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Immune photothermal

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https://www.readbyqxmd.com/read/30053487/prussian-blue-nanoparticles-synthesis-surface-modification-and-application-in-cancer-treatment
#1
REVIEW
Milan Gautam, Kishwor Poudel, Chul Soon Yong, Jong Oh Kim
This review outlines recently developed Prussian blue nanoparticle (PB NPs)-based multimodal imaging-guided chemo-photothermal strategies for cancer diagnosis and treatment in order to provide insight into the future of the field. The primary limitation of existing therapeutics is the lack of selectivity in drug delivery: they target healthy and cancerous cells alike. In this paper, we provide a thorough review of diverse synthetic and surface engineering techniques for PB NP fabrication. We have elucidated the various targeting approaches employed to deliver the therapeutic and imaging ligands into the tumor area, and outlined methods for enhancement of the tumor ablative ability of the NPS, including several important combinatorial approaches...
July 24, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30020768/laser-immunotherapy-in-combination-with-perdurable-pd-1-blocking-for-the-treatment-of-metastatic-tumors
#2
Lihua Luo, Chunqi Zhu, Hang Yin, Mengshi Jiang, Junlei Zhang, Bing Qin, Zhenyu Luo, Xiaoling Yuan, Jie Yang, Wei Li, Yongzhong Du, Jian You
A convenient and feasible therapeutic strategy for malignant and metastatic tumors was constructed here by combining photothermal ablation (PTA)-based laser immunotherapy with perdurable PD-1 blockade immunotherapy. Hollow gold nanoshells (HAuNS, a photothermal agent) and AUNP12 (an anti PD-1 peptide, APP) were co-encapsulated into poly(lactic- co-glycolic) acid (PLGA) nanoparticles. Unlike monoclonal PD-1/PD-L1 antibodies, PD-1 peptide inhibitor shows lower cost and immunotoxicity but needs frequent administration due to its rapid clearance in vivo...
July 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29981170/nanoparticle-based-photothermal-and-photodynamic-immunotherapy-for-tumor-treatment
#3
REVIEW
Xiaoyang Hou, Yingkai Tao, Yanyu Pang, Xinxin Li, Yanqun Liu, Guan Jiang
Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion, and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various anti-tumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines, and the transformation of memory T lymphocytes...
July 7, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29952075/photothermal-therapy-enhanced-the-effectiveness-of-imiquimod-against-refractory-cutaneous-warts-through-boosting-immune-responses
#4
Lei Shi, Min Luo, Fuhe Zhang, Linglin Zhang, Bo Wang, Pei Liu, Yunfeng Zhang, Haiyan Zhang, Degang Yang, Guolong Zhang, Feifan Zhou, Herbert Stepp, Ronald Sroka, Wei-Richard Chen, Xiuli Wang
Refractory cutaneous warts are difficult to eliminate. In-situ photo-immunotherapy (ISPI) is an innovative treatment concept combining local photothermal therapy (PTT) and topical immunotherapy using imiquimod. To compare the efficacy of ISPI versus topical imiquimod alone, a prospective randomized controlled trial was performed with patients suffering from refractory cutaneous warts. In both groups, approximately 50% of the skin surface containing warts was treated for 6 weeks. On the basis of topical imiquimod, ISPI includes an additional 808 nm laser irradiation...
