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anti cancer nano

Xin-Shuai Wang, Xue-Zhen Ding, Xiao-Cen Li, Yixuan He, De-Jiu Kong, Li Zhang, Xiao-Chen Hu, Jun-Qiang Yang, Meng-Qi Zhao, She-Gan Gao, Tzu-Yin Lin, Yuanpei Li
The prognosis of esophageal squamous cell carcinoma is poor. We hereby presented a highly integrated and clinically relevant precision nanomedicine strategy to target ESCC molecularly and physically for significant improvement of the treatment efficacy. We firstly identified PI3K overexpression in patient samples and its relation to poor patient survival. With our highly versatile tumor-targeted drug delivery platform (DCM), we were able to load a potent but toxic docetaxel (DTX) and a PI3K inhibitor (AZD8186) with favorable physical properties...
July 2, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Hugo Groult, Isabel García-Álvarez, Lorenzo Romero-Ramírez, Manuel Nieto-Sampedro, Fernando Herranz, Alfonso Fernández-Mayoralas, Jesús Ruiz-Cabello
The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides...
July 25, 2018: Nanomaterials
Yan Wang, Xiuqi Liang, Rongsheng Tong, Jin Yang, Yanxue Yang, Jian Zhong, Qinjie Wu, Changyang Gong, Jiying Yu, Lulu Cai
Gambogic acid (GA) possesses good anti-tumor efficacy in preclinical studies, however, its poor hydrophilicity, short blood circulation time and side effect limited its clinical application. In this work, monomethyl poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) copolymer was synthesized and used to encapsulate GA by a facile one-step solid dispersion and form nano-sized micelles (GA micelles). The GA micelles exhibited small average particle size (29±2 nm), high encapsulation efficiency (92.1±0.3%), and long drug release time-in vitro...
October 1, 2018: Journal of Biomedical Nanotechnology
Reza Jafari, Naime Majidi Zolbanin, Jafar Majidi, Fatemeh Atyabi, Mehdi Yousefi, Farhad Jadidi-Niaragh, Leili Aghebati-Maleki, Dariush Shanehbandi, Mohammad-Sadegh Soltani Zangbar, Houshang Rafatpanah
Background: Targeted co-delivery of siRNA and a chemotherapeutic drug is an attractive approach to cancer drug design and treatment. This study was carried out to design an anti-Mucin 1 aptamer (Apt)-conjugated chitosan nanoparticle (NP) for targeted co-delivery of insulin-like growth factor receptor 1 (IGF-1R) siRNA and docetaxel (DTX) to SKBR3 cells. Methods: Characterization of nano-drugs, cellular uptake of NPs, cell viability, and gene expression studies were evaluated based on metastatic breast cancer cells...
July 25, 2018: Iranian Biomedical Journal
Wendu Duan, Yan Liu
Purpose: Targeted hepatocellular carcinoma therapy was carried out to improve the efficacy of liver cancer treatment. The purpose of this study was to design an N-acetylgalactosamine (NAcGal) modified and pH sensitive doxorubicin (DOX) prodrug (NAcGal-DOX) for the construction of lipid nanoparticles (LNPs). Methods: NAcGal-DOX and sorafenib (SOR) co-loaded LNPs were designed and the synergistic effects were evaluated on human hepatic carcinoma (HepG2) cells in vitro and anti-hepatic carcinoma mice model in vivo...
2018: Drug Design, Development and Therapy
Jinzhao Liu, Jia Dong, Ting Zhang, Qiang Peng
The continuing increase of cancer morbidity and death rate requires efficient therapeutic strategies. The traditional chemotherapy usually fails to treat cancer or prolong survival rate due to its toxicity to normal cells, side effects and lack of targeting capacity. In recent years, nanomaterials have shown great potentials to treat various cancers efficiently. Graphene-based nanomaterials, especially graphene oxide (GO) and reduced GO (rGO), have arisen as promising candidates for cancer therapy. Due to their unique physicochemical and optical properties including the extremely large surface area, modifiable active groups, great biocompatibility and strong photothermal effect, they can act either as tunable carriers or active agents for advanced chemotherapeutics delivery and cancer therapy...
July 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Haiyan Hu, Jing Wang, Hong Wang, Tao Tan, Jie Li, Zhiwan Wang, Kaoxiang Sun, Yaping Li, Zhiwen Zhang
Lymph metastasis is a vital pathway of cancer cell dissemination, and insidious lymph node metastasis increases the risk of distant cancer metastasis. Current therapies for lymph metastasis are largely restricted by limited targeting and penetration capacity. Herein, we report that an r9 cell-penetrating peptide-based cabazitaxel nanovehicle (r9-CN) displays prominent lymph metastasis targeting and deep penetration ability after intravenous injection for effective anti-metastasis therapy. Methods: The r9-CN and CN nanovehicles were prepared by thin film dispersion, using DSPE-PEG2000 as the nano-carrier material and cabazitaxel as the model drug to fabricate r9-modified nano-micelles by self-assembly...
