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MPO Heart disease

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https://www.readbyqxmd.com/read/27882252/sj%C3%A3-gren-s-syndrome-complicated-by-myeloid-natural-killer-cell-precursor-acute-leukemia-case-report-and-review-of-the-literature
#1
Hao Feng, Jianlin Qiao, Ningning Ding, Wei Chen, Kunming Qi, Xiuying Pan, Jiang Cao, Kailin Xu
We report a case of Sjögren's syndrome (SS) complicated by myeloid/natural killer (NK) cell precursor acute leukemia (M/NKPAL). A 75-year-old woman with a previous SS history for 2 years was routinely treated. Peripheral blood progenitor cells were increased, and subsequent bone marrow cell morphology examination showed the presence of acute myeloid leukemia type M4. However, flow cytometry analysis revealed that CD7/CD56/CD33/CD34/HLA-DR/cCD3 were all positive and myeloperoxidase- (MPO-) specific staining, other T cells, NK cells, and myeloid markers were all negative...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27814628/inflammatory-biomarkers-of-coronary-heart-disease
#2
Hongyu Li, Kai Sun, Ruiping Zhao, Jiang Hu, Zhiru Hao, Fei Wang, Yaojun Lu, Fu Liu, Yong Zhang
Coronary heart disease (CHD), characterized by inflammation and accumulation of plaques mainly comprised of lipids, calcium and inflammatory cells in the walls of coronary arteries. CHD is exacerbated by specific cardiovascular risk factors, such as obesity, diabetes mellitus, and hypertension. The current review focuses on the critical role of traditional inflammatory biomarkers, including interleukin-6, C-reactive protein (CRP), complement, CD40 and myeloperoxidase (MPO), in the pathogenesis of CHD.
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27658709/comparing-fluorescence-based-cell-free-assays-for-the-assessment-of-antioxidative-capacity-of-high-density-lipoproteins
#3
Fumiyoshi Tsunoda, Stefania Lamon-Fava, Katalin V Horvath, Ernst J Schaefer, Bela F Asztalos
BACKGROUND: Population studies have shown an inverse association between high-density lipoprotein (HDL) cholesterol levels and risk of coronary heart disease (CHD). HDL has different functions, including the ability to protect biological molecules from oxidation. Our aim was to evaluate the performance of two fluorescence-based assays in assessing the antioxidative capacity of HDL. METHODS: We compared the antioxidative capacity of HDL with the phospholipid 2',7'-dichlorodihydrofluorescein (DCF) assay and the dihydrorhodamine 123 (DHR) assay in controls and in subjects at increased risk of CHD, including subjects with established CHD, and subjects with elevated plasma triglycerides (TG), serum amyloid A (SAA), or myeloperoxidase (MPO) levels...
September 22, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27613897/protective-effect-of-nicotine-on-sepsis-induced-oxidative-multi-organ-damage-role-of-neutrophils
#4
Zarife Nigâr Özdemir-Kumral, Dilek Özbeyli, Ahmet Faruk Özdemir, M Buğra Karaaslan, Kübra Kaytaz, Mustafa F Kara, Olgu Enis Tok, Feriha Ercan, Berrak Ç Yeğen
INTRODUCTION: Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs targeted by sepsis. METHODS: Male Wistar albino rats received tap water with (5 mg/kg) or without nicotine for 14 days. Under ketamine anesthesia, sepsis (n=50) was induced by ligation and punction of the cecum, while sham group (n=8) had only laparotomy...
August 3, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27464538/-the-clinical-analysis-of-46-cases-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#5
Q Zhang, H Q Zhou, Y H Li, J Guo, P H Xu, M H Lu, X L Liu, L Wang, S G Li
OBJECTIVE: To investigate the clinical features of patients with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), and to explore the disease activity of AAV patients and the relationship with prognosis. METHODS: The clinical data of 46 cases of AAV patients in the First Affiliated Hospital of PLA General Hospital were analyzed retrospectively.The clinical and laboratory features of each clinical subtype were compared.The disease activity of AAV and the relationship between disease activity and prognosis were evaluated...
