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https://www.readbyqxmd.com/read/28941387/management-protocols-for-status-epilepticus-in-the-pediatric-emergency-room-systematic-review-article
#1
REVIEW
Cheuk C Au, Ricardo G Branco, Robert C Tasker
OBJECTIVE: This systematic review of national or regional guidelines published in English aimed to better understand variance in pre-hospital and emergency department (ED) treatment of status epilepticus. SOURCES: Systematic search of national or regional guidelines (January 2000 to February 2017) contained within PubMed and Google Scholar databases, and article reference lists. The search keywords were status epilepticus, prolonged seizure, treatment, and guideline...
September 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28941364/nonalcoholic-fatty-liver-disease-incidence-and-impact-on-metabolic-burden-and-death-a-20-year-community-study
#2
Alina M Allen, Therneau M Terry, Joseph J Larson, Alexandra Coward, Virend K Somers, Patrick S Kamath
Recent population-based data on nonalcoholic fatty liver disease (NAFLD) epidemiology in general and incidence in particular, are lacking. We examined trends in NAFLD incidence in a US community, and the impact of NAFLD on incident metabolic comorbidities (MC), cardiovascular (CV) events and mortality. A community cohort of all adults diagnosed with NAFLD in Olmsted County, MN between 1997-2014 was constructed using the Rochester Epidemiology Project database. The yearly incidence rate was calculated. The impact of NAFLD on incident MC, CV events and mortality was studied using a multi-state model, with a 4:1 age and sex-matched general population as reference...
September 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28941363/maintenance-of-distal-intestinal-structure-in-the-face-of-prolonged-fasting-a-comparative-examination-of-species-from-five-vertebrate-classes
#3
Marshall D McCue, Celeste A Passement, David K Meyerholz
It was recently shown that fasting alters the composition of microbial communities residing in the distal intestinal tract of animals representing five classes of vertebrates [i.e., fishes (tilapia), amphibians (toads), reptiles (leopard geckos), birds (quail), and mammals (mice)]. In the current study, we tested the hypothesis that the extent of tissue reorganization in the fasted distal intestine was correlated with the observed changes in enteric microbial diversity. Segments of intestine adjacent to those used for the microbiota study were examined histologically to quantify cross-sectional and mucosal surface areas as well as thicknesses of mucosa, submucosa, and tunica muscularis...
September 23, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28941361/hepatitis-c-virus-testing-for-case-identification-in-persons-born-during-1945-1965-results-from-three-randomized-controlled-trials
#4
Anthony K Yartel, David B Rein, Kimberly Ann Brown, Katherine Krauskopf, Omar I Massoud, Cynthia Jordan, Natalie Kil, Alex D Federman, David R Nerenz, Joanne E Brady, Danielle L Kruger, Bryce D Smith
CDC and U.S. Preventive Services Task Force recommend one-time hepatitis C virus (HCV) testing for persons born during 1945-1965 (birth cohort). However, few studies estimate the effect of birth cohort (BC) testing implementation on HCV diagnoses in primary care settings. We aimed to determine the probability of identifying HCV infections in primary care using targeted BC testing compared with usual care at three academic medical centers. From December 2012 to March 2014, each center compared one of three distinct interventions to usual care using an independently-designed randomized controlled trial...
September 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28941359/loss-of-interaction-between-plectin-and-type-xvii-collagen-results-in-epidermolysis-bullosa-simplex
#5
Ken Natsuga, Wataru Nishie, Machiko Nishimura, Satoru Shinkuma, Mika Watanabe, Kentaro Izumi, Hideki Nakamura, Yoshiaki Hirako, Hiroshi Shimizu
Plectin is a linker protein that interacts with intermediate filaments and β4 integrin in hemidesmosomes of the epidermal basement membrane zone (BMZ). Type XVII collagen (COL17) has been suggested as another candidate plectin binding partner in hemidesmosomes. Here, we demonstrate that plectin-COL17 binding helps to maintain epidermal BMZ organization. We identified an epidermolysis bullosa (EB) simplex patient as having markedly diminished expression of plectin and COL17 in skin. The patient is compound heterozygous for sequence variants in the plectin gene ( PLEC); one is a truncation and the other is a small in-frame deletion sequence variant...
September 23, 2017: Human Mutation
https://www.readbyqxmd.com/read/28941357/microrna-in-alzheimer-s-disease-revisited-implications-for-major-neuropathological-mechanisms
#6
Reihaneh Dehghani, Farzaneh Rahmani, Nima Rezaei
Pathology of Alzheimer's disease (AD) goes far beyond neurotoxicity resulting from extracellular deposition of amyloid β (Aβ) plaques. Aberrant cleavage of amyloid precursor protein and accumulation of Aβ in the form of the plaque or neurofibrillary tangles are the known primary culprits of AD pathogenesis and target for various regulatory mechanisms. Hyper-phosphorylation of tau, a major component of neurofibrillary tangles, precipitates its aggregation and prevents its clearance. Lipid particles, apolipoproteins and lipoprotein receptors can act in favor or against Aβ and tau accumulation by altering neural membrane characteristics or dynamics of transport across the blood-brain barrier...
