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Massimiliano Orri, Lea C Perret, Gustavo Turecki, Marie-Claude Geoffroy
BACKGROUND: Irritability is gaining considerable attention as a risk factor for suicide-related outcomes (suicide mortality, attempt, and ideation). However, the evidence of this association is scant. We conducted a systematic review of the evidence regarding the associations between irritability and suicide-related outcomes across the life-course. METHODS: We conducted a systematic search on Medline and PsycINFO (up to January 2018) for original articles published in English investigating the association between irritability and suicide-related outcomes...
July 4, 2018: Journal of Affective Disorders
Josephine V Seale, Richard A Hutchinson, Paul F Fleming, Ajay Sinha, Stephen T Kempley, Shahid M Husain, Michael R Millar
BACKGROUND: Necrotising enterocolitis (NEC) is a significant cause of infant morbidity and mortality, disproportionately affecting those of extreme prematurity and/or very low birth weight. A number of risk factors have been identified, including an association between the use of antibiotics, and the subsequent development of NEC. AIM: This review sought to address whether the choice of antibiotic(s) used to treat infants with suspected late-onset sepsis (LOS) influences the risk of developing NEC...
July 2, 2018: Early Human Development
Shasha Liu, Xiaoxia Liu, Xun Zhang, Meiyun Shi, Hecheng Wang, Yajun Liu
Crizotinib, a drug for anaplastic lymphoma kinase (ALK) positive and c-ros oncogene 1 receptor tyrosine kinase (ROS1) positive non-small cell lung cancer (NSCLC), was structurally optimized via a strategy of structure based fragment replacing. Computational study showed it was beneficial for interaction of crizotinib and ALK to increase the distance between pyridyl ring and phenyl ring in crizotinib, and thus a series of novel glycol diaryl ethers were synthesized. The in vitro anti-tumor activity of synthesized compounds was studied in NSCLC cell line H2228 and neurobalstoma cell line SH-SY5Y...
July 19, 2018: Chemical Biology & Drug Design
Liguo Zhu, Jie Jiang, Xiangjun Zhai, Aileen Baecker, Hong Peng, Jiao Qian, MingHao Zhou, Ci Song, Yan Zhou, Jianfang Xu, Hongjian Liu, Dong Hang, Zhibin Hu, Hongbin Shen, Zuo-Feng Zhang, Fengcai Zhu
BACKGROUND & AIMS: Although non-alcoholic fatty liver disease (NAFLD) has been studied extensively, the potential risk factors for NAFLD among chronic hepatitis B (CHB) patients have not been fully known. METHODS: A population-based cohort of adult CHB patients without a history of alcohol drinking or NAFLD were recruited and followed up from October 2012 to January 2015 in Jiangsu province, China. Using Cox proportional hazards regression model, potential risk factors including viral and metabolic factors for NAFLD were evaluated...
July 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Lucie-Marie Scailteux, Nathalie Rioux-Leclercq, Sébastien Vincendeau, Frédéric Balusson, Emmanuel Nowak, Emmanuel Oger
BACKGROUND: To assess the association between 5α-reductase inhibitor (5-ARI) use and high grade (Gleason score 8-10) prostate cancer. METHODS: We set up a population-based nested matched case-control study using the French Health Insurance Database linked to data from all Brittany (France) path labs. Among 74,596 men with ≥ 1 drug reimbursement for symptomatic benign prostate hypertrophy between January 1, 2010 through December 31, 2011, 767 incident prostate cancer cases between January 1, 2012 through December 31, 2013 were matched on age and delay between the first observed delivery of drug for benign prostate hypertrophy (5-ARI, alpha-blockers or phytotherapy) and diagnostic date of the case to five controls, using an incidence density sampling design...
July 19, 2018: BJU International
Tom Jg Gevers, B W Marcel Spanier, Peter B Veendrick, Jan Maarten Vrolijk
BACKGROUND & AIM: Obesity and metabolic syndrome are increasingly recognized as risk factors for hepatocellular adenomas (HCA). There is still sparse evidence whether weight loss or bariatric surgery could induce HCA regression in these patients. In this brief report we describe the effect of weight loss on HCA regression in severe obese patients that had undergone bariatric surgery in our center. METHODS: We performed an Electronic Patient Database search and included all patients who underwent bariatric surgery in our bariatric referral center and had an ICD-10 code of benign neoplasm of liver in our center from (2006-2017)...
