Jienan Wang, Qi Zhou, Qi Dong, Jian Shen, Junnian Hao, Dong Li, Tiantian Xu, Xiaojun Cai, Wenkun Bai, Tao Ying, Yuehua Li, Li Zhang, Yueqi Zhu, Longchen Wang, Jianrong Wu, Yuanyi Zheng
Stent-assisted coiling is a main treatment modality for intracranial aneurysms (IAs) in clinics, but critical challenges remain to be overcome, such as exogenous implant-induced stenosis and reliance on antiplatelet agents. Herein, an endovascular approach is reported for IA therapy without stent grafting or microcatheter shaping, enabled by active delivery of thrombin (Th) to target aneurysms using innovative phase-change material (PCM)-coated magnetite-thrombin (Fe3 O4 -Th@PCM) FTP nanorobots. The nanorobots are controlled by an integrated actuation system of dynamic torque-force hybrid magnetic fields...
May 6, 2024: Small