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Immune photothermal

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https://www.readbyqxmd.com/read/30540972/self-assembled-cpg-oligodeoxynucleotides-conjugated-hollow-gold-nanospheres-to-enhance-cancer-associated-immunostimulation
#1
Jing Luo, Yang Cheng, Xiao-Yan He, Yi Liu, Na Peng, Zhi-Wei Gong, Kui Wu, Tao Zou
To realize efficiently cellular uptake and enhance the immunostimulation, thiolated cytosine-phosphate-guanine (CpG) oligodeoxynucleotides (ODNs) were self-assembled on hollow gold nanospheres (HGNs) to form CpG-HGNs. The cellular uptake of CpG-HGNs in immune cells was studied in RAW 264.7 cells. Due to the enhanced delivery efficiency, CpG-HGNs exhibited a higher immune stimulatory activity compared with CpG ODNs, resulting in a dramatically enhanced secretion of proinflammatory cytokines. In addition, CpG-HGNs showed low cytotoxicity in RAW 264...
December 3, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30476523/nanotechnology-based-photoimmunological-therapies-for-cancer
#2
Yong Li, Xiaosong Li, Feifan Zhou, Austin Doughty, Ashley R Hoover, Robert E Nordquist, Wei R Chen
Phototherapy is a non-invasive or minimally invasive therapeutic strategy. Immunotherapy uses different immunological approaches, such as antibodies, vaccines, immunoadjuvants, and cytokines to stimulate the host immune system to fight against diseases. In cancer treatment, phototherapy not only destroys tumor cells, but also induces immunogenic tumor cell death to initiate a systemic anti-tumor immune response. When combined with immunotherapy, the effectiveness of phototherapy can be enhanced. Because of their special physical, chemical, and sometimes immunological properties, nanomaterials have also been used to enhance phototherapy...
November 23, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30457701/recent-advances-in-cell-membrane-camouflaged-nanoparticles-for-cancer-phototherapy
#3
REVIEW
Xu Zhen, Penghui Cheng, Kanyi Pu
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation, and low accumulation in target sites. Cell-membrane coating has emerged as a potential way to overcome these limitations, owing to the abundant proteins on the surface of cell membranes that can be inherited to the cell membrane-camouflaged nanoparticles...
November 20, 2018: Small
https://www.readbyqxmd.com/read/30406152/the-application-of-nanoparticle-based-drug-delivery-systems-in-checkpoint-blockade-cancer-immunotherapy
#4
REVIEW
Huan Zhao, Yuanqi Li, Dan Wei, Hongrong Luo
Tumor is the most serious threat to human beings. Although war against cancer has been launched over forty years, cancer treatment is still far away from being satisfactory. Immunotherapy, especially checkpoint blockade immunotherapy, is a rising star that shows a promising future. To fulfill the requirement of depleting primary tumor and inhibiting tumor metastasis and recurrence, many researchers combined checkpoint blockade immunotherapy with other treatment strategies to extend the treatment outcome. Photodynamic therapy could induce immunogenic cell death, and checkpoint blockade could further accelerate the immunity; therefore, combining these two strategies publishes many papers...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30319892/highly-sensitive-and-specific-noninvasive-in-vivo-alcohol-detection-using-wavelength-modulated-differential-photothermal-radiometry
#5
Xinxin Guo, Khashayar Shojaei-Asanjan, Di Zhang, Koneswaran Sivagurunathan, Qiming Sun, Peng Song, Andreas Mandelis, Bo Chen, Matt Goledzinowski, Qun Zhou, Felix Comeau
This paper reports the application of wavelength modulated differential photothermal radiometry (WM-DPTR) to blood alcohol (ethanol) concentration (BAC) measurements in the mid-infrared range to prevent impaired driving. In-vivo alcohol consumption measurements performed in the BAC range of interest (0-80 mg/dl) with an optimal wavelength pair demonstrated the alcohol detection capability of WM-DPTR with high resolution (~5 mg/dl) and a low detection limit (~10 mg/dl). Oral glucose tolerance tests using both glucose and alcohol sensitive wavelength pairs in the normal-to-hyperglycemia range (~80-320 mg/dl) proved the blood glucose screening ability and ethanol detection specificity of WM-DPTR...
