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anti cancer nano

Steven J Tobin, Devin L Wakefield, Veronica Jones, Xueli Liu, Daniel Schmolze, Tijana Jovanović-Talisman
All breast cancers are assessed for levels of human epidermal growth factor receptor 2 (HER2). Fluorescence in situ hybridization (FISH) and immunohistochemistry are currently used to determine if a patient is eligible for anti-HER2 therapy. Limitations of both tests include variability and relatively long processing times. Additionally, neither test determines whether HER2 contains the extracellular domain. While truncated in some tumors, this domain is required for binding of the therapeutic antibody trastuzumab...
October 11, 2018: Scientific Reports
Alessandro Capo, Romina Sepe, Gianluca Pellino, Marco Milone, Umberto Malapelle, Simona Pellecchia, Francesco Pepe, Nunzio Antonio Cacciola, Michele Manigrasso, Sara Bruzzaniti, Guido Sciaudone, Giovanni Domenico De Palma, Mario Galgani, Francesco Selvaggi, Giancarlo Troncone, Alfredo Fusco, Sabato D'Auria, Pierlorenzo Pallante
Even if cancer specific biomarkers are present in peripheral blood of cancer patients, it is very difficult to detect them with conventional technology because of their low concentration. A potential cancer biomarker is the HMGA1b protein, whose overexpression is a feature of several human malignant neoplasias. By taking advantage of the surface plasmon resonance (SPR) phenomenon, we realized a specific nano/technology-based assay for cancer detection. More in details, anti-HMGA1b monoclonal antibodies, whose affinity was previously defined by ELISA, were immobilized onto metallic surfaces to develop a direct SPR-based assay...
October 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Zhijuan Yang, Qian Chen, Jiawen Chen, Ziliang Dong, Rui Zhang, Jingjing Liu, Zhuang Liu
Despite the promises of applying nano-photosensitizers (nano-PSs) for photodynamic therapy (PDT) against cancer, severe tumor hypoxia and limited tumor penetration of nano-PSs would lead to nonoptimized therapeutic outcomes of PDT. Therefore, herein a biocompatible nano-PS is prepared by using tamoxifen (TAM), an anti-estrogen compound, to induce self-assembly of chlorin e6 (Ce6) modified human serum albumin (HSA). The formed HSA-Ce6/TAM nanocomplexes, which are stable under neutral pH with a diameter of ≈130 nm, would be dissociated into individual HSA-Ce6 and TAM molecules under the acidic tumor microenvironment, owing to the pH responsive transition of TAM from hydrophobic to hydrophilic...
October 11, 2018: Small
Seong Jae Kang, Hwa Yeon Jeong, Min Woo Kim, In Ho Jeong, Moon Jung Choi, Young Myoung You, Chan Su Im, In Ho Song, Tae Sup Lee, Yong Serk Park
Cancer theranosis is an emerging field of personalized medicine which enables individual anti-cancer treatment by monitoring the therapeutic responses of cancer patients. Based on a consideration of the nano-bio interactions related to the blood circulation of systemically administered nanoparticles in humans, as well as extravasation and active targeting, lipid micellar nanoparticles were co-loaded with paclitaxel (PTX) and quantum dots (QDs) to generate a theranostic delivery vehicle. To provide with a tumor-targeting capability, either an antibody or an aptamer against the epidermal growth factor receptor (EGFR) was conjugated to the micelle surface...
October 11, 2018: Nanoscale
Francesco Roncato, Fatlum Rruga, Elena Porcù, Elisabetta Casarin, Roberto Ronca, Federica Maccarinelli, Nicola Realdon, Giuseppe Basso, Ronen Alon, Giampietro Viola, Margherita Morpurgo
Nowadays, personalized cancer therapy relies on small molecules, monoclonal antibodies, or antibody-drug conjugates (ADC). Many nanoparticle (NP)-based drug delivery systems are also actively investigated, but their advantage over ADCs has not been demonstrated yet. Here, using the Avidin-Nucleic-Acid-Nano-Assemblies (ANANAS), a class of polyavidins multifuctionalizable with stoichiometric control, we compare quantitatively anti-EGFR antibody(cetuximab)-targeted NPs to the corresponding ADC. We show that ANANAS tethering of cetuximab promotes a more efficient EGFR-dependent vesicle-mediated internalization...
