keyword
MENU ▼
Read by QxMD icon Read
search

Prefrontal cortex

keyword
https://www.readbyqxmd.com/read/29240804/different-involvement-of-medial-prefrontal-cortex-and-dorso-lateral-striatum-in-automatic-and-controlled-processing-of-a-future-conditioned-stimulus
#1
Francisco Pérez-Díaz, Estrella Díaz, Natividad Sánchez, Juan Pedro Vargas, John M Pearce, Juan Carlos López
Recent studies support the idea that stimulus processing in latent inhibition can vary during the course of preexposure. Controlled attentional mechanisms are said to be important in the early stages of preexposure, while in later stages animals adopt automatic processing of the stimulus to be used for conditioning. Given this distinction, it is possible that both types of processing are governed by different neural systems, affecting differentially the retrieval of information about the stimulus. In the present study we tested if a lesion to the dorso-lateral striatum or to the medial prefrontal cortex has a selective effect on exposure to the future conditioned stimulus (CS)...
2017: PloS One
https://www.readbyqxmd.com/read/29240023/immediate-effects-of-transcranial-direct-current-stimulation-on-obsession-induced-anxiety-in-refractory-obsessive-compulsive-disorder-a-pilot-study
#2
Doron Todder, Adi Gershi, Zvi Perry, Zeev Kaplan, Joseph Levine, Keren Avirame
OBJECTIVE: Studies have shown that transcranial direct current stimulation (tDCS) has immediate effects on brain activity. The aim of this study was to investigate the potential use of tDCS to regulate obsession-induced anxiety immediately after symptom provocation in patients with refractory obsessive-compulsive disorder (OCD). METHODS: Twelve patients with refractory OCD received cathode, anode, and sham transcranial direct current stimulation over the medial prefrontal cortex conjugant to pharmacological treatment in a crossover design...
December 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29239789/anterior-cingulate-volume-predicts-response-to-psychotherapy-and-functional-connectivity-with-the-inferior-parietal-cortex-in-major-depressive-disorder
#3
Fabio Sambataro, Nadja Doerig, Jürgen Hänggi, Robert Christian Wolf, Janis Brakowski, Martin Grosse Holtforth, Erich Seifritz, Simona Spinelli
In major depressive disorder (MDD), the anterior cingulate cortex (ACC) has been associated with clinical outcome as well as with antidepressant treatment response. Nonetheless, the association between individual differences in ACC structure and function and the response to cognitive behavioral therapy (CBT) is still unexplored. For this aim, twenty-five unmedicated patients with MDD were scanned with structural and resting state functional magnetic resonance imaging before the beginning of CBT treatment. ACC morphometry was correlated with clinical changes following psychotherapy...
November 24, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29239776/differential-release-of-dopamine-in-the-nucleus-accumbens-evoked-by-low-versus-high-frequency-medial-prefrontal-cortex-stimulation
#4
Daniel F Hill, Kate L Parent, Christopher W Atcherley, Stephen L Cowen, Michael L Heien
The medial prefrontal cortex (mPFC) coordinates goal-directed behaviors, which may be mediated through mPFC regulation of dopamine release in the nucleus accumbens (NAc). Furthermore, frequency-specific oscillatory activity between the frontal cortex and downstream structures may facilitate inter-region communication. Although high-frequency (e.g., 60 Hz) mPFC stimulation is known to increase basal dopamine levels in the NAc, little is known about how phasic dopamine release is affected by mPFC stimulation...