2018: Theranostics
Rui Gao, Xuan Mei, Dongpeng Yan, Ruizheng Liang, Min Wei
Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibility. Here, we develop near-infrared laser activated supramolecular photosensitizers (isophthalic acid/layered double hydroxide nanohybrids) for efficient two-photon photodynamic therapy. The singlet oxygen quantum yield of nanohybrid is up to 0...
July 18, 2018: Nature Communications
Antonietta Arcella, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Anna Laura Capriotti, Luigi Frati, Maria Antonietta Oliva, Georgia Tsaouli, Rossella Rota, Isabella Screpanti, Morteza Mahmoudi, Giulio Caracciolo
Temozolomide (TMZ) is the current first-line chemotherapy for treatment of glioblastoma multiforme (GBM). However, similar to other brain therapeutic compounds, access of TMZ to brain tumors is impaired by the blood-brain barrier (BBB) leading to poor response for GBM patients. To overcome this major hurdle, we have synthesized a set of TMZ-encapsulating nanomedicines made of four cationic liposome (CL) formulations with systematic changes in lipid composition and physical-chemical properties. The targeting nature of this nanomedicine is provided by the recruitment of proteins, with natural targeting capacity, in the biomolecular corona (BC) layer that forms around CLs after exposure to human plasma (HP)...
July 31, 2018: ACS Chemical Neuroscience
Asmaa E Kassab, Rasha A Hassan
A series of novel benzotriazole N-acylarylhydrazone hybrids was synthesized according fragment-based design strategy. All the synthesized compounds were evaluated for their anticancer activity against 60 human tumor cell lines by NCI (USA). Five compounds: 3d, 3e, 3f, 3o and 3q exhibited significant to potent anticancer activity at low concentrations. Compound 3q showed the most prominent broad-spectrum anticancer activity against 34 tumor cell lines, with mean growth inhibition percent of 45.80%. It exerted the highest potency against colon HT-29 cell line, with cell growth inhibition 86...
July 10, 2018: Bioorganic Chemistry
Li Zong, Zifeng Pi, Shu Liu, Junpeng Xing, Zhiqiang Liu, Fengrui Song
RATIONALE: Multidrug resistance (MDR) occurs frequently and has a major challenge in tumor treatment. Lipid composition in cell membrane and the redox balance are closely associated with the development of MDR. The liquid extraction surface analysis in combination with mass spectrometry (LESA-MS) has the characteristics of minimal sample preparation, rapid analysis, high sensitivity and high throughput, and has obtained wide applications. METHODS: The LESA-MS was employed to in situ determine the lipids and other specific metabolites of intact MCF-7/ADR cells (adriamycin-resistant breast cancer cells) and its parental MCF-7/S cells grew on the glass slide...
July 12, 2018: Rapid Communications in Mass Spectrometry: RCM
Himabindu Padinjarathil, Manu M Joseph, B S Unnikrishnan, G U Preethi, R Shiji, M G Archana, S Maya, H P Syama, T T Sreelekha
Galactomannan isolated from the fruit rind of Punica granatum was previously reported to have excellent antioxidant, immunomodulatory and anticancer properties against both human and murine cancer cells. This polysaccharide was proved to be an anticancer agent either alone or as an adjuvant to chemotherapy. An exploration leads to the fabrication of silver nanoparticles with an average size around 30 nm and a negative surface charge of 35.2 mV using this biopolymer which acted both as reducing and capping agent and displayed good stability and biocompatibility...
July 3, 2018: International Journal of Biological Macromolecules
Xin Sun, Xiao Yan, Wei Zhuo, Jinke Gu, Ke Zuo, Wei Liu, Li Liang, Ya Gan, Gang He, Hua Wan, Xiaojun Gou, Hubing Shi, Jianping Hu
The anti-PD-L1 monoclonal antibody (mAb) targeting PD-1/PD-L1 immune checkpoint has achieved outstanding results in clinical application and has become one of the most popular anti-cancer drugs. The mechanism of molecular recognition and inhibition of PD-L1 mAbs is not yet clear, which hinders the subsequent antibody design and modification. In this work, the trajectories of PD-1/PD-L1 and nanobody/PD-L1 complexes were obtained via comparative molecular dynamics simulations. Then, a series of physicochemical parameters including hydrogen bond, dihedral angle distribution, p K a value and binding free energy, and so forth, were all comparatively analyzed to investigate the recognition difference between PD-L1 and PD-1 and nanobody...