October 4, 2018: Nature Communications
Can Liu, Huiqing Xie, Jingang Yu, Xiaoqing Chen, Shijie Tang, Lichun Sun, Xiang Chen, Defei Peng, Xiangyan Zhang, Jianda Zhou
Background: Nowadays, the combination of microRNA (miR) is attracting increased attention in clinical cancer trials. However, the clinical use of miR is highly limited because of certain properties such as instability, low-specificity distribution, and metabolic toxicity. Methods: In order to improve the anti-tumor efficacy and reduce the side effects of miR in treating melanoma, a combination of graphene oxide (GO), chitosan (CS), and a cellular penetrating peptide, MPG, was prepared with solid dispersion method in this research...
2018: Drug Design, Development and Therapy
Jianhua Zhu, Qiang Huo, Ming Xu, Fen Yang, Yang Li, Huihui Shi, Yimin Niu, Yang Liu
The treatment of metastatic tumors is highly desirable in clinics, which has also increased the interest in the design of nanoscale drug delivery systems. Bone metastasis is one of the most common pathways in the metastasis of breast cancer, and it is also an important cause for tumor recurrence and death. The aryl boronate group, as an acid-labile linker, has been introduced into nano-assemblies in recent years. Especially, as a proteasome inhibitor anticancer drug with a boric acid group, bortezomib can facilitate the formation of pH-sensitive aryl boric acid ester linkage with the catecholic group...
October 4, 2018: Nanoscale
Hong Chen, Huizi Sha, Lianru Zhang, Hanqing Qian, Fangjun Chen, Naiqin Ding, Liulian Ji, Anqing Zhu, Qiuping Xu, Fanyan Meng, Lixia Yu, Yan Zhou, Baorui Liu
Background: There is currently much interest in cancer cell targeting and tumor penetrating for research and therapeutic purposes. Purpose: To improve targeting delivery of antitumor drugs to gastric cancer, in this study, a tumor-targeting biocompatible drug delivery system derived from erythrocyte membrane for delivering paclitaxel (PTX) was constructed. Methods: Erythrocyte membrane of human red blood cells (RBCs) were used for preparing of erythrocyte membrane-derived vesicles...
2018: International Journal of Nanomedicine
Tomáš Etrych, Lenka Daumová, Eva Pokorná, Diana Tušková, Ondřej Lidický, Věra Kolářová, Jan Pankrác, Luděk Šefc, Petr Chytil, Pavel Klener
In this study, we report the in vivo anti-lymphoma efficacy and diagnostic potential of newly designed near-infrared fluorescent dye containing polymer-doxorubicin conjugates using murine models of malignant lymphomas including one cell line-derived xenograft (RAJI) and two patient-derived lymphoma xenografts (VFN-D1 and VFN-M2). Two types of passively targeted conjugates differing in architecture of the polymer backbone were synthesized. One of the conjugates was designed using a single linear polymer chain, and the second was more sophisticated with a star-shaped high-molecular-weight (HMW) polymer employing a dendrimer core...
September 22, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu
The common existence of hypoxia in solid tumors has been heavily researched because it renders tumors more resistant to most standard therapeutic methods, such as radiotherapy (RT), chemotherapy, and photodynamic therapy (PDT), and is associated with a more malignant phenotype and poor survival in patients with tumors. The development of hypoxia modulation methods for advanced therapeutic activity is therefore of great interest but remains a considerable challenge. Since the significant development of nanotechnology and nanomedicine, functionalized nanomaterials can be exploited as adjuvant "drugs" for these oxygen-dependent standard therapies or as hypoxia initiators for advanced new therapies to solid tumors...