July 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27464537/-the-clinical-manifestation-and-analysis-of-eosinophilic-granulomatous-vasculitis
#6
F Su, Q Qiu, D M Cai, L Q Liang, X Y Yang
OBJECTIVE: To evaluate the clinical features, treatment and prognosis of Eosinophilic Granulomatous Vasculitis. METHODS: We analyzed retrospectively the clinical and laboratory features, treatment and prognosis of 43 patients with Eosinophilic Granulomatous Vasculitis who admitted to the Department of Rheumatology of the First Affiliated University Hospital of Sun Yat-sen University between 2005 and 2014. RESULTS: Of the 43 patients, 31 patients (72...
July 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27431791/the-protective-effect-of-herbal-polysaccharides-on-ischemia-reperfusion-injury
#7
Qianqian Dong, Xiao Lin, Lan Shen, Yi Feng
Ischemia-reperfusion (IR) injury is one of the common ischemic diseases in organs such as brain, heart, kidney, liver, and intestine, which often leads to cell apoptosis and organ failure. The study of herbal polysaccharides for IR injury has a long time, and has laid a solid foundation for the next research work. The purpose of this review is to objectively appraise the current experimental research situation of treating IR injury in organs by polysaccharides from traditional Chinese medicines. Twenty-four kinds of polysaccharides that show effective treatment in organ ischemia were mentioned on the review...
July 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27318339/-the-significance-of-a-4-183-da-peptide-of-dermcidin-protein-in-the-early-diagnosis-and-differential-diagnosis-of-acute-coronary-syndrome
#8
Feng Kai, Liu Lifeng, Song Haijing, Liu Xianhua, Xia Hu
OBJECTIVE: To investigate the predictive value of 4,183 Da peptide of dermcidin protein in the early diagnosis and differential diagnosis of ischemic heart disease. METHODS: A prospective controlled study was conducted. Serum samples were drawn from 161 patients with acute coronary'syndrome [ACS, including 46 patients with unstable angina (UA), 23 with acute non-ST elevation myocardial infarction, and 92 with acute ST segment elevation myocardial infarction], 111 subjects for routine physical examination, including 45 patients with hypertension history, 42 with coronary heart disease, 22 with diabetes, and 54 patients with non-ACS (including pulmonary embolism, aortic dissection, aneurysm, arrhythmia, myocarditis, coronary myocardial bridge, pleurisy, pneumothorax pneumomediastinum, rib fracture, reflux esophagitis, peptic ulcer, and pancreatitis) to serve as controls...
December 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27269252/esmolol-attenuates-lung-injury-and-inflammation-in-severe-acute-pancreatitis-rats
#9
Luyao Zhang, Yao Nie, Yishan Zheng, Lu Ke, Zhihui Tong, Weiqin Li, Jieshou Li
BACKGROUND: Recent studies suggest that beta-adrenergic blockers attenuate systemic inflammation and improve survival in sepsis. We investigated whether esmolol can reduce lung injury and modulate inflammatory response in a rat model of severe acute pancreatitis (SAP). METHODS: A taurocholate-induced SAP was used, with or without continuously intravenous pumping of esmolol (15 mg/kg/h). Heart rate and arterial pressure were monitored. Nine hrs after esmolol administration, blood was drawn for blood gas analyses and cytokine (interleukin(IL)-6, tumor necrosis factor (TNF)-α) detections, lungs and pancreata were isolated for measurements of myeloperoxidase (MPO) activity and histological damage...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27010894/regular-exercise-alleviates-renovascular-hypertension-induced-cardiac-endothelial-dysfunction-and-oxidative-injury-in-rats
#10
Z N O Kumral, G Sener, S Ozgur, M Koc, S Suleymanoglu, C Hurdag, B C Yegen
The importance of physical activity in the management of renovascular diseases is well-known, but lacks evidence of underlying mechanisms. The purpose of the study was to elucidate the protective/therapeutic effects of regular exercise on experimental renovascular hypertension (RVH)-induced oxidative stress and cardiac dysfunction. Wistar albino rats underwent a RVH surgery (2K1C, Goldblatt). Three weeks later half of the rats started swimming exercise for 9 weeks (n = 15), while the sedentary RVH group (n = 15) had no exercise during that period...