July 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Abel Carreras, Efrem Bernuz, Xavier Marugan, Miquel Llunell, Pere Alemany
Despite its undeniable problems from a philosophical point of view, the concept of molecular structure, with attributes such as shape and symmetry, directly borrowed from the description of macroscopic objects, is nowadays central to most of the chemical sciences. Descriptions such as "the tetrahedral" carbon atom or "octahedral coordination complexes" are widely used as much in elementary textbooks as in the most up-to-date research articles. The definition of molecular shape is, however, not as simple as it might seem at first sight...
July 19, 2018: Chemistry: a European Journal
Pierre Kuhn, Jacques Sizun, Charlotte Casper
AIM: Hospitalised newborn infants may be stressed due to inappropriate sensory stimuli and early separation from their families, that can negatively impact their neurodevelopment. The French Group of Reflection and Evaluation of the Environment of Newborns (GREEN) issues guidelines based on environmental neonatology and family centred care. The first recommendation focuses on private family rooms versus large shared rooms. METHODS: These guidelines are based on a systematic evaluation of the literature providing different grades of evidence...
July 19, 2018: Acta Paediatrica
Yang Lee, Sanjukta Chakraborty, Cynthia J Meininger, Mariappan Muthuchamy
OBJECTIVE: Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects the metabolic function of cells, and consequently impairs tissue function. We hypothesized that insulin resistance in lymphatic endothelial cells (LECs) decreases eNOS activity, disrupts barrier integrity increases permeability, and activates mitochondrial dysfunction and pro-inflammatory signaling pathways...
July 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Marie-Laure Laroche, Marianne Teste, Julien Vanoost, Hélène Geniaux
An inappropriate immunologic response has been suggested to play a role in the pathogenesis of hidradenitis suppurativa (HS). Adalimumab was the first TNF-α inhibitor approved for moderate to severe HS. We report on a case of HS (Hurley stage 2) in a 39-year-old man, who had received fusidic acid and isotretinoin treatments without evident benefit during the last 8 years. The patient noticed a reduction in the number of lesions and quality of life (DLQI from 27 to 6) in the 2 months following verapamil initiation for cluster headache...
July 19, 2018: Fundamental & Clinical Pharmacology
Philip J Sanders, Benjamin Thompson, Paul M Corballis, Michael Maslin, Grant D Searchfield
Long-term potentiation is a form of synaptic plasticity thought to play an important role in learning and memory. Recently non-invasive methods have been developed to induce and measure activity similar to long-term potentiation in humans. Sensory tetani (trains of quickly repeating auditory or visual stimuli) alter the electroencephalogram in a manner similar to electrical stimulation that results in long-term potentiation. This review briefly covers the development of long-term potentiation research before focusing on in vivo human studies that produce long-term potentiation-like effects using auditory and visual stimulation...
July 19, 2018: European Journal of Neuroscience
M Herrador-Colmenero, F Harrison, E Villa-González, C Rodríguez-López, F B Ortega, J R, A P Jones, P Chillón
AIM: To study the associations of weather conditions with the travel mode choice for commuting to and from school. METHODS: A total of 6,979 Spanish youths aged 7 to 18 years old (80% adolescents aged 12-18 years old, 51% male) completed a 5-day survey of mode of commuting to school in autumn, winter, and spring. Weather data from the nearest weather station to each school was registered. We used Google Maps™ to calculate the distance from home to school. Multilevel logistic regression models were used to estimate odds of active travel based on weather and season...
July 19, 2018: Scandinavian Journal of Medicine & Science in Sports
Yichao Wang, Katrina J Allen, Noor H A Suaini, Rachel L Peters, Anne-Louise Ponsonby, Jennifer J Koplin
BACKGROUND: Asian children born in Australia have higher rates of eczema and nut allergy than non-Asian children. However, it is not known whether this country of birth differential exists for other allergies or anaphylaxis risk. OBJECTIVE: We investigated the influence of maternal and child's country of birth on the prevalence of parent-reported eczema, asthma, food allergy, and being diagnosed by a doctor as being "at risk of anaphylaxis". METHODS: We assessed the relationship between mother and child country of birth and allergies using the 2010 School Entrant Health Questionnaire, completed for 57,005 5-year old children (85...
July 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Tara Neubrand, Natasha Cabrera, Stacey Coss, Anthony Watkins, Michael DiStefano
Each year, an average of 16,000 children require cardiopulmonary resuscitation (CPR) for cardiopulmonary arrest in the United States, and their survival is largely dependent on the provision of optimal and timely resuscitation in concordance with current professional guidelines.1,2 As a profession, emergency department (ED) providers regularly perform inadequate resuscitation for children with cardiopulmonary arrest, and the quality of CPR provided for these patients is not in accordance with accepted standards of care...
July 19, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Wahid Bouida, Kaouthar Beltaief, Mohamed Amine Msolli, Noussaiba Azaiez, Houda Ben Soltane, Adel Sekma, Imen Trabelsi, Hamdi Boubaker, Mohamed Habib Grissa, Mehdi Methemem, Riadh Boukef, Zohra Dridi, Asma Belguith, Semir Nouira
OBJECTIVES: We aim to determine the benefit of two different doses magnesium sulfate (MgS) compared to placebo in rate control of rapid atrial fibrillation (AF) managed in the emergency department (ED). METHODS: We undertook a randomized, controlled, double-blind clinical trial in 3 university hospital EDs between August 2009 and December 2014. Patients >18years with rapid AF (>120 bpm) were enrolled and randomized to 9g intravenous MgS (High dose group, n=153), 4...
July 19, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Ziyao Liang, Zhuo Shen, Yong Zhang, Daode Ji, Jiqiu Li, Alan Warren, Xiaofeng Lin
Four new species of Vorticella, V. parachiangi sp. n., V. scapiformis sp. n., V. sphaeroidalis sp. n., and V. paralima sp. n., were isolated from coastal brackish waters of southern China. Their morphology, infraciliature, and silverline system were investigated based on observations of specimens both in vivo and following silver staining. Vorticella parachiangi sp. n. is distinguished by: a J-shaped macronucleus; a single dorsally located contractile vacuole; a two-rowed infundibular polykinetid 3, in which row 1 is shorter than row 2; 21-31 silverlines between peristome and aboral trochal band, 6-11 between aboral trochal band and scopula...
July 19, 2018: Journal of Eukaryotic Microbiology
M Rizzo, K D Ducheyne, C Deelen, M Beitsma, S Cristarella, M Quartuccio, T A E Stout, M de Ruijter-Villani
BACKGROUND: Advanced mare age is associated with declining fertility and an increased risk of early pregnancy loss. Compromised oocyte quality is probably the primary reason for reduced fertility, but the defects predisposing to embryonic death are unknown. In women, advanced age predisposes to chromosome segregation errors during meiosis, which lead to embryonic aneuploidy and a heightened risk of miscarriage. OBJECTIVES: To evaluate the effect of advanced mare age on chromosome alignment and meiotic spindle morphology in in vitro matured (IVM) oocytes...
July 19, 2018: Equine Veterinary Journal
Hirokazu Tsubone, Tatsushi Mutoh
We studied the effect of glucose supply on mitochondrial respiratory function (MRF) of neonatal rat cardiomyocytes, using a novel extracellular flux analysis. Fundamental respiratory parameters regarding oxygen consumption rate in mitochondria showed glucose concentration-dependent changes, where a significant increase or decrease in these parameters was observed to be associated with glucose concentrations ranging between 10% and 1,000% of the concentration used in standard medium (3,151 mg/L), respectively...
July 19, 2018: Clinical and Experimental Pharmacology & Physiology
Giulia Gava, Ilaria Mancini, Silvia Cerpolini, Maurizio Baldassarre, Renato Seracchioli, Maria Cristina Meriggiola
OBJECTIVE: To retrospectively evaluate and compare safety and efficacy of short and long-acting testosterone (T) parenteral formulations over five years in transmen. DESIGN AND METHODS: Fifty transmen between 21-42 years of age were enrolled. Twenty-five received T undecanoate 1000 mg IM (weeks 0 and 6 then every 12-16 weeks) and 25 received T enanthate 250 mg IM (every 3-4 weeks). Hormonal and biochemical parameters, anthropometric characteristics and blood pressure were assessed at baseline and then every 12 months...
July 19, 2018: Clinical Endocrinology
Juan Wu, Jie Yang, Jie Zhao, Jingrong Wu, Xuan Zhang, W Keung Leung, Weibin Sun
AIM: We report a rare case of periodontal Ehlers-Danlos syndrome (pEDS) associated with severe periodontitis and tooth loss in a Chinese family. MATERIAL AND METHODS: The proband complained of gingival bleeding and mobility, which were also reported in his mother, and maternal uncle and his maternal grandmother and great-grandfather in the past. All family members underwent oral, physical, dermatological, and genetic examinations. RESULTS: Oral manifestation of family members affected with pEDS presented severe periodontitis with multiple or total tooth loss...
July 19, 2018: Journal of Clinical Periodontology
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