September 20, 2018: Accounts of Chemical Research
Minzhi Zhao, Haiyun Li, Linyang Fan, Yan Ma, He Gong, Wenjia Lai, Qiaojun Fang, Zhiyuan Hu
The first nano-platform commercialized as a drug delivery system was a liposomal formulation. The application of liposome technology resolved the issues of paclitaxel (PTX) insolubility and eliminated the use of solvents causing toxic side-effects, which enabled to apply higher drug doses leading to an enhanced drug efficacy. The growth-inhibitory activity of liposome-encapsulated PTX was retained in vitro against a variety of tumor cell. To investigate the drug efficacy in the system biological level, quantitative proteomic analysis was employed to study the molecular mechanism of the anti-tumor effect of Lipusu® (lip) compared with PTX on lung cancer cell A549...
September 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Jun Zhao, Zhilan Xiao, Tingting Li, Huiqin Chen, Ying Yuan, Y Alan Wang, Cheng-Hui Hsiao, Diana S-L Chow, Willem W Overwijk, Chun Li
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult cancers to treat. It is refractory to most existing therapies, including immunotherapies, due to the presence of an excessive desmoplastic stroma, which restricts penetration of drugs and cytotoxic CD8+ T cells. Stromal modulation has shown promising results in the enhancement of immune checkpoint blockade treatment in PDAC. We demonstrate here effective stromal modulation by a polymeric micelle-based nanoformulation to codeliver a sonic hedgehog inhibitor (cyclopamine, abbreviated as CPA) and a cytotoxic chemotherapy drug (paclitaxel, abbreviated as PTX)...
September 21, 2018: ACS Nano
Naby Hadilou, Ali Navid Khoshgenab, Mitra Amoli-Diva, Rasoul Sadighi-Bonabi
Three magneto-plasmonic nanohybrids were synthesized using Au and Ag-coated Fe3 O4 nanoparticles (NPs) modified dual pH- and temperature-responsive triblock copolymer of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) to serve as drug carriers with potential of using in both photothermal and controlled/targeted chemo-therapies. The internal superparamagnetic core gives the carriers targeted-delivery characteristics and surface plasmon resonance (SPR)-based noble metallic Au/Ag shells give them on-demand photothermal and photo-triggering release properties...
September 5, 2018: Journal of Pharmaceutical Sciences
Zakir M O Rzayev, Ulviye Bunyatova, Jonathan F Lovell, Weipeng Shen, Tim Thomay, Alexander Cartwright
The subject of this work is synthesis and characterization of novel multifunctional nanocomposite (8/2A-NC) consisting (1) carboxymethyl cellulose (CMC) as a matrix biopolymer and poly (maleic acid-alt-acrylic acid) as a reactive synthetic partner matrix polymer; (2) octadecyl amine montmorillonite (ODA-MMT) reactive organoclay provide intercalated silicate layers structures and aqueous colloidal dispersing medium, and MMT as carriers and targeting agents for anticancer agents in drug delivery systems, respectively...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Yanhong Duo, Min Yang, Zhenya Du, Chuhan Feng, Chen Xing, Yanping Wu, Zhenhua Xie, Fang Zhang, Laiqiang Huang, Xiaowei Zeng, Hongbo Chen
Various drugs have been designed in the past to act on intracellular targets. For the desired effects to be exerted, these drugs should reach and accumulate in specific subcellular organelles. CX-5461 represents a potent small-molecule inhibitor of rRNA synthesis that specifically inhibits the transcription driven by RNA polymerase (Pol) I and induces tumor cell death through triggering a pro-death autophagy. In the current study an innovative kind of CX-5461-loaded mesoporous silica nano-particles enveloped by polyethylene glycol (PEG), polydopamine (PDA) and AS-1411 aptamer (MSNs-CX-5461@PDA-PEG-APt) with the aim of treating cancer cells was constructed, in which the high-surface-area MSNs allowed for high drug loading, PDA acted as gatekeeper to prevent the leakage of CX-5461 from MSNs, PEG grafts on PDA surfaces increased the stable and biocompatible property in physiological condition, and AS-1411 aptamer promoted the nucleolar accumulation of CX-5461...