November 15, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29238313/differential-neural-processing-of-social-exclusion-and-inclusion-in-adolescents-with-non-suicidal-self-injury-and-young-adults-with-borderline-personality-disorder
#5
Rebecca C Brown, Paul L Plener, Georg Groen, Dominik Neff, Martina Bonenberger, Birgit Abler
Introduction: Non-suicidal self-injury (NSSI) is a symptom of borderline personality disorder (BPD). However, NSSI often occurs independently of BPD. Altered neural processing of social exclusion has been shown in adolescents with NSSI and adults with BPD with additional alterations during social inclusion in BPD patients. Aims of this study were to investigate differences in neural processing of social inclusion and exclusion situations between adolescents with NSSI and young adults with BPD and NSSI...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29238310/parameter-based-evaluation-of-attentional-impairments-in-schizophrenia-and-their-modulation-by-prefrontal-transcranial-direct-current-stimulation
#6
Nadine Gögler, Irina Papazova, Tatiana Oviedo-Salcedo, Nina Filipova, Wolfgang Strube, Johanna Funk, Hermann J Müller, Kathrin Finke, Alkomiet Hasan
Background: Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods: In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bundesen's Theory of Visual Attention (TVA) to (i) identify specific visual attentional parameters affected in schizophrenia and (ii) assess, as a proof of concept, the potential of single-dose anodal transcranial direct current stimulation (tDCS; 20 min, 2 mA) to the left dorsolateral prefrontal cortex to modulate these attentional parameters...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29238235/oppositional-defiant-disorder-current-insight
#7
REVIEW
Abhishek Ghosh, Anirban Ray, Aniruddha Basu
Oppositional defiant disorder (ODD) is diagnosed broadly on the basis of frequent and persistent angry or irritable mood, argumentativeness/defiance, and vindictiveness. Since its inception in the third Diagnostic and Statistical Manual of Mental Disorders, epidemiological and longitudinal studies have strongly suggested a distinct existence of ODD that is different from other closely related externalizing disorders, with different course and outcome and possibly discrete subtypes. However, several issues, such as symptom threshold, dimensional versus categorical conceptualization, and sex-specific symptoms, are yet to be addressed...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29237282/modulation-of-salience-network-intranetwork-resting-state-functional-connectivity-in-women-with-chronic-migraine
#8
X Michelle Androulakis, Chris Rorden, B Lee Peterlin, Kaitlin Krebs
Objective To investigate the intranetwork resting state fMRI connectivity within the Salience Network of chronic migraine with and without medication overuse headache. Methods We compared 351 pairs of intranetwork connectivity in chronic migraine (n = 13) and chronic migraine with medication overuse headache (n = 16) compared to matched controls, and between each chronic migraine subgroup. Results Compared to controls, 17 pairs of intranetwork connections in chronic migraine and 27 pairs in chronic migraine with medication overuse headache were decreased...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29236921/intermittent-theta-burst-transcranial-magnetic-stimulation-for-autism-spectrum-disorder-an-open-label-pilot-study
#9
Caio Abujadi, Paul E Croarkin, Bianca B Bellini, Helena Brentani, Marco A Marcolin
OBJECTIVE: Theta-burst stimulation (TBS) modulates synaptic plasticity more efficiently than standard repetitive transcranial magnetic stimulation delivery and may be a promising modality for neuropsychiatric disorders such as autism spectrum disorder (ASD). At present there are few effective interventions for prefrontal cortex dysfunction in ASD. We report on an open-label, pilot study of intermittent TBS (iTBS) to target executive function deficits and restricted, repetitive behaviors in male children and adolescents with ASD...
December 11, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29236787/efficient-enhancement-of-information-in-the-prefrontal-cortex-during-the-presence-of-reward-predicting-stimuli
#10
Camilo J Mininni, César F Caiafa, B Silvano Zanutto, Kuei Y Tseng, Sergio E Lew
The prefrontal cortex (PFC) is a key brain structure for decision making, behavioural flexibility and working memory. Neurons in PFC encode relevant stimuli through changes in their firing rate, although the metabolic cost of spiking activity puts strong constrains to neural codes based on firing rate modulation. Thus, how PFC neural populations code relevant information in an efficient way is not clearly understood. To address this issue we made single unit recordings in the PFC of rats performing a GO/NOGO discrimination task and analysed how entropy between pairs of neurons changes during cue presentation...