June 28, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29938166/fever-inspired-immunotherapy-based-on-photothermal-cpg-nanotherapeutics-the-critical-role-of-mild-heat-in-regulating-tumor-microenvironment
#5
Yan Li, Lianghua He, Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, Tianbin Ren, Donglu Shi, Yongyong Li
Although there have been more than 100 clinical trials, CpG-based immunotherapy has been seriously hindered by complications in the immunosuppressive microenvironment of established tumors. Inspired by the decisive role of fever upon systemic immunity, a photothermal CpG nanotherapeutics (PCN) method with the capability to induce an immunofavorable tumor microenvironment by casting a fever-relevant heat (43 °C) in the tumor region is developed. High-throughput gene profile analysis identifies nine differentially expressed genes that are closely immune-related upon mild heat, accompanied by IL-6 upregulation, a pyrogenic cytokine usually found during fever...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29923229/rapid-biofilm-eradication-on-bone-implants-using-red-phosphorus-and-near-infrared-light
#6
Lei Tan, Jun Li, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Shengli Zhu, Zhaoyang Li, Xubo Yuan, Yufeng Zheng, Kelvin W K Yeung, Haobo Pan, Xianbao Wang, Shuilin Wu
Bone-implant-associated infections are common after orthopedic surgery due to impaired host immune response around the implants. In particular, when a biofilm develops, the immune system and antibiotic treatment find it difficult to eradicate, which sometimes requires a second operation to replace the infected implants. Most strategies have been designed to prevent biofilms from forming on the surface of bone implants, but these strategies cannot eliminate the biofilm when it has been established in vivo. To address this issue, a nonsurgical, noninvasive treatment for biofilm infection must be developed...
June 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29893126/triple-stimuli-responsive-magnetic-hollow-porous-carbon-based-nanodrug-delivery-system-for-magnetic-resonance-imaging-guided-synergistic-photothermal-chemotherapy-of-cancer
#7
Fan Wu, Ming Zhang, Hanwen Lu, Dong Liang, Yaliang Huang, Yonghong Xia, Yuqing Hu, Shengqiang Hu, Jianxiu Wang, Xinyao Yi, Jun Zhang
The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(γ-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (Fe3 O4 ) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy...
July 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29878757/photothermal-activatable-fe-3-o-4-superparticle-nanodrug-carriers-with-pd-l1-immune-checkpoint-blockade-for-anti-metastatic-cancer-immunotherapy
#8
Rui Ge, Cangwei Liu, Xue Zhang, Wenjing Wang, Binxi Li, Jie Liu, Yi Liu, Hongchen Sun, Daqi Zhang, Yuchuan Hou, Hao Zhang, Bai Yang
Checkpoint blockade immunotherapy has shown great potential in clinical cancer therapy, but the body's systemic immune must be fully activated and generates a positive tumor-specific immune cell response. In this work, we demonstrate the design of the immune-adjuvant nanodrug carriers on the basis of poly(ethylene glycol)- block-poly(lactic- co-glycolic acid) copolymer-encapsulated Fe3 O4 superparticles (SPs), in which imiquimod (R837), a kind of Toll-like receptor 7 agonist, is loaded. The nanodrug carriers are defined as Fe3 O4 -R837 SPs...
June 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29876215/photosensitizer-micelles-together-with-ido-inhibitor-enhance-cancer-photothermal-therapy-and-immunotherapy
#9
Jinrong Peng, Yao Xiao, Wenting Li, Qian Yang, Liwei Tan, Yanpeng Jia, Ying Qu, Zhiyong Qian
The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism-related enzymes is a promising strategy to stimulate immune response. Here, a nanosystem (NLG919/IR780 micelles) with the properties of photothermal conversion and regulation of the tryptophan metabolic pathway is used to suppress the growth of the tumor margin beyond effective PTT and promote tumor PTT and immunotherapy...
May 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29774068/platelet-camouflaged-nanococktail-simultaneous-inhibition-of-drug-resistant-tumor-growth-and-metastasis-via-a-cancer-cells-and-tumor-vasculature-dual-targeting-strategy
#10
Lijia Jing, Haijing Qu, Dongqi Wu, Chaojian Zhu, Yongbo Yang, Xing Jin, Jian Zheng, Xiangsheng Shi, Xiufeng Yan, Yang Wang
Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult to inhibit the growth of MDR cancer due to its chemoresistance. Furthermore, MDR cancers are more likely to metastasize, causing a high mortality among cancer patients. In this study, a nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) to efficiently inhibit the growth and metastasis of drug-resistant tumors via a cancer cells and tumor vasculature dual-targeting strategy...