February 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26776662/-ajwa-dates-phoenix-dactylifera-l-extract-ameliorates-isoproterenol-induced-cardiomyopathy-through-downregulation-of-oxidative-inflammatory-and-apoptotic-molecules-in-rodent-model
#11
Mohammed Al-Yahya, Mohammad Raish, Mansour S AlSaid, Ajaz Ahmad, Ramzi A Mothana, Mohammed Al-Sohaibani, Mohammed S Al-Dosari, Mohammad K Parvez, Syed Rafatullah
BACKGROUND/PURPOSE: Ajwa, a special variety of Saudi Arabian dates (Phoenix dactylifera L.) is a rich source of nutrients, fibers and bioactive molecules. While previous studies have shown the therapeutic value of dates phytoconstituents in liver and kidney diseases etc., its cardioprotective potential remains elusive. We therefore, investigated the cardioprotective effect of lyophilized Ajwa extract (AJLE) ex vivo as well as in vivo. METHODS: Ex vivo cardioprotective effect of AJLE was evaluated on DCFH-toxicated cardiomyoblast cells (H9C2)...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26714302/binding-of-human-myeloperoxidase-to-red-blood-cells-molecular-targets-and-biophysical-consequences-at-the-plasma-membrane-level
#12
Irina V Gorudko, Alexey V Sokolov, Ekaterina V Shamova, Daria V Grigorieva, Elena V Mironova, Igor V Kudryavtsev, Sergey A Gusev, Alexander A Gusev, Andrey V Chekanov, Vadim B Vasilyev, Sergey N Cherenkevich, Oleg M Panasenko, Alexander V Timoshenko
Myeloperoxidase (MPO) is an oxidant-producing enzyme that can also bind to cellular surface proteins. We found that band 3 protein and glycophorins A and B were the key MPO-binding targets of human red blood cells (RBCs). The interaction of MPO with RBC proteins was mostly electrostatic in nature because it was inhibited by desialation, exogenic sialic acid, high ionic strength, and extreme pH. In addition, MPO failed to interfere with the lectin-induced agglutination of RBCs, suggesting a minor role of glycan-recognizing mechanisms in MPO binding...
February 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/26276886/elevated-plasma-marinobufagenin-an-endogenous-cardiotonic-steroid-is-associated-with-right-ventricular-dysfunction-and-nitrative-stress-in-heart-failure
#13
David J Kennedy, Kevin Shrestha, Brendan Sheehey, Xinmin S Li, Anuradha Guggilam, Yuping Wu, Michael Finucan, Alaa Gabi, Charles M Medert, Kristen Westfall, Allen Borowski, Olga Fedorova, Alexei Y Bagrov, W H Wilson Tang
BACKGROUND: Plasma levels of cardiotonic steroids are elevated in volume-expanded states, such as chronic kidney disease, but the role of these natriuretic hormones in subjects with heart failure (HF) is unclear. We sought to determine the prognostic role of the cardiotonic steroids marinobufagenin (MBG) in HF, particularly in relation to long-term outcomes. METHODS AND RESULTS: We first measured plasma MBG levels and performed comprehensive clinical, laboratory, and echocardiographic assessment in 245 patients with HF...
November 2015: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26249551/iga-nephropathy-with-anti-neutrophil-cytoplasmic-antibody-seropositivity
#14
Xin Huang, Yuan Wang, Lijiao Xie, Ying Zhang, Sha Tang, Shiwei Yin, Xuejing Gao, Juan Cai, Weili Wang, Jun Zhang, Jinghong Zhao, Yunjian Huang, Yafei Li, Jingbo Zhang
BACKGROUND: There are few reports of IgA nephropathy (IgAN) with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. METHODS: The authors report the clinical and pathological findings in 14 patients with IgAN and ANCA seropositivity. RESULTS: These retrospective cases consisted of 4 men and 10 women with a mean age of 44.4 ± 12.7 years. ANCA-positivity was documented by EUROBlot kits and indirect immunofluorescence in all patients...