July 7, 2018: International Journal of Molecular Sciences
Qi Sun, Xiaoli Wang, Chunying Cui, Jing Li, Yifan Wang
Background: Graphene oxide (GO) has attracted intensive interest in biological and medical fields in recent years due to its unique physical, chemical, and biological properties. In our previous work, we proved that GO could deliver small interfering RNA (siRNA) into cells and downregulate the expression of the desired gene. Methods: This study investigated the potential of a modified GO nanocarrier for co-delivery of siRNA and doxorubicin (DOX) for enhanced cancer therapy...
2018: International Journal of Nanomedicine
Junaid Khan, Amit Alexander, Ajazuddin, Swarnlata Saraf, Shailendra Saraf
Utilizing the diverse features of biocompatible polymers to target drugs into the tumor/s has been a research hotspot since last decade. Such polymeric conjugates of anti-cancer drugs have proven their potential in providing sustained release of drugs with reduced systemic toxicity and improved tumor retention. Polymers like polyethylene glycol (PEG), N-(2-Hydroxypropyl) methacrylamide (HPMA), Polylactic-co-glycolic acid (PLGA), Polyamidoamine (PAMAM), and others remain exploited for their specific as well as shared characteristics in the rational delivery of anti-cancer agents...
June 28, 2018: International Journal of Pharmaceutics
Jiali Zhai, Rodney B Luwor, Nuzhat Ahmed, Ruth Escalona, Fiona H Tan, Celesta Fong, Julian Ratcliffe, Judith A Scoble, Calum J Drummond, Nhiem Tran
Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer. However, due to nonspecific targeting of the drug and the presence of toxic solvents required for dissolving PTX prior to injection, there are several serious side effects associated with this treatment. In this study, we explored self-assembled lipid-based nanoparticles as PTX carriers, which were able to improve its antitumour efficacy against ovarian cancer. The nanoparticles were also functionalized with epidermal growth factor receptor (EGFR) antibody fragments to explore the benefit of tumor active targeting...
July 20, 2018: ACS Applied Materials & Interfaces
Shan-Jen Lin, Yu-Tang Chin, Yih Ho, Szu-Yi Chou, Yu-Chen Sh Yang, André Wendindondé Nana, Kuan-Wei Su, Yee-Tong Lim, Kuan Wang, Sheng-Yang Lee, Ya-Jung Shih, Yi-Ru Chen, Jacqueline Whang-Peng, Paul J Davis, Hung-Yun Lin, Earl Fu
Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K...
June 28, 2018: Food and Chemical Toxicology
Qingming Xia, Chunai Gong, Fenfen Gu, Zhuo Wang, Chuling Hu, Lijuan Zhang, Lei Qiang, Xueying Ding, Shen Gao, Yuan Gao
Immuno-based oncotherapy has been successfully implemented for cancer treatment. In the present study, we developed a Oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs (CpG ODNs) nano-delivery system based on Multi-walled carbon nanotubes (MWCNTs) conjugated with H3R6 polypeptide (MHR-CpG) for prostate cancer immunotherapy. The in vitro and in vivo toxicity data revealed that the prepared MHR showed high biocompatibility. Confocal laser scanning microscopy confirmed that MHR-CpG could specifically target the endosomal TLR9...
September 1, 2018: Journal of Biomedical Nanotechnology
Ramneek Kaur, Shilpi Verma, Prachi Joshi, Surinder P Singh, Manisha Singh
Despite several advancements in the biomedical sciences, an efficient cancer therapy still remains a challenge. Nanomedicines have shown potential to overcome certain roadblocks faced in the existing treatment modalities. Losartan potassium (LP) which is a known vasodilator also exhibits anti fibrolytic and anti-metastatic properties altogether. Further, also being a potential angiotensin II type 1 receptor antagonist, it has been well explored for down regulating tumourogenic biomarkers like VEGF-A (Vascular endothelial growth factor A) and suppression of neovascularization, making it a suitable drug to target for cancer treatment...
October 1, 2018: Journal of Nanoscience and Nanotechnology
Baiyan Sui, Xin Liu, Jiao Sun
The development of nanomaterials for stable, controlled delivery of drugs and efficient suppression of tumor growth with desirable biosafety remains challenging in the nano-biomedical field. In this study, we prepared and optimized mesoporous bioactive glass (MBG) nanospheres to establish a functional drug delivery system and analyzed the effect of the dendritic mesoporous structure on drug loading and release. We then utilized an in vitro model to examine the biological effects of dendritic MBG nanospheres on normal and tumor cells and studied the molecular mechanism underlying specific tumor suppression by MBG nanospheres...
July 18, 2018: ACS Applied Materials & Interfaces
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