2018: Theranostics
https://www.readbyqxmd.com/read/29721075/combining-photothermal-therapy-and-immunotherapy-against-melanoma-by-polydopamine-coated-al-2-o-3-nanoparticles
#11
Wenfei Chen, Ming Qin, Xiaoyan Chen, Qin Wang, Zhirong Zhang, Xun Sun
Photothermal therapy (PTT) can be an effective antitumor therapy, but it may not completely eliminate tumor cells, leading to the risk of recurrence or metastasis. Here we describe nanocarriers that allow combination therapy involving PTT and immunotherapy. Nanocarriers are prepared by coating Al2 O3 nanoparticles with non-toxic, biodegradable polydopamine, which shows high photothermal efficiency. A near-infrared laser irradiation can kill the majority of tumor tissues, resulting in the release of tumor-associated antigens...
2018: Theranostics
https://www.readbyqxmd.com/read/29665282/photothermal-therapy-generates-a-thermal-window-of-immunogenic-cell-death-in-neuroblastoma
#12
Elizabeth E Sweeney, Juliana Cano-Mejia, Rohan Fernandes
A thermal "window" of immunogenic cell death (ICD) elicited by nanoparticle-based photothermal therapy (PTT) in an animal model of neuroblastoma is described. In studies using Prussian blue nanoparticles to administer photothermal therapy (PBNP-PTT) to established localized tumors in the neuroblastoma model, it is observed that PBNP-PTT conforms to the "more is better" paradigm, wherein higher doses of PBNP-PTT generates higher cell/local heating and thereby more cell death, and consequently improved animal survival...
May 2018: Small
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#13
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652059/targeted-delivery-of-tungsten-oxide-nanoparticles-for-multifunctional-anti-tumor-therapy-via-macrophages
#14
Bin Zheng, Yang Bai, Hongbin Chen, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Xiaoli Wu, Hanjie Wang, Jin Chang
Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tumor cells by activating the anti-tumor immune response and photothermal therapy (PTT). In this design, macrophages cause the phagocytosis of tumor cells and activate the anti-tumor immune response by secreting plenty of cytokines. Meanwhile, to improve the tumor-killing effect and track the collaborative therapy system in vivo, a novel nanoplatform based on tungsten oxide (W18O49, WO) nanoparticles and fluorescent dyes loaded in polylactic-co-glycolic acid (PLGA) for PTT has been successfully constructed...
May 29, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29626502/sustained-release-of-anti-pd-1-peptide-for-perdurable-immunotherapy-together-with-photothermal-ablation-against-primary-and-distant-tumors
#15
Lihua Luo, Jie Yang, Chunqi Zhu, Mengshi Jiang, Xiaomeng Guo, Wei Li, Xiaoyi Yin, Hang Yin, Bin Qin, Xiaoling Yuan, Qingpo Li, Yongzhong Du, Jian You
Immune checkpoint PD-1/PD-L1 blockade has emerged as a successful immunotherapy strategy for treating several types of malignant tumors. A constant and proper drug concentration during the treatment is important because the long-term activation of the immune system is urgently needed to perdurably recognize and attack cancer cells for a better therapeutic effect with minimum side effects. However, practically few related studies have been reported to date. In this study, we constructed a therapeutic strategy combining PD-1 blocking with photothermal ablation for malignant tumors by co-encapsulating anti-PD-1 peptide (APP) and hollow gold nanoshell (HAuNS) into biodegradable Poly (d, l-lactic-co-glycolide) nanoparticles (APP- and HAuNS-loaded PLGA nanoparticles, AA@PN)...
May 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29540781/chemo-photothermal-therapy-combination-elicits-anti-tumor-immunity-against-advanced-metastatic-cancer
#16
Jutaek Nam, Sejin Son, Lukasz J Ochyl, Rui Kuai, Anna Schwendeman, James J Moon
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma...