2017: PloS One
https://www.readbyqxmd.com/read/29235190/intrinsic-functional-connectivity-of-the-central-extended-amygdala
#11
Rachael M Tillman, Melissa D Stockbridge, Brendon M Nacewicz, Salvatore Torrisi, Andrew S Fox, Jason F Smith, Alexander J Shackman
The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)-plays a critical role in triggering fear and anxiety and is implicated in the development of a range of debilitating neuropsychiatric disorders. Although it is widely believed that these disorders reflect the coordinated activity of distributed neural circuits, the functional architecture of the EAc network and the degree to which the BST and the Ce show distinct patterns of functional connectivity is unclear...
December 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29235036/expression-of-dha-metabolizing-enzyme-alox15-is-regulated-by-selective-histone-acetylation-in-neuroblastoma-cells
#12
Christabel Fung-Yih Ho, Claire Poh-Ee Bon, Yee-Kong Ng, Deron R Herr, Jui-Sheng Wu, Teng-Nan Lin, Wei-Yi Ong
The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety. In this study, we elucidated epigenetic regulation of Alox15 via histone modifications in neuron-like cells. Treatment of undifferentiated SH-SY5Y human neuroblastoma cells with the histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate significantly increased Alox15 mRNA expression...
December 12, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29234834/contributions-of-prolonged-contingent-and-non-contingent-cocaine-exposure-to-escalation-of-cocaine-intake-and-glutamatergic-gene-expression
#13
Kyle L Ploense, Philip Vieira, Lana Bubalo, Gema Olivarria, Amanda E Carr, Karen K Szumlinski, Tod E Kippin
Similar to the pattern observed in people with substance abuse disorders, laboratory animals will exhibit escalation of cocaine intake when the drug is available over prolonged periods of time. Here, we investigated the contribution of behavioral contingency of cocaine administration on escalation of cocaine intake and gene expression in the dorsal medial prefrontal cortex (dmPFC) in adult male rats. Rats were allowed to self-administer intravenous cocaine (0.25 mg/infusion) under either limited cocaine-(1 h/day), prolonged cocaine-(6 h/day), or limited cocaine-(1 h/day) plus yoked cocaine-access (5 h/day); a control group received access to saline (1 h/day)...
December 12, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29234739/effects-of-cross-rearing-with-social-peers-on-myelination-in-the-medial-prefrontal-cortex-of-a-mouse-model-with-autism-spectrum-disorder
#14
Manabu Makinodan, Kazuki Okumura, Daisuke Ikawa, Yasunori Yamashita, Kazuhiko Yamamuro, Michihiro Toritsuka, Sohei Kimoto, Takahira Yamauchi, Takashi Komori, Yoshinori Kayashima, Hiroki Yoshino, Akio Wanaka, Toshifumi Kishimoto
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction, poor communication skills, and repetitive/restrictive behaviors. Recent studies have indicated that early rehabilitative intervention can alleviate the symptoms of individuals with ASD. However, it remains unknown whether rehabilitative intervention can restore brain structures such as myelin, which generally shows abnormalities in individuals with ASD. Therefore, in the present study, we used a mouse model of ASD (BTBR mice) that demonstrated asocial behaviors and hypomyelination in the medial prefrontal cortex (mPFC) to investigate whether interaction with social peers (C57BL/6J mice) has an effect on myelination...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29234492/no-preliminary-evidence-of-differences-in-astrocyte-density-within-the-white-matter-of-the-dorsolateral-prefrontal-cortex-in-autism
#15
Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chana
Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes has not been conducted. Such an investigation is further warranted by an increasing role for neuroinflammation in autism pathogenesis, with astrocytes being key players in this process. We present the first study of astrocyte density and morphology within the white matter of the dorsolateral prefrontal cortex (DLPFC) in individuals with autism. Methods: DLPFC formalin-fixed sections containing white matter from individuals with autism (n = 8, age = 4-51 years) and age-matched controls (n = 7, age = 4-46 years) were immunostained for glial fibrillary acidic protein (GFAP)...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29234277/investigating-the-usability-and-acute-effects-of-a-bedside-video-console-to-prefrontal-cortical-activity-alterations-a-preclinical-study-in-healthy-elderly