October 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30288240/an-all-in-one-antitumor-and-anti-recurrence-metastasis-nanomedicine-with-multi-drug-co-loading-and-burst-drug-release-for-multi-modality-therapy
#6
Ji-Chun Yang, Yue Shang, Yu-Hao Li, Yu Cui, Xue-Bo Yin
Drug-loading often suffers from tedious procedures, limited loading efficiency, slow release, and therefore a low curative effect. Cancer easily recurs and metastasizes even after a solid tumor is removed. Herein, we report a simple strategy with multi-drug co-loading and burst drug release for a high curative effect and anti-recurrence/metastasis. CuS nanoparticles, protoporphyrin IX, and doxorubicin were added to the precursors of ZIF-8 with one-pot co-loading during the formation of ZIF-8 for chemo-, photothermal-, and photodynamic-therapy to eliminate solid tumors...
September 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/30279723/combination-of-nir-therapy-and-regulatory-t-cell-modulation-using-layer-by-layer-hybrid-nanoparticles-for-effective-cancer-photoimmunotherapy
#7
Wenquan Ou, Liyuan Jiang, Raj Kumar Thapa, Zar Chi Soe, Kishwor Poudel, Jae-Hoon Chang, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The efficacy of combined near-infrared (NIR) and immune therapies for inhibiting tumor growth and recurrence has gained increasing research attention. Regulatory T cells in the tumor microenvironment constitute a major obstacle in achieving robust CD8+ T cell antitumor immunotherapy. In the present study, we designed a photoimmunotherapy-based strategy involving a combination of photothermal and photodynamic therapies, followed by Treg cell suppression, for eliciting an immune response with IR-780- and imatinib-loaded layer-by-layer hybrid nanoparticles...
2018: Theranostics
https://www.readbyqxmd.com/read/30236026/gold-nanoparticles-mediated-photothermal-therapy-and-immunotherapy
#8
Yang Liu, Bridget M Crawford, Tuan Vo-Dinh
Cancer has been a significant threat to human health with more than eight million deaths each year in the world. Therefore, there is a significant need for novel technologies to effectively treat cancer and ultimately reduce cancer recurrences, treatment costs, number of radical cystectomies and mortality. A promising therapeutic platform for cancer is offered by nanoparticle-mediated therapy. This review highlights the development and applications of various nanoparticle platforms for photo-induced hyperthermia and immunotherapy...
September 2018: Immunotherapy
https://www.readbyqxmd.com/read/30232481/bsa-bioinspired-gold-nanorods-loaded-with-immunoadjuvant-for-the-treatment-of-melanoma-by-combined-photothermal-therapy-and-immunotherapy
#9
Benqing Zhou, Jun Song, Meng Wang, Xin Wang, Jielin Wang, Eric W Howard, Feifan Zhou, Junle Qu, Wei R Chen
The development of therapeutic methods that can effectively delay tumor growth, inhibit tumor metastases, and protect the host from tumor recurrence still faces challenges. Nanoparticle-based combination therapy may provide an effective therapeutic strategy. Herein, we show that bovine serum albumin (BSA)-bioinspired gold nanorods (GNRs) were loaded with an immunoadjuvant for combined photothermal therapy (PTT) and immunotherapy for the treatment of melanoma. In this work, cetyltrimethylammonium bromide (CTAB)-coated GNRs were successively decorated with polyethylene glycol (PEG) and BSA, and loaded with an immunoadjuvant imiquimod (R837)...
November 29, 2018: Nanoscale
https://www.readbyqxmd.com/read/30223092/platelet-mimicking-nanoparticles-co-loaded-with-w-18-o-49-and-metformin-alleviate-tumor-hypoxia-for-enhanced-photodynamic-therapy-and-photothermal-therapy
#10
Huaqin Zuo, Junxian Tao, Hua Shi, Jian He, Zhengyang Zhou, Chao Zhang
W18 O49 -mediated photodynamic therapy (PDT) and photothermal therapy (PTT) are limited by the easily oxidized property and tumor hypoxia. Here, we report the development of platelet membranes as nanocarriers to co-load W18 O49 nanoparticles (NPs) and metformin (PM-W18 O49 -Met NPs). Platelet membranes can protect W18 O49 from oxidation and immune evasion, and increase the accumulation of W18 O49 in tumor sites via the passive EPR effect and active adhesion between platelets and cancer cells. The introduction of metformin (Met), a typical anti-diabetic drug, can alleviate the tumor hypoxia through reducing oxygen consumption...
