toward spinal canal...
2015: Pan African Medical Journal
Ashleen R Knutsen, Sean L Borkowski, Edward Ebramzadeh, Colleen L Flanagan, Scott J Hollister, Sophia N Sangiorgio
Recently, as an alternative to metal spinal fusion cages, 3D printed bioresorbable materials have been explored; however, the static and fatigue properties of these novel cages are not well known. Unfortunately, current ASTM testing standards used to determine these properties were designed prior to the advent of bioresorbable materials for cages. Therefore, the applicability of these standards for bioresorbable materials is unknown. In this study, an image-based topology and a conventional 3D printed bioresorbable poly(ε)-caprolactone (PCL) cervical cage design were tested in compression, compression-shear, and torsion, to establish their static and fatigue properties...
September 2015: Journal of the Mechanical Behavior of Biomedical Materials
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