#16
Ruud H Knols, Jaap Swanenburg, Dino De Bon, Federico Gennaro, Martin Wolf, Bernard Krüger, Dominique Bettex, Eling D de Bruin
Elderly people at risk of developing cognitive decline; e.g., following surgery, may benefit from structured, challenging, and repetitive cognitive video training. This study assessed usability and acute effects of a newly developed bedside console (COPHYCON). Fifteen healthy elderly individuals performed a one-time 80-min intervention, including cognitive video games aimed at improving awareness and selective attention. Perceived usefulness and perceived ease of use (Technology Acceptance Model) were assessed together with measures of the achieved game level, reaction times, (in-) correct responses during ALERT and SELECT game play...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29233801/getting-to-the-root-of-fine-motor-skill-performance-in-dentistry-brain-activity-during-dental-tasks-in-a-virtual-reality-haptic-simulation
#17
Suzanne Perry, Susan M Bridges, Frank Zhu, W Keung Leung, Michael F Burrow, Jamie Poolton, Rich Sw Masters
BACKGROUND: There is little evidence considering the relationship between movement-specific reinvestment (a dimension of personality which refers to the propensity for individuals to consciously monitor and control their movements) and working memory during motor skill performance. Functional near-infrared spectroscopy (fNIRS) measuring oxyhemoglobin demands in the frontal cortex during performance of virtual reality (VR) psychomotor tasks can be used to examine this research gap. OBJECTIVE: The aim of this study was to determine the potential relationship between the propensity to reinvest and blood flow to the dorsolateral prefrontal cortices of the brain...
December 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29232965/structural-and-functional-changes-in-the-somatosensory-cortex-in-euthymic-females-with-bipolar-disorder
#18
Luciano Minuzzi, Sabrina K Syan, Mara Smith, Alexander Hall, Geoffrey Bc Hall, Benicio N Frey
OBJECTIVE: Current evidence from neuroimaging data suggests possible dysfunction of the fronto-striatal-limbic circuits in individuals with bipolar disorder. Somatosensory cortical function has been implicated in emotional recognition, risk-taking and affective responses through sensory modalities. This study investigates anatomy and function of the somatosensory cortex in euthymic bipolar women. METHODS: In total, 68 right-handed euthymic women (bipolar disorder = 32 and healthy controls = 36) between 16 and 45 years of age underwent high-resolution anatomical and functional magnetic resonance imaging during the mid-follicular menstrual phase...
December 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29232484/juvenile-social-experience-and-differential-age-related-changes-in-the-dendritic-morphologies-of-subareas-of-the-prefrontal-cortex-in-rats
#19
B T Himmler, R Mychasiuk, A Nakahashi, S M Himmler, S M Pellis, B Kolb
Juvenile social interactions have been shown to influence the dendritic complexity of neurons in the prefrontal cortex. In particular, social play induces pruning of the cells in the medial prefrontal cortex (mPFC), whereas interacting with multiple partners, whether those interactions involve play or not, increases the complexity of cells in the orbital frontal cortex (OFC). Previous studies suggest that these changes differ in their stability during adulthood. In the present study, rats were reared in groups of either four (quads) or two (pairs) and the brains of the rats from each rearing condition were then harvested at 60 days (i...
December 12, 2017: Synapse
https://www.readbyqxmd.com/read/29231139/catechol-o-methyltransferase-cognition-and-alzheimer-s-disease
#20
Matea Nikolac Perkovic, Dubravka Svob Strac, Lucija Tudor, Marcela Konjevod, Gordana Nedic Erjavec, Nela Pivac
OBJECTIVE: Cognition is a complex trait representing a set of all mental abilities and processes related to knowledge. Although diverse brain regions are involved, most cognitive processes appear to engage cortical regions. The activity of dopaminergic neurons in prefrontal cortex represents a biological substrate underlying cognitive functions. Alzheimer's disease (AD) is the most frequent dementia associated with cognitive impairments. Cognitive impairment in AD starts slow with discrete deterioration in memory, language, thinking and reasoning, but it progresses into more severe and debilitating cognitive dysfunction...
December 11, 2017: Current Alzheimer Research
keyword
keyword
15747
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"