September 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30141614/c-c-chemokine-ligand-2-ccl2-recruits-macrophage-membrane-camouflaged-hollow-bismuth-selenide-nanoparticles-to-facilitate-photothermal-sensitivity-and-inhibit-lung-metastasis-of-breast-cancer
#11
Hongjuan Zhao, Li Li, Junli Zhang, Cuixia Zheng, Kaili Ding, Huifang Xiao, Lei Wang, Zhenzhong Zhang
Poor tumor accumulation, rapid clearance from blood circulation, and high risk of invasive and metastasis are the major barriers that encumber the conventional nanodrug-based tumor therapy. In this work, macrophage membrane (M)-camouflaged quercetin (QE)-loaded hollow bismuth selenide nanoparticles (abbreviated as M@BS-QE NPs) are fabricated for combination therapy of breast cancer. The resulting M@BS-QE NPs are comprehensively characterized, possessing prolonged circulation life, as well as accelerated and enhanced tumoritropic accumulation, compared with those of bare BS NPs because of the immune evading capacity, C-C chemokine ligand 2 (CCL2)-mediated recruitment properties, and active targeting ability...
September 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30141569/light-triggered-biomimetic-nanoerythrocyte-for-tumor-targeted-lung-metastatic-combination-therapy-of-malignant-melanoma
#12
Wen Liu, Miaoliang Ruan, Yanming Wang, Rongguang Song, Xin Ji, Jiake Xu, Jian Dai, Wei Xue
Red blood cell (RBC) membrane-cloaked nanoparticles, reserving the intact cell membrane structure and membrane protein, can gain excellent cell-specific functions such as long blood circulation and immune escape, providing a promising therapy nanoplatform for drug delivery. Herein, a novel RBC membrane biomimetic combination therapeutic system with tumor targeting ability is constructed by embedding bovine serum albumin (BSA) encapsulated with 1,2-diaminocyclohexane-platinum (II) (DACHPt) and indocyanine green (ICG) in the targeting peptide-modified erythrocyte membrane (R-RBC@BPtI) for enhancing tumor internalization and synergetic chemophototherapy...
September 2018: Small
https://www.readbyqxmd.com/read/30053487/prussian-blue-nanoparticles-synthesis-surface-modification-and-application-in-cancer-treatment
#13
REVIEW
Milan Gautam, Kishwor Poudel, Chul Soon Yong, Jong Oh Kim
This review outlines recently developed Prussian blue nanoparticle (PB NPs)-based multimodal imaging-guided chemo-photothermal strategies for cancer diagnosis and treatment in order to provide insight into the future of the field. The primary limitation of existing therapeutics is the lack of selectivity in drug delivery: they target healthy and cancerous cells alike. In this paper, we provide a thorough review of diverse synthetic and surface engineering techniques for PB NP fabrication. We have elucidated the various targeting approaches employed to deliver the therapeutic and imaging ligands into the tumor area, and outlined methods for enhancement of the tumor ablative ability of the NPS, including several important combinatorial approaches...
October 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30020768/laser-immunotherapy-in-combination-with-perdurable-pd-1-blocking-for-the-treatment-of-metastatic-tumors
#14
Lihua Luo, Chunqi Zhu, Hang Yin, Mengshi Jiang, Junlei Zhang, Bing Qin, Zhenyu Luo, Xiaoling Yuan, Jie Yang, Wei Li, Yongzhong Du, Jian You
A convenient and feasible therapeutic strategy for malignant and metastatic tumors was constructed here by combining photothermal ablation (PTA)-based laser immunotherapy with perdurable PD-1 blockade immunotherapy. Hollow gold nanoshells (HAuNS, a photothermal agent) and AUNP12 (an anti PD-1 peptide, APP) were co-encapsulated into poly(lactic- co-glycolic) acid (PLGA) nanoparticles. Unlike monoclonal PD-1/PD-L1 antibodies, PD-1 peptide inhibitor shows lower cost and immunotoxicity but needs frequent administration due to its rapid clearance in vivo...
August 28, 2018: ACS Nano
https://www.readbyqxmd.com/read/29981170/nanoparticle-based-photothermal-and-photodynamic-immunotherapy-for-tumor-treatment
#15
REVIEW
Xiaoyang Hou, Yingkai Tao, Yanyu Pang, Xinxin Li, Guan Jiang, Yanqun Liu
Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various antitumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes...