September 23, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28941353/making-it-work-a-bsn-faculty-s-process-of-curriculum-redesign
#7
Shannon Elliott, Glynda Rees, Eileen Shackell, Joan Walker
Curriculum renewal is an ongoing reality for all undergraduate nursing programs and is often a challenge for educators in preparing nursing students for practice. In response to constantly changing educational strategies, methodologies and knowledge, a BSN nursing program determined that a curriculum redesign was necessary. This article outlines a BSN faculty's curriculum redesign process from the perspective of the Curriculum Development Team. The process of building a knowledge base, establishing a foundation, designing the curriculum, involving faculty and lessons learned are outlined...
September 21, 2017: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/28938794/association-between-plant-based-diets-and-plasma-lipids-a-systematic-review-and-meta-analysis
#8
Yoko Yokoyama, Susan M Levin, Neal D Barnard
Context: Although a recent meta-analysis of randomized controlled trials showed that adoption of a vegetarian diet reduces plasma lipids, the association between vegetarian diets and long-term effects on plasma lipids has not been subjected to meta-analysis. Objective: The aim was to conduct a systematic review and meta-analysis of observational studies and clinical trials that have examined associations between plant-based diets and plasma lipids. Data Sources: MEDLINE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched for articles published in English until June 2015...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938776/meta-analytic-study-of-organic-acids-as-an-alternative-performance-enhancing-feed-additive-to-antibiotics-for-broiler-chickens
#9
G V Polycarpo, I Andretta, M Kipper, V C Cruz-Polycarpo, J C Dadalt, P H M Rodrigues, R Albuquerque
The effect of organic acids as an alternative to antibiotics on the performance of broiler chickens was evaluated by meta-analysis, identifying and quantifying the main factors that influence results. A total of 51,960 broilers from 121 articles published between 1991 and 2016 were used. Interactions of additives [non-supplemented group (control), organic acids, and growth promoter antibiotics] with microbial challenge (with or without inoculation of pathogenic microorganisms) were studied on performance variables...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938713/invited-commentary-can-issues-with-reproducibility-in-science-be-blamed-on-hypothesis-testing
#10
Clarice R Weinberg
In the accompanying article (Am J Epidemiol. 2017;186(6):646-647), Dr. Timothy Lash makes a forceful case that the problems with reproducibility in science stem from our "culture" of null hypothesis significance testing. He notes that when attention is selectively given to statistically significant findings, the estimated effects will be systematically biased away from the null. Here I revisit the recent history of genetic epidemiology and argue for retaining statistical testing as an important part of the tool kit...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938702/correction-endothelial-microparticles-delivering-microrna-155-into-t-lymphocytes-are-involved-in-the-initiation-of-acute-graft-versus-host-disease-following-allogeneic-hematopoietic-stem-cell-transplantation
#11
Ran Zhang, Xiaoxiao Wang, Mei Hong, Ting Luo, Miaomiao Zhao, Haorui Shen, Jun Fang, Xiaojie Li, Sibin Zang, Ping Chen, Dimin Nie, Peng Zheng, Qiuling Wu, Linghui Xia
[This corrects the article DOI: 10.18632/oncotarget.15579.].
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938701/correction-elevated-microrna-135a-is-associated-with-pulmonary-arterial-hypertension-in-experimental-mouse-model
#12
Hyun-Wook Lee, Sung-Hyun Park
[This corrects the article DOI: 10.18632/oncotarget.16011.].