September 2015: Clinical Nephrology
https://www.readbyqxmd.com/read/26179062/increased-carotid-artery-intima-media-thickness-and-myeloperoxidase-level-in-children-with-newly-diagnosed-juvenile-idiopathic-arthritis
#15
Jaanika Ilisson, Maksim Zagura, Kersti Zilmer, Erik Salum, Kaire Heilman, Anneli Piir, Vallo Tillmann, Jaak Kals, Mihkel Zilmer, Chris Pruunsild
INTRODUCTION: Juvenile idiopathic arthritis (JIA) is a frequent childhood rheumatic disease characterized by chronic inflammation. The latter has been related to impairment of arterial functional-structural properties, atherogenesis and later cardiovascular events. The objective of this study was to examine intima-media thickness (IMT) and the parameters of arterial stiffness in children with JIA at diagnosis and their correlation with JIA subtype and markers of inflammation and atherosclerosis...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26132583/salivary-matrix-metalloproteinase-8-and-9-and-myeloperoxidase-in-relation-to-coronary-heart-and-periodontal-diseases-a-subgroup-report-from-the-parokrank-study-periodontitis-and-its-relation-to-coronary-artery-disease
#16
Nilminie Rathnayake, Anders Gustafsson, Anna Norhammar, Barbro Kjellström, Björn Klinge, Lars Rydén, Taina Tervahartiala, Timo Sorsa
BACKGROUND AND OBJECTIVE: Matrix metalloproteinase (MMP) -8, -9 and myeloperoxidase (MPO) are inflammatory mediators. The potential associations between MMP-8, -9, MPO and their abilities to reflect cardiovascular risk remains to be evaluated in saliva. The objective of this study was to investigate the levels and associations of salivary MMP-8, -9, MPO and tissue inhibitors of metalloproteinase (TIMP)-1 in myocardial infarction (MI) patients and controls with or without periodontitis...
2015: PloS One
https://www.readbyqxmd.com/read/26125725/clinical-analysis-of-patients-with-myeloperoxidase-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#17
Z W Shuai, Y F Lv, M M Zhang, Z Y Hu
This prospective study analyzed the clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis and explored the relationship between MPO-ANCA and clinical manifestations of the associated vasculitis in 132 p-ANCA and MPO-ANCA-positive patients (average age, 62.3 ± 14.8 years) who were initially diagnosed with ANCA-associated vasculitis. The p-ANCA and MPO-ANCA levels in peripheral blood were detected in all patients. Among these, 128 (97%) had microscopic polyangiitis (MPA), 3 (2...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26075398/therapeutic-efficacy-of-a-subunit-vaccine-in-controlling-chronic-trypanosoma-cruzi-infection-and-chagas-disease-is-enhanced-by-glutathione-peroxidase-over-expression
#18
Shivali Gupta, Charity Smith, Sarah Auclair, Anahi De Jesus Delgadillo, Nisha Jain Garg
Trypanosoma cruzi-induced oxidative and inflammatory responses are implicated in chagasic cardiomyopathy. In this study, we examined the therapeutic utility of a subunit vaccine against T. cruzi and determined if glutathione peroxidase (GPx1, antioxidant) protects the heart from chagasic pathogenesis. C57BL/6 mice (wild-type (WT) and GPx1 transgenic (GPxtg) were infected with T. cruzi and at 45 days post-infection (dpi), immunized with TcG2/TcG4 vaccine delivered by a DNA-prime/Protein-boost (D/P) approach...
2015: PloS One
https://www.readbyqxmd.com/read/26061545/protein-carbamylation-and-cardiovascular-disease
#19
REVIEW
Frederik H Verbrugge, W H Wilson Tang, Stanley L Hazen
Carbamylation constitutes a posttranslational modification of proteins or amino acids and results from different pathways in vivo. First is the non-enzymatic reaction between isocyanic acid, a decomposition product of urea, and either the N-terminus or the ɛ-amino group of lysine residues. Isocyanic acid levels, while low in vivo, are in equilibrium with urea and are thus increased in chronic and end-stage renal diseases. An alternative pathway involves the leukocyte heme protein myeloperoxidase, which catalyzes the oxidation of thiocyanate in the presence of hydrogen peroxide, producing isocyanate at inflammation sites...
September 2015: Kidney International
https://www.readbyqxmd.com/read/26051132/-automated-measurement-of-biomarkers-for-the-diagnosis-of-acute-myocardial-infarction
#20
Ferenc Kovács, Ibolya Kocsis, Marina Varga, Enikő Sárváry, György Bicsák
INTRODUCTION: Cardiac biomarkers have a prominent role in the diagnosis of acute myocardial infarction. AIM: The aim of the authors was to study the diagnostic effectiveness of automated measurement of cardiac biomarkers. METHOD: Myeloperoxidase, high-sensitivity C-reactive protein, myoglobin, heart-type fatty acid binding protein, creatine kinase, creatine kinase MB, high-sensitivity troponin I and T were measured. RESULTS: The high-sensitivity troponin I was the most effective (area under curve: 0...
June 14, 2015: Orvosi Hetilap
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