July 7, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29952075/photothermal-therapy-enhanced-the-effectiveness-of-imiquimod-against-refractory-cutaneous-warts-through-boosting-immune-responses
#16
Lei Shi, Min Luo, Fuhe Zhang, Linglin Zhang, Bo Wang, Pei Liu, Yunfeng Zhang, Haiyan Zhang, Degang Yang, Guolong Zhang, Feifan Zhou, Herbert Stepp, Ronald Sroka, Wei-Richard Chen, Xiuli Wang
Refractory cutaneous warts are difficult to eliminate. In-situ photo-immunotherapy (ISPI) is an innovative treatment concept combining local photothermal therapy (PTT) and topical immunotherapy using imiquimod. To compare the efficacy of ISPI versus topical imiquimod alone, a prospective randomized controlled trial was performed with patients suffering from refractory cutaneous warts. In both groups, approximately 50% of the skin surface containing warts was treated for 6 weeks. On the basis of topical imiquimod, ISPI includes an additional 808 nm laser irradiation...
June 28, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29938166/fever-inspired-immunotherapy-based-on-photothermal-cpg-nanotherapeutics-the-critical-role-of-mild-heat-in-regulating-tumor-microenvironment
#17
Yan Li, Lianghua He, Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, Tianbin Ren, Donglu Shi, Yongyong Li
Although there have been more than 100 clinical trials, CpG-based immunotherapy has been seriously hindered by complications in the immunosuppressive microenvironment of established tumors. Inspired by the decisive role of fever upon systemic immunity, a photothermal CpG nanotherapeutics (PCN) method with the capability to induce an immunofavorable tumor microenvironment by casting a fever-relevant heat (43 °C) in the tumor region is developed. High-throughput gene profile analysis identifies nine differentially expressed genes that are closely immune-related upon mild heat, accompanied by IL-6 upregulation, a pyrogenic cytokine usually found during fever...
June 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29923229/rapid-biofilm-eradication-on-bone-implants-using-red-phosphorus-and-near-infrared-light
#18
Lei Tan, Jun Li, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Shengli Zhu, Zhaoyang Li, Xubo Yuan, Yufeng Zheng, Kelvin W K Yeung, Haobo Pan, Xianbao Wang, Shuilin Wu
Bone-implant-associated infections are common after orthopedic surgery due to impaired host immune response around the implants. In particular, when a biofilm develops, the immune system and antibiotic treatment find it difficult to eradicate, which sometimes requires a second operation to replace the infected implants. Most strategies have been designed to prevent biofilms from forming on the surface of bone implants, but these strategies cannot eliminate the biofilm when it has been established in vivo. To address this issue, a nonsurgical, noninvasive treatment for biofilm infection must be developed...
August 2018: Advanced Materials
https://www.readbyqxmd.com/read/29893126/triple-stimuli-responsive-magnetic-hollow-porous-carbon-based-nanodrug-delivery-system-for-magnetic-resonance-imaging-guided-synergistic-photothermal-chemotherapy-of-cancer
#19
Fan Wu, Ming Zhang, Hanwen Lu, Dong Liang, Yaliang Huang, Yonghong Xia, Yuqing Hu, Shengqiang Hu, Jianxiu Wang, Xinyao Yi, Jun Zhang
The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(γ-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (Fe3 O4 ) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy...
July 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29878757/photothermal-activatable-fe-3-o-4-superparticle-nanodrug-carriers-with-pd-l1-immune-checkpoint-blockade-for-anti-metastatic-cancer-immunotherapy
#20
Rui Ge, Cangwei Liu, Xue Zhang, Wenjing Wang, Binxi Li, Jie Liu, Yi Liu, Hongchen Sun, Daqi Zhang, Yuchuan Hou, Hao Zhang, Bai Yang
Checkpoint blockade immunotherapy has shown great potential in clinical cancer therapy, but the body's systemic immune must be fully activated and generates a positive tumor-specific immune cell response. In this work, we demonstrate the design of the immune-adjuvant nanodrug carriers on the basis of poly(ethylene glycol)- block-poly(lactic- co-glycolic acid) copolymer-encapsulated Fe3 O4 superparticles (SPs), in which imiquimod (R837), a kind of Toll-like receptor 7 agonist, is loaded. The nanodrug carriers are defined as Fe3 O4 -R837 SPs...
June 20, 2018: ACS Applied Materials & Interfaces
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