March 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29508543/photothermally-controlled-mhc-class-i-restricted-cd8-t-cell-responses-elicited-by-hyaluronic-acid-decorated-gold-nanoparticles-as-a-vaccine-for-cancer-immunotherapy
#17
Fengqiang Cao, Mengmeng Yan, Yijia Liu, Lanxia Liu, Guilei Ma
Cancer vaccines aim to induce a strong major histocompatibility complex class I (MHC-I)-restricted CD8+ cytotoxic T-cell response, which is an important prerequisite for successful cancer immunotherapy. Herein, a hyaluronic acid (HA) and antigen (ovalbumin, OVA)-decorated gold nanoparticle (AuNPs)-based (HA-OVA-AuNPs) vaccine is developed for photothermally controlled cytosolic antigen delivery using near-infrared (NIR) irradiation and is found to induce antigen-specific CD8+ T-cell responses. Chemical binding of thiolated HA and OVA to AuNPs facilitates antigen uptake of dendritic cells via receptor-mediated endocytosis...
May 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29377647/cellular-uptake-and-tissue-biodistribution-of-functionalized-gold-nanoparticles-and-nanoclusters
#18
María A Escudero-Francos, Vanesa Cepas, Pedro González-Menédez, Rosana Badía-Laíño, Marta E Díaz-García, Rosa M Sainz, Juan C Mayo, David Hevia
In this study, the in vitro uptake by fibroblasts and in vivo biodistribution of 15 nm 11-mercaptoundecanoicacid-protected gold nanoparticles (AuNPs-MUA) and 3 nm glutathione- and 3 nm bovine serum albumin-protected gold nanoclusters (AuNCs@GSH and AuNCs@BSA, respectively) were evaluated. In vitro cell viability was examined after gold nanoparticle treatment for 48 h, based on MTT assays and analyses of morphological structure, the cycle cell, cellular doubling time, and the gold concentration in cells. No potential toxicity was observed at any studied concentration (up to 10 ppm) for AuNCs@GSH and AuNCs@BSA, whereas lower cell viability was observed for AuNPs-MUA at 10 ppm than for other treatments...
February 2017: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29344312/an-endogenous-vaccine-based-on-fluorophores-and-multivalent-immunoadjuvants-regulates-tumor-micro-environment-for-synergistic-photothermal-and-immunotherapy
#19
Ling Li, Suleixin Yang, Linjiang Song, Yan Zeng, Tao He, Ning Wang, Chuan Yu, Tao Yin, Li Liu, Xiawei Wei, Qinjie Wu, Yuquan Wei, Li Yang, Changyang Gong
Recently, near-infrared (NIR) light-based photothermal therapy (PTT) has been widely applied in cancer treatment. However, in most cases, the tissue penetration depth of NIR light is not sufficient and thus photothermal therapy is unable to completely eradicate deep, seated tumors inevitably leading to recurrence of the tumor. Due to this significant limitation of NIR, improved therapeutic strategies are urgently needed. Methods: We developed an endogenous vaccine based on a novel nanoparticle platform for combinatorial photothermal ablation and immunotherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29339567/erythrocyte-membrane-coated-gold-nanocages-for-targeted-photothermal-and-chemical-cancer-therapy
#20
Dao-Ming Zhu, Wei Xie, Yu-Sha Xiao, Meng Suo, Ming-Hui Zan, Qing-Quan Liao, Xue-Jia Hu, Li-Ben Chen, Bei Chen, Wen-Tao Wu, Li-Wei Ji, Hui-Ming Huang, Shi-Shang Guo, Xing-Zhong Zhao, Quan-Yan Liu, Wei Liu
Recently, red blood cell (RBC) membrane-coated nanoparticles have attracted much attention because of their excellent immune escapability; meanwhile, gold nanocages (AuNs) have been extensively used for cancer therapy due to their photothermal effect and drug delivery capability. The combination of the RBC membrane coating and AuNs may provide an effective approach for targeted cancer therapy. However, few reports have shown the utilization of combining these two technologies. Here, we design erythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy...
January 17, 2018: Nanotechnology
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