August 30, 2018: Acta Biomaterialia
Minori Kawai, Takashi Nakamura, Naoya Miura, Mio Maeta, Hiroki Tanaka, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Kota Tange, Yuta Nakai, Hiroki Yoshioka, Hideyoshi Harashima, Hidetaka Akita
Cytoplasmic DNA triggers cellular immunity via activating the stimulator of interferon genes pathway. Since DNA is degradable and membrane impermeable, delivery system would permit cytoplasmic delivery by destabilizing the endosomal membrane for the use as an adjuvant. Herein, we report on the development of a plasmid DNA (pDNA)-encapsulating lipid nanoparticle (LNP). The structural components include an SS-cleavable and pH-activated lipid-like material that mounts vitamin E as a hydrophobic scaffold, and dual sensing motifs that are responsive to the intracellular environment (ssPalmE)...
August 29, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Sri Vishnu Kiran Rompicharla, Prakruti Trivedi, Preeti Kumari, Omkara Swami Muddineti, Sowmya Theegalapalli, Balaram Ghosh, Swati Biswas
Vorinostat (VOR), a potent HDAC inhibitor, suffers from low solubility and poor absorption, which hinders its successful application in therapy, especially in the treatment of solid tumors. In this study, an effort to improve the physicochemical characteristics of VOR was made by encapsulating it in PEG-PLGA copolymeric micelles. VOR-loaded PEG-PLGA micelles (VOR-PEG-PLGA) were produced by thin-film hydration and physicochemically characterized. The PEG-PLGA micelles had an average size of 124.06 ± 2.6 nm, polydispersity index of 0...
August 21, 2018: AAPS PharmSciTech
Lukasz J Ochyl, Joseph D Bazzill, Charles Park, Yao Xu, Rui Kuai, James J Moon
Despite the promise and advantages of autologous cancer cell vaccination, it remains challenging to induce potent anti-tumor immune responses with traditional immunization strategies with whole tumor cell lysate. In this study, we sought to develop a simple and effective approach for therapeutic vaccination with autologous whole tumor cell lysate. Endogenous cell membranes harvested from cancer cells were formed into PEGylated nano-vesicles (PEG-NPs). PEG-NPs exhibited good serum stability in vitro and draining efficiency to local lymph nodes upon subcutaneous administration in vivo...
November 2018: Biomaterials
Vinod Vijay Subhash, Mei Shi Yeo, Lingzhi Wang, Shi Hui Tan, Foong Ying Wong, Win Lwin Thuya, Woei Loon Tan, Praveen C Peethala, Mu Yar Soe, David S P Tan, Nisha Padmanabhan, Erkan Baloglu, Sharon Shacham, Patrick Tan, H Phillip Koeffler, Wei Peng Yong
Exportin-1 (XPO1) controls the nucleo-cytoplasmic trafficking of several key growth regulatory and tumor suppressor proteins. Nuclear export blockade through XPO1 inhibition is a target for therapeutic inhibition in many cancers. Studies have suggested XPO1 upregulation as an indicator of poor prognosis in gastric cancer. In the current study, we investigated the anti-tumor efficacy of selective inhibitors of nuclear export (SINE) compounds KPT-185, KTP-276 and clinical stage selinexor (KPT-330) in gastric cancer...
August 16, 2018: Scientific Reports
Jesmin Mondal, Mousumi Patra, Ashis Kumar Panigrahi, Anisur Rahman Khuda-Bukhsh
BACKGROUND: Cisplatin is a widely-used potent anti-cancer drug having severe side-effects precluding its sustained use. OBJECTIVES: Poly (lactide-co-glycolide) (PLGA)-nanoparticles loaded Boldine, an antioxidant ingredient of ethanolic extract of Boldo plant (Peumus boldus) was tested in cancer mice model, Mus musculus to examine if it could reduce unwanted Cisplatin-induced toxicity in normal tissue. MATERIAL AND METHODS: Nano-encapsulation of Boldine was done by following the standardized solvent displacement method...
August 13, 2018: Journal of Ayurveda and Integrative Medicine
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