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938698/a-systematic-review-of-malignancy-associated-hemophagocytic-lymphohistiocytosis-that-needs-more-attentions
#13
REVIEW
Hongluan Wang, Lixia Xiong, Weiping Tang, Ying Zhou, Fei Li
As an infrequent but potentially life-threatening hyperinflammatory syndrome, hemophagocytic lymphohistiocytosis (HLH) is clinically characterized with prolonged fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. Malignancy-associated HLH (M-HLH), one type of acquired HLH, usually presents variable overlaps of symptoms with other types of HLH, thus resulting in higher incidence of misdiagnosis and mortality. In recent years, with the increasing awareness to this disease, the diagnosis and management of HLH have gained more and more attention, and improvements have been made accordingly...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938697/intensity-modulated-radiotherapy-for-hepatocellular-carcinoma-dosimetric-and-clinical-results
#14
REVIEW
Sun Hyun Bae, Won Il Jang, Hee Chul Park
Since the introduction of 3-dimensional conformal radiotherapy (3DCRT), new radiotherapy techniques have expanded the indication of radiotherapy for the treatment of hepatocellular carcinoma (HCC), from the hitherto palliative to a now curative-intent purpose. Intensity-modulated radiotherapy (IMRT), currently the most advanced radiotherapy technique, is considered an attractive option for the treatment of HCC, and is more widely applied because it can deliver a higher dose to the tumor than 3DCRT while sparing surrounding normal organs...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938690/p-akt-as-a-potential-poor-prognostic-factor-for-gastric-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Fang Cao, Cong Zhang, Wei Han, Xiao-Jiao Gao, Jun Ma, Yong-Wei Hu, Xing Gu, Hou-Zhong Ding, Li-Xia Zhu, Qin Liu
To understand the relationship between p-Akt expression and the prognosis of patients with gastric cancer, we searched six databases, Pubmed, EMBASE, Cochrane Library, CNKI, Wanfang and CBM for relevant articles in order to conduct this metaanalysis. The pooled hazard ratios and corresponding 95%CI of overall survival were calculated to evaluate the prognostic value of p-Akt expression in patients with gastric cancer. With 2261 patients combined from 13 available studies, the pooled HR showed a poor prognosis in patients with gastric cancer in the univariate analysis (HR=1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938677/comparison-of-18-fdg-pet-pet-ct-and-bone-scintigraphy-for-detecting-bone-metastases-in-patients-with-nasopharyngeal-cancer-a-meta-analysis
#16
Chuanhui Xu, Ruiming Zhang, Huanlei Zhang, Zhenyan Zhang
OBJECTIVE: We performed a meta-analysis to compare the diagnostic efficacy of (18)FDG PET/PET-CT and bone scintigraphy (BS) for diagnosing bone metastatic cancers in nasopharyngeal cancer patients. RESULTS: 6 studies (1238 patients) fulfilled the inclusion criteria. The pooled sensitivities for (18)FDG PET/PET-CT and BS were 0.81 (95% confidence interval [CI] = 0.70 to 0.98) and 0.39 (95% CI = 0.26 to 0.54), specificities were 0.99 (95% CI = 0.98 to 0.99) and 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938670/statins-and-the-risk-of-cirrhosis-in-hepatitis-b-or-c-patients-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#17
Yaqin Wang, Jianping Xiong, Meng Niu, Xiaowei Chen, Long Gao, Qirun Wu, Kechuang Zheng, Ke Xu
Hepatitis B and hepatitis C are leading causes of chronic liver disease, particularly cirrhosis. Recently, several studies have observed that statins have an inverse relationship with cirrhosis in hepatitis B or C patients. However, no published meta-analysis studied the protective effect of statins on cirrhosis. Thus, we conducted a systematic review and meta-analysis of published observational studies to better understand the relationship between statins and the risk of cirrhosis. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science for articles published before April 2017...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938669/hepatitis-b-virus-infection-and-decreased-risk-of-stroke-a-meta-analysis
#18
Yaqin Wang, Jianping Xiong, Xi Chen, Meng Niu, Xiaowei Chen, Yuheng Guan, Kechuang Zheng, Ke Xu
Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the corresponding 95% confidence intervals (CIs)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938668/systematic-review-and-meta-analysis-cholecystectomy-and-the-risk-of-cholangiocarcinoma
#19
Jianping Xiong, Yaqin Wang, Hanchun Huang, Jin Bian, Anqiang Wang, Junyu Long, Ying Zheng, Xinting Sang, Yiyao Xu, Xin Lu, Haitao Zhao
Studies have reported that cholecystectomy may increase the risk of cholangiocarcinoma. However, this association is controversial. Thus, we conducted a systematic review and meta-analysis to explore the relationship between cholecystectomy and the risk of cholangiocarcinoma. Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science published before February 2017. We used the random effects model proposed by DerSimonian and Laird to quantify the relationship between cholecystectomy and risk of cholangiocarcinoma...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938667/lncrnas-as-prognostic-molecular-biomarkers-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#20
Chuqian Zheng, Xiuxia Liu, Leifeng Chen, Zheng Xu, Jianghua Shao
The latest studies have shown that long non-coding RNAs (lncRNAs) may be considered markers as their expression levels were abnormal in cancer and can be used as a molecular biomarker for the potential assessment of cancer prognosis. In this study, we aimed to assess the prognostic value of lncRNA as marker of patients with hepatocellular carcinoma. We performed a detailed search of the PubMed and Embase databases for articles on the prognostic value of various lncRNAs in HCC. We then carefully extracted the relevant data from the articles, and we used the meta-analysis method to analyze these results; heterogeneity and publication bias were also evaluated...
August 29, 2017: